Spherical Displays: Technology and Visualization

IU's Cyberinfrastructure Building is home to the 97th installation of the National Oceanic and Atmospheric Administration's Science On a Sphere(SoS). The presentation discusses how the Advanced Visualization Lab uses spherical display technology to present visualizations on a wide range of data, including oceanographic, atmospheric, astronomical, political, and economic.

Experiences in Higher Education with SOS

Talk presented at the December 2, 2015 SOS Users Collaborative Network Meeting in Portland, Oregon.Staff from Indiana University's Advanced Visualization Lab will present lessons learned from our initial 2.5 years supporting the use of SOS for research, education, and creative activity. We will discuss the challenges and opportunities of hosting SOS at a research university and then detail unique development efforts that go beyond traditional science. Such efforts include our use of real-time Google Analytics, streamgraphs for time-based visualizations, spherical panoramas, and art exhibits

Game story space of professional sports: Australian rules football

Sports are spontaneous generators of stories. Through skill and chance, the script of each game is dynamically written in real time by players acting out possible trajectories allowed by a sport\u27s rules. By properly characterizing a given sport\u27s ecology of game stories, we are able to capture the sport\u27s capacity for unfolding interesting narratives, in part by contrasting them with random walks. Here we explore the game story space afforded by a data set of 1310 Australian Football League (AFL) score lines. We find that AFL games exhibit a continuous spectrum of stories rather than distinct clusters. We show how coarse graining reveals identifiable motifs ranging from last-minute comeback wins to one-sided blowouts. Through an extensive comparison with biased random walks, we show that real AFL games deliver a broader array of motifs than null models, and we provide consequent insights into the narrative appeal of real games

The state of the Martian climate

60°N was +2.0°C, relative to the 1981–2010 average value (Fig. 5.1). This marks a new high for the record. The average annual surface air temperature (SAT) anomaly for 2016 for land stations north of starting in 1900, and is a significant increase over the previous highest value of +1.2°C, which was observed in 2007, 2011, and 2015. Average global annual temperatures also showed record values in 2015 and 2016. Currently, the Arctic is warming at more than twice the rate of lower latitudes

Intestinal Tumorigenesis Is Not Affected by Progesterone Signaling in Rodent Models

Clinical data suggest that progestins have chemopreventive properties in the development of colorectal cancer. We set out to examine a potential protective effect of progestins and progesterone signaling on colon cancer development. In normal and neoplastic intestinal tissue, we found that the progesterone receptor (PR) is not expressed. Expression was confined to sporadic mesenchymal cells. To analyze the influence of systemic progesterone receptor signaling, we crossed mice that lacked the progesterone receptor (PRKO) to the ApcMin/+ mouse, a model for spontaneous intestinal polyposis. PRKO-ApcMin/+mice exhibited no change in polyp number, size or localization compared to ApcMin/+. To examine effects of progestins on the intestinal epithelium that are independent of the PR, we treated mice with MPA. We found no effects of either progesterone or MPA on gross intestinal morphology or epithelial proliferation. Also, in rats treated with MPA, injection with the carcinogen azoxymethane did not result in a difference in the number or size of aberrant crypt foci, a surrogate end-point for adenoma development. We conclude that expression of the progesterone receptor is limited to cells in the intestinal mesenchyme. We did not observe any effect of progesterone receptor signaling or of progestin treatment in rodent models of intestinal tumorigenesis

Current treatment of double hit and double expressor lymphoma

A 60-year-old female presented with abdominal pain and distension. Following computed tomography scans of the abdomen and pelvis, she was taken urgently to the operating room, with the belief that she had appendicitis with perforation. At laparotomy, the findings were consistent with an ovarian carcinoma; there was extensive infiltration of the ovary, bowel, and omental deposits. Cytoreductive surgery was performed including total abdominal hysterectomy and bilateral salpingo-oophorectomy. The final pathology, however, revealed infiltration with medium-sized atypical lymphoid cells positive for CD20, CD10, MYC, BLC2, and BCL6 by immunohistochemistry. MYC and BCL2 translocations were identified by fluorescence in situ hybridization consistent with a diagnosis of high-grade B-cell lymphoma with rearrangements of MYC and BCL2 With the current data available, what is the optimal treatment of this patient?</p

Cytopenia after CAR-T Cell Therapy—A Brief Review of a Complex Problem

Chimeric Antigen Receptor T-cell (CAR-T) immunotherapy has emerged as an efficacious and life extending treatment modality with high response rates and durable remissions in patients with relapsed and refractory non-Hodgkin lymphoma (NHL), follicular lymphoma, and B-cell acute lymphoblastic leukemia (B-ALL) as well as in other diseases. Prolonged or recurrent cytopenias after CAR-T therapy have increasingly been reported at varying rates, and the pathogenesis of this complication is not yet well-understood but is likely contributed to by multiple factors. Current studies reported are primarily retrospective, heterogeneous in terms of CAR-Ts used and diseases treated, non-uniform in definitions of cytopenias and durations for end points, and vary in terms of recommended management. Prospective studies and correlative laboratory studies investigating the pathophysiology of prolonged cytopenias will enhance our understanding of this phenomenon. This review summarizes knowledge of these cytopenias to date

State Return-to-Learn Youth Sports Concussion Laws

Concussion management in youth sports is an important public health issue. Currently, all U.S. states have return-to-play (RTP) provisions in their concussion laws limiting a student\u27s return to sports after suffering a concussion. Another type of limitation is a return-to-learn (RTL) provision. Whereas RTP provisions limit reentry into sports, RTL provisions center on academics. Although numerous studies have documented the effect of concussions on student academic performance, few laws contain RTL provisions. Research based on 2014 data presented by The Network for Public Health Law found only seven states with RTL restrictions. The objective of this research is to give a current presentation of U.S. states with RTL laws. A comparative analysis and a discussion of relevant policy issues will be included. The presentation will educate a lay audience. Laws of the 50 U.S. states and the District of Columbia were systematically reviewed. An analysis through December 2015 has been conducted and will continue throughout the spring 2016 legislative sessions. Legal research was conducted by means of WestlawNext and state legislative websites. Queries used consist of variable search terms to elicit laws applicable to concussion, traumatic brain injury, RTP, and RTL. Preliminary findings indicate 9 states have enacted RTL laws. An analysis extended through June 2016 is expected to reveal additional states with RTL laws. As compared to RTP restrictions, states have been slow to enact RTL provisions. The increased inclusion of RTL provisions in state concussion laws will improve public health. Numerous variations across states merit discussion

Welcome Session with Awards and Readings

Welcome remarks by Mayor Richard Howorth and Dr. Joseph Urgo, chair of the Department of English. William Faulkner Society Fellow, Donald M. Kartiganer. Presentation of Eudora Welty Awards in Creative Writing by Charles Reagan Wilson. Mr. Twain, Meet Mr. Faulkner. Dramatic reading written and directed by Roseanna Whitlow, with performances by from Faulkner\u27s Fiction: Voices from Yoknapatawpha, selected and arranged by Betty Harrington and George Kehoe