Imaging Cognitive Impairment and Impulse Control Disorders in Parkinson's Disease

Dementia and mild forms of cognitive impairment as well as neuropsychiatric symptoms (i. e., impulse control disorders) are frequent and disabling non-motor symptoms of Parkinson's disease (PD). The identification of changes in neuroimaging studies for the early diagnosis and monitoring of the cognitive and neuropsychiatric symptoms associated with Parkinson's disease, as well as their pathophysiological understanding, are critical for the development of an optimal therapeutic approach. In the current literature review, we present an update on the latest structural and functional neuroimaging findings, including high magnetic field resonance and radionuclide imaging, assessing cognitive dysfunction and impulse control disorders in PD

O mercado de produtos de oliveiral en España: Situación actual e perspectivas

Traballo de Fin de Grao en Administración e Dirección de Empresas. Curso 2014-2015No presente traballo lévase a cabo un estudo de mercado dos produtos do sector do oliveiral en España. O obxetivo principal é o de amosar as oportunidades e as inclinacións deste sector na actualidade, realizando para iso unha análise dende o punto de vista da oferta e da demanda e obtendo información de fontes secundarias.En primeiro lugar, faise unha análise polo lado da oferta, tendo en conta a produción e as vendas netas do total do sector e das subcategorías de produto, así como a súa evolución con respecto ás campañas pasadas. Amósanse os datos das principais macromagnitudes, é dicir, das hectáreas que se destinan ao oliveiral e das empresas que se adican ao dito sector. Estúdase a situación da Balanza Comercial e dos principais axentes fabricantes e distribuidores que interveñen no proceso.En segundo lugar, a análise realízase polo lado da demanda, facendo un estudo do consumo e do gasto dos españois en termos totais e per cápita, tanto para o total do sector como para as subcategorías de produto, a nivel nacional e por Comunidades Autónomas. Analízase o peso que teñen as subcategorías de produto dentro do sector e o peso que ten o sector do oliveiral dentro do total da alimentación. Ademais analízanse as novas inclinacións na compra dos consumidores españois e o gasto entre os distintos produtos do sector olíveo. A continuación realízase un estudo para identificar aqueles segmentos de mercado potenciais, tendo en conta os diferentes perfís socioeconómicos españois. Tamén se presentan as denominacións de orixe coas que conta España na actualidade, tanto en aceite de oliva como en olivas de mesa. Por último, amósase unha análise DAFO, co que se procura plasmar a situación actual do sector do oliveiral

The influence of lifestyles to cope with stress over mental health in pregnant and postpartum women during the COVID-19 pandemic

The COVID-19 pandemic afected daily life routines and lifestyles of pregnant and postpartum women and increased their stress and risk of sufering from mental health problems. The aim of this study was to analyse which sociodemographic variables, COVID-19 exposure variables and lifestyles to cope with stress variables predicted anxiety, depression, and PTSD symptoms in pregnant and postpartum women during the COVID-19 pandemic. A cross-sectional design was performed with a sample of 3356 Spanish women participating in the Riseup-PPD-COVID-19 study. These participants completed an online survey composed of measures of anxiety (GAD-7), depression (EPDS), and PTSD related to COVID-19 (Checklist DSM-5), as well as demographics, exposure to COVID-19, and lifestyles to cope with stress. Regarding results, 47.2% showed depression and a third reported anxiety, whereas moderate scores were observed in PTSD symptoms. The most commonly used strategies to cope with stress in the COVID-19 pandemic were talking with friends and family and increasing time with social networks. Better results in mental health were associated with coping strategies such as talking with family and friends or participating in family activities, physical activity, sleeping well at night, eating healthier, and increasing personal care. Furthermore, poor results in mental health were observed in those participants who increased time with screens, ate fast food, reported substance use, and talked more frequently with health professionals. More symptoms were also observed in younger women, primiparous women, and those who reported more exposure to COVID-19. The results underline the need to strengthen the mental health of pregnant and postpartum women

Associations between sedentary time, physical activity and bone health among older people using compositional data analysis

