Character of somatic and psycho-emotional disorders in children with various types of juvenile arthritis

Rheumatic diseases in children are a source of serious medical, social, and personal problems due to the prevalence, and severity of pain syndrome, progressive course with involvement of internal organs and disorders in the psycho-emotional sphere in the pathological process. The nature of somatic and psycho-emotional disorders was studied in 70 children aged 7 years - 16 years old with various types of Juvenile Rheumatoid Arthritis (JRA). The severe course of the disease, and as a result, disability, leads to emotional instability and social maladjustment of children. The predominance of articular forms with a primary lesion of the joints of the lower extremities and their deformation was remarkable. In children with a systemic variant of JRA, kidney damage was detected in the form of urinary syndrome and tubulointerstitial nephritis. Headache was the leading clinical manifestation of autonomic disorders caused by vascular disorders.</p

Parkinson’s disease dementia and dementia with lewy bodies differences and similarities

The second most common neurodegenerative disease causing dementia in the population over 65 years is Parkinson´s Disease Dementia (PDD), sharing many clinical, genetic, pathophysiological, imaging, and morphological features with Dementia with Lewy Bodies (DLB). There is an ongoing debate whether these two diseases are separate diseases, just different phenotypes on the basis of the same Lewy Body pathology or the same disease. The differences are rather few and many authors tend to believe that PDD and DLB may be manifestations of the same neurodegenerative disorder.Based on a single examination, without regard to the temporal sequence of events, it is difficult or impossible to differentiate a single patient with parkinsonism as PDD or DLB. The relative timing when cognitive and motor symptoms appear, applying the 1-year rule, could be helpful in clinical practice in distinguishing the diseases. The subtle differences are hard to observe with more executive problems in PDD and a tendency of more easily triggered psychotic problems in DLB. Eventually, PDD and DLB might be the same disease - as long as unquestionable biomarkers definitely distinguishing both entities are not found.</p

The activity of crude bromoacetyl-L-carnitine preparations against Trypanosoma brucei and the roles of threonine/pyruvate in non-hexose/glycerol ATP production

The Trypanosoma brucei group trypanosomes (Trypanosoma brucei gambiense and Trypanosoma brucei rhodesiense) cause an invariably fatal disease in humans, and Trypanosoma brucei brucei a fatal disease in cattle, if left untreated [1].&nbsp;</p

About the connection of the electron binding energy of a single carbon anion with binding energies of an electron attached to carbon molecules

We demonstrate that the model of zero-range potentials can be successfully employed for the description of attached electrons in atomic and molecular anions, for example, negatively charged carbon clusters. To illustrate the capability of the model we calculate the energies of the attached electron for the family of carbon cluster anions consisting of two-, three- (equilateral triangle) and four (tetrahedron) carbon atoms equidistant from each other as well as for a C3 molecule having a chain structure. The considered approach can be easily extended to carbon clusters containing an arbitrary number of atoms arranged in an arbitrary configuration.</p

A remark on a perturbed Benjamin-Bona-Mahony type equation and its complete integrability

In the Letter, we study a perturbed Benjamin-Bona-Mahony nonlinear equation, which was derived for describing shallow water waves and possessing a rich Lie symmetry structure. Based on the gradient-holonomic integrability checking scheme applied to this equation, we have analytically constructed its infinite hierarchy of conservation laws, derived two compatible Poisson structure and stated its complete integrability.</p

Determinism and chaos – a story about Big Bang, singularity and the future of mankind

People have always tried to understand and tame the nature around them. It is a well-known fact that the sanest and safe approach from a psychological point of view is to focus on the present moment, the here and now. Nevertheless, we keep looking and living in the past or daydreaming and making predictions about what the future will bring. This paper is looking at this topic trying to unify several perspectives, stemming from a very diverse set of disciplines: biology, genetics, economics and cryptography, which are apparently working in parallel to solve the same problem. They all aim to find a theory of everything, one that can make sense out of chaos, light out of darkness and that can accurately predict the future based on present and past events. The current paper is supposed to inspire researchers to ask themselves tough questions, sometimes completely outside of their comfort zone, that can lead to discoveries with a huge positive impact on us all.</p

