Migración de la plataforma Exchange 2013 a versión 2019 para el área de infraestructura en una entidad del Estado

Este proyecto redactado aporta como una referencia técnica que admite reconocer la continuación del proceso de migración de la plataforma Microsoft Exchange en la entidad del estado a la última versión disponible, el cual constituye los parámetros y recursos indispensables que pueden ayudar de referencia para la ejecución de los cambios sobre un ambiente de producción. La metodología que se aplicó para diseñar la migración del servidor de correo en base a Microsoft tiene 5 fases las cuales son visión, planificación, desarrollo, estabilización, implantación, además la metodología aplicada en este proyecto es Microsoft Solutions Framework. Se demostró que después de la migración, Microsoft Exchange 2019 tiene predeterminado el TLS 1.2 y deshabilita los algoritmos antiguos, adicionalmente se da importancia a los algoritmos de intercambio de claves de curva elíptica por los algoritmos de curva no elíptica, solucionando las vulnerabilidades de seguridad. Finalmente, en base a las experiencias surgidas durante el desarrollo de esta migración, también se establece un esquema en el cual puede ser utilizado no solo por la entidad estatal, sino también por otras entidades, empresas para su uso y migrar a otras versiones para su proceso. exitosamente.This drafted project provides as a technical reference that admits to recognize the continuation of the process of migration of the Microsoft Exchange platform in the state entity to the latest available version, which constitutes the essential parameters and resources that can be used as a referencefor the implementation of changes in a production environment.The methodology that was applied to design the migration of the mail server based on Microsoft has 5 phases which are: vision, planning, development, stabilization, implementation and in addition the methodology applied in this project is Microsoft Solutions Framework.It was shown that after the migration, Microsoft Exchange 2019 has default TLS 1.2 and disables old algorithms, in addition importance is given to algorithms for exchange of elliptical curve keys by non-elliptical curve algorithms, solving security vulnerabilities.Finally, based on the experiences that emerged during the development of this migration, a scheme is also established in which it can be used not only by the state entity, but also by other entities, companies for use and migrate to other versions for your process successfully.Campus Lima Centr

Find cancer early: Evaluation of a community education campaign to increase awareness of cancer signs and symptoms in people in regional Western Australians

Introduction: Cancer outcomes for people living in rural and remote areas are worse than for those living in urban areas. Although access to and quality of cancer treatment are important determinants of outcomes, delayed presentation has been observed in rural patients. Methods: Formative research with people from rural Western Australia (WA) led to the Find Cancer Early campaign. Find Cancer Early was delivered in three regions of WA, with two other regions acting as controls. Staff delivered the campaign using a community engagement approach, including promotion in local media. Television communications were not used to minimize contamination in the control regions. The campaign evaluation was undertaken at 20 months via a computer-assisted telephone interview (CATI) survey comparing campaign and control regions. The primary outcome variable was knowledge of cancer signs and symptoms. Results: Recognition and recall of Find Cancer Early and symptom knowledge were higher in the campaign regions. More than a quarter of those who were aware of the campaign reported seeing the GP as a result of their exposure. Conclusion: Despite limited use of mass media, Find Cancer Early successfully improved knowledge of cancer symptoms and possibly led to changes in behavior. Social marketing campaigns using community development can raise awareness and knowledge of a health issue in the absence of television advertising

