3,704 research outputs found
High-Responsivity Graphene-Boron Nitride Photodetector and Autocorrelator in a Silicon Photonic Integrated Circuit
Graphene and other two-dimensional (2D) materials have emerged as promising
materials for broadband and ultrafast photodetection and optical modulation.
These optoelectronic capabilities can augment complementary
metal-oxide-semiconductor (CMOS) devices for high-speed and low-power optical
interconnects. Here, we demonstrate an on-chip ultrafast photodetector based on
a two-dimensional heterostructure consisting of high-quality graphene
encapsulated in hexagonal boron nitride. Coupled to the optical mode of a
silicon waveguide, this 2D heterostructure-based photodetector exhibits a
maximum responsivity of 0.36 A/W and high-speed operation with a 3 dB cut-off
at 42 GHz. From photocurrent measurements as a function of the top-gate and
source-drain voltages, we conclude that the photoresponse is consistent with
hot electron mediated effects. At moderate peak powers above 50 mW, we observe
a saturating photocurrent consistent with the mechanisms of electron-phonon
supercollision cooling. This nonlinear photoresponse enables optical on-chip
autocorrelation measurements with picosecond-scale timing resolution and
exceptionally low peak powers
Blood salvage device for use during ruptured ectopic pregnancy in lowâresource countries
Peer Reviewedhttp://deepblue.lib.umich.edu/bitstream/2027.42/135522/1/ijgo74.pd
Quercetin 3-Glucoside Protects Neuroblastoma (SH-SY5Y) Cells in Vitro against Oxidative Damage by Inducing Sterol Regulatory Element-binding Protein-2-mediated Cholesterol Biosynthesis
The flavonoid quercetin 3-glucoside (Q3G) protected SH-SY5Y, HEK293, and MCF-7 cells against hydrogen peroxide-induced oxidative stress. cDNA microarray studies suggested that Q3G-pretreated cells subjected to oxidative stress up-regulate the expression of genes associated with lipid and cholesterol biosynthesis. Q3G pretreatment elevated both the expression and activation of sterol regulatory element-binding protein-2 (SREBP-2) only in SH-SY5Y cells subjected to oxidative stress. Inhibition of SREBP-2 expression by small interfering RNA or small molecule inhibitors of 2,3-oxidosqualene:lanosterol cyclase or HMG-CoA reductase blocked Q3G-mediated cytoprotection in SH-SY5Y cells. By contrast, Q3G did not protect either HEK293 or MCF-7 cells via this signaling pathway. Moreover, the addition of isopentenyl pyrophosphate rescued SH-SY5Y cells from the inhibitory effect of HMG-CoA reductase inhibition. Last, Q3G pretreatment enhanced the incorporation of [(14)C]acetate into [(14)C]cholesterol in SH-SY5Y cells under oxidative stress. Taken together, these studies suggest a novel mechanism for flavonoid-induced cytoprotection in SH-SY5Y cells involving SREBP-2-mediated sterol synthesis that decreases lipid peroxidation by maintaining membrane integrity in the presence of oxidative stress
Weak Interaction Studies with 6He
The 6He nucleus is an ideal candidate to study the weak interaction. To this
end we have built a high-intensity source of 6He delivering ~10^10 atoms/s to
experiments. Taking full advantage of that available intensity we have
performed a high-precision measurement of the 6He half-life that directly
probes the axial part of the nuclear Hamiltonian. Currently, we are preparing a
measurement of the beta-neutrino angular correlation in 6He beta decay that
will allow to search for new physics beyond the Standard Model in the form of
tensor currents.Comment: 5 pages, 4 figures, proceedings for the Eleventh Conference on the
Intersections of Particle and Nuclear Physics (CIPANP 2012
A massive proto-cluster of galaxies at a redshift of z {\approx} 5.3
Massive clusters of galaxies have been found as early as 3.9 Billion years
(z=1.62) after the Big Bang containing stars that formed at even earlier
epochs. Cosmological simulations using the current cold dark matter paradigm
predict these systems should descend from "proto-clusters" - early
over-densities of massive galaxies that merge hierarchically to form a cluster.
