Designing wireframes as assessment in the study of adolescent mental health

Applications (apps) have become commonplace in the treatment of adolescent mental health problems. This study set out to explore whether it is possible to prepare undergraduate counselling students to use these professional tools, as part of an assessment regime. Using the software “Pencil Project” students enrolled in an undergraduate counselling degree were required to design wireframes for an app to support adolescent mental wellbeing. Evaluation methodology employing a concurrent quan-qual mixed method was used. Marks earned for student presentations of their wireframes, along with marker comments were analysed followed by a thematic analysis of student reflections of their learning experience. Students reported that this authentic learning approach to counselling constructs was innovative and positive. This positive engagement was reflected in student grades where all students earned a ‘pass’ or better and their reflections revealed the experience to be transformative. By sharing lessons learned this paper contributes to the literature in innovations in technology enhanced learning. While further iterations are required, it is hoped that this study provides the groundwork for those interested in pursuing the design of wireframes as a method to measure students’ application of knowledge

Estrés oxidativo en peces inducido por retardantes de flama bromados, una revisión

Background. Flame retardants are compounds that are applied as additives to various products in order to reduce fire risks, among the most used are brominated flame retardants (BFR) due to their cost and efficiency. These compounds can reach and impact aquatic environments; however, a review of oxidative stress in fish is lacking. Goals. To provide a review on the induction of oxidative stress in fish induced by brominated flame retardants and to contribute new lines of research. Methods. A Google Scholar search was carried out and thirty articles were considered according to the inclusion criteria. Results. Brominated flame retardants are capable of inducing reactive oxygen species, damage to cell membranes, proteins and DNA, as well as mo- difying the response of biomarkers related to antioxidant defence. It was also found in in vitro studies that a possible cause of oxidative stress induction by these compounds occurs through alterations in mitochondrial activity that cause increases in the production of reactive oxygen species. Conclusions. It is necessary to increase studies that consider BFR mixtures, particularly tetrabromobisphenol A and the new brominated flame retardants because their presence in the environment is likely due to the absence of regulatory restrictions on their use. Carry out studies with fish species with reduced geographical distribution due to their high susceptibility to pollutants. Use biomarkers that involve oxidative damage and antioxidant defences to obtain a broad panorama of these phenomena in the same study and contribute to other toxicological investigations that collaborate in the establishment of standards that control the release of these pollutants into the environment.Antecedentes. Los retardantes de flama son compuestos que se aplican como aditivos a diversos productos con el fin de reducir riesgos de incendios, entre los más usados se encuentran los retardantes de flama bromados (RFB) por su costo y eficiencia. Estos compuestos pueden alcanzar e impactar a los ambientes acuáticos; sin embargo, se carece de una revisión sobre el estrés oxidativo que ocasionan en los peces. Objetivos. Proveer una revisión sobre la inducción de estrés oxidativo en peces ocasionado por retardantes de flama bromados y aportar nuevas líneas de investigación. Métodos. Se realizó una búsqueda en Google Académico y se consideraron treinta artículos de acuerdo a los criterios de inclusión. Resultados. Los retardantes de flama bromados son capaces de inducir especies reactivas del oxígeno, daños en las membranas celulares, proteínas y en el ADN, así como modificar la respuesta de biomarcadores relacionados con la defensa antioxidante. También se encontró en estudios in vitro que una posible causa de inducción de es- trés oxidativo por estos compuestos ocurre a través de alteraciones en la actividad mitocondrial que causa incrementos en la producción de especies reactivas del oxígeno. Conclusiones. Es necesario incrementar estudios que consideren mezclas de RFB, particularmente, al tetrabromobisfenol A y a los nuevos retardantes de flama bromados debido a que su presencia en el ambiente es probable por la ausencia de restricciones normativas en su uso. Realizar estudios con especies de peces con reducida distribución geográfica por su alta susceptibilidad a contaminantes. Utilizar biomarcadores que involucren al daño oxidativo y a las defensas antioxidantes en un mismo estudio para obtener un panorama amplio de estos fenómenos y contribuir con otras investigaciones toxicológicas que colaboren al establecimiento de normas que controlen la liberación de estos contaminantes al ambiente

Caracterización litogeoquímica de los batolitos de Las Lomas y Noque en el departamento de Piura y su comparación con los batolitos de la Cordillera Blanca y Challaviento