Introduction : Aging is associated with a progressive decrease in bone mass (BM), and being physical active is one of the main strategies to combat this continuous loss. Nonetheless, because daily time is limited, time spent on each movement behavior is co-dependent. The aim of this study was to determine the relationship between BM and movement behaviors in elderly people using compositional data analysis. Methods : We analyzed 871 older people [395 men (76.9 +/- 5.3y) and 476 women (76.7 +/- 4.7y)]. Time spent in sedentary behavior (SB), light physical activity (LPA) and moderate-to-vigorous physical activity (MVPA), was assessed using accelerometry. BM was determined by bone densitometry (DXA). The sample was divided according to sex and bone health indicators. Results : The combined effect of all movement behaviors (PA and SB) was significantly associated with whole body, leg and femoral region BM in the whole sample (p<0.05), with leg and pelvic BM (p<0.05) in men and, with whole body, arm and leg BM (p<0.05) in women. In men, arm and pelvic BM were negatively associated with SB and whole body, pelvic and leg BM were positively associated with MVPA (p<0.05). In women, whole body and leg BM were positively associated with SB. Arm and whole body BM were positively associated and leg BM was negatively associated with LPA and arm BM was negatively associated with MVPA (p<0.05). Women without bone fractures spent less time in SB and more in LPA and MVPA than the subgroup with bone fractures. Conclusion : We identified that the positive effect of MVPA relative to the other behaviors on bone mass is the strongest overall effect in men. Furthermore, women might decrease bone fracture risk through PA increase and SB reduction, despite the fact that no clear benefits of PA for bone mass were found

The agenda for integral urban development in Spain (1994-2013)

Desde los años noventa la Unión Europea viene desarrollando programas e iniciativas de intervención integral con el objetivo de promover el desarrollo urbano, en general, y reducir los procesos de desigualdad socioespacial en las ciudades, en particular. En buena medida estas políticas han ido generando un conjunto de prácticas que vienen redundando en la progresiva elaboración de una estrategia para las áreas urbanas en Europa, a la que suele denominarse, ‘agenda urbana’ (Comisión Europea, 2014). Pero, ¿cuál ha sido la agenda promovida por los proyectos desarrollados durante las dos últimas décadas?, o de otra forma, ¿cuál ha sido la experiencia que permitiría ir definiendo una agenda urbana para las ciudades españolas?. En este trabajo presentamos un ejercicio básico para tratar de responder a estas cuestiones mediante el análisis de los proyectos desarrollados en el marco de los programas URBAN y URBANA en España (1994-2013).Since the 1990s, the European Union has launched comprehensive programs and initiatives that promote integrated urban development, the goal being improved urban development, in general, and a reduction of socio spatial inequalities in cities, in particular. The policies generated as a result of these programs and initiatives have shaped a European strategy that promotes integrated urban development, the so-called “urban agenda”. But, what in fact is the agenda that has been promoted by these initiatives during the last two decades? And, what are the experiences that would help define an urban agenda for Spanish cities? This article presents a basic analysis to respond to these questions, analyzing projects done in the framework of URBAN and URBANA programs in Spain (1994-2013)

Cross-sectional and prospective associations of sleep, sedentary and active behaviors with mental health in older people: a compositional data analysis from the Seniors-ENRICA-2 study

Abstract Background Most studies on the effects of sleep, sedentary behavior (SB), and physical activity (PA) on mental health did not account for the intrinsically compositional nature of the time spent in several behaviors. Thus, we examined the cross-sectional and prospective associations of device-measured compositional time in sleep, SB, light PA (LPA) and moderate-to-vigorous PA (MVPA) with depression symptoms, loneliness, happiness, and global mental health in older people (≥ 65 years). Methods Data were taken from the Seniors-ENRICA-2 study, with assessments in 2015–2017 (wave 0) and 2018–2019 (wave 1). Time spent in sleep, SB, LPA and MVPA was assessed by wrist-worn accelerometers. Depression symptoms, loneliness, happiness, and global mental health were self-reported using validated questionnaires. Analyses were performed using a compositional data analysis (CoDA) paradigm and adjusted for potential confounders. Results In cross-sectional analyses at wave 0 (n = 2489), time-use composition as a whole was associated with depression and happiness (all p < 0.01). The time spent in MVPA relative to other behaviors was beneficially associated with depression (γ = -0.397, p < 0.001), loneliness (γ = -0.124, p = 0.017) and happiness (γ = 0.243, p < 0.001). Hypothetically, replacing 30-min of Sleep, SB or LPA with MVPA was beneficially cross-sectionally related with depression (effect size [ES] ranged -0.326 to -0.246), loneliness (ES ranged -0.118 to -0.073), and happiness (ES ranged 0.152 to 0.172). In prospective analyses (n = 1679), MVPA relative to other behaviors at baseline, was associated with favorable changes in global mental health (γ = 0.892, p = 0.049). We observed a beneficial prospective effect on global mental health when 30-min of sleep (ES = 0.521), SB (ES = 0.479) or LPA (ES = 0.755) were theoretically replaced for MVPA. Conclusions MVPA was cross-sectionally related with reduced depression symptoms and loneliness and elevated level of happiness, and prospectively related with enhanced global mental health. Compositional isotemporal analyses showed that hypothetically replacing sleep, SB or LPA with MVPA could result in modest but significantly improvements on mental health indicators. Our findings add evidence to the emerging body of research on 24-h time-use and health using CoDA and suggest an integrated role of daily behaviors on mental health in older people

