Assimetria de informação e preços diários de ações no Brasil

This paper has the goal of analyzing the association between asymmetric information, measured by Corwin-Schultz bid ask spread estimator, and stock prices in the Brazilian stock market. Daily data from 64 corporations over a period of 10 years were examined using the Johansen-Fisher panel cointegration technique in order to assess the validity of asymmetric information measurements in shorter periods than in previous studies. The results indicate that asymmetric information anticipates stock prices over a period of up to two days in a theoretically consistent way. Future research may control the results via traditional finance variables.Este trabajo tuvo como objetivo analizar la asociación entre información asimétrica, medida a través del estimador Corwin-Schultz, y las cotizaciones bursátiles en el mercado de valores brasileño. Los datos diarios de 64 empresas, en un período de 10 diez años, se examinaron utilizando la técnica de cointegración de panel de Johansen-Fisher para evaluar la validez de una medida de información asimétrica en períodos más cortos que los estudios anteriores. Los resultados indican que la información asimétrica anticipa los precios de las acciones en un período de hasta dos días, de una manera teóricamente consistente. Las investigaciones futuras deberían controlar los resultados mediante variables financieras tradicionales.Este trabalho tem como objetivo analisar a associação entre informação assimétrica, medida pelo estimador Corwin-Schultz, e cotizações bursáteis no mercado brasileiro de ações. Foram analisados dados diários de 64 empresas, durante um perídodo de 10 anos, pela técnica de cointegração para dados em painel de Johansen-Fisher, para avaliar a validade de uma medida de informação assimétrica em períodos inferiores aos de estudos anteriores. Os resultados indicam que a informação assimétrica antecipa o preço das ações em um período de até 2 dias, de maneira teoricamente consistente. Pesquisas futuras deveriam controlar os resultados mediante variáveis financeiras tradicionais

Assimetria de informação e preços diários de ações no Brasil

This paper has the goal of analyzing the association between asymmetric information, measured by Corwin-Schultz bid ask spread estimator, and stock prices in the Brazilian stock market. Daily data from 64 corporations over a period of 10 years were examined using the Johansen-Fisher panel cointegration technique in order to assess the validity of asymmetric information measurements in shorter periods than in previous studies. The results indicate that asymmetric information anticipates stock prices over a period of up to two days in a theoretically consistent way. Future research may control the results via traditional finance variables.Este trabajo tuvo como objetivo analizar la asociación entre información asimétrica, medida a través del estimador Corwin-Schultz, y las cotizaciones bursátiles en el mercado de valores brasileño. Los datos diarios de 64 empresas, en un período de 10 diez años, se examinaron utilizando la técnica de cointegración de panel de Johansen-Fisher para evaluar la validez de una medida de información asimétrica en períodos más cortos que los estudios anteriores. Los resultados indican que la información asimétrica anticipa los precios de las acciones en un período de hasta dos días, de una manera teóricamente consistente. Las investigaciones futuras deberían controlar los resultados mediante variables financieras tradicionales.Este trabalho tem como objetivo analisar a associação entre informação assimétrica, medida pelo estimador Corwin-Schultz, e cotizações bursáteis no mercado brasileiro de ações. Foram analisados dados diários de 64 empresas, durante um perídodo de 10 anos, pela técnica de cointegração para dados em painel de Johansen-Fisher, para avaliar a validade de uma medida de informação assimétrica em períodos inferiores aos de estudos anteriores. Os resultados indicam que a informação assimétrica antecipa o preço das ações em um período de até 2 dias, de maneira teoricamente consistente. Pesquisas futuras deveriam controlar os resultados mediante variáveis financeiras tradicionais

NEDD4-1 is a key regulator of epidermal homeostasis and wound repair

The ubiquitin ligase Nedd4-1 plays key roles in organ development, tissue homeostasis and cancer, but its functions in the skin are largely unknown. Here we show perturbations in keratinocyte proliferation and terminal differentiation, epidermal barrier function, and hair follicle cycling as well as increased UV-induced apoptosis in mice lacking Nedd4-1 in keratinocytes. In particular, re-epithelialization of full-thickness excisional wounds was delayed in the mutant mice. This was caused by severely impaired migration and proliferation of Nedd4-1-deficient keratinocytes. Therefore, a few keratinocytes, which had escaped recombination and expressed Nedd4-1, obtained a growth advantage and contributed to re-epithelialization. Mechanistically, Nedd4-1-deficient keratinocytes failed to efficiently activate the Erk1/2 mitogen-activated kinases and the YAP transcriptional co-activator. These results identify Nedd4-1 as an essential player in wound repair through its effect on mitogenic and motogenic signaling pathways in keratinocytes.ISSN:0022-202XISSN:1523-174

Using Numbers Creates Value for Health Professionals: A Quantitative Study of Pain Management in Palliative Care

Improvement methodology is based on processes to achieve quality and safety in health care in order to improve patient care, especially in management. The aim of this study was to identify differences regarding the method of estimating pain within palliative care in north-eastern Sweden. The study comprised three different data collections—questions from 22 staff members who worked in palliative care, data from the Swedish Palliative Registry, and patients’ medical records. Data were analyzed using a quantitative approach to measure the proportion of differences and similarities in everyday pain management. The two categories “Documentation of Pain Management” and “Pain Management Activities” were identified and illustrated how repeated pain management measurements contributed to a clearer view of pain management activities. The use of numbers instead of words contributed to a better, clearer, and more unified documentation of pain ratings. Use of validated rating tools regarding patients last week of life increased from 47%–100%. This study may inspire better routines to estimate pain and quantify no pain in palliative care. Evidence-based measurement tools from the patient’s perspective, can improve pain management