[ESP] Las variedades litológicas predominantes de los dos batolitos son tonalita y granodiorita, provenientes de magmas félsicos. La relación SiO2 vs. Sm/Yb permite determinar que ambos son de la misma edad. Las rocas son de naturaleza subalcalina de las series calcoalcalinas de medio y alto potasio, con un carácter metaluminoso. Los diagramas de discriminación tectonomagmática indican que son granitos de arco volcánico. Los elementos traza y tierras raras también muestran características típicas de rocas asociadas a subducción. La profundidad de la fuente magmática es menor de 20 km y la ausencia de granate indica que no hay contaminación mantélica. Ambos provienen de magmas húmedos, el batolito Las Lomas es del tipo “I” y de la serie de la magnetita, asociado a elementos calcófilos y a la mineralización de Cu-Mo, el batolito Noque del tipo “S” y de la serie de la Ilmenita, asociado a elementos litófilos, y no cae en ningún campo de mineralización específica. Comparando a los batolitos, los del norte son calcoalcalinos de medio K, los del centro y sur son calcoalcalinos de alto K, presencia de granate en el centro y sur, y todos los granitoides son de naturaleza de arco volcánico. Los batolitos del norte caen en el campo de los anorogénicos y los del centro y sur de los campos de tipo “I” y “S”. Los granitos del norte la profundidad de su fuente magmática alcanza menos de 20 km, la Cordillera Blanca 60 km y Challaviento 40 km. Las edades varían desde las más antiguas Las Lomas, Noque, Challaviento y la más joven la Cordillera Blanca coincidiendo con las dataciones radiométricas.[ENG] The predominant lithological varieties of the two Batholiths are tonalite, granodiorite from felsic magmas. The SiO2 vs. Sm / Yb to determine that both are of the same age. The rocks are nature of subalkaline and calc-alkaline series of medium and high potassium with metaluminous character. Tectonomagmatic diagrams indicate that they are of volcanic arc granites. Trace elements and rare earth rocks also they show typical features associated with subduction. The depth of the magma source is less than 20 km and the absence of garnet mantle indicate no contamination mantle. Both come from wet magmas, the batholith Las Lomas is of the type “I” and the of magnetite series, associated with chalcophile elements and Cu-Mo mineralization, the Batholith Noque type “S” and the ilmenite series associatedlithophile elements, and does not fall into any specific field of mineralization. Comparing the batholith, the North are medium-K, calc-alkaline, the center and south are high-K calc-alkaline, the presence of garnet in the center and south, and all are nature of volcanic arc granitoids. North Batholiths fall into the field of anorogenic and the central and southern batholiths of type “I” and “S”. North granites depth of its source magma reaches less than 20 kilometers, the Cordillera Blanca Challaviento 60 Km and 40Km. The ages range from the oldest Las Lomas, Noque, Challaviento and the younger the Cordillera Blanca coinciding with radiometric dating

Synthesis of functionalized fluorescent silver nanoparticles and their toxicological effect in aquatic environments (Goldfish) and HEPG2 cells

Silver nanoparticles, AgNPs, are widely used in our daily life, mostly due to their antibacterial, antiviral, and antifungal properties. However, their potential toxicity remains unclear. In order to unravel this issue, emissive AgNPs were first synthetized using an inexpensive photochemical method, and then their permeation was assessed in vivo in goldfish and in vitro in human hepatoma cells (HepG2). In addition, the oxidative stress caused by AgNPs was assessed in enzymes such as glutathione-S-transferase (GST), catalase (CAT), and in lipid peroxidation (LPO). This study demonstrates that the smallest sized AgNPs@ 3 promote the largest changes in gold fish livers, whereas AgNPs@ 1 were found to be toxic in HEPG2 cells depending on both the size and functionalized/stabilizer ligand

Prevalence estimation of significant fibrosis because of NASH in Spain combining transient elastography and histology

Acord transformatiu CRUE-CSICBackground & Aims: Non-alcoholic fatty liver disease (NAFLD) has become a major public health problem, but the prevalence of fibrosis associated with non-alcoholic steatohepatitis (NASH) is largely unknown in the general population. This study aimed to provide an updated estimation of the prevalence of NASH fibrosis in Spain. Methods: This was an observational, retrospective, cross-sectional, population-based study with merged data from two Spanish datasets: a large (N = 12 246) population-based cohort (ETHON), including transient elastography (TE) data, and a contemporary multi-centric biopsy-proven NASH cohort with paired TE data from tertiary centres (N = 501). Prevalence for each NASH fibrosis stage was estimated by crossing TE data from ETHON dataset with histology data from the biopsy-proven cohort. Results: From the patients with valid TE in ETHON dataset (N = 11 440), 5.61% (95% confidence interval [95% CI]: 2.53-11.97) had a liver stiffness measurement (LSM) ≥ 8 kPa. The proportion attributable to NAFLD (using clinical variables and Controlled Attenuation Parameter) was 57.3% and thus, the estimated prevalence of population with LSM ≥ 8 kPa because of NAFLD was 3.21% (95% CI 1.13-8.75). In the biopsy-proven NASH cohort, 389 patients had LSM ≥ 8 kPa. Among these, 37% did not have significant fibrosis (F2-4). The estimated prevalence of NASH F2-3 and cirrhosis in Spain's adult population were 1.33% (95% CI 0.29-5.98) and 0.70% (95% CI 0.10-4.95) respectively. Conclusions: These estimations provide an accurate picture of the current prevalence of NASH-related fibrosis in Spain and can serve as reference point for dimensioning the therapeutic efforts that will be required as NASH therapies become available

