40 research outputs found
Global, regional, and national comparative risk assessment of 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks, 1990-2015: a systematic analysis for the Global Burden of Disease Study 2015
- Author
- Aasvang GM
- Abajobir AA
- Abate KH
- Abbafati C
- Abbas KM
- Abd-Allah F
- Abdulle AM
- Abera SF
- Abraham B
- Abu-Raddad LJ
- Abyu GY
- Adebiyi AO
- Adedeji IA
- Ademi Z
- Adou AK
- Adsuar JC
- Afshin A
- Agardh EE
- Agarwal A
- Agrawal A
- Ajala ON
- Akinyemiju TF
- Al-Aly Z
- Alam K
- Alam NKM
- Aldhahri SF
- Aldridge RW
- Alemu ZA
- Alexander LT
- Ali R
- Alkerwi A
- Alla F
- Allebeck P
- Alsharif U
- Altirkawi KA
- Alvarez Martin E
- Alves Silveira DG
- Alvis-Guzman N
- Amare AT
- Amberbir A
- Amegah AK
- Amini H
- Ammar W
- Amrock SM
- Andersen HH
- Anderson BO
- Anderson HR
- Antonio CAT
- Anwar P
- Aquino Faraon EJ
- Arnlov J
- Artaman A
- Asayesh H
- Asghar RJ
- Assadi R
- Atique S
- Avokpaho EFGA
- Awasthi A
- Azzopardi P
- Bacha U
- Badawi A
- Baernighausen T
- Bahit MC
- Balakrishnan K
- Bans C
- Barac A
- Barber RM
- Barker-Collo SL
- Barquera S
- Barregard L
- Barrero LH
- Basu S
- Bazargan-Hejazi S
- Beardsley J
- Beatriz Heredia-Pi I
- Beatriz Lawrynowicz AE
- Bedi N
- Beghi E
- Bell ML
- Bello AK
- Bennett DA
- Bensenor IM
- Berhane A
- Bernabe E
- Betsu BD
- Beyene AS
- Bhala N
- Bhansali A
- Bhatt S
- Bhutta ZA
- Biadgilign S
- Bicer BK
- Bikbov B
- Biryukov S
- Bisanzio D
- Bjertness E
- Blore JD
- Borschmann R
- Boufous S
- Bourne RRA
- Brainin M
- Brauer M
- Brazinova A
- Breitborde NJK
- Brenner H
- Broday DM
- Brugha TS
- Brunekreef B
- Burnett R
- Butt ZA
- Cahill LE
- Caicedo AJP
- Calabria B
- Cardenas R
- Carmen Gomez-Cabrera M
- Carpenter D
- Casey DC
- Castaneda-Oquela CA
- Castillo Rivas J
- Catala-Lopez F
- Cercy K
- Chang J-C
- Charlson FJ
- Chiang PP-C
- Chibalabala M
- Chimed-Ochir O
- Chisumpa VH
- Chitheer AA
- Choi J-YJ
- Christensen H
- Christopher DJ
- Ciobanu LG
- Coates MM
- Cohen AJ
- Colquhoun SM
- Cooper LT
- Cooperrider K
- Cornaby L
- Cortinovis M
- Crump JA
- Cuevas-Nasu L
- Damasceno A
- Dandona L
- Dandona R
- Darby SC
- Dargan PI
- das Neves J
- Davis AC
- Davletov K
- De la Cruz-Gongora V
- De Leo D
- Defo BK
- Degenhardt L
- Del Gobbo LC
- del Pozo-Cruz B
- Dellavalle RP
- Deribew A
- Des Jarlais DC
- Dharmaratne SD
- Dhillon PK
- Diaz-Tome C
- Dicker D
- Dimbuene ZT
- Ding EL
- Dolores Sanchez-Nino M
- Dorsey ER
- Doyle KE
- Driscoll TR
- Duan L
- Dubey M
- Duncan BB
- Elyazar I
- Endries AY
- Ermakov SP
- Erskine HE
- Eshrati B
- Estanislao Castro R
- Esteghamati A
- Estep K
- Factors GBDR
- Fahimi S
- Farid TA
- Faro A
- Farvid MS
- Farzadfar F
- Feigin VL
- Fereshtehnejad S-M
- Fernandes JG
- Ferrari AJ
- Filipa de Castro E
- Fischer F
- Fitchett JRA
- Fleming T
- Foigt N
- Foreman K
- Forouzanfar MH
- Fowkes FGR
- Francisco Hernandez-Llanes N
- Franklin RC
- Frostad JJ
- Fuerst T
- Fullman N
- Futran ND
- Gakidou E
- Garcia-Basteiro AL
- Gebrehiwot TT
- Gebremedhin AT
- Geleijnse JM
- Gessner BD
- Gething PW
- Giref AZ
- Giroud M
- Gishu MD
- Godwin WW
- Goenka S
- Gomez-Dantes H
- Gona P
- Goodridge A
- Gopalani SV
- Gotay CC
- Goto A
- Gouda HN
- Griswold M
- Gugnani HC
- Guillemin F
- Guo Y
- Gupta R
- Gupta R
- Gutierrez RA
- Haagsma JA
- Hafezi-Nejad N
- Haile D
- Hailu GB
- Halasa YA
- Hamadeh RR
- Hamidi S
- Handal AJ
- Hankey GJ
- Hao Y
- Harb HL
- Harikrishnan S
- Hassanvand MS
- Hassen TA
- Havmoeller R
- Heydarpour P
- Hoek HW
- Hoffman HJ
- Horino M
- Horita N
- Hosgood HD
- Hoy DG
- Hsairi M
- Htet AS
- Hu G
- Huang JJ
- Husseini A
- Hutchings SJ
- Huybrechts I
- Iburg KM
- Idrisov BT
- Ileanu BV
- Inoue M
- Jacobs TA
- Jacobsen KH
- Jahanmehr N
- Jakovljevic MB
- Jansen HAFM
- Jassal SK
- Javanbakht M
- Jayatilleke AU
- Jee SH
- Jeemon P
- Jha V
- Jiang Y
- Jibat T
- Jin Y
- Johnson CO
- Jonas JB
- Kabir Z
- Kalkonde Y
- Kamal R
- Kan H
- Karch A
- Karema CK
- Karimkhani C
- Kasaeian A
- Kaul A
- Kawakami N
- Kazi DS
- Keiyoro PN
- Kemp AH
- Kengne AP
- Keren A
- Kesavachandran CN
- Khader YS
- Khan AR
- Khan EA
- Khan G
- Khang Y-H
- Khatibzadeh S
- Khera S
- Khoja TAM
- Khubchandani J
- Kiadaliri AA
- Kieling C
- Kim C-I
- Kim D
- Kimokoti RW
- Kinfu Y
- Kissoon N
- Kivipelto M
- Knibbs LD
- Kokubo Y
- Kopec JA
- Koul PA
- Koyanagi A
- Kravchenko M
- Kromhout H
- Krueger H
- Ku T
- Kuchenbecker RS
- Kuipers EJ
- Kumar GA
- Kwan GF
- Kyu HH
- Lal DK
- Lalloo R
- Lallukka T
- Lan Q
- Landon N
- Larson HJ
- Larsson A
- Latif AA
- Leasher JL
- Leigh J
- Leung J
- Levi M
- Levy TS
- Li X
- Li Y
- Liang J
- Liang X
- Lim SS
- Liu PY
- Liu S
- Lloyd BK
- Logroscino G
- Lopez AD
- Lotufo PA
- Lozano R
- Lunevicius R
- Maclntyre M
- Mahdavi M
- Mahesh PA
- Majdan M
- Majeed A
- Malekzadeh R
- Malta DC
- Manamo WAA
- Mapoma CC
- Marcenes W
- Marczak L
- Maria Haro J
- Martin RV
- Martinez-Raga J
- Masiye F
- Matsushita K
- Matzopoulos R
- Mayosi BM
- McGrath JJ
- McKee M
- Meaney PA
- Medina C
- Mehari A
- Mekonnen AB
- Melaku YA
- Memish ZA
- Mena-Rodriguez F
- Mendoza W
- Mensah GA
- Mensink GBM
- Meretoja A
- Meretoja TJ
- Mesfin YM
- Mhimbira FA
- Miller TR
- Mills EJ
- Mirarefin M
- Misganaw A
- Mock CN
- Mohammadi A
- Mohammed S
- Mokdad AH
- Mola GLD
- Monasta L
- Montanez Hernandez JC
- Montico M
- Moradi-Lakeh M
- Morawska L
- Mori R
- Mozaffarian D
- Mueller UO
- Mullany E
- Mumford JE
- Murray CJL
- Murthy GVS
- Nachega JB
- Naghavi M
- Naheed A
- Nangia V
- Nassiri N
- Neal B
- Newton JN
- Ng M
- Nguyen QL
- Nisar MI
- Norheim OF
- Norman RE
- Norrving B
- Nyakarahuka L
- Obermeyer CM
- Ogbo FA
- Oh I-H
- Oladimeji O
- Olivares PR
- Olsen H
- Olusanya BO
- Olusanya JO
- Opio JN
- Oren E
- Orozco R
- Ortiz A
- Ota E
- Pana A
- Park E-K
- Parry CD
- Parsaeian M
- Patel T
- Patil ST
- Patten SB
- Patton GC
- Pearce N
- Pereira DM
- Perico N
- Pesudovs K
- Pete PMN
- Petzold M
- Phillips MR
- Piel FB
- Pillay JD
- Plass D
- Polinder S
- Pond CD
- Pope CA
- Pope D
- Popova S
- Poulton RG
- Pourmalek F
- Prasad NM
- Qorbani M
- Quintanilla BPA
- Rabiee RHS
- Radfar A
- Rafay A
- Rahimi-Movaghar V
- Rahman M
- Rahman MHU
- Rahman SU
- Rai RK
- Rajsic S
- Raju M
- Ram U
- Rana SM
- Ranganathan K
- Rao P
- Razo Garcia CA
- Refaat AH
- Rehm CD
- Rehm J
- Reinig N
- Reitsma MB
- Remuzzi G
- Resnikoff S
- Ribeiro AL
- Ricardo Campos-Nonato I
- Rivera JA
- Rodriguez A
- Rodriguez-Ramirez S
- Rojas-Rueda D
- Rolm HS
- Roman Y
- Ronfani L
- Roshandel G
- Roth GA
- Rothenbacher D
- Roy A
- Saleh MM
- Salomon JA
- Sanabria JR
- Sanchez-Pimienta TG
- Sandar L
- Santomauro DF
- Santos IS
- Sarmiento-Suarez R
- Sartorius B
- Satpathy M
- Savic M
- Sawhney M
- Schmidhuber J
- Schmidt MI
- Schneider IJC
- Schoettker B
- Schutte AE
- Schwebel DC
- Scott JG
- Seedat S
- Sepanlou SG
- Servan-Mori EE
- Shaheen A
- Shahraz S
- Shaikh MA
- Sharma R
- She J
- Sheikhbahaei S
- Shen J
- Sheth KN
- Shi P
- Shibuya K
- Shigematsu M
- Shin M-J
- Shiri R
- Shishani K
- Shiue I
- Shrime MG
- Sigfusdottir ID
- Silva DAS
- Silverberg JI
- Simard EP
- Sindi S
- Singh A
- Singh JA
- Singh PK
- Slepak EL
- Sofia E Sa Farinha C
- Soljak M
- Soneji S
- Sorensen RJD
- Sposato LA
- Sreeramareddy CT
- Stathopoulou V
- Steckling N
- Steel N
- Stein DJ
- Stein MB
- Stockl H
- Stranges S
- Stroumpoulis K
- Sunguya BF
- Sur PJ
- Swaminathan S
- Sykes BL
- Szoeke CEI
- Tabares-Seisdedos R
- Takahashi K
- Talongwa RT
- Tanne D
- Tavakkoli M
- Taye BW
- Taylor HR
- Tedla BA
- Tefera WM
- Tegegne TK
- Tekle DY
- Terkawi AS
- Thakur JS
- Thomas BA
- Thomas ML
- Thomson AJ
- Thorne-Lyman AL
- Thrift AG
- Thurston GD
- Tillmann T
- Tobe-Gai R
- Tobollik M
- Topor-Madry R
- Topouzis F
- Towbin JA
- Tran BX
- Tsilimparis N
- Tura AK
- Tuzcu EM
- Tyrovolas S
- Ukwaja KN
- Undurraga EA
- Uneke CJ
- Uthman OA
- van Donkelaar A
- van Os J
- Varakin YY
- Vasankari T
- Veerman JL
- Venketasubramanian N
- Violante FS
- Vollset SE
- Vos T
- Wagner GR
- Wagner JA
- Waller SG
- Wang H
- Wang J
- Wang L
- Wang Y
- Weichenthal S
- Weiderpass E
- Weintraub RG
- Werdecker A
- Westerman R
- Whiteford HA
- Wijeratne T
- Wiysonge CS
- Wolfe CDA
- Won S
- Woolf AD
- Wubshet M
- Xavier D
- Xu G
- Yadav AK
- Yakob B
- Yalew AZ
- Yano Y
- Yaseri M
- Ye P
- Yip P
- Yonemoto N
- Yoon S-J
- Younis MZ
- Yu C
- Zaidi Z
- Zaki MES
- Zhao Y
- Zhou M
- Zhu J
- Zipkin B
- Zodpey S
- Zuhlke LJ
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2016
- Field of study
