114 research outputs found
Enhancing the work of teacher training as volunteers in classrooms
Lehramt-Studierende können vom ersten Studiensemester an Praxiserfahrung sammeln, wenn sie eine "Patenschaft" für eine Schulklasse übernehmen. Dabei stehen nicht Fachwissenschaft und -didaktik im Vordergrund, sondern Erfahrungen im sozialen System einer Schulklasse. Begleitet und gefördert wird diese Arbeit durch eine Lehrveranstaltung in der Universität. (DIPF/Orig.)Teacher training students can gather practical experience starting in the first semester by taking the role of sponsors for classrooms. Here, the focus is less on scientific knowledge and didactics but on the classroom as a social system. The work is guided and supported by seminars taught at the university. (DIPF/Orig.
Nuclear Charge Radius of Be
The nuclear charge radius of Be was precisely determined using the
technique of collinear laser spectroscopy on the transition in the Be ion. The mean square charge radius increases
from Be to Be by \delta ^{10,12} = 0.69(5) \fm^{2}
compared to \delta ^{10,11} = 0.49(5) \fm^{2} for the
one-neutron halo isotope Be. Calculations in the fermionic molecular
dynamics approach show a strong sensitivity of the charge radius to the
structure of Be. The experimental charge radius is consistent with a
breakdown of the N=8 shell closure.Comment: 5 pages, 3 figure
Collinear laser spectroscopy of atomic cadmium
Hyperfine structure and factors of the atomic 5s\,5p\,\; ^3\rm{P}_2
\rightarrow 5s\,6s\,\; ^3\rm{S}_1 transition are determined from collinear
laser spectroscopy data of Cd and Cd. Nuclear
magnetic moments and electric quadrupole moments are extracted using reference
dipole moments and calculated electric field gradients, respectively. The
hyperfine structure anomaly for isotopes with and nuclear
ground states and isomeric states is evaluated and a linear
relationship is observed for all nuclear states except . This
corresponds to the Moskowitz-Lombardi rule that was established in the mercury
region of the nuclear chart but in the case of cadmium the slope is
distinctively smaller than for mercury. In total four atomic and ionic levels
were analyzed and all of them exhibit a similar behaviour. The electric field
gradient for the atomic 5s\,5p\,\; ^3\mathrm{P}_2 level is derived from
multi-configuration Dirac-Hartree-Fock calculations in order to evaluate the
spectroscopic nuclear quadrupole moments. The results are consistent with those
obtained in an ionic transition and based on a similar calculation.Comment: 12 pages, 5 figure
Precision Test of Many-Body QED in the Be Fine Structure Doublet Using Short-Lived Isotopes
Absolute transition frequencies of the 2s\; ^2{\rm S}_{1/2} \rightarrow
2p\;^2\mathrm{P}_{1/2,3/2} transitions in Be were measured for the
isotopes Be. The fine structure splitting of the state and its
isotope dependence are extracted and compared to results of \textit{ab initio}
calculations using explicitly correlated basis functions, including
relativistic and quantum electrodynamics effects at the order of
and . Accuracy has been improved in both the theory and
experiment by 2 orders of magnitude, and good agreement is observed. This
represents one of the most accurate tests of quantum electrodynamics for
many-electron systems, being insensitive to nuclear uncertainties.Comment: 5 pages, 2 figure
Xanthohumol attenuates tumour cell-mediated breaching of the lymphendothelial barrier and prevents intravasation and metastasis
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Numerical and experimental investigations for insulation particle transport phenomena in water flow
The investigation of insulation debris generation, transport and sedimentation becomes more important with regard to reactor safety research for pressurized and boiling water reactors, when considering the long-term behaviour of emergency core coolant systems during all types of loss of coolant accidents (LOCA). The insulation debris released near the break during a LOCA incident consists of a mixture of a disparate particle population that varies with size, shape, consistency and other properties. Some fractions of the released insulation debris can be transported into the reactor sump, where it may perturb or impinge on the emergency core cooling systems. Open questions of generic interest are for example the particle load on strainers and corresponding pressure-drop, the sedimentation of the insulation debris in a water pool, its possible re-suspension and transport in the sump water flow. A joint research project on such questions is being performed in cooperation with the University of Applied Science Zittau/Görlitz and the Forschungszentrum Dresden-Rossendorf. The project deals with the experimental investigation and the development of computational fluid dynamic (CFD) models for the description of particle transport phenomena in coolant flow. While the experiments are performed at the University Zittau/Görlitz, the theoretical work is concentrated at Forschungszentrum Dresden-Rossendorf. In the present paper, the basic concepts for computational fluid dynamic (CFD) modelling are described and experimental results are presented. Further experiments are designed and feasibility studies were performed
In vitro characterisation of the anti-intravasative properties of the marine product heteronemin
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Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity.
