Redox stress defines the small artery vasculopathy of hypertension: how do we bridge the bench-to-bedside gap?

Although convincing experimental evidence demonstrates the importance of vascular reactive oxygen and nitrogen species (RONS), oxidative stress, and perturbed redox signaling as causative processes in the vasculopathy of hypertension, this has not translated to the clinic. We discuss this bench-to-bedside disparity and the urgency to progress vascular redox pathobiology from experimental models to patients by studying disease-relevant human tissues. It is only through such approaches that the unambiguous role of vascular redox stress will be defined so that mechanism-based therapies in a personalized and precise manner can be developed to prevent, slow, or reverse progression of small-vessel disorders and consequent hypertension

Invariant manifolds and equilibrium states for non-uniformly hyperbolic horseshoes

In this paper we consider horseshoes containing an orbit of homoclinic tangency accumulated by periodic points. We prove a version of the Invariant Manifolds Theorem, construct finite Markov partitions and use them to prove the existence and uniqueness of equilibrium states associated to H\"older continuous potentials.Comment: 33 pages, 6 figure

Caracterização de compósitos de poliolefinas recicladas com fibras de açaí.

bitstream/CNPDIA-2009-09/11899/1/DOC36_2008.pd

The Trichoptera of Panama XIII. Further new country records for caddisflies (Insecta: Trichoptera) from the Republic of Panama

The Republic of Panama currently includes 414 recorded species of Trichoptera. Herein we add two new genera (Hydroptilidae: Angrisanoia Ozdikmen, 2008 and Mayatrichia Mosely, 1937) and 17 new country records (Philopotamidae: Chimarra (C.) tapanti Blahnik, Wormaldia bolivari Muñoz-Quesada and Holzenthal, and Wormaldia zunigae Muñoz-Quesada and Holzenthal; Hydropsychidae: Centromacronema pygmaeum Botosaneanu; Hydroptilidae: Brysopteryx esparta Harris and Holzenthal, Byrsopteryx solisi Harris and Holzenthal, Costatrichia falsa Santos, Takiya, and Nessimian, Mayatrichia illobia Harris and Holzenthal, Metrichia amplitudinis Bueno-Soria and Holzenthal, Ochrotrichia boquillas Moulton and Harris, O. conformalis Bueno-Soria and Holzenthal, O. quinealensis Bueno-Soria and Holzenthal, and O. unica Bueno-Soria and Santiago; Leptoceridae: Triaenodes morai Holzenthal and Andersen; Odontoceridae: Marilia kingsolveri Bueno-Soria and Rojas-Ascencio; and, Helicopsychidae: Helicopsyche alajuela Johanson and Holzenthal and Helicopsyche breviterga Flint) to Panama’s caddisfly fauna. The newly recorded taxa increase Panama’s total known caddisfly fauna to 431 species, distributed among 15 families and 55 genera. These results are part of an ongoing effort to characterize the caddisfly fauna of Panama, and to evaluate the aquatic insect diversity of the country’s major watersheds (cuencas). La República de Panamá actualmente incluye 414 especies registradas de Trichoptera. Aquí agregamos dos nuevos géneros (Hydroptilidae: Angrisanoia Ozdikmen, 2008 y Mayatrichia Mosely, 1937) y 17 nuevos registros para el país (Philopotamidae: Chimarra (C.) tapanti Blahnik, Wormaldia bolivari Muñoz-Quesada y Holzenthal, y Wormaldia zunigae Muñoz-Quesada y Holzenthal; Hydropsychidae: Centromacronema pygmaeum Botosaneanu; Hydroptilidae: Brysopteryx esparta Harris y Holzenthal, Byrsopteryx solisi Harris y Holzenthal, Costatrichia falsa Santos, Takiya, y Nessimian, Mayatrichia illobia Harris y Holzenthal, Metrichia amplitudinis Bueno-Soria y Holzenthal, Ochrotrichia boquillas Moulton y Harris, Ochrotrichia conformalis Bueno-Soria y Holzenthal, Ochrotrichia quinealensis Bueno-Soria y Holzenthal, y Ochrotrichia unica Bueno-Soria y Santiago; Leptoceridae: Triaenodes morai Holzenthal y Andersen; Odontoceridae: Marilia kingsolveri Bueno-Soria y Rojas- Ascencio; y, Helicopsychidae: Helicopsyche alajuela Johanson y Holzenthal y Helicopsyche breviterga Flint) a la fauna de Trichoptera de Panamá. Los taxones recien reportados aumentan el total de la fauna de Trichoptera de Panamá a 431 especies, distribuidas en 15 familias y 55 géneros. Estos resultados son parte de un esfuerzo continuo para caracterizar la fauna de Trichoptera y para evaluar la diversidad de insectos acuáticos de las principales cuencas hidrográficas (cuencas) de Panamá