SummaryBackground The Global Burden of Diseases, Injuries, and Risk Factors Study 2015 provides an up-to-date synthesis of the evidence for risk factor exposure and the attributable burden of disease. By providing national and subnational assessments spanning the past 25 years, this study can inform debates on the importance of addressing risks in context. Methods We used the comparative risk assessment framework developed for previous iterations of the Global Burden of Disease Study to estimate attributable deaths, disability-adjusted life-years (DALYs), and trends in exposure by age group, sex, year, and geography for 79 behavioural, environmental and occupational, and metabolic risks or clusters of risks from 1990 to 2015. This study included 388 risk-outcome pairs that met World Cancer Research Fund-defined criteria for convincing or probable evidence. We extracted relative risk and exposure estimates from randomised controlled trials, cohorts, pooled cohorts, household surveys, census data, satellite data, and other sources. We used statistical models to pool data, adjust for bias, and incorporate covariates. We developed a metric that allows comparisons of exposure across risk factors—the summary exposure value. Using the counterfactual scenario of theoretical minimum risk level, we estimated the portion of deaths and DALYs that could be attributed to a given risk. We decomposed trends in attributable burden into contributions from population growth, population age structure, risk exposure, and risk-deleted cause-specific DALY rates. We characterised risk exposure in relation to a Socio-demographic Index (SDI). Findings Between 1990 and 2015, global exposure to unsafe sanitation, household air pollution, childhood underweight, childhood stunting, and smoking each decreased by more than 25%. Global exposure for several occupational risks, high body-mass index (BMI), and drug use increased by more than 25% over the same period. All risks jointly evaluated in 2015 accounted for 57·8% (95% CI 56·6–58·8) of global deaths and 41·2% (39·8–42·8) of DALYs. In 2015, the ten largest contributors to global DALYs among Level 3 risks were high systolic blood pressure (211·8 million [192·7 million to 231·1 million] global DALYs), smoking (148·6 million [134·2 million to 163·1 million]), high fasting plasma glucose (143·1 million [125·1 million to 163·5 million]), high BMI (120·1 million [83·8 million to 158·4 million]), childhood undernutrition (113·3 million [103·9 million to 123·4 million]), ambient particulate matter (103·1 million [90·8 million to 115·1 million]), high total cholesterol (88·7 million [74·6 million to 105·7 million]), household air pollution (85·6 million [66·7 million to 106·1 million]), alcohol use (85·0 million [77·2 million to 93·0 million]), and diets high in sodium (83·0 million [49·3 million to 127·5 million]). From 1990 to 2015, attributable DALYs declined for micronutrient deficiencies, childhood undernutrition, unsafe sanitation and water, and household air pollution; reductions in risk-deleted DALY rates rather than reductions in exposure drove these declines. Rising exposure contributed to notable increases in attributable DALYs from high BMI, high fasting plasma glucose, occupational carcinogens, and drug use. Environmental risks and childhood undernutrition declined steadily with SDI; low physical activity, high BMI, and high fasting plasma glucose increased with SDI. In 119 countries, metabolic risks, such as high BMI and fasting plasma glucose, contributed the most attributable DALYs in 2015. Regionally, smoking still ranked among the leading five risk factors for attributable DALYs in 109 countries; childhood underweight and unsafe sex remained primary drivers of early death and disability in much of sub-Saharan Africa. Interpretation Declines in some key environmental risks have contributed to declines in critical infectious diseases. Some risks appear to be invariant to SDI. Increasing risks, including high BMI, high fasting plasma glucose, drug use, and some occupational exposures, contribute to rising burden from some conditions, but also provide opportunities for intervention. Some highly preventable risks, such as smoking, remain major causes of attributable DALYs, even as exposure is declining. Public policy makers need to pay attention to the risks that are increasingly major contributors to global burden. Funding Bill & Melinda Gates Foundation
Impact of volatile phenols and their precursors on wine quality and control measures of Brettanomyces/Dekkera yeasts
- Author
- A Barata
- A Barata
- A Barata
- A Baublis
- A Bornet
- A Caridi
- A Costa
- A Delcroix
- A Morata
- A Morata
- A Morata
- A Morata
- A Morata
- A Oelofse
- A Oelofse
- A Santos
- A Santos
- AM Mayer
- AM Vivar-Quintana
- AP Pöllnitz
- AR Goodey
- C Dallas
- CA Sims
- CR Smith
- CW Nagel
- Cédric Brandam
- D Chassagne
- D Chassagne
- D Dubourdieu
- D Heatherbell
- D Kadim
- D Matejícek
- D Peyron
- D Salameh
- DAN Edlin
- DAN Edlin
- DM Goldberg
- Dominique Salameh
- E Gómez-Plaza
- E Haslam
- E Puértolas
- EM Snowdon
- F Calderón
- F Palomero
- F Schmid
- FJ Francis
- G Lustrato
- GH Fleet
- H Gerós
- H Kawamoto
- H Liao
- I Dugelay
- I Dugelay
- I Froudière
- I McMurrough
- I Tchobanov
- I Tchobanov
- J Bakker
- J Donovan
- JA Couto
- JD Baranowski
- JJ Macheix
- JM Salmon
- JN Boidron
- Joyce Kheir
- JX Castillo-Sánchez
- K Koyoma
- KC Fugelsang
- KL Sacchi
- L Barthelmebs
- L Conterno
- L Dias
- L Dias
- L Godoy
- L Godoy
- L González-Arenzana
- L Gómez-Rivas
- L Nedervelde Van
- LJ Pérez-Prieto
- M Ciani
- M Ciani
- M Enrique
- M Malfeito-Ferreira
- M Monagas
- M Rentzsch
- MG Aguilar Uscanga
- MJ Cabrita
- MMn Giusti
- MT Lisanti
- N Rodrigues
- N Vivas
- NAM Eskin
- NL Umiker
- P Avar
- P Barbin
- P Caboni
- P Chatonnet
- P Chatonnet
- P Chatonnet
- P Chatonnet
- P Chatonnet
- P Dubois
- P Dubois
- P Ho
- P Schreier
- P Silva
- P Valentão
- P Vuchot
- Pierre Strehaiano
- PM Izquierdo-Cañas
- PX Etievant
- PX Etievant
- R Baumes
- R Guzzon
- R Larcher
- R Stefano Di
- R Suárez
- Roger Lteif
- RV Boulton
- S Benito
- S Benito
- S Benito
- S Guyot
- S Rayne
- SA Goldsworthy
- SM Basha
- T Garde-Cerdán
- T Garde-Cerdán
- T Garde-Cerdán
- T Garde-Cerdán
- T Heresztyn
- T Okuda
- T Shinohara
- V Cheynier
- V Ducruet
- V Gerbaux
- V Gerbaux
- V Gerbaux
- V Gerbaux
- V Harris
- V Harris
- V Millet
- V Renouf
- V Renouf
- V Renouf
- VL Singleton
- WJ Toit Du
- WR Sponholz
- Y Vasserot
- ZM Jin
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/11/2013
- Field of study
Volatile phenols are aromatic compounds and one of the key molecules responsible for olfactory defects in wine. The yeast genus Brettanomyces is the only major microorganism that has the ability to covert hydroxycinnamic acids into important levels of these compounds, especially 4-ethylphenol and 4-ethylguaiacol, in red wine. When 4-ethylphenols reach concentrations greater than the sensory threshold, all wine’s organoleptic characteristics might be influenced or damaged. The aim of this literature review is to provide a better understanding of the physicochemical, biochemical, and metabolic factors that are related to the levels of p-coumaric acid and volatile phenols in wine. Then, this work summarizes the different methods used for controlling the presence of Brettanomyces in wine and the production of ethylphenols
Carbon Dioxide Utilisation -The Formate Route
- Author
- A Alissandratos
- A Bar-Even
- A Bassegoda
- A Cornish-Bowden
- A Fihri
- A Hochheimer
- A Morozan
- A Rajapakshe
- AA Alekseeva
- AJ Clough
- AJ Martín
- AJ Morris
- AM Appel
- AP Lothrop
- AR Oliveira
- AS Agarwal
- AV Mesentsev
- B El-Zahab
- B Loges
- B Loges
- B Zhang
- BK Maiti
- BR Duffus
- C Coelho
- C Costa
- C Costentin
- C Federsel
- C Mourato
- C Pinske
- C Radon
- C Sebban
- C Vinals
- C Ziebart
- CA Huff
- CD Brondino
- CF Nielsen
- CM Cordas
- CM Silveira
- CS Mota
- CS Mota
- D Kopljar
- D Niks
- D Niks
- D Niks
- D Paul
- D Pletcher
- DE Edmondson
- DG Nocera
- DH Nam
- DK Nilov
- DT Whipple
- E Graf
- EE Benson
- EI Stiefel
- EI Stiefel
- EV Filippova
- F Gassner
- F Gloaguen
- F Zinoni
- FA Armstrong
- FA Bok
- FA Bok
- FM Schwarz
- FM Schwarz
- G Bruant
- G Dong
- G Plunkett
- GA Filonenko
- GA Filonenko
- GL Wilson
- GN George
- GN George
- H Abaibou
- H Choe
- H Hwang
- H Li
- H Raaijmakers
- H Raaijmakers
- H Takeda
- H Wang
- H Zhong
- HCA Raaijmakers
- HL Jiang
- HR Jhong
- I Tsujisho
- IA Berg
- IG Shabalin
- J Friedebold
- J Johannes
- J Pommier
- J Qiao
- J Schneider
- J Szczesny
- JC Boyington
- JF Heidelberg
- JF Hull
- JN Bandaria
- JPG Malthouse
- JR McKone
- JS Blanchard
- JS McDowall
- JS Mcdowall
- JS Olson
- JS Yoo
- JS-C Liou
- JT Bays
- K Bagramyan
- K Muller
- K Sakai
- K Sakai
- K Sakai
- K Sakai
- K Sakai
- K Schirwitz
- K Schuchmann
- K Schuchmann
- K Sordakis
- K Trchounian
- KP Sokol
- KP Sokol
- L Babujee
- L Barelli
- L Maia
- L Zhang
- LB Maia
- LB Maia
- LE Bevers
- LF Pan
- LM Walker
- M Boll
- M Ihara
- M Jormakka
- M Jormakka
- M Leopoldini
- M Martins
- M Martins
- M Miller
- M Rivas
- M Roger
- M Tiberti
- M Wang
- M Xia
- M Yadav
- M Yadav
- M Yuan
- MC Schoelmerich
- MD Doherty
- MF Kuehnel
- MJ Almendra
- MJ Axley
- MJ Axley
- MJ Barber
- MK Johnson
- ML Clark
- MP Coughlan
- MR DuBois
- MS Faber
- MS Jeletic
- N Kato
- N Kornienko
- NMFSA Cerqueira
- NS Rotberg
- P Arnoux
- P Arnoux
- P Du
- P Friedlingstein
- P Kottenhahn
- P Munshi
- P Preuster
- P Schrapers
- P Worm
- P Xiao
- PA Bertram
- PD Tran
- PG Jessop
- PG Jessop
- PG Jessop
- Q Guo
- R Castillo
- R Hille
- R Hille
- R Langer
- R Miyatani
- R Tanaka
- R Thome
- RC Bray
- RK Thauer
- RK Yadav
- S Bursakov
- S Das
- S Enthaler
- S Enthaler
- S Fukuzumi
- S Grimaldi
- S Gutteridg
- S Gutteridge
- S Gutteridge
- S Ikeyama
- S Kim
- S Kuwabata
- S Kuwabata
- S Losse
- S Moret
- S Navalon
- S Sahin
- S Schlager
- S Singh
- S Srikanth
- S Wesselbaum
- S-F Hsu
- SH Kim
- SK Kuk
- SM da Silva
- SM Silva
- SVV Khangulov
- SW Ragsdale
- SY Lee
- T Hartmann
- T Hartmann
- T Hartmann
- T Noji
- T Reda
- T Wagner
- T Young
- TJ Schmeier
- U Muller
- UJ Kilgore
- V Artero
- V Fourmond
- V Fourmond
- V Massey
- V Müller
- VI Tishkov
- VI Tishkov
- VN Gladyshev
- VO Popov
- VS Lamzin
- VS Thoi
- W Cui
- W Leitner
- W Wang
- W Wang
- W-H Wang
- WE Robinson
- WF Chen
- WF Martin
- WT Eckenhoff
- X Lu
- X Yu
- X Yu
- X Yu
- X Zhou
- Y Amao
- Y Amao
- Y Himeda
- Y Izumi
- Y Maenaka
- Y Oh
- Y Tamaki
- YM Liu
- Publication venue
- Springer International Publishing
- Publication date
- 01/01/2021
- Field of study
UIDB/50006/2020 CEEC-Individual 2017 Program Contract.The relentless rise of atmospheric CO2 is causing large and unpredictable impacts on the Earth climate, due to the CO2 significant greenhouse effect, besides being responsible for the ocean acidification, with consequent huge impacts in our daily lives and in all forms of life. To stop spiral of destruction, we must actively reduce the CO2 emissions and develop new and more efficient “CO2 sinks”. We should be focused on the opportunities provided by exploiting this novel and huge carbon feedstock to produce de novo fuels and added-value compounds. The conversion of CO2 into formate offers key advantages for carbon recycling, and formate dehydrogenase (FDH) enzymes are at the centre of intense research, due to the “green” advantages the bioconversion can offer, namely substrate and product selectivity and specificity, in reactions run at ambient temperature and pressure and neutral pH. In this chapter, we describe the remarkable recent progress towards efficient and selective FDH-catalysed CO2 reduction to formate. We focus on the enzymes, discussing their structure and mechanism of action. Selected promising studies and successful proof of concepts of FDH-dependent CO2 reduction to formate and beyond are discussed, to highlight the power of FDHs and the challenges this CO2 bioconversion still faces.publishersversionpublishe