Polyamine catabolism via spermine oxidase in the pathogenesis and treatment of hyperglycemia and diabetes mellitus-A short discussion

Diabetes mellitus can be described as chronic, endocrine dysfunction of pathophysiological regulation related to glucose and insulin. Hyperglycemia is the most common and intensely related complication of this dysfunction and has countless methods of pathogenicity. Hyperglycemia has the ability to exacerbate a degenerative positive feedback loop within critical tissues. Considering the fact that pancreatic hormonal regulation has played an increasingly considerable role in serum glucose homeostasis, here we begin a discussion into the implication of polyamine catabolism as a pathway with a mechanism that would contribute considerably to the necrosis and dysfunction of islet cells in the pancreas. The pathogenicity of this mechanism focuses on how the sustained increase in free radical production by hyperglycemic induction extenuates several complications in diabetes mellitus. The oxidation of spermine to spermidine produces hydrogen peroxide, as well as 3-aminopropanol (which spontaneously converts to acrolein) and spermidine (the precursor for the substrate of this reaction). This increase in reactive oxygen species exhibits the ability to inhibit autophagy and apoptosis as well as stimulate fat necrosis within the cells of the pancreas. Considering the islet cells of the pancreas play an extremely important role in glucose homeostasis, small changes in concentrations of these ROS are able to eliminate large regulatory factors while going undetected in the analysis of disease processes and therapeutics.&nbsp;</p

Confirm that the imaginary number i is a closed field

In the History of mathematics of mankind, some strange symbols appeared when dealing with some mathematical problems, which were defined as imaginary numbers by mankind. The imaginary number has been idle for a long time since it was discovered. Later, mathematicians such as Gauss moved the imaginary number to the mathematical plane (Complex plane).Humans have also learned the difference between imaginary and real numbers, and have obtained the difference between the two types of numbers on the square root.My contribution is to discover the inconsistency between real and imaginary numbers.I have discovered a new method of calculating imaginary number logic that is deeply hidden.2020 Mathematics Subject Classification: 03G27, 03F07, 03D45, 11U09, 08A05, 08A40.&nbsp;</p

Two methods for determining combinatorial identities

Two methods are presented for determining advanced combinatorial identities. The first is based on extending the original identity so that it can be expressed in terms of hypergeometric functions whereupon tabulated values of the functions can be used to reduce the identity to a simpler form. The second is a computer method based on Koepf's version of the Wilf-Zeilberger approach that has been implemented in a suite of intrinsic routines in Maple. As a consequence, some new identities are presented.&nbsp;</p

Experimental and theoretical studies of the influence of the bench elements on the transient operation of the turbine

The energy parameters obtained during the tests of turbines of power units on the stand differ from those in the product. The research data, which results are presented in the materials of the paper, are aimed at analyzing the discrepancies between the parametric indicators of power units and bench tests of the turbines. The novelty of the obtained results reveals the direct and inverse relationship of changes in the amplitude-frequency characteristics of the elements of the stand (depending on the realized turbine power) with the obtained results of measuring the turbine power on the stand. We developed and described an algorithm for constructing dynamic analysis during the formation of the wave field of the test bench for turbines both in transient modes and in stationary modes corresponding to a constant number of turbine revolutions. It is shown that, by using the algorithm of modal deduction and conditions of dynamic excitation of vibrations from the tested turbine with elements of studying its power, it is possible to construct transients with certain reliability when the number of revolutions of the turbine changes, i.e. its power. The diagnostic model has a novelty since it allows not only to assess of the influence of the elements of the stand on the nature of the transient process when measuring turbine power in transient modes, taking into account the frequency adjustment when changing the revolutions of the turbine and the elements of the stand but also to form requirements for the frequency tuning of the stand. To clarify the transfer function of the "stand–turbine" system, a modal analysis was applied, which made it possible to clarify the structure of the transfer function in the frequency range of the natural (partial) frequencies of the elements of the stand when the restructuring of the wave field during the transient operation of the turbine, but also when the turbine reaches the specified power.</p