These proto-cluster regions themselves are built-up hierarchically and so are
expected to contain extremely massive galaxies which can be observed as
luminous quasars and starbursts. However, observational evidence for this
scenario is sparse due to the fact that high-redshift proto-clusters are rare
and difficult to observe. Here we report a proto-cluster region 1 billion years
(z=5.3) after the Big Bang. This cluster of massive galaxies extends over >13
Mega-parsecs, contains a luminous quasar as well as a system rich in molecular
gas. These massive galaxies place a lower limit of >4x10^11 solar masses of
dark and luminous matter in this region consistent with that expected from
cosmological simulations for the earliest galaxy clusters.Comment: Accepted to Nature, 16 Pages, 6 figure
A structured collaborative approach to intervention design using a modified intervention mapping approach: a case study using the Management and Interventions for Asthma (MIA) project for South Asian children
Background:
To describe how using a combined approach of community-based participatory research and intervention mapping principles could inform the development of a tailored complex intervention to improve management of asthma for South Asian (SA) children; Management and Interventions for Asthma (MIA) study.
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Methods:
A qualitative study using interviews, focus groups, workshops, and modified intervention mapping procedures to develop an intervention planning framework in an urban community setting in Leicester, UK. The modified form of intervention mapping (IM) included: systematic evidence synthesis; community study; families and healthcare professionals study; and development of potential collaborative intervention strategies. Participants in the community study were 63 SA community members and 12 key informants; in-depth semi-structured interviews involved 30 SA families, 14 White British (WB) families and 37 Healthcare Professionals (HCPs) treating SA children living with asthma; prioritisation workshops involved 145 SA, 6 WB and 37 HCP participants; 30 participants in finalisation workshops.
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Results:
Two key principles were utilised throughout the development of the intervention; community-based participatory research (CBPR) principles and intervention mapping (IM) procedures. The CBPR approach allowed close engagement with stakeholders and generated valuable knowledge to inform intervention development. It accounted for diverse perceptions and experiences with regard to asthma and recognised the priorities of patients and their families/caregivers for service improvement. The âACT on Asthmaâ programme was devised, comprising four arms of an intervention strategy: education and training, clinical support, advice centre and raising awareness, to be co-ordinated by a central team.
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Conclusions:
The modified IM principles utilised in this study were systematic and informed by theory. The combined IM and participatory approach could be considered when tailoring interventions for other clinical problems within diverse communities. The IM approach to intervention development was however resource intensive. Working in meaningful collaboration with minority communities requires specific resources and a culturally competent methodology
Engineering high charge transfer n-doping of graphene electrodes and its application to organic electronics.
Using thermally evaporated cesium carbonate (Cs2CO3) in an organic matrix, we present a novel strategy for efficient n-doping of monolayer graphene and a âŒ90% reduction in its sheet resistance to âŒ250 Ohm sq(-1). Photoemission spectroscopy confirms the presence of a large interface dipole of âŒ0.9 eV between graphene and the Cs2CO3/organic matrix. This leads to a strong charge transfer based doping of graphene with a Fermi level shift of âŒ1.0 eV. Using this approach we demonstrate efficient, standard industrial manufacturing process compatible graphene-based inverted organic light emitting diodes on glass and flexible substrates with efficiencies comparable to those of state-of-the-art ITO based devices.Funding via EU FP7 programme Grafol (Grant No. 285275) and EPSRC programme GRAPHTED (Grant No. EP/K016636/1) is acknowledged. P.R.K. acknowledges the Lindemann Trust Fellowship. J.A.A.-W. acknowledges a Research Fellowship from Churchill College, Cambridge. A.C.V. acknowledges the Conacyt Cambridge Scholarship and Roberto Rocca Fellowship.This is the author accepted manuscript. The final version is available from the Royal Society of Chemistry via http://dx.doi.org/10.1039/C5NR03246
