174 research outputs found
Genome plasticity favours double chromosomal Tn4401b-blaKPC-2 transposon insertion in the Pseudomonas aeruginosa ST235 clone
- Author
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 05/06/2020
- Field of study
High Quality Long-Term CD4+ and CD8+ Effector Memory Populations Stimulated by DNA-LACK/MVA-LACK Regimen in Leishmania major BALB/c Model of Infection
- Author
- A Haque
- A Khamesipour
- A Reyes-Sandoval
- AB Macedo
- aJ Ramsay
- B Dondji
- C Bogdan
- Carlos Oscar S. Sorzano
- Carmen Elena Gómez
- D Doroud
- DC Tscharke
- DR Faria
- E Mougneau
- E Papadogiannakis
- E Pérez-Jiménez
- E Tapia
- Ernesto Mejías-Pérez
- FY Liew
- FY Liew
- G Gonzalez-Aseguinolaza
- HW Murray
- I Ramos
- I Ramos
- I Ramos
- J Cote-Sierra
- J Garcia-Arriaza
- JL Najera
- L Xin
- Lucas Sánchez-Sampedro
- M Nateghi Rostami
- Mariano Esteban
- Mauricio Martins Rodrigues
- MM Gherardi
- MS Duthie
- P Launois
- P Launois
- P Launois
- P Mooij
- P Wilhelm
- Pa Darrah
- PA Darrah
- PC Melby
- PO Rigato
- Ra Seder
- S Pingel
- SBH Ahmed
- SJ Green
- SL Croft
- SL Reiner
- SP Perfetto
- TS Keesen
- V Julia
- WG Ferlin
- Publication venue
- Public Library of Science
- Publication date
- 01/01/2012
- Field of study
Heterologous vaccination based on priming with a plasmid DNA vector and boosting with an attenuated vaccinia virus MVA recombinant, with both vectors expressing the Leishmania infantum LACK antigen (DNA-LACK and MVA-LACK), has shown efficacy conferring protection in murine and canine models against cutaneus and visceral leishmaniasis, but the immune parameters of protection remain ill defined. Here we performed by flow cytometry an in depth analysis of the T cell populations induced in BALB/c mice during the vaccination protocol DNA-LACK/MVA-LACK, as well as after challenge with L. major parasites. In the adaptive response, there is a polyfunctional CD4+ and CD8+ T cell activation against LACK antigen. At the memory phase the heterologous vaccination induces high quality LACK-specific long-term CD4+ and CD8+ effector memory cells. After parasite challenge, there is a moderate boosting of LACK-specific CD4+ and CD8+ T cells. Anti-vector responses were largely CD8+-mediated. The immune parameters induced against LACK and triggered by the combined vaccination DNA/MVA protocol, like polyfunctionality of CD4+ and CD8+ T cells with an effector phenotype, could be relevant in protection against leishmaniasis
Complex evolutionary history of the Mexican stoneroller Campostoma ornatum Girard, 1856 (Actinopterygii: Cyprinidae)
- Author
- A Moreno-Letelier
- A Pompa-Domínguez
- AA Echelle
- AA Echelle
- AA Echelle
- AA Echelle
- AJ Drummond
- AR Rogers
- AR Templeton
- Arizona Game and Fish Department
- B Chernoff
- BM Burr
- C Badgley
- CC Reeves
- CI Ortega-Rosas
- CM Bossu
- CS Goldberg
- D Posada
- DA Hendrickson
- DD Coblentz
- DJ Fraser
- DL Swofford
- DM Gleeson
- DR Brooks
- DR Montgomery
- E Zarza
- EE Nunez
- F Camarena-Rosales
- FT Ledig
- FW Allendorf
- G Ceballos
- G Voelker
- HL Bart
- I Dupanloup
- Ignacio Doadrio
- J Alcocer
- J Colborn
- J Lyons
- J Schaefer
- JA Huey
- JA López
- JD Durand
- JE McCormack
- JE McCormack
- JI Mead
- JJ Morrone
- JP Huelsenbeck
- JW Demastes
- L Excoffier
- L Ferrari
- LJ Rissler
- M Clement
- M Stephens
- MA Anducho-Reyes
- Marta Vila
- MJ Blum
- ND Mundahl
- Nuria Remón
- O Domínguez-Domínguez
- O Domínguez-Domínguez
- Omar Domínguez-Domínguez
- P Librado
- PW Hedrick
- R Conant
- R Pérez-Rodríguez
- R Zardoya
- RA Mittermeier
- RC Cashner
- RC Garrick
- RJ Edwards
- RJ Petit
- RM Wood
- Rodolfo Pérez-Rodríguez
- RR Miller
- RV Arellano
- RW Bryson
- S Chow
- S Contreras-Balderas
- S Contreras-Balderas
- S Contreras-Balderas
- S Guindon
- SE Meek
- SE Metcalfe
- SE Ramos-Onsins
- TE Dowling
- TL Erwin
- WL Minckley
- WL Minckley
- YX Fu
- Publication venue
- BioMed Central
- Publication date
- 01/01/2011
- Field of study