Carbon-based nanomaterials for gold (III) recovery: kinetics and loading investigations

Currently, the development of different smart technology to recover or eliminate strategic or toxic metals from liquid effluent is constant. Among the different process developed to the treatment of liquid effluents bearing these types of metallic elements, include chemical or electrochemical precipitation, membrane based technology, ion exchange and adsorption. Adsorption is a high efficiency, cost-effectiveness and easily handing method to recover pollutants or strategic metals. Nowadays a research challenge is the development of new adsorbents. Among nanomaterials, carbon nanomaterials have adequate properties to be used as metal adsorbent. On the other hand gold is one of the most precious elements in the world. The price in 2015 of this strategic metal is 1.376 $/kg. Besides its uses in jewellery it is highly used in different industries, so it is important the gold recovery from liquid effluents generated from these various industries. The adsorption method is a way to treat these types of effluents, characterized for their low gold concentration. The aim of this research was to optimize various operational parameters, and thus obtain efficient carbon nanotubes processing for gold (III)-bearing effluents. The adsorption of gold (III) by carbon nanofibers (CNF), carbon multiwalled (MWCN) and carbon multiwalled with carboxyl group (MWCN_ox) systems were investigated. The experimental parameters which may influence gold adsorption were investigated, i.e. stirring speed of the aqueous solutions, adsorbent dosage, acid concentration, temperature etc. Figure 1 shows the effect of the acid concentration on the Au(III) adsorption to the three adsorbent. It can be seen that the adsorption Au(III) decreases with the increase of HCl concentration. Probalby it is due the existence of other gold species, such as HAuCl4, at the higher hydrochloric solution against the presence of the predominant AuCl4- species in the more dilute HCl solutions which are more adsorbable than the gold-acid form. SEM studies of gold loaded carbon nanomaterials show on the surface dark particles, Figure 2. The EDS of the dark particles show two peaks for Lα(9.7 keV) and Mα (2.1 keV) characteristic of metallic gold. Probably this reduction occurs on the carbon surface, related with the metal reduction. The isotherm and kinetic studies of the carbon nanomaterial-Au(III) system show a different behavior in function of the carbon nanomaterial used as adsorbent. The experimental data obtained using the MWCNT and CNF fit better to a pseudo second order equation and an isotherm Freundlich model. The three carbon nanomaterials, appeared to be a promising material for recovery of Au(III) from this type of acid solutions in the optimal experimental for each one of them condition.Peer reviewe

Diagnosing Business Processes Execution using Choreography Analysis

This work presents a proposal to diagnose business processes that form a global process using a choreography analysis. The diagnosis is based on distributed diagnosis since the business process is formed by a process orchestrations modelled by a set of activities. These business processes have two different types of activities, with internal and external interaction. In this paper the knowledge of the whole business process is divided in different processes. In means that each user has a local point of view of the information of the organization, it also happens in distributed system, where neither agent has global information of how the system is modelled. This work propose a methodology to diagnose the business processes, analyzing only the interactions between the activities of different processes. In order to perform the fault detection for business processes, an algorithm has been defined based on distributed diagnosis. Also some definitions about model-based diagnosis have been redefined to be adapted to business processes diagnosis.Ministerio de Educación y Ciencia DIP2006-15476-C02-0

Measuring depression in Primary Health Care in Spain : Psychometric properties and diagnostic accuracy of HSCL-5 and HSCL-10