Laparoscopy in management of appendicitis in high-, middle-, and low-income countries: a multicenter, prospective, cohort study.
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- Abantanga F
- Abbas M
- Abbo O
- Abd El Galeel A
- Abd El Hameed OS
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- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
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- Abdel-Wahab NYE
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- Youssif JH
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- Zalabia MF
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- Zapata Ponze De Leon M
- Zardab A
- Zegarra S
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- Zerihun AB
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- Zilinskiene R
- Zimmermann EF
- Zuber M
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2018
- Field of study
BACKGROUND: Appendicitis is the most common abdominal surgical emergency worldwide. Differences between high- and low-income settings in the availability of laparoscopic appendectomy, alternative management choices, and outcomes are poorly described. The aim was to identify variation in surgical management and outcomes of appendicitis within low-, middle-, and high-Human Development Index (HDI) countries worldwide. METHODS: This is a multicenter, international prospective cohort study. Consecutive sampling of patients undergoing emergency appendectomy over 6 months was conducted. Follow-up lasted 30 days. RESULTS: 4546 patients from 52 countries underwent appendectomy (2499 high-, 1540 middle-, and 507 low-HDI groups). Surgical site infection (SSI) rates were higher in low-HDI (OR 2.57, 95% CI 1.33-4.99, p = 0.005) but not middle-HDI countries (OR 1.38, 95% CI 0.76-2.52, p = 0.291), compared with high-HDI countries after adjustment. A laparoscopic approach was common in high-HDI countries (1693/2499, 67.7%), but infrequent in low-HDI (41/507, 8.1%) and middle-HDI (132/1540, 8.6%) groups. After accounting for case-mix, laparoscopy was still associated with fewer overall complications (OR 0.55, 95% CI 0.42-0.71, p < 0.001) and SSIs (OR 0.22, 95% CI 0.14-0.33, p < 0.001). In propensity-score matched groups within low-/middle-HDI countries, laparoscopy was still associated with fewer overall complications (OR 0.23 95% CI 0.11-0.44) and SSI (OR 0.21 95% CI 0.09-0.45). CONCLUSION: A laparoscopic approach is associated with better outcomes and availability appears to differ by country HDI. Despite the profound clinical, operational, and financial barriers to its widespread introduction, laparoscopy could significantly improve outcomes for patients in low-resource environments. TRIAL REGISTRATION: NCT02179112
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
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- AKI Research Group
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- Garrido EM
- Garrouste M
- Gaspard N
- Gasparovic V
- Gattinoni L
- Gaudard P
- Gavranovic Z
- Gavrychenko D
- Gayat E
- Geantot MA
- Gemmell L
- Gemmell LK
- Genc D
- Genève C
- Georgopoulos D
- Geri G
- GETGAG Working Group
- GETGAG/SEMICYUC
- Ghabina S
- Ghazal S
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- Gherli T
- Ghosh S
- Giannantonio M
- Giannopoulos A
- Giesinger RE
- Gigorro RG
- Gil EM
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- Gimillo MR
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- Gioia A
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- Glogoski MZ
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- Godinho I
- Godoy K
- Goldsworthy M
- Golovnya E
- Gomes AA
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- Gomez SE
- Gommers D
- Gommers D
- Gonzalez CA
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- Gonzalez V
- Gonzalez-Engroba R
- González AS
- González BS
- González JC
- González-Jiménez AI
- Gonçalves B
- Goodwin S
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- Gordillo-Brenes A
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- Gordon M
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- Gouveia J
- Gracia RM
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- Granada RM
- Granados PR
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- Grangé S
- Grangé S
- Granillo JF
- Grassi L
- Grasso S
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- Green RS
- Greer M
- Gregory S
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- Grossestreuer A
- Guanziroli M
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- Gubianas CM
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- Gupta D
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- Hadley JS
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- Hayakawa M
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- Hernandis V
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- Herrera AN
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- Herruzo-Aviles A
- Heunks LM
- Hewitt H
- Heyne T
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- Hidalgo C
- Hikasa Y
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- Himpe D
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- Hirayama T
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- Hollands S
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- Horvat A
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- Howes D
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- Hravnak M
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- Huber W
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- Hutchison R
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- Jang BH
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- Jansen D
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
- Jardim JJ
- Jardim M
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- Jonas M
- Jonas M
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- Jones C
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- Jovaisa T
- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Kaczirek K
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- Kalenka A
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- Kaneko M
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- Kleinpell R
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- WIND study group
- WIND study group
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- Yılmaz G
- Yilmazer F
- Yodice P
- Yokoyama M
- Yonis H
- Yonis H
- Yonis H
- Yoon SZ
- Yoruk F
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- Yoshida T
- Yoshida T
- Yoshida T
- Yoshihiro S
- Yoshitake E
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- Yuzawa J
- Zabaletta WJ
- Zabini D
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- Zaien I
- Zakynthinos S
- Zanello M
- Zani D
- Zarantonello F
- Zayas B
- Zepeda EM
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- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Pooled analysis of WHO Surgical Safety Checklist use and mortality after emergency laparotomy
- Author
- Aahlin EK
- Aamer A
- Aaniana K
- Ababneh A
- Abaliksta T
- Abantanga F
- Abantanga F
- Abbas A
- Abbas M
- Abbasy J
- Abbo O
- Abbo O
- Abbott T
- Abbouch M
- Abd El Galeel A
- Abd El Hameed OS
- Abd El Hamid N
- Abd El Salam Y
- Abd El Slam M
- Abd El-Salam F
- Abd Elrasoul Y
- Abd-Elmawla M
- Abd-Elrasoul Y
- Abdallah E
- Abdallah E
- Abdel-Aty A
- Abdel-Hameed N
- Abdel-Kader SM
- Abdel-Wahab NYE
- Abdelaal A
- Abdelaty M
- Abdelazeam AR
- Abdelazim G
- Abdelaziz MA
- Abdelbadeai K
- Abdelfatah A
- AbdelFattah I
- Abdelgelil A
- Abdelghany S
- Abdelhady S
- Abdelhamed R
- Abdelhamid A
- Abdelhaq A
- Abdelkader M
- Abdelkader M
- Abdelkader O
- Abdelkareem A
- Abdelkhalek M
- Abdelmageed E
- Abdelmotaleb I
- Abdelraheim M
- Abdelraouf AM
- Abdelrouf DM
- Abdelshafy M
- Abdelshakour M
- Abdrabou AK
- Abdul-Latif S
- Abdulaziz H
- Abdulaziz M
- Abdulbagi O
- Abdulgawad M
- Abdulhakeem EM
- Abdullah AAN
- Abdullah MA
- Abdullah N
- Abdullah NAN
- Abdullah NAN
- Abdullahi L
- Abdurrazzaaq A
- Abebe NS
- Abebe NS
- Abem OE
- Aber A
- Abington E
- Abiola O
- Aboarab A
- Aboelella M
- Aboelmagd O
- Aboelsoud MR
- Aboraya M
- Aboraya M
- Abouelnasr A
- Aboul-Naga MS
- Abouzahra A
- Abouzaid A
- Abozaid M
- Abozeid K
- Abozyed MAF
- Abu Qumbos A
- Abu-toyour M
- Abubakr M
- Abudeeb H
- Abuowda Y
- Abuqwaider E
- Abusalem L
- Abuseif M
- Abushamleh S
- Acharya P
- Ackom E
- Acquah E
- Adam A
- Adam N
- Adams R
- Adamu A
- Adawi I
- Adawi M
- Adebanjo A
- Adebanjo A
- Adebola O
- Adedeji A
- Adekoya A
- Adel A
- Adel A
- Adel BE
- Adel I
- Adella FJ
- Adelshone A
- Ademuyiwa A
- Ademuyiwa A
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Ademuyiwa AO
- Adenekan B
- Adeniran J
- Adeniran J
- Adeniyi A
- Adeniyi A
- Adesanya O
- Adesanya O
- Adesina A
- Adesina A
- Adesuyi A
- Adeyeye A
- Adeyeye A
- Adeyeye A
- Adham W
- Adhitama N
- Adil M
- Adisa AO
- Adisa AO
- Adu-Aryee N
- Afana S
- Afandy A
- Afifi AM
- Afzal M
- Agalianos C
- Agalianos C
- Agarwal A
- Agarwal A
- Agarwal A
- Agbedinu K
- Agius M
- Aglan A
- Aguado Suarez N
- Aguilar-Jimenez J
- Aguilera M
- Aguilera ML
- Aguilera ML
- Aguilera ML
- Aguilera O
- Aguilera-Arevalo M-L