<p>Abstract</p> <p>Background</p> <p>Studies of the phylogeography of Mexican species are steadily revealing genetic patterns shared by different species, which will help to unravel the complex biogeographic history of the region. <it>Campostoma ornatum </it>is a freshwater fish endemic to montane and semiarid regions in northwest Mexico and southern Arizona. Its wide range of distribution and the previously observed morphological differentiation between populations in different watersheds make this species a useful model to investigate the biogeographic role of the Sierra Madre Occidental and to disentangle the actions of Pliocene tecto-volcanic processes <it>vs </it>Quaternary climatic change. Our phylogeographic study was based on DNA sequences from one mitochondrial gene (<it>cytb</it>, 1110 bp, n = 285) and two nuclear gene regions (S7 and RAG1, 1822 bp in total, n = 56 and 43, respectively) obtained from 18 to 29 localities, in addition to a morphological survey covering the entire distribution area. Such a dataset allowed us to assess whether any of the populations/lineages sampled deserve to be categorised as an evolutionarily significant unit.</p> <p>Results</p> <p>We found two morphologically and genetically well-differentiated groups within <it>C. ornatum</it>. One is located in the northern river drainages (Yaqui, Mayo, Fuerte, Sonora, Casas Grandes, Santa Clara and Conchos) and another one is found in the southern drainages (Nazas, Aguanaval and Piaxtla). The split between these two lineages took place about 3.9 Mya (CI = 2.1-5.9). Within the northern lineage, there was strong and significant inter-basin genetic differentiation and also several secondary dispersal episodes whit gene homogenization between drainages. Interestingly, three divergent mitochondrial lineages were found in sympatry in two northern localities from the Yaqui river basin.</p> <p>Conclusions</p> <p>Our results indicate that there was isolation between the northern and southern phylogroups since the Pliocene, which was related to the formation of the ancient Nazas River paleosystem, where the southern group originated. Within groups, a complex reticulate biogeographic history for <it>C. ornatum </it>populations emerges, following the taxon pulse theory and mainly related with Pliocene tecto-volcanic processes. In the northern group, several events of vicariance promoted by river or drainage isolation episodes were found, but within both groups, the phylogeographic patterns suggest the occurrence of several events of river capture and fauna interchange. The Yaqui River supports the most diverse populations of <it>C. ornatum</it>, with several events of dispersal and isolation within the basin. Based on our genetic results, we defined three ESUs within <it>C. ornatum </it>as a first attempt to promote the conservation of the evolutionary processes determining the genetic diversity of this species. They will likely be revealed as a valuable tool for freshwater conservation policies in northwest Mexico, where many environmental problems concerning the use of water have rapidly arisen in recent decades.</p
Molecular characterization of Trypanosoma cruzi Mexican strains and their behavior in the mouse experimental model
- Author
- Alvarado CAP
- Andrade SG
- Andrade SG
- Araujo SMG
- Barrera-Pérez MA
- Ben Younes-Chennoufi A
- Biagi FF
- Bice DE
- Bosseno MF
- Bosseno MF
- Brisse S
- Burgos JM
- Cruz-Reyes A
- Cuartero CM
- César Gómez-Hernández
- D'Avila DA
- Dias JCP
- Dumonteil E
- Eliane Lages-Silva
- Espinoza B
- Francisco Trujillo Contreras
- Frank FM
- Gabriel Antônio Nogueira Nascentes
- Garcia GA
- Gomez-Hernandez C
- Guarner J
- Guzman-Bracho C
- Henrique Borges Kappel
- José Alejandro Martinez-Ibarra
- Karine Rezende-Oliveira
- Lana M
- Lara Rocha Batista
- Lisboa CV
- Lozano-Kasten F
- Luis Eduardo Ramírez
- Macedo AM
- Magalhaes JB
- Magallón-Gastélum E
- Martinez-Ibarra JA
- Melnikov VG
- Moncayo A
- Monteon VM
- Mortara RA
- O'Connor O
- Roellig DM
- Ruiz-Sanchez R
- Santos VM
- Souto RP
- Steindel M
- Velasco Castrejon O
- Vera-Cruz JM
- Winker PB
- Zingales B
- Publication venue
- 'FapUNIFESP (SciELO)'
- Publication date
- Field of study
Diversity and distribution of azooxanthellate corals in the Colombian Caribbean
- Author
- A Friedlander
- A Gracia
- A Gracia
- A Gracia
- A Lindner
- A Roa-Varón
- AK Matsumoto
- B Werding
- Bert W. Hoeksema
- BW Hoeksema
- BW Hoeksema
- BW Hoeksema
- BW Hoeksema
- CA Andrade
- CA Andrade
- CA Andrade
- CB García
- D Alonso