Formation rates of core collapse SNe and GRBs

We study the evolution of stars that may be the progenitors of long-soft gamma-ray burst (GRBs) -- rotating naked helium stars presumed to have lost their envelopes to winds or companions. Our aim is to investigate the formation and development of single and binary systems and from this population evaluate the rates of interesting individual species. Using a rapid binary evolution algorithm, that enables us to model the most complex binary systems and to explore the effect of metallicity on GRB production, we draw the following conclusions. First we find that, if we include an approximate treatment of angular momentum transport by mass loss, the resulting spin rates for single stars become too low to form a centrifugally supported disc that can drive a GRB engine. Second massive stars in binaries result in enough angular momentum -- due to spin-orbit tidal interactions -- to form a centrifugally supported disc and are thus capable of supplying a sufficient number of progenitors. This holds true even if only a small fraction of bursts are visible to a given observer and the GRB rate is several hundred times larger than the observed rate. Third low-metallicity stars aid the formation of a rapidly rotating, massive helium cores at collapse and so their evolution is likely to be affected by the local properties of the ISM. This effect could increase the GRB formation rate by a factor of 5-7 at Z=Z_solar/200. Finally we quantify the effects of mass loss, common-envelope evolution and black-hole formation and show that more stringent constraints to many of these evolution parameters are needed in order to draw quantitative conclusions from population synthesis work.Comment: 37 pages, 14 figures, MNRAS in pres

El teatro y su relación con la creatividad de niños de 3ro EGB de la escuela Mauricio Hermenejildo Domínguez.

El presente trabajo de investigación tiene como objetivo analizar la relación entre el teatro y la creatividad en alumnos de tercer grado de la Escuela de Educación Básica Mauricio Hemerejildo Domínguez durante el periodo lectivo 2023-2024. Se utiliza una metodología cualitativa, como herramientas recolección de datos se utilizó la ficha de observación y encuesta de igual modo la información fue extraída de la revisión de fuentes confiables disponibles en Scopus, Dialnet y Scielo. Se encontró que la creatividad y el pensamiento son aspectos fundamentales que todo escolar debe poseer, puesto que fortalecen destrezas y habilidades. El teatro se convierte en un medio para representar situaciones de la vida real y permite que el estudiante se convierta en el principal enfoque del aprendizaje. El teatro es utilizado como estrategia para fomentar la creatividad en los estudiantes de tercer grado de la Escuela de Educación Básica Mauricio Hemerejildo Domínguez. En conclusión, el teatro dentro de la educación no solo tiene como finalidad crear temas de interés social, sino también ayudar a la comprensión de los diferentes discursos presentes en el aula y la aplicación de la creatividad en el contexto escolar es una herramienta para potenciar el desarrollo de los estudiante

Eicosapentaenoic Acid Is Associated with Decreased Incidence of Alzheimer’s Dementia in the Oldest Old

Background. Omega-3 (n-3) and omega-6 (n-6) polyunsaturated fatty acids (PUFAs) may have different effects on cognitive health due to their anti- or pro-inflammatory properties. Methods. We aimed to prospectively examine the relationships between n-3 and n-6 PUFA contents in serum phospholipids with incident all-cause dementia and Alzheimer’s disease dementia (AD). We included 1264 non-demented participants aged 84 ± 3 years from the German Study on Ageing, Cognition, and Dementia in Primary Care Patients (AgeCoDe) multicenter-cohort study. We investigated whether fatty acid concentrations in serum phospholipids, especially eicosapentaenoic acid (EPA), docosahexaenoic acid (DHA), alpha-linolenic acid (ALA), linoleic acid (LA), dihomo-γ-linolenic acid (DGLA), and arachidonic acid (AA), were associated with risk of incident all-cause dementia and AD. Results. During the follow-up window of seven years, 233 participants developed dementia. Higher concentrations of EPA were associated with a lower incidence of AD (hazard ratio (HR) 0.76 (95% CI 0.63; 0.93)). We also observed that higher concentrations of EPA were associated with a decreased risk for all-cause dementia (HR 0.76 (95% CI 0.61; 0.94)) and AD (HR 0.66 (95% CI 0.51; 0.85)) among apolipoprotein E ε4 (APOE ε4) non-carriers but not among APOE ε4 carriers. No other fatty acids were significantly associated with AD or dementia. Conclusions. Higher concentrations of EPA were associated with a lower risk of incident AD. This further supports a beneficial role of n-3 PUFAs for cognitive health in old age