- Ahlonsou G
- Ahlqvist S
- Ahlqvist S
- Ahlqvist S
- Ahmed A
- Ahmed A
- Ahmed A
- Ahmed EA
- Ahmed H
- Ahmed H
- Ahmed H
- Ahmed LAM
- Ahmed S
- Ahmed S
- Ahmed SM
- Ahounou EYS
- Aigrain Y
- Aiyaman C
- Ajah J
- Ajai O
- Ajao A
- Ajao AE
- Ajiboye A
- Akatibo E
- Akeel N
- Akhtar M
- Akoto E
- Akpenyi O
- Al Amin S
- Al Attar SM
- Al Awwad S
- Al Barrawi FE
- Al Bastawis F
- Al Meligy A
- Al Rafati AAR
- Al Raouf EA
- Al Saied G
- Al Subaie N
- Al-Aarag AA-R
- Al-Azraqi IAA
- Al-Bahrani A
- Al-Buhaisi A
- Al-Dakka E
- Al-Faifi JJ
- Al-faqawi M
- Al-farram H
- Al-Hameedi HII
- Al-Hasani RKMJ
- Al-khatib A
- Al-Mallah A
- Al-Marakby D
- Al-Mousa M
- Al-Nahrawi S
- Al-Obaedi O
- Al-saqqa S
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- Al-shammari A
- Al-Slaibi I
- Al-taher T
- Alaael-Dein S
- Alada M
- Alahmady O
- Alakaloko F
- Alakaloko F
- Alaloul E
- Alamin S
- Alamoudi M
- Alamoudi U
- Albeladi B
- Albiety A
- Alcca Ticona W
- Aldalaq A
- Aldhafeeri S
- Aledrisy M
- Alejos Bermudez YE
- Alexander P
- Alexander P
- Alexander P
- Alexandre C
- Alfarsi MA
- Alghamdi A
- Alghamdi B
- Alghamdi M
- Alghamdi MSA
- Algohary O
- Alhabli I
- Alhady K
- Alhammali T
- Alhassan B
- Alhazmi W
- Alhendy M
- Alherz M
- Ali A
- Ali A
- Ali A
- Ali CDM
- Ali E
- Ali FM
- Ali H
- Ali S
- Ali SAWEW
- Ali SS
- Ali THA
- Ali W
- Alihonou T
- Alimi Q
- Alis H
- Aliyu H
- Aliyu M
- Aliyu S
- Aljboor K
- Aljiffry M
- Aljiffry M
- Aljohani E
- Aljohani E
- Aljohani S
- Alkaaki A
- Alkammash A
- Alkelani M
- Alkhabbaz D
- Alkhouri M
- Allam M
- Allam M
- Allam Y
- Allegri A
- Allegri A
- Allen JLY
- Allott R
- Almallah A
- Almoflihi A
- Almuallem S
- Almy J
- Alnaby MH
- Alnawam E
- Alnuqaydan SA
- Alnusairat A
- Alomar IN
- Alqahtani E
- Alqahtani S
- Alrahawy M
- Alrajraji M
- Alrifaie A
- AlRowais M
- Alsaggaf M
- Alsaggaf MU
- Alsaggaf MU
- Alser OH
- Alshareef R
- Altaf A
- Altaf A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamimi A
- Altamini A
- Altarayra M
- Althwainy A
- Altibi A
- Altinel Y
- Altinel Y
- Altoe F
- Altwigry AM
- Altwijri A
- Alvarado Jaramillo R
- Alvarez Barreda LM
- Alvi AR
- Alwafai MG
- Aly AK
- Aly MYM
- Alyacoubi S
- Alyahya R
- Alyami R
- Alyami R
- AlYoussef I
- Alzahrani A
- Alzahrani M
- Alzahrani M
- Alzayat T
- Aman NF
- Amandito R
- Amandito R
- Amandito R
- Amandito R
- Ambrona-Zafra D
- Ambrozeviciute V
- Ameen M
- Amer MA
- Amin HAA
- Amin J
- Amin J
- Amjad M
- Ammar M
- Ammar MS
- Amoah M
- Amoako J
- Amoako PT
- Amoako-Boateng M
- Amole I
- Amreia M
- Amreia M
- Anandkumar D
- Anderson D
- Anderson F
- Anderson R
- Anderson-Knight H
- Andersson L
- Andika FFA
- Andreotti D
- Andres Garcia-Marin J
- Andress C
- Andriola V
- Ang YL
- Angelieri D
- Anis E
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Ansaloni L
- Antar S
- Antezana D
- Anthoulakis C
- Anthoulakis C
- Antoniozzi A
- Anwar AW
- Anwar N
- Anwer W
- Anyanwu L-J
- Anyanwu L-J
- Aonzo P
- Appeadu-Mensah W
- Appiah EK
- Aql S
- Aquilino F
- Arachchi PP
- Arachchige LAJJ
- Arafa O
- Arafa S
- Arango MCM
- Arango MCM
- Aranzabal Durand SY
- Araujo R
- Arcudi C
- Ardley R
- Arenas A
- Arevalo Azmitia JR
- Arias Pacheco RD
- Arman S
- Arman S
- Armando ChunguiBravo J
- Armellini A
- Arnaud A
- Arnaud AP
- Arnaud AP
- Arnaud AP
- Arroyo Basto CA
- Arshad MM
- Arslan E
- Arsyad HM
- Arthur T
- Arulampalam T
- Aruldas N
- Asal M
- Asar YH
- Asare-Bediako K
- Asele FA
- Ashour A
- Ashour A
- Ashour K
- Ashraf SF
- Ashtari M
- Ashton A
- Asi F
- Asilah SMD
- Assal A
- Assouto PA
- Asturia S
- Asumah H
- Ata A
- Ata AAA
- Ata AY
- Atiyeh A
- Atkins ET
- Atkinson K
- Atobatele K
- Attallah NA
- Attard M
- Attia A
- Attia AM
- Augestad KM
- Aung KP
- Austraite A
- Aviles S
- Avoka A
- Awad I
- Awad SA
- Awadallah S
- Awuku-Asabre J
- Ayad S
- Ayandipo O
- Ayandipo OO
- Aydin MC
- Ayyar S
- Aziz DNA
- Aziz MRA
- Aziz NA
- Azizeldine MG
- Azmitia Mendizabal CA
- Azodo IA
- Azzie G
- Azzie G
- Azzis O
- Baba S
- Bachri H
- Badawy M
- Badenjki MA
- Badicel M
- Badr A
- Badr MFM
- Badwi NM
- Badwi NM
- Badwy A
- Bahar S
- Baheeg M
- Bailey K
- Baillie K
- Baillie K
- Baird A
- Bakhaidar M
- Baki BE
- Bakr A
- Bakry HM
- Bala M
- Balalis D
- Baldacchino M
- Balducci G
- Balila RMH
- Balkan AZA
- Ballouhey Q
- Balmaceda R
- Balmaceda R
- Balmaceda R
- Balogun F
- Baltrunas R
- Baluch F
- Bamford R
- Bamicha A
- Bamicha A
- Banaitis VJ
- Bandi A
- Bandoh D
- Bani-Sadar A
- Banipal GS
- Baraka H
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- Karumnas P
- Kaselis N
- Kaselis N
- Kasem E
- Kasem EA
- Kasputyte S
- Kaul A
- Kazanavicius D
- Kedar A
- Kefalidi E
- Keke KR
- Kelany M
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- Kennedy M
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- Khafagy T
- Khairy H
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- Khatri C
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- Khedr AE-RH
- Khoja A
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- Khokha D
- Khokha V
- Khosla S
- Khouri Ferreira SA
- Khreishi R
- Khreishi R
- Khulu LB
- Khyrallh A
- Kiasat A
- Kidd T
- Kielty P
- Kim MY-H
- Kim S-H
- Kim SB
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- Kinandu K
- King R
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- Kirby A
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- Kjellin A
- Klappenbach R
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- Koay KL
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- Kojo ATT
- Kojo ATT
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- Kolosov A
- Komolafe O
- Kondrotas P
- Kong C
- Kong SN
- Kong V
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- Konstantina K
- Kontos M
- Kordorwu HEK
- Korkolis D
- Kosai NR
- Kosai NR
- Kose E
- Koskenvuo L
- Kostov E
- Kotb AHE-B
- Kotecha D
- Koto MZ
- Kotobi H
- Koumpa F
- Kouraklis G
- Kourdouli A
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- Krishna K
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- Kyrou G
- Kyziridis D
- L'Heveder A
- La Brocca A
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- Labib P
- Ladukas A
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- Lakshmi HN
- Lam FY
- Lam JCY
- Lam WH
- Lamanna GL
- Lanau MIV
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- Lap G
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- Latif A
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- Laurie K
- Lauzikas G
- Law JH
- Lawal A
- Lawal AO
- Lawal T
- Lawal TA
- Lawani I
- Lawther R
- Lazzari G
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- Lazzarini Cury AD
- Le VTH
- Leal A
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- Lecompte J-F
- Lee C
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- Lee F
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- Lee KY
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- Leppaniemi A
- Leppaniemi A
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- Leusink A
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- Li KKK
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- Liew I
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- Lilford R
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- Lim G
- Lim H
- Lim J
- Lim PJ
- Lim SJ
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- Lim SY
- Limache S
- Limaye N
- Limoges B
- Linares Delgado MSDFT
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- lo Conte A
- loaloa MR
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- Macchitella Y
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- Macfarlane A
- Machaca M
- Machain Vega GM
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- Maciejec L
- Madiba T
- Madkor MH
- Madrid Barrientos LA
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- Magee C
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- Manfreda S
- Mangan C
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- Manipal CE
- Maniscalco A
- Mann T
- Mannu GS
- Mano MJB
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- Marples L
- Marret J-B
- Marroquin Rodriguez DE
- Marshall DC
- Martian B-V
- Martin A
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- Matos-Puig R
- Mattar O
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- Mirza A
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- Mistry A
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- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed MA
- Mohamed MAEH
- Mohamed MM
- Mohamed O
- Mohamed SR
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
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- Mohammed MMH
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- Monteleone M
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- Montes I
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- Montoya Botero JA
- Montrimaite M
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- Moore R
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- Mosalum O
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- Sadig N
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- Sahel S
- Saidbadr A
- Sakr A
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- Salah OM
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- Salma U
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- Samalavicius NE
- Samaraweera DI
- Samih H
- Samir A
- Samison LH
- Sammarco G
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- Samy S
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- Sanz S
- Sapci I
- Saqlain M
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- Scott M
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- Semeda N
- Semiz A
- Sena-Ruiz F
- Senanayake KJ
- Senanayake WSMKJ
- Setiawan J
- Seto DM
- Seyoum N
- Sfougaris D
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- Shachykava T
- Shah A
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- Shahbaz AR