Surgical multicenter collaborative studies: ¿What happen in Latin America?

Antecedentes: GlobalSurg es un grupo internacional de investigadores que tiene como propósito la conducción y la diseminación de robustos estudios colaborativos, internacionales y multicéntricos. Objetivo: Exponer las estrategias necesarias y las barreras encontradas en la conducción de estudios multicéntricos masivos en cirugía. Método: Durante el segundo semestre del año 2020 se llevó a cabo el estudio Surg-Week Prospective International Cohort Study, hasta la fecha el estudio internacional más grande en el campo de la cirugía, con 141,582 pacientes incluidos. Un total de 4975 miniequipos, de uno a cinco integrantes, recopilaron datos de 116 países de todos los continentes. Resultados: La creación de un sitio web oficial del estudio, reportes con información relevante vía e-mail o grupos vía WhatsApp, conformación de un comité de diseminación del protocolo, dictado de webinars sobre publicaciones recientes del equipo, designación de líderes nacionales e internacionales, y la divulgación por medio de sociedades, fueron las estrategias utilizadas para el desarrollo de la investigación. Sin embargo, las barreras detectadas para llevar a cabo el estudio multicéntrico fueron variadas. Conclusiones: Los trabajos colaborativos permiten establecer redes entre diferentes profesionales con el fin de mejorar la calidad de la gestión, las políticas sanitarias y la atención a los pacientes en tiempos de constante cambio.Background: GlobalSurg is an international group of researchers whose purpose is to conduct and disseminate robust collaborative, international and multicenter studies. Objective: To expose the necessary strategies and the barriers crossed in conducting massive multicenter studies in surgery. Method: During the second semester of 2020, the study Surg-Week Prospective International Cohort Study was carried out. Surg-Week has been the largest international study in the field of surgery to date, with 141,582 patients included. A total of 4975 mini-teams, of between 1 and 5 members, collected data from 116 countries on all continents. Results: The creation of an official website for the study, reports with relevant information via email or groups via WhatsApp, formation of a Dissemination Committee of the protocol, delivery of webinars on recent team publications, appointment of leaders at the national and international level, and outreach through partnerships, were the strategies used for the development of the research. However, the barriers turned out to involve different aspects. Conclusions: Collaborative work allows establishing networks between different professionals with the goal of improving the quality of management, health policies and care of our patients in a timely manner of constant change

The LOFAR Two Meter Sky Survey: Deep Fields, I -- Direction-dependent calibration and imaging

The Low Frequency Array (LOFAR) is an ideal instrument to conduct deep extragalactic surveys. It has a large field of view and is sensitive to large-scale and compact emission. It is, however, very challenging to synthesize thermal noise limited maps at full resolution, mainly because of the complexity of the low-frequency sky and the direction dependent effects (phased array beams and ionosphere). In this first paper of a series, we present a new calibration and imaging pipeline that aims at producing high fidelity, high dynamic range images with LOFAR High Band Antenna data, while being computationally efficient and robust against the absorption of unmodeled radio emission. We apply this calibration and imaging strategy to synthesize deep images of the Boötes and Lockman Hole fields at ∼150 MHz, totaling ∼80 and ∼100 h of integration, respectively, and reaching unprecedented noise levels at these low frequencies of .30 and .23 µJy beam−1 in the inner ∼3 deg2 . This approach is also being used to reduce the LOTSS-wide data for the second data release

Efficacy of Neoadjuvant Carboplatin plus Docetaxel in Triple-Negative Breast Cancer: Combined Analysis of Two Cohorts

Recent studies demonstrate that addition of neoadjuvant (NA) carboplatin (Cb) to anthracycline/taxane chemotherapy improves pathological complete response (pCR) in triple negative breast cancer (TNBC). Effectiveness of anthracycline-free, platinum combinations in TNBC is not well known. Here we report efficacy of NA carboplatin + docetaxel (CbD) in TNBC