Many genetic loci affect circulating lipid levels, but it remains unknown whether lifestyle factors, such as physical activity, modify these genetic effects. To identify lipid loci interacting with physical activity, we performed genome-wide analyses of circulating HDL cholesterol, LDL cholesterol, and triglyceride levels in up to 120,979 individuals of European, African, Asian, Hispanic, and Brazilian ancestry, with follow-up of suggestive associations in an additional 131,012 individuals. We find four loci, in/near CLASP1, LHX1, SNTA1, and CNTNAP2, that are associated with circulating lipid levels through interaction with physical activity; higher levels of physical activity enhance the HDL cholesterol-increasing effects of the CLASP1, LHX1, and SNTA1 loci and attenuate the LDL cholesterol-increasing effect of the CNTNAP2 locus. The CLASP1, LHX1, and SNTA1 regions harbor genes linked to muscle function and lipid metabolism. Our results elucidate the role of physical activity interactions in the genetic contribution to blood lipid levels
Therapeutic hypothermia for acute ischaemic stroke. Results of a European multicentre, randomised, phase III clinical trial
Introduction: We assessed whether modest systemic cooling started within 6 hours of symptom onset improves functional outcome at three months in awake patients with acute ischaemic stroke. Patients and methods: In this European randomised open-label clinical trial with blinded outcome assessment, adult patients with acute ischaemic stroke were randomised to cooling to a target body temperature of 34.0–35.0°C, started within 6 h after stroke onset and maintained for 12 or 24 h, versus standard treatment. The primary outcome was the score on the modified Rankin Scale at 91 days, as analysed with ordinal logistic regression. Results: The trial was stopped after inclusion of 98 of the originally intended 1500 patients because of slow recruitment and cessation of funding. Forty-nine patients were randomised to hypothermia versus 49 to standard treatment. Four patients were lost to follow-up. Of patients randomised to hypothermia, 15 (31%) achieved the predefined cooling targets. The primary outcome did not differ between the groups (odds ratio for good outcome, 1.01; 95% confidence interval, 0.48–2.13; p = 0.97). The number of patients with one or more serious adverse events did not differ between groups (relative risk, 1.22; 95% confidence interval, 0.65–1.94; p = 0.52). Discussion: In this trial, cooling to a target of 34.0–35.0°C and maintaining this for 12 or 24 h was not feasible in the majority of patients. The final sample was underpowered to detect clinically relevant differences in outcomes. Conclusion: Before new trials are launched, the feasibility of cooling needs to be improved
Multi-ancestry genome-wide association study accounting for gene-psychosocial factor interactions identifies novel loci for blood pressure traits
Psychological
and social factors are known to influence blood pressure (BP) and risk
of hypertension and associated cardiovascular diseases. To identify
novel BP loci, we carried out genome-wide association meta-analyses of
systolic, diastolic, pulse, and mean arterial BP, taking into account
the interaction effects of genetic variants with three psychosocial
factors: depressive symptoms, anxiety symptoms, and social support.
Analyses were performed using a two-stage design in a sample of up to
128,894 adults from five ancestry groups. In the combined meta-analyses
of stages 1 and 2, we identified 59 loci (p value < 5e−8), including
nine novel BP loci. The novel associations were observed mostly with
pulse pressure, with fewer observed with mean arterial pressure. Five
novel loci were identified in African ancestry, and all but one showed
patterns of interaction with at least one psychosocial factor.
Functional annotation of the novel loci supports a major role for genes
implicated in the immune response (PLCL2), synaptic function and neurotransmission (LIN7A and PFIA2), as well as genes previously implicated in neuropsychiatric or stress-related disorders (FSTL5 and CHODL).
These findings underscore the importance of considering psychological
and social factors in gene discovery for BP, especially in non-European
populations
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