Deep, ultra-high-resolution radio imaging of submillimetre galaxies using Very Long Baseline Interferometry
We present continent-scale VLBI - obtained with the European VLBI Network
(EVN) at a wavelength of 18cm - of six distant, luminous submm-selected
galaxies (SMGs). Our images have a synthesized beam width of ~30 milliarcsec
FWHM - three orders of magnitude smaller in area than the highest resolution
VLA imaging at this wavelength - and are capable of separating radio emission
from ultra-compact radio cores (associated with active super-massive black
holes - SMBHs) from that due to starburst activity. Despite targeting compact
sources - as judged by earlier observations with the VLA and MERLIN - we
identify ultra-compact cores in only two of our targets. This suggests that the
radio emission from SMGs is produced primarily on larger scales than those
probed by the EVN, and therefore is generated by star formation rather than an
AGN - a result consistent with other methods used to identify the presence of
SMBHs in these systems.Comment: MNRAS, in pres
Very High Gas Fractions and Extended Gas Reservoirs in z=1.5 Disk Galaxies
We present evidence for very high gas fractions and extended molecular gas
reservoirs in normal, near-infrared selected (BzK) galaxies at z~1.5, based on
multi-configuration CO[2-1] observations obtained at the IRAM PdBI. Six of the
six galaxies observed were securely detected. High resolution observations
resolve the CO emission in four of them, implying sizes of order of 6-11 kpc
and suggesting the presence of rotation. The UV morphologies are consistent
with clumpy, unstable disks, and the UV sizes are consistent with the CO sizes.
The star formation efficiencies are homogeneously low and similar to local
spirals - the resulting gas depletion times are ~0.5 Gyr, much higher than what
is seen in high-z submm galaxies and quasars. The CO luminosities can be
predicted to within 0.15 dex from the star formation rates and stellar masses,
implying a tight correlation of the gas mass with these quantities. We use
dynamical models of clumpy disk galaxies to derive dynamical masses. These
models are able to reproduce the peculiar spectral line shapes of the CO
emission. After accounting for the stellar and dark matter masses we derive gas
masses of 0.4-1.2x10^11 Msun. The conversion factor is very high:
alpha_CO=3.6+-0.8, consistent with the Galaxy but four times higher than that
of local ultra-luminous IR galaxies. The gas accounts for an impressive 50-65%
of the baryons within the galaxies' half light radii. We are witnessing truly
gas-dominated galaxies at z~1.5, a finding that explains the high specific SFRs
observed for z>1 galaxies. The BzK galaxies can be viewed as scaled-up versions
of local disk galaxies, with low efficiency star formation taking place inside
extended, low excitation gas disks. They are markedly different than local
ULIRGs and high-z submm galaxies, which have more excited and compact gas.Comment: Accepted for publication in Astrophysical Journal, 22 pages, 18
figures, minor revision
Magnetism and transport in transparent high-mobility BaSnO3 films doped with La, Pr, Nd, and Gd
We have explored the effect of magnetic rare-earth dopants substitutionally incorporated on the Ba sites of BaSnO3 in terms of electronic transport, magnetism, and optical properties. We show that for Ba0.92R0.08SnO3 thin films (where R=La,Pr,Nd,Gd), there is a linear increase of mobility with carrier concentration across all doping schemes. La-doped films have the highest mobilities, followed by Pr- and Nd-doped films. Gd-doped samples have the largest ionic size mismatch with the Ba site and correspondingly the lowest carrier concentrations and electron mobilities. However, crystallinity does not appear to be a strong predictor of transport phenomena; our results suggest that point defects more than grain boundaries are key ingredients in tuning the conduction of BaSnO3 films grown by pulsed laser deposition. Pronounced, nonhysteretic x-ray magnetic dichroism signals are observed for Pr-, Nd-, and Gd-doped samples, indicating paramagnetism. Finally, we probe the optical constants for each of the BaSnO3 doping schemes and note that there is little change in the transmittance across all samples. Together these results shed light on conduction mechanisms in BaSnO3 doped with rare-earth cations
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