Polimorfismos del gen CLEC7A y riesgo de infección fúngica

Memoria del trabajo de investigación para optar al Título de Máster en Investigación Biomédica presentado por Cristina de Ramón Sánchez en la Universidad de Valladolid, Instituto de Biología y Genética Molecular (IBGM), Dpto. Daño tisular inmune e Inmunidad Innata.Los pacientes con enfermedades oncohematológicas tienen mayor riesgo de padecer infecciones fúngicas que la población general debido a la inmunosupresión producida por la propia enfermedad y a los efectos indeseables de los tratamientos que reciben. Esta combinación de factores de riesgo implica altas tasas de comorbilidad y mortalidad por lo que sería necesario establecer estrategias de prevención estandarizadas y fundamentadas en estudios con evidencia científica. Las infecciones fúngicas más frecuentes son las producidas por Aspergillus en el caso de los pacientes sometidos a trasplante de médula y por Candida en situaciones más convencionales, aunque infecciones por Cryptococcus y Pneumocystis jiroveci no son inusuales.Peer Reviewe

Polimorfismos del gen CLEC7A y riesgo de infección fúngica

Los pacientes con enfermedades oncohematológicas tienen mayor riesgo de padecer infecciones fúngicas que la población general debido a la inmunosupresión producida por la propia enfermedad y a los efectos indeseables de los tratamientos que reciben. Esta combinación de factores de riesgo implica altas tasas de comorbilidad y mortalidad por lo que sería necesario establecer estrategias de prevención estandarizadas y fundamentadas en estudios con evidencia científica. Las infecciones fúngicas más frecuentes son las producidas por Aspergillus en el caso de los pacientes sometidos a trasplante de médula y por Candida en situaciones más convencionales, aunque infecciones por Cryptococcus y Pneumocystis jiroveci no son inusuales.Máster en Investigación Biomédic

Un túmulo funerario neoclásico en Arequipa (Perú).

Sin resume

Legal measures to prevent and manage soil contamination and to increase food safety for consumer health: the case of Spain

[EN] This article contains a brief overview of the European and Spanish environmental law framework for the prevention of soil contamination, for the management of contaminated soils and for consumers health protection in relation to agricultural crops. Some important aspects of the legislative framework for the prevention and management of soil contamination include recognising the possible risk to both human health and ecosystems that certain agricultural and industrial activities pose given the use of organic and inorganic chemical substances of a hazardous nature and pathogenic microorganisms. It is worth highlighting the milestone that many national constitutions include about the right to the environment. This right entails the obligation to protect it and to, therefore, protect soil from any degradation, including contamination. Legislation that protects soil from contamination and, consequently human health and ecosystems, is related mainly to agricultural activities (use of sewage sludge on farmlands, use of wastewater for irrigation, use of organic fertilisers and pesticides), and to industrial and commercial soil-contaminating activities. Consumer protection may be achieved through a legal system of environmental liability, specific measures to prevent contaminants entering soil, managing contaminated soils and a food traceability system. It is crucial to make the penalties for soil contamination offenses, and for violators of protective prohibitions, effective, proportionate and dissuasive. Global standards and guidelines on soil contamination could provide national legislative systems with substantive and procedural legal mechanisms to help prevent and manage soil contamination.This research was conducted as part of Project DER2015-65810-P, funded by the Spanish Ministry of Economy and Competitiveness, and by Project GVPROMETEOII2015-014, funded by the Regional Ministry of Culture, Education and Sport of the Valencian Autonomous Community, and by Projects HYDЯOSIL (CGL2011-28776-C02-02) and SILWAMED (CGL2014-58127-C3-2), funded by the Spanish Ministry of Science and Innovation and FEDER funds.Ramón Fernández, F.; Lull, C. (2019). Legal measures to prevent and manage soil contamination and to increase food safety for consumer health: the case of Spain. Environmental Pollution. 250(julio):883-891. https://doi.org/10.1016/j.envpol.2019.04.074S883891250juli

Alternativas energéticas ante el impacto social causado por la degradación medioambiental

17th Conference of the International Association for People-Environment Studies, febrero 2002, A Coruñ

The use of two relations in L-fuzzy contexts

In the analysis of relations among the elements of two sets it is usual to obtain different values depending on the point of view from which these relations are measured. The main goal of the paper is the modelization of these situations by means of a generalization of the L-fuzzy concept analysis called L-fuzzy bicontext. We study the L-fuzzy concepts of these L-fuzzy bicontexts obtaining some interesting results. Specifically, we will be able to classify the biconcepts of the L-fuzzy bicontext. Finally, a practical case is developed using this new tool.This work has been partially supported by the Research Group “Intelligent Systems and Energy (SI+E)” of the Basque Government, under Grant IT677-13, by the Research Groups “Artificial Intelligence and Approximate Reasoning” and “Adquisición de conocimiento y minería de datos, funciones especiales y métodos numéricos avanzados” of the Public University of Navarra and by project TIN2013-40765-P