Síndrome de Hanhart – caso clínico

Introdução: Em 1950 Hanhart descreveu três casos de aglossia e deformidades dos membros. A associação de malformações oromandibulares e dos membros é rara, veriÞcando -se grande variabilidade fenotípica entre os casos descritos. Caso Clínico: Gravidez com diagnóstico pré -natal ecográ-Þ co (24 semanas) de agenesia do pé direito, ausência do primeiro dedo do pé esquerdo e presença apenas da primeira falange do primeiro e quinto dedos da mão esquerda. Às 38 semanas de gestação nasce um recém -nascido, sexo masculino, com hipotonia generalizada e diÞ culdade respiratória com necessidade de manobras de reanimação. Ao exame físico destacava -se a presença de microretrognatia, microstomia e várias malformações ósseas a nível das mãos e pés. Desde as primeiras horas de vida que apresentou quadro de apneias com dessaturações recorrentes vindo a falecer na decorrência de um desses episódios. Discussão: A associação de microstomia, microretrognatia, hipoglossia, malformações dos membros e atingimento dos pares cranianos, permite -nos estabelecer o diagnóstico clínico de Síndrome de Hanhart. O seu diagnóstico nem sempre é fácil,dada a grande variabilidade fenotípica

Divergência genética entre genótipos de milho quanto ao teor de carotenoides nos grãos.

A biofortificação é uma alternativa eficiente no combate às deficiências de micronutrientes na população humana. Em milho, os programas de melhoramento para biofortificação visam à obtenção de materiais com altos teores de Fe, Zn e carotenoides precursores de vitamina A, o que requer estudos preliminares de variabilidade genética e diversidade entre genótipos. O objetivo deste trabalho foi estimar a divergência genética entre genótipos de milho quanto ao teor e perfil de carotenoides nos grãos. Foram utilizados dados obtidos do Ensaio Nacional de Variedades de Milho, no ano agrícola 2004/2005, no total de dez genótipos avaliados em dois ambientes. Avaliaram-se os teores de carotenoides totais (CT), a e β-carotenos, luteína, zeaxantina, β-criptoxantina, o somatório de carotenoides precursores de vitamina A (total de β-caroteno + ½ de a-caroteno + ½ de β-criptoxantina = Pró-VA) e a produtividade de grãos. Observaram-se médias de carotenoides nos genótipos avaliados relativamente baixas quando comparadas àquelas relatadas na literatura para linhagens-elite. Os caracteres que mais contribuíram para a diversidade genética entre os genótipos estudados foram luteína e zeaxantina. O efeito do ambiente na expressão do caráter coloca dúvidas quanto à validade das análises de diversidade em um único ambiente, enfatizando a necessidade de que os estudos sejam efetuados em condições ambientais múltiplas

Canonical Analysis of the Jackiw-Teitelboim Model in the Temporal Gauge. I. The Classical Theory

As a preparation for its quantization in the loop formalism, the 2-dimensional gravitation model of Jackiw and Teitelboim is analysed in the classical canonical formalism. The dynamics is of pure constraints as it is well-known. A partial gauge fixing of the temporal type being performed, the resulting second class constraints are sorted out and the corresponding Dirac bracket algebra is worked out. Dirac observables of this classical theory are then calculated.Comment: 15 pages, Latex. Misprint correction

Consistency of cruise data of the CARINA database in the Atlantic sector of the Southern Ocean

Initially a North Atlantic project, the CARINA carbon synthesis was extended to include the Southern Ocean. Carbon and relevant hydrographic and geochemical ancillary data from cruises all across the Arctic Mediterranean Seas, Atlantic and Southern Ocean were released to the public and merged into a new database as part of the CARINA synthesis effort. Of a total of 188 cruises, 37 cruises are part of the Southern Ocean, including 11 from the Atlantic sector. The variables from all Southern Ocean cruises, including dissolved inorganic carbon (TCO2), total alkalinity, oxygen, nitrate, phosphate and silicate, were examined for cruise-to-cruise consistency in one collective effort. Seawater pH and chlorofluorocarbons (CFCs) are also part of the database, but the pH quality control (QC) is described in another Earth System Science Data publication, while the complexity of the Southern Ocean physics and biogeochemistry prevented a proper QC analysis of the CFCs. The area-specific procedures of quality control, including crossover analysis between stations and inversion analysis of all crossover data (i.e. secondary QC), are briefly described here for the Atlantic sector of the Southern Ocean. Data from an existing, quality controlled database (GLODAP) were used as a reference for our computations – however, the reference data were included into the analysis without applying the recommended GLODAP adjustments so the corrections could be independently verified. The outcome of this effort is an internally consistent, high-quality carbon data set for all cruises, including the reference cruises. The suggested corrections by the inversion analysis were allowed to vary within a fixed envelope, thus accounting for natural variability. The percentage of cruises adjusted ranged from 31% (for nitrate) to 54% (for phosphate) depending on the variable