- Shaheen A
- Shahine A
- Shahzad N
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- Sharma A
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- Soreide JA
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- Souaibou YI
- Souaibou YI
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- Stoddart M
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- Sund M
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- Sundstrom SM
- Suresh S
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- Sutanto EPR
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- Swaroop M
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- Tabiri S
- Tabiri S
- Tabiri S
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- Tawfik G
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- Teasdale E
- Teasdale E
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- Torrance HD
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- Wold TB
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- Yeung ENW
- Yeung MHA
- Yifieyeh A
- Yildirim R
- Yip C
- Ymeri S
- Yoganathan P
- Yolcu S
- Yong CO
- Yong GL
- Younis A
- Youssef D
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- Zapata Ponze De Leon M
- Zapata F
- Zarb C
- Zardab A
- Zegarra S
- Zeidan S
- Zelada Alvarez II
- Zerihun AB
- Zeta Solis LA
- Zhang Z
- Zheng F
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- Zilinskiene R
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- Ziubryte G
- Zohair A
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- Zuber M
- Zuber M
- Zuk G
- Zulkifli A
- Zumbuhl L
- Publication venue
- Publication date
- 15/10/2018
- Field of study
Background The World Health Organization (WHO) Surgical Safety Checklist has fostered safe practice for 10 years, yet its place in emergency surgery has not been assessed on a global scale. The aim of this study was to evaluate reported checklist use in emergency settings and examine the relationship with perioperative mortality in patients who had emergency laparotomy. Methods In two multinational cohort studies, adults undergoing emergency laparotomy were compared with those having elective gastrointestinal surgery. Relationships between reported checklist use and mortality were determined using multivariable logistic regression and bootstrapped simulation. Results Of 12 296 patients included from 76 countries, 4843 underwent emergency laparotomy. After adjusting for patient and disease factors, checklist use before emergency laparotomy was more common in countries with a high Human Development Index (HDI) (2455 of 2741, 89.6 per cent) compared with that in countries with a middle (753 of 1242, 60.6 per cent; odds ratio (OR) 0.17, 95 per cent c.i. 0.14 to 0.21, P <0001) or low (363 of 860, 422 per cent; OR 008, 007 to 010, P <0.001) HDI. Checklist use was less common in elective surgery than for emergency laparotomy in high-HDI countries (risk difference -94 (95 per cent c.i. -11.9 to -6.9) per cent; P <0001), but the relationship was reversed in low-HDI countries (+121 (+7.0 to +173) per cent; P <0001). In multivariable models, checklist use was associated with a lower 30-day perioperative mortality (OR 0.60, 0.50 to 073; P <0.001). The greatest absolute benefit was seen for emergency surgery in low- and middle-HDI countries. Conclusion Checklist use in emergency laparotomy was associated with a significantly lower perioperative mortality rate. Checklist use in low-HDI countries was half that in high-HDI countries.Peer reviewe
No se fían
- Author
- A Gelman
- A Olvera
- A Salerno
- A Sorokin
- AM Cladera
- B de Las Rivas
- B Mau
- BG Spratt
- C Fraser
- C Salcedo
- C Silva
- CL Nesbo
- D Falush
- D Mayor
- D Posada
- DA Diavatopoulos
- DB Rusch
- DS Guttman
- DS Guttman
- E Meats
- EJ Feil
- EJ Feil
- EJ Feil
- EM Goss
- FM Cohan
- GA Watterson
- GW Tyson
- H Bernstein
- HP Narra
- I Lo
- I Tamas
- J Maynard Smith
- J Thaipadungpanit
- JA Castillo
- JFC Kingman
- JM Eppley
- JR Gilsdorf
- KA Jolley
- KL Vergin
- L Baldo
- L Diancourt
- L Diancourt
- L Lemee
- M Arvand
- M Coscolla
- M Enersen
- M Frapolli
- M Perez-Losada
- M Vos
- MC Enright
- MC Enright
- MCJ Maiden
- MCJ Maiden
- Michiel Vos
- MP Stumpf
- N Bisharat
- N Gonzalez-Escalona
- N Lodders
- NR Chowdhury
- P Fearnhead
- P Nicolas
- P Ruiz-Garbajosa
- PH Harvey
- PK Hayes
- R Milkman
- RA Fisher
- RA Stoddard
- RE Michod
- RJ Redfield
- RJ Redfield
- RJ Whitaker
- RR Hudson
- RT Papke
- S Suerbaum
- S Wright
- SF Sarkar
- SR Miller
- ST Walk
- T Rasback
- THOMAS H. JUKES
- V Souza
- WL Homan
- WP Hanage
- WP Hanage
- X Didelot
- Xavier Didelot
- Y Pannekoek
- Y Tanabe
- Publication venue
- 1996
- Publication date
- 01/01/1996
- Field of study
It is a standard practice to test for the signature of homologous recombination in studies examining the genetic diversity of bacterial populations. Although it has emerged that homologous recombination rates can vary widely between species, comparing the results from different studies is made difficult by the diversity of estimation methods used. Here, Multi Locus Sequence Typing (MLST) datasets from a wide variety of bacteria and archaea are analyzed using the ClonalFrame method. This enables a direct comparison between species and allows for a first exploration of the question whether phylogeny or ecology is the primary determinant of homologous recombination rate
Alcohol use and burden for 195 countries and territories, 1990-2016: a systematic analysis for the Global Burden of Disease Study 2016
- Author
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- Geleijnse JM
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- Gotay CC
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- Jackson MD
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- Kassa TDD
- Katikireddi SV
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- Khader Y
- Khafaie MA
- Khalil IA
- Khan MN
- Khang Y-H
- Khater MM
- Khubchandani J
- Kim C-I
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- Kim YJ
- Kimokoti RW
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- Kisa A
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- Kochhar S
- Kosen S
- Koul PA
- Koyanagi A
- Krishan K
- Kulkarni VS
- Kumar P
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- Lalloo R
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- Levi M
- Li Y
- Lim L-L
- Linn S
- Liu S
- Lobato-Cordero A
- Long HN
- Lotufo PA
- Machado IE
- Madotto F
- Mahesh PA
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- Majeed A
- Malekzadeh R
- Malta DC
- Mapoma CC
- Maria Haro J
- Martinez-Raga J
- Maulik PK
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- Mehta V
- Meier T
- Mekonen T
- Meles KG
- Melese A
- Memiah PTN
- Mendoza W
- Mengistu DT
- Mensah GA
- Meretoja TJ
- Mezgebe HB
- Miazgowski T
- Milicevic MMMS
- Miller TR
- Mini GK
- Mirica A
- Mirrakhimov EM
- Moazen B
- Mohammad KA
- Mohammadifard N
- Mohammed S
- Mokdad AH
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- Mousavi SM
- Mukhopadhyay S
- Murray CJL
- Musa KI
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- Nangia V
- Nansseu JR
- Nayak MSDP
- Nejjari C
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- Ngunjiri JW
- Ningrum DNA
- Nirayo YL
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- Ofori-Asenso R
- Ogbo FA
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- Oladimeji O
- Olagunju AT
- Olivares PR
- Olusanya BO
- Olusanya JO
- Oommen AM
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- Ortega-Altamirano DD
- Ortiz JR
- Ota E
- Owolabi MO
- Oyekale AS
- Pana A
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- Parry CDH
- Parsian H
- Patle A
- Patton GC
- Paudel D
- Petzold M
- Phillips MR
- Pillay JD
- Postma MJ
- Pourmalek F
- Prabhakaran D
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- Ram U
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- Ranabhat CL
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- Reiner RC
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- Ronfani L
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- Roth GA
- Roy A
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- Sahebkar A
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- Sarker AR
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- Sartorius B
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- Schaub MP
- Schmidt MI
- Schneider IJC
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- Schutte AE
- Schwendicke F
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- Shukla SR
- Sigfusdottir ID
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- Soares Filho AM
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- Sorensen RJD
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- Sufiyan MB
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- Truelsen TC
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- Uthman OA
- Valdez PR
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- Venkateswaran V
- Venketasubramanian N
- Violante FS
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- Yirsaw BD
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- Zamani M
- Zhang X
- Zimsen SRM
- Zodpey S
- Publication venue
- ELSEVIER SCIENCE INC
- Publication date
- 22/09/2018
- Field of study
BACKGROUND:
Alcohol use is a leading risk factor for death and disability, but its overall association with health remains complex given the possible protective effects of moderate alcohol consumption on some conditions. With our comprehensive approach to health accounting within the Global Burden of Diseases, Injuries, and Risk Factors Study 2016, we generated improved estimates of alcohol use and alcohol-attributable deaths and disability-adjusted life-years (DALYs) for 195 locations from 1990 to 2016, for both sexes and for 5-year age groups between the ages of 15 years and 95 years and older.