Simultaneous MITSuME gRI monitoring of S5 0716+714

We present results of our intra-night optical flux monitoring observations of S5 0716+714 done simultaneously in gRI filters. The observations were done using Multicolor Imaging Telescopes for Survey and Monstrous Explosions (MITSuME) instrument on the 50 cm telescope at the Okayama Astrophysical Observatory over 30 nights between 11 March 2008 and 8 May 2008. Of these 30 nights, 22 nights have continuous (without any break) observations with duration ranging from 1 to 6 hours and hence were considered for intra-night optical variability (INOV). In total we have 4888 datapoints which were simultaneous in gR and I filters. Of the 22 nights considered for INOV, the object showed flux variability on 19 nights with the amplitude of variability in the I-band ranging from ~4% to ~55%. The duty cycle for INOV was thus found to be 83%. No time lag between different bands was noticed on most of the nights, except for 3 nights where the variation in g was found to lead that of the I band by 0.3 to 1.5 hrs. On inter-night timescales, no lag was found between g and I bands. On inter-night timescales as well as intra-night timescales on most of the nights, the amplitude of variability was found to increase toward shorter wavelengths. The flux variations in the different bands were not achromatic, with the blazar tending to become bluer when brighter both on inter-night and intra-night timescales; and this might be attributed to the larger amplitude variation at shorter wavelengths. A clear periodic variation of 3.3 hrs was found on 1 April 2008 and a hint for another possible periodic variability of 4 hrs was found on 31 March 2008. During our 30 days of observations over a 2 month period the source has varied with an amplitude of variability as large as ~80%.Comment: 11 pages, 8 figures and 5 tables, Accepted in MNRA

From Macroscopic to Microscopic: Experimental and Computational Methods to Investigate Bio-tribology

Tribology is an important factor (among other factors) during biological interactions of devices and tissues. The paper discusses how new computational and experimental methods can be used to understand and improve the design and development of medical devices at macro and micro scales to sustain life beyond 50 years. We have used pre-clinical experiments and computational methods to understand interactions between orthopaedic implants at the macro scale. The computational model has been validated with experiments. Now this computational model can predict damage in implants for different patients. One such application was successfully tried and tested in collaboration with University National Autonomous Mexico. This methodology can be used in future to design patient specific, affordable (using 3D printing) and robust implants which will be useful for developing countries like Vietnam, India and Mexico. Improvement of catheter designs is important to reduce damage to the internal tissues while being used for cardiovascular problems. We are developing new experimental techniques (in micro scale) that can be used to understand the interaction of cells with the catheter material. These will help reduce the hospital costs incurred during longer stay of the patients admitted for cardiovascular related problems

Evidence for charge localization in the ferromagnetic phase of La_(1-x)Ca_(x)MnO_3 from High real-space-resolution x-ray diffraction

High real-space-resolution atomic pair distribution functions of La_(1-x)Ca_(x)MnO_3 (x=0.12, 0.25 and 0.33) have been measured using high-energy x-ray powder diffraction to study the size and shape of the MnO_6 octahedron as a function of temperature and doping. In the paramagnetic insulating phase we find evidence for three distinct bond-lengths (~ 1.88, 1.95 and 2.15A) which we ascribe to Mn^{4+}-O, Mn^{3+}-O short and Mn^{3+}-O long bonds respectively. In the ferromagnetic metallic (FM) phase, for x=0.33 and T=20K, we find a single Mn-O bond-length; however, as the metal-insulator transition is approached either by increasing T or decreasing x, intensity progressively appears around r=2.15 and in the region 1.8 - 1.9A suggesting the appearance of Mn^{3+}-O long bonds and short Mn^{4+}-O bonds. This is strong evidence that charge localized and delocalized phases coexist close to the metal-insulator transition in the FM phase.Comment: 8 pages, 8 postscript figures, submitted to Phys. Rev.