Depression has a high prevalence among European countries. Several instruments have been designed to assess its symptoms in different populations. The Hopkins Symptom Checklist 25 (HSCL-25) scale has been identified as valid, reproducible, effective, and easy to use. There are short versions of this scale that could be useful in Primary Care (PC) settings, but their psychometric properties are unknown. To assess in PC patients the psychometric properties and diagnostic accuracy of the Spanish version of the HSCL-10 and the HSCL-5 consisting of 10 and 5 items, respectively. A multicenter, cross-sectional study was carried out at six PC centers in Spain. The HSCL-25 was administered to outpatients aged 45-75 who also participated in the structured Composite International Diagnostic Interview (CIDI). HSCL-10 and HSCL-5 were assessed and compared to HSCL-25 regarding total score correlation, internal consistency, and criterion validity against the gold-standard CIDI. This is a methodological study from a secondary data analysis and the primary data has been previously published. Out of 790 patients, 767 completed the HSCL-25 and 736 the CIDI interview (96.0%). Cronbach's Alpha was 0.84 for HSCL-10 and 0.77 for HSCL-5. The known-group method and confirmatory factor analysis were acceptable for the establishment of construct validity. Sensitivity was 79.7% (CI95%, 67.7-88.0%) for HSCL-10, and 78.0% (CI95%, 65.9-86.6%) for HSCL-5, whereas specificity was 83% (CI95%, 80.0-85.7%) for HSCL-10, and 72.8% (CI95%, 69.3-76.0%) for HSCL-5. Area under the curve against CIDI was 0.88 (CI95%, 0.84-0.92%) for HSCL-10, and 0.85 (CI95%, 0.81-0.89%) for HSCL-5. Optimum cutoff point calculated with Youden Index was 1.90 for the HSCL-10 and 1.80 for the HSCL-5. HSCL-10 and HSCL-5 are reliable and valid tools to detect depression symptoms and can be used in PC settings

Functional correlates of response inhibition in impulse control disorders in Parkinson’s disease

Available online 11 September 2021.Impulse control disorder is a prevalent side-effect of Parkinson’s disease (PD) medication, with a strong negative impact on the quality of life of those affected. Although impulsivity has classically been associated with response inhibition deficits, previous evidence from PD patients with impulse control disorder (ICD) has not revealed behavioral dysfunction in response inhibition. In this study, 18 PD patients with ICD, 17 PD patients without this complication, and 15 healthy controls performed a version of the conditional Stop Signal Task during functional magnetic resonance imaging. Whole-brain contrasts, regions of interest, and functional connectivity analyses were conducted. Our aim was to investigate the neural underpinnings of two aspects of response inhibition: proactive inhibition, inhibition that has been prepared beforehand, and restrained inhibition, inhibition of an invalid inhibitory tendency. We observed that, in respect to the other two groups, PD patients with ICD exhibited hyperactivation of the stopping network bilaterally while performing proactive inhibition. When engaged in restrained inhibition, they showed hyperactivation of the left inferior frontal gyrus, an area linked to action monitoring. Restrained inhibition also resulted in changes to the functional co-activation between inhibitory regions and left inferior parietal cortex and right supramarginal gyrus. Our findings indicate that PD patients with ICD completed the inhibition task correctly, showing altered engagement of inhibitory and attentional areas. During proactive inhibition they showed bilateral hyperactivation of two inhibitory regions, while during restrained inhibition they showed additional involvement of attentional areas responsible for alerting and orienting.This work was supported by grants from the Carlos III Institute of Health (PI11/02109) and the ERA-Neuron program (PIM2010ERN- 0033). Additionally, the authors received the following grants and honoraria: T.E.-P. received a grant from the Spanish Ministry of Economy and Competitiveness (BES-2016-079489). P.M.P.-A. was supported by grants from the Spanish Ministry of Economy and Competitiveness (RYC-2014-15440), the Spanish Ministry of Science and Innovation (PGC2018-093408-B-I00), and the Fundación Tatiana Pérez de Guzmán el Bueno. I.N.-G. was the recipient of a Rio Hortega grant (CM16/00033) from the Carlos III Institute of Health. I.N.-G. received honoraria from Zambon and TEVA for travel and accommodation to attend scientific meetings. M.C.R.-O. received financial support for her research from national and local government institutions in Spain (Carlos III Institute of Health, Basque Country Government, Diputacion Foral Guipuzcoa, and CIBERNED). M.C.R.-O. received honoraria from Zambon, Bial, and Boston Scientific for lectures, travel, and accommodation to attend scientific meetings. BCBL acknowledges support from the Basque Government through the BERC 2018-2021 program