METHODS:
Using 694 data sources of individual and population-level alcohol consumption, along with 592 prospective and retrospective studies on the risk of alcohol use, we produced estimates of the prevalence of current drinking, abstention, the distribution of alcohol consumption among current drinkers in standard drinks daily (defined as 10 g of pure ethyl alcohol), and alcohol-attributable deaths and DALYs. We made several methodological improvements compared with previous estimates: first, we adjusted alcohol sales estimates to take into account tourist and unrecorded consumption; second, we did a new meta-analysis of relative risks for 23 health outcomes associated with alcohol use; and third, we developed a new method to quantify the level of alcohol consumption that minimises the overall risk to individual health.
FINDINGS:
Globally, alcohol use was the seventh leading risk factor for both deaths and DALYs in 2016, accounting for 2·2% (95% uncertainty interval [UI] 1·5–3·0) of age-standardised female deaths and 6·8% (5·8–8·0) of age-standardised male deaths. Among the population aged 15–49 years, alcohol use was the leading risk factor globally in 2016, with 3·8% (95% UI 3·2–4·3) of female deaths and 12·2% (10·8–13·6) of male deaths attributable to alcohol use. For the population aged 15–49 years, female attributable DALYs were 2·3% (95% UI 2·0–2·6) and male attributable DALYs were 8·9% (7·8–9·9). The three leading causes of attributable deaths in this age group were tuberculosis (1·4% [95% UI 1·0–1·7] of total deaths), road injuries (1·2% [0·7–1·9]), and self-harm (1·1% [0·6–1·5]). For populations aged 50 years and older, cancers accounted for a large proportion of total alcohol-attributable deaths in 2016, constituting 27·1% (95% UI 21·2–33·3) of total alcohol-attributable female deaths and 18·9% (15·3–22·6) of male deaths. The level of alcohol consumption that minimised harm across health outcomes was zero (95% UI 0·0–0·8) standard drinks per week.
INTERPRETATION:
Alcohol use is a leading risk factor for global disease burden and causes substantial health loss. We found that the risk of all-cause mortality, and of cancers specifically, rises with increasing levels of consumption, and the level of consumption that minimises health loss is zero. These results suggest that alcohol control policies might need to be revised worldwide, refocusing on efforts to lower overall population-level consumption.
FUNDING:
Bill & Melinda Gates Foundation
Global variation in anastomosis and end colostomy formation following left-sided colorectal resection
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- Elgendy Fi
- Elgheriany M
- Elhadad A
- Elhadary Nm
- Elhadry S
- Elhalawany E
- Elhamouly S
- Elhelbawy Ms
- Elhendawy A
- Elhendawy Aoa
- Elhoseny G
- Elhusseiny Aae
- Elkadsh I
- Elkady F
- Elkelany A
- Elkelany A
- Elkelany A
- Elkelany A
- Elkhadrawi M
- Elkhalek Ea
- Elkholy A
- Elkholy Ss
- Elkolaly Ss
- Elkorashy Am
- Ellison Q
- Elmashala A
- Elmasry M
- Elmelegy R
- Elmihy S
- Elnagar A
- Elnajjar Ma
- Elnemr Ae
- Elrasoul Ya
- Elrazek Aa
- Elsabbagh N
- Elsameea Aa
- Elsawahly Dme
- Elsawy A
- Elsayed M
- Elsayed M
- Elsayed N
- Elsayed Nar
- Elsayed Zm
- Elsebaaye Ao
- Elsehimy M
- Elsemelawy R
- Elshaar M
- Elshaer K
- Elshaer M
- Elshaer M
- Elshafay Ae
- Elshami M
- Elshanwany S
- Elsharkawy Aa
- Elsheikh S
- Elsherbiney S
- Elsherbiny As
- Elsherif Fa
- Elshobary M
- Elsiddig M
- Elsobky S
- Elsorogy Deaa
- Elwaey A
- Elwakil H
- Elwan A
- Elwan A
- Elwy E
- Elzahed N
- Elzayat I
- Elzayat M
- Elzayyat I
- Elzowawi F
- Emadeldin D
- Emadeldin H
- Emara E
- Emile S
- Eng C
- English W
- Esam A
- Escobar Eg.
- Espin-Basany E
- Espinoza F
- Espinoza Kt
- Espinoza Kt
- Essam A
- Essam Aa
- Essam M
- Essoun S
- Esteban E
- Estee Mm
- Estupinian S
- Etchill E
- Etchill E
- Etienne S
- Etman M
- Etwire V
- Evajelista Cv
- Evans D
- Evans E
- Eysa A
- Eyssartier E
- Ezzat E
- Ezzat T
- Faboya O
- Faccincani R
- Fadel A
- Fahiem A
- Fahim M
- Fahy C
- Fairfield C
- Fairfield C
- Fairfield C
- Fakher R
- Falaschi F
- Falco N
- Falzon M
- Farag A
- Farag S
- Farah A
- Farahat Mm
- Faraz A
- Fares M
- Farfan Esf
- Farhad M
- Farhan-Alanie Mmh
- Farhangmehr N
- Farinella E
- Farmakis K
- Farooq T
- Farouk Sam
- Farquharson A
- Farrugia A
- Farrugia A
- Faruq A
- Fathy Am
- Fattah Aa
- Fatuga A
- Faturoti O
- Faturoti O
- Faure A
- Fautz T
- Favero A
- Fawzy A
- Feidantsis T
- Felipe Co
- Fergany A
- Fergusson Sj
- Fergusson Sj
- Fergusson Sj
- Fermani C
- Fermani Cg
- Ferná
- Fernandes C
- Fernandez-Bueno F
- Fernandez-Vega L
- Ferousis C
- Ferreira Sak
- Ferrero E
- Fievet L
- Filatau A
- Findlay-Cooper K
- Firdouse M
- Firdouse M
- Firdouse M
- Firwana A
- Fitsum A
- Fitzgerald Je
- Florez Ljg
- Foco M
- Fok Cyj
- Fontana T
- Foo Cc
- Forlin L
- Forno W
- Fouad A
- Fouad D
- Fouad D
- Fourcade L
- Fowler Aj
- Fozard T
- Fozard T
- Frade F
- Fraga Gp
- Franco H
- Francois P
- Francois-Coridon H
- Francone E
- Freitas Av
- Frey D
- Frisk B
- Fuentes-Rivera L
- Fujii F
- Furqan Mm
- Gü
- Gü
- Gaafar S
- Gaarder T
- Gad A
- Gad Mo
- Gadelkarim M
- Gadhvi V
- Gado A
- Gaiž
- Gaignard E
- Gaignard E
- Gala T
- Gala T
- Galiqi G
- Galleano R
- Gallo G
- Galloway S
- Galvez Cp
- Gamal D
- Gamal E
- Gamal H
- Gamal S
- Gamaly E
- Gamil D
- Gan C
- Gan Yy
- Gani Ma
- Garaycochea O
- Garcí
- Garcí
- Garcí
- Garcia-Florez L
- Garcia-Marin Ja
- Garcia-Perez Jm
- Garland A
- Gash K
- Gash K
- Gash K
- Gastaldi P
- Gasteratos K
- Gaujoux S
- Gavagna L
- Gbessi Dg
- Gemeah M
- Gemenetzis G
- Gemenetzis G
- George R
- Germanos S
- Germanos S
- Gerosa A
- Gerosa A
- Geuoshy A
- Ghaben A
- Ghandora N
- Ghanem A
- Ghanem E
- Ghanem S
- Ghanem S
- Ghannam M
- Gharib A
- Gharib A
- Ghazy Aa
- Gheith A
- Ghetia M
- Ghetia M
- Ghonaim Ma
- Ghoneem M
- Ghoneim O
- Giacci L
- Giardino Fr
- Giavarini L
- Giglio Mc
- Gilbert R
- Gilbert Rw
- Giles J
- Gillespie M
- Gimzewska M
- Giraldo Rsr
- Giuliani S
- Giuliani S
- Giuriato Tf
- Gkiokas G
- Glasbey J
- Glasbey J
- Glasbey Jc
- Glasbey Jc
- Glover Te
- Glover-Addy H
- Glynn M
- Gobin N
- Gobin N
- Goh Cc
- Goh Cc
- Goh W
- Gohar Meam
- Gokani S
- Goldin E
- Golding D
- Gomaa A
- Gomah M
- Gonzalez M
- Gonzalez Sc
- Goodstein M
- Gosling S
- Gosling Sg
- Gouda A
- Gould L
- Gouldthorpe C
- Gouvas N
- Gouws J
- Graffeille V
- Graffieille V
- Gran M
- Grandinetti Pp
- Grant A
- Grasset E
- Grasset E
- Grassi V
- Gratton R
- Gravante G
- Gravante G
- Gray D
- Grech N
- Green N
- Grella Mg