Influence of personality and modality on peer assessment evaluation perceptions using Machine Learning techniques

The successful instructional design of self and peer assessment in higher education poses several challenges that instructors need to be aware of. One of these is the influence of students’ personalities on their intention to adopt peer assessment. This paper presents a quasi-experiment in which 85 participants, enrolled in the first-year of a Computer Engineering programme, were assessed regarding their personality and their acceptance of three modalities of peer assessment (individual, pairs, in threes). Following a within-subjects design, the students applied the three modalities, in a different order, with three different activities. An analysis of the resulting 1195 observations using ML techniques shows how the Random Forest algorithm yields significantly better predictions for three out of the four adoption variables included in the study. Additionally, the application of a set of eXplainable Artificial Intelligence (XAI) techniques shows that Agreeableness is the best predictor of Usefulness and Ease of Use, while Extraversion is the best predictor of Compatibility, and Neuroticism has the greatest impact on global Intention to Use. The discussion highlights how, as it happens with other innovations in educational processes, low levels of Consciousness is the most consistent predictor of resistance to the introduction of peer assessment processes in the classroom. Also, it stresses the value of peer assessment to augment the positive feelings of students scoring high on Neuroticism, which could lead to better performance. Finally, the low impact of the peer assessment modality on student perceptions compared to personality variables is debated.This work has been partially funded by the University of Alicante’s Redes-I3CE de investigación en docencia universitaria del Instituto de Ciencias de la Educación (REDES-I3CE-2020-5069), by the EU Erasmus+ Programme (EduTech (609785-EPP-1-2019-1-ES-EPPKA2-CBHE-JP) and SkoPS (2020-1-DE01-KA226HE-005772) projects), by the Spanish Ministry of Science and Innovation (Access@IoT (PID2019-111196RB-I00) project), by the GVA (AICO/2020/143) project, and by the UCLM group cofinanced with ERDF funds (research grant 2021-GRIN-30993)

Role of quorum sensing in UVA-induced biofilm formation in Pseudomonas aeruginosa

Pseudomonas aeruginosa, a versatile bacterium present in terrestrial and aquatic environments and a relevant opportunistic human pathogen, is largely known for the production of robust biofilms. The unique properties of these structures complicate biofilm eradication, because they make the biofilms very resistant to diverse antibacterial agents. Biofilm development and establishment is a complex process regulated by multiple regulatory genetic systems, among them is quorum sensing (QS), a mechanism employed by bacteria to regulate gene transcription in response to population density. In addition, environmental factors such as UVA radiation (400–315 nm) have been linked to biofilm formation. In this work, we further investigate the mechanism underlying the induction of biofilm formation by UVA, analysing the role of QS in this phenomenon. We demonstrate that UVA induces key genes of the Las and Rhl QS systems at the transcriptional level. We also report that pelA and pslA genes, which are essential for biofilm formation and whose transcription depends in part on QS, are significantly induced under UVA exposure. Finally, the results demonstrate that in a relA strain (impaired for ppGpp production), the UVA treatment does not induce biofilm formation or QS genes, suggesting that the increase of biofilm formation due to exposure to UVA in P. aeruginosa could rely on a ppGpp-dependent QS induction.Fil: Pezzoni, Magdalena. Comisión Nacional de Energía Atómica. Gerencia de Area de Aplicaciones de la Tecnología Nuclear. Gerencia de Radiobiología (Centro Atómico Constituyentes); Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; ArgentinaFil: Pizarro, Ramón Augusto. Comisión Nacional de Energía Atómica. Gerencia de Area de Aplicaciones de la Tecnología Nuclear. Gerencia de Radiobiología (Centro Atómico Constituyentes); ArgentinaFil: Costa, Cristina Susana. Comisión Nacional de Energía Atómica. Gerencia de Area de Aplicaciones de la Tecnología Nuclear. Gerencia de Radiobiología (Centro Atómico Constituyentes); Argentin

The gender-job satisfaction paradox through time and countries

Much has been written about the so-called gender-job satisfaction paradox, derived from the fact that a significant number of empirical studies found that women reported higher levels of job satisfaction than their male counterparts, although they had what were considered ‘worse’ jobs in terms of pay and other nonmonetary working conditions. In this article, we use a procedure to compare the relative performance of groups when their achievements are described by distributions of outcomes over an ordered set of categories, the Balanced Worth Vector (BWV), to analyse whether women consistently report to be more satisfied at work than men in different periods of time and countries. The BWV offers a cardinal, complete and transitive evaluation that is based in the likelihood of getting better results. In our setting, the BWV methodology provides a complete ranking of the countries covered by the European Working Conditions Survey according to the relative levels of job satisfaction with working conditions that women and men in each country report. Our results indicate a decreasing gender differential over time and substantial differences across countries, proving that the gender-gap paradox cannot be considered a widespread phenomenon