Nicotinamide as potential biomarker for Alzheimer’s disease: A translational study based on metabolomics

Introduction: The metabolic routes altered in Alzheimer's disease (AD) brain are poorly understood. As the metabolic pathways are evolutionarily conserved, the metabolic profiles carried out in animal models of AD could be directly translated into human studies.Methods: We performed untargeted Nuclear Magnetic Resonance metabolomics in hippocampus of McGill-R-Thy1-APP transgenic (Tg) rats, a model of AD-like cerebral amyloidosis and the translational potential of these findings was assessed by targeted Gas Chromatography-Electron Impact-Mass Spectrometry in plasma of participants in the German longitudinal cohort AgeCoDe.Results: In rat hippocampus 26 metabolites were identified. Of these 26 metabolites, nine showed differences between rat genotypes that were nominally significant. Two of them presented partial least square-discriminant analysis (PLS-DA) loadings with the larger absolute weights and the highest Variable Importance in Projection (VIP) scores and were specifically assigned to nicotinamide adenine dinucleotide (NAD) and nicotinamide (Nam). NAD levels were significantly decreased in Tg rat brains as compared to controls. In agreement with these results, plasma of AD patients showed significantly reduced levels of Nam in respect to cognitively normal participants. In addition, high plasma levels of Nam showed a 27% risk reduction of progressing to AD dementia within the following 2.5 years, this hazard ratio is lost afterwards.Discussion: To our knowledge, this is the first report showing that a decrease of Nam plasma levels is observed couple of years before conversion to AD, thereby suggesting its potential use as biomarker for AD progression

α-Galactosylceramide and peptide-based nano-vaccine synergistically induced a strong tumor suppressive effect in melanoma

α-Galactosylceramide (GalCer) is a glycolipid widely known as an activator of Natural killer T (NKT) cells, constituting a promising adjuvant against cancer, including melanoma. However, limited clinical outcomes have been obtained so far. This study evaluated the synergy between GalCer and major histocompatibility complex (MHC) class I and MHC class II melanoma-associated peptide antigens and the Toll-Like Receptor (TLR) ligands CpG and monophosphoryl lipid A (MPLA), which we intended to maximize following their co-delivery by a nanoparticle (NP). This is expected to improve GalCer capture by dendritic cells (DCs) and subsequent presentation to NKT cells, and simultaneously induce an anti-tumor specific T-cell mediated immunity. The combination of GalCer with melanoma peptides and TLR ligands successfully restrained tumor growth. The tumor volume in these animals was 5-fold lower than the ones presented by mice immunized with NPs not containing GalCer. However, tumor growth was controlled at similar levels by GalCer entrapped or in its soluble form, when mixed with antigens and TLR ligands. Those two groups showed an improved infiltration of T lymphocytes into the tumor, but only GalCer-loaded nano-vaccine induced a prominent and enhanced infiltration of NKT and NK cells. In addition, splenocytes of these animals secreted levels of IFN-γ and IL-4 at least 1.5-fold and 2-fold higher, respectively, than those treated with the mixture of antigens and adjuvants in solution. Overall, the combined delivery of the NKT agonist with TLR ligands and melanoma antigens via this multivalent nano-vaccine displayed a synergistic anti-tumor immune-mediated efficacy in B16F10 melanoma mouse model. STATEMENT OF SIGNIFICANCE: Combination of α-galactosylceramide (GalCer), a Natural Killer T (NKT) cell agonist, with melanoma-associated antigens presented by MHC class I (Melan-A:26) and MHC class II (gp100:44) molecules, and Toll-like Receptor (TLR) ligands (MPLA and CpG), within nanoparticle matrix induced a prominent anti-tumor immune response able to restrict melanoma growth. An enhanced infiltration of NKT and NK cells into tumor site was only achieved when the combination GalCer, antigens and TLR ligands were co-delivered by nanovaccine