- Gribauskaite J
- Griffiths E
- Griffiths E
- Griffiths M
- Grima T
- Grisin E
- Grizhja B
- Grobler Dc
- Grosos C
- Grossart C
- Guasti Bpsj
- Gudal A
- Gudal A
- Gudal A
- Gudlaugsdottir K
- Guevara R
- Guglielmo V
- Gui D
- Gulbinas A
- Gulcicek Ob
- Gulielmi A
- Gultom Pa
- Gumar M
- Gunaseelan K
- Gunawan R
- Guner A
- Gunnarsson U
- Guo W
- Gupta A
- Gustafsson U
- Gyamfi Fe
- Gyanchandani N
- Gyedu A
- Habeeb Ma
- Habeeb O
- Habeebullah A
- Hache-Marliere M
- Haddad N
- Hafez At
- Hafez M
- Hafez M
- Hafez S
- Haffreingue A
- Hafiz S
- Hagan R
- Hagar A
- Haines M
- Haines S
- Hajeh H
- Hakim H
- Halhouli O
- Halhouli O
- Halicioglu I
- Hall E
- Hall N
- Hall Nj
- Hall Tf
- Hallam S
- Haloho A
- Hamad Mgm
- Hamaguchi Jlh
- Hamarshi A
- Hamasaki J
- Hamdan A
- Hamdan M
- Hamed Mf
- Hamill D
- Hammad A
- Hammad A
- Hammad Am
- Hampton M
- Hampton Mi
- Hamsho W
- Hanafy M
- Hand C
- Hanks A
- Hanley I
- Hanoun S
- Hanrahan M
- Hanrahan M
- Hanrahan M
- Hanrahan M
- Hantour U
- Hantour U
- Hany E
- Haque M
- Har Pa
- Haraux E
- Harbord P
- Haroun A
- Harper E
- Harrison Em
- Harrison Em
- Harrison N
- Harrison P
- Harrison R
- Hartford L
- Harvey N
- Hasan A
- Hasan A
- Hasan D
- Hasanah A
- Hasanain D
- Hascoet J
- Hashad E
- Hasheminia A
- Hashim A
- Hashish A
- Hashish M
- Haslegrave A
- Hasnan Mb
- Hassaan A
- Hassaan A
- Hassan A
- Hassan A
- Hassan A
- Hassan Ata
- Hassan I
- Hassan M
- Hassan Omm
- Hassan S
- Hassan Z
- Hassanain M
- Hassanain M
- Hassanein Ab
- Havemann I
- Hawkins W
- Heard R
- Heath J
- Heffernan D
- Hegazy Em
- Hegazy Y
- Helene Fc
- Helguero-Santin Lm
- Hemeda D
- Hemingway D
- Hemmila M
- Hemmila M
- Henderson L
- Henderson L
- Heng He
- Henric N
- Henry F
- Henshall De
- Herebat A
- Herikstad R
- Herrera N
- Herrera-Matta J
- Herrod P
- Hervieux E
- Hervieux E
- Hesham O
- Hettiarachchi Ts
- Hewage K
- Heywood Eg
- Highcock S
- Hilal K
- Hinojosa C
- Hjertberg M
- Hjertberg M
- Hmila S
- Ho A
- Ho Cw
- Ho W
- Ho Wc
- Hodonou F
- Hogea M
- Holte S
- Holton P
- Homeida A
- Hoogakker E
- Horobjowsky A
- Hosein Sp
- Hosh M
- Hossaini S
- Hossameldin A
- Houlden C
- Howells L
- Howie Ee
- Hrora A
- Huaman E
- Huaraya Rc
- Humm G
- Hunter K
- Hussain M
- Hussein A
- Hussein S
- Husseini M
- Husseiny R
- Hutch W
- Huwait A
- Iş
- Iacono C
- Iannone I
- Ibraheem Aa
- Ibraheem Hi
- Ibrahem Aa
- Ibrahem Aa
- Ibrahim A
- Ibrahim A
- Ibrahim A
- Ibrahim Am
- Ibrahim E
- Ibrahim Em
- Ibrahim I
- Ibrahim K
- Ibrahim M
- Ibrahim Mh
- Ibrahim Y
- Idress T
- Idris F
- Idris Sai
- Iftekhar F
- Iftikhar Z
- Iftikhar Z
- Ignatavicius P
- Ihediwa G
- Imoro O
- Ingabire Jca
- Ingabire Jca
- Ingabire Jca
- Ioannidis O
- Iordache Fm
- Iqbal Fm
- Iqbal Mr
- Ireland P
- Irtan S
- Irtan S
- Irwin G
- Irwin G
- Irwin G
- Irwin G
- Ishak N
- Iskandar F
- Ismaï
- Ismaï
- Ismaï
- Ismaï
- Ismail A
- Ismail M
- Ismail M
- Ismail Mjb
- Ismail Mk
- Ismail Sa
- Israelsson L
- Ivros N
- Iyer D
- Iyer D
- Iyer D
- Jabal Ms
- Jabbar A
- Jaber S
- Jackson P
- Jacobe M
- Jaffry Z
- Jaffry Z
- Jaich R
- Jain P
- Jama Gm
- Jamal L
- Janardha Kc
- Janik M
- Jankus T
- Jaradat D
- Jaramillo Ra
- Jarmin M
- Jasaitis K
- Javaid M
- Javed O
- Javed O
- Jawaid M
- Jayathilake Ab
- Jck Ng
- Jean-Francois C
- Jeffery A
- Jeffery A
- Jenner E
- Jennings L
- Jennings V
- Jennings V
- Jensen E
- Jenvey C
- Jeo Ws
- Jeon H
- Jeremic L
- Jethwani Dl
- Jeyakumar J
- Jeyakumar J
- Jha M
- Jimenez J
- Jimenez-Morillas P
- Joel Lwl
- Johanna N
- Johnson K
- Johnston R
- Jokubauskas M
- Jokubauskas M
- Jokubonis K
- Jones C
- Jones C
- Jones E
- Jones Tf
- Jonnalagadda R
- Joosten J
- Jordan H
- Jotautas V
- Jotautas V
- Jovine E
- Jovine E
- Jubran Af
- Juciute S
- Julaihi R
- Jurdell E
- Kaafarani H
- Kabariti R
- Kabariti R
- Kabba J
- Kabongo K
- Kache S
- Kaci Aa
- Kadiwar S
- Kalakouti E
- Kalles V
- Kalles V
- Kalles V
- Kamarajah Sk
- Kamarulzamil Sna
- Kamil R
- Kamya S
- Kanani A
- Kandil Am
- Kandil H
- Kang Mk
- Kanta Th
- Karabacak U
- Karabelias G
- Karabulut K
- Karahan Sr
- Karakahya M
- Karandikar S
- Karandikar S
- Kariem N
- Karim A
- Karim R
- Karim S
- Karismaningtyas H
- Karjiker P
- Karkeet M
- Karkeet M
- Karlo R
- Karlo R
- Karousos D
- Karumnas P
- Kaselis N
- Kaselis N
- Kasem E
- Kasem Ea
- Kasputyte S
- Kaul A
- Kazanavicius D
- Kedar A
- Kefalidi E
- Keke Kr
- Kelany M
- Kenibar A
- Kennedy Ed
- Kennedy M
- Kennedy R
- Keogh K
- Kerley R
- Kershaw S
- Kesinger M
- Khafagy T
- Khairy H
- Khairy H
- Khajanchi M
- Khaled H
- Khalifah E
- Khalili M
- Khalique A
- Khallaf S
- Khamajeet A
- Khan A
- Khan K
- Khan Ma
- Khan R
- Khan S
- Khan T
- Khan Za
- Kharsa S
- Khatri C
- Khatri C
- Khattab K
- Khedr Aeh
- Khg Li
- Khoja A
- Khoja A
- Khokha D
- Khokha V
- Khosla S
- Khreishi R
- Khreishi R
- Khulu Lb
- Khyrallh A
- Kiasat A
- Kidd T
- Kielty P
- Kim My
- Kim Sb
- Kim Sh
- Kimaro M
- Kinandu K
- King R
- King S
- King S
- Kinnera Sv
- Kiran Rp
- Kirby A
- Kirishnan A
- Kirupagaran A
- Kiudelis M
- Kjellin A
- Kkk Li
- Klappenbach R
- Knight S
- Koay Kl
- Kobal Bb
- Koh C
- Koh H
- Koh Py
- Koh S
- Koh S
- Kojo Att
- Kojo Att
- Kojo Att
- Kolosov A
- Komolafe O
- Kondrotas P
- Kong C
- Kong Sn
- Kong V
- Kong V
- Konstantina K
- Kontos M
- Kordorwu Hek
- Korkolis D
- Kosai Nr
- Kosai Nr
- Kose E
- Koskenvuo L
- Kostov E
- Kotb Ahe
- Kotecha D
- Koto Mz
- Kotobi H
- Koumpa F
- Kouraklis G
- Kourdouli A
- Kourdouli A
- Kretzmann H
- Krishna K
- Kruspi S
- Kufeji D
- Kulasabanathan K
- Kuliavas J
- Kumar B
- Kumar B
- Kumar B
- Kumar Bs
- Kumar Mn
- Kumar S
- Kumar S
- Kumar S
- Kumar S
- Kumar T
- Kumwenda D
- Kushwaha S
- Kushwaha S
- Kusi K
- Kutkevicius J
- Kwakyeafriyie P
- Kwatiwani C
- Kwizera S
- Kwok Sh
- Kyereh M
- Kyriazanos I
- Kyrou G
- Kyziridis D
- Ló
- L&apos
- La Brocca A
- la Medina AR
- la Medina AR
- la Medina AR
- Labib P
- Ladukas A
- Lafferty K
- Lagunavicius K
- Lai Ac
- Lakhani Sm
- Lakshmi Hn
- Lam Fy
- Lam Jcy
- Lam Wh
- Lamanna Gl
- Lanau Miv
- Lando J
- Landolfo G
- Landolfo G
- Lap G
- Lapitan Mc
- Lapitan Mc
- Larsen Jw
- Lasek A
- Lasheen A
- Lasheen Kt
- Latif A
- Laufer Lav
- Laugzemys E
- Laugzemys E
- Laurie K
- Lauzikas G
- Law Jh
- Lawal A
- Lawal Ao
- Lawal T
- Lawal Ta
- Lawani I
- Lawther R
- Lazzari G
- Lazzari V
- Leal A
- Leal M
- Lecompte Jf
- Lee C
- Lee Ex
- Lee F
- Lee K
- Lee Kc
- Lee Ky
- Lee Tsb
- Lemaire Sb
- Leone N
- Leong Fqh
- Leppä
- Leppä
- Leroux J
- Leung Kw
- Leung Mf
- Leusink A
- Lewis J
- Li Ws
- Licari L
- Lieske B
- Lieske B
- Liew I
- Liew I
- Lilford R
- Lilford R
- Lilford Rj
- Lim G
- Lim H
- Lim J
- Lim Pj
- Lim Sj
- Lim Sj
- Lim Sy
- Limache S
- Limaye N
- Limoges B
- Lintin L
- Lipnickas V
- Litvin A
- Liu Q
- Liu Q
- Livesey A
- Livingston M
- Ljuhar D
- Lo Conte A
- Loaloa Mr
- Lockey J
- Lohse Has
- Lohse Has
- Loizides S
- Lokman Maa
- Longstaff L
- Lopez Ce
- Lopez Lip
- Lopez M
- Lopez M
- Lopez-Arevalo C
- Lorenzon L
- Lossius Wj
- Loughran D
- Low X
- Luc Ar
- Luck J
- Luck J
- Luck J
- Luglio G
- Lund J
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- Lundgren Po
- Luque Gb
- Luque L
- Luque L
- Lytras D
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- Má
- Mé
- Mü
- Mañ
- Ma J
- Mabitsela Me
- Mabrouk M
- Macchiavello R
- Macchitella Y
- Macchitella Y
- Macdermid E
- Macdonald A
- Macdonald E
- Macdonald L
- Maceviciute K
- Macfarlane A
- Machaca M
- Maciejec L
- Madiba T
- Madkor Mh
- Maffioli A
- Maffioli A
- Magdy A
- Magdy B
- Magdy E
- Magdy H
- Magdy M
- Magdy S
- Magee C
- Maghrabi A
- Maghrabi Aa
- Magri D
- Mahamood Ab
- Mahanty S
- Maharaj G
- Mahdi A
- Mahdi S
- Mahdi S
- Maher Me
- Mahmoud B
- Mahmoud H
- Mahmoud M
- Mahmoud Ma
- Mahmoud Mi
- Mahmoud S
- Mahmoud Sme
- Mahmud K
- Maillot B
- Maimbo M
- Maimbo M
- Mairs Ng
- Maison K
- Maistry N
- Majauskyté
- Majbar A
- Majid Ahha
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- Major Cp
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- Mak T
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- Makinde M
- Makupe A
- Malavenda M
- Malik K
- Malik P
- Malik Ta
- Mamdouh E
- Mamdouh R
- Manatakis Dk
- Manfreda S
- Mangan C
- Mangan C
- Mangiapane M
- Manipal Ce
- Maniscalco A
- Mann T
- Mannu Gs
- Manriquez-Reyes M
- Mansor Ey
- Mansour B
- Mansour S
- Mansuri A
- Mao P
- Mapasse D
- Maple N
- Maraie N
- Marey A
- Marey As
- Margaritis M
- Mariani A
- Marinkovic B
- Marinos C
- Marks E
- Marples L
- Marret Jb
- Marshall Dc
- Martian Bv
- Martin A
- Mas R
- Mason C
- Mata Lps
- Matheu A
- Mathew Sw
- Matos-Puig R
- Matta Jjh
- Mattar O
- Matter Sm
- Mauro L
- Mayasari M
- Mazelyte R
- Mazrimas P
- Mazzella A
- Mcaleer E
- Mcaleer S
- Mccarthy K
- Mccarthy M
- Mccarthy M
- McCullagh D
- Mcdonald R
- McGarvie S
- Mcguigan A
- McIntosh K
- Mcintosh R
- Mcintyre Cj
- Mcintyre N
- Mcintyre R
- Mckechnie D
- Mclachlan G
- Mclean Al
- Mclean K
- McMorran D
- Mcnish D
- Mcphee A
- Mealy K
- Mehdi A
- Mehrez S
- Mejia Agv
- Melo R
- Melo R
- Mendel H
- Mendez M
- Mendez N
- Mendizabal Caa
- Mendoza I
- Menegussi J
- Mensah E
- Menshawy A
- Mentula P
- Meqbil J
- Mericliler M
- Merlini D
- Merlini D
- Merlo Ms
- Mesbah N
- Meshref A
- Metwally Mm
- Migliore M
- Miguel Gps
- Mihaljevic Al
- Mihanovic J
- Mihanovic J
- Mijuskovic B
- Mikalauskas S
- Mikalauskas S
- Mikuckyte D
- Mikwar Z
- Milligan W
- Milligan W
- Mingrone P
- Minguez G
- Minocha A
- Minocha A
- Miranda C
- Mircea H
- Mirghani D
- Mironescu A
- Mironescu A
- Mironescu As
- Mironescu As
- Mirza A
- Mirza S
- Mistry A
- Mitrasinovic S
- Mitroudi M
- Mitroudis N
- Mittal A
- Mitul Ar
- Mitul Ar
- Miyasato Hs
- Mizzi C
- Mizzi S
- Mlotshwa M
- Moaty M
- Mochet S
- Modolo Mm
- Modolo Mm
- Modolo Mm
- Moe Tt
- Mogan Yp
- Moghazy Me
- Mohamed A
- Mohamed A
- Mohamed Am
- Mohamed Ar
- Mohamed B
- Mohamed F
- Mohamed I
- Mohamed M
- Mohamed Ma
- Mohamed Maeh
- Mohamed Mm
- Mohamed O
- Mohamed Sr
- Mohameden A
- Mohammad A
- Mohammad A
- Mohammed A
- Mohammed A
- Mohammed Ae
- Mohammed Ar
- Mohammed H
- Mohammed Mm
- Mohammed Mmh
- Mohammed S
- Mohan H
- Mohan M
- Mohan M
- Mok Yt
- Mokhtar A
- Molina G
- Mollo Mc
- Monaghan E
- Monaghan E
- Monrad-Hansen Pw
- Montejo Msg
- Monteleone M
- Monteleone M
- Montes I
- Montes I
- Montrimaite M
- Montrimaite M
- Moodley Y
- Moore R
- Moore R
- Mora Jjv
- Morais Pab
- Morales C
- Moran Aer
- Morandi E
- Moreira G
- Moreno Sc
- Morgan C
- Morgan C
- Morshedy Em
- Morsi A
- Morsi M
- Morton D
- Morton D
- Morton R
- Mosad A
- Mosalum O
- Mostafa Ha
- Mostafa M
- Mostafa M
- Mousa M
- Moussa O
- Moustafa A
- Mouttalib S
- Mowafy B
- Mphatsoe Am
- Mshelbwala P
- Msiska N
- Msosa V
- Msosa V
- Muddebihal U
- Mukin Adf
- Muktar U
- Mukuzunga C
- Muller C
- Muller C
- Munera A
- Munhoz Mm
- Munipalle Pc
- Muntean L
- Muntean Li
- Muralha N
- Murphy J
- Murray A
- Murutoglu B
- Musa Aek
- Musleh A
- Musowoya J
- Mussad A
- Mustafa M
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- Publication venue
- 'Wiley'
- Publication date
- 27/11/2018
- Field of study
Background
End colostomy rates following colorectal resection vary across institutions in high-income settings, being influenced by patient, disease, surgeon and system factors. This study aimed to assess global variation in end colostomy rates after left-sided colorectal resection.
Methods
This study comprised an analysis of GlobalSurg-1 and -2 international, prospective, observational cohort studies (2014, 2016), including consecutive adult patients undergoing elective or emergency left-sided colorectal resection within discrete 2-week windows. Countries were grouped into high-, middle- and low-income tertiles according to the United Nations Human Development Index (HDI). Factors associated with colostomy formation versus primary anastomosis were explored using a multilevel, multivariable logistic regression model.
Results
In total, 1635 patients from 242 hospitals in 57 countries undergoing left-sided colorectal resection were included: 113 (6·9 per cent) from low-HDI, 254 (15·5 per cent) from middle-HDI and 1268 (77·6 per cent) from high-HDI countries. There was a higher proportion of patients with perforated disease (57·5, 40·9 and 35·4 per cent; P < 0·001) and subsequent use of end colostomy (52·2, 24·8 and 18·9 per cent; P < 0·001) in low- compared with middle- and high-HDI settings. The association with colostomy use in low-HDI settings persisted (odds ratio (OR) 3·20, 95 per cent c.i. 1·35 to 7·57; P = 0·008) after risk adjustment for malignant disease (OR 2·34, 1·65 to 3·32; P < 0·001), emergency surgery (OR 4·08, 2·73 to 6·10; P < 0·001), time to operation at least 48 h (OR 1·99, 1·28 to 3·09; P = 0·002) and disease perforation (OR 4·00, 2·81 to 5·69; P < 0·001).
Conclusion
Global differences existed in the proportion of patients receiving end stomas after left-sided colorectal resection based on income, which went beyond case mix alone
Protective Role of Spore Structural Components in Determining Bacillus subtilis Spore Resistance to Simulated Mars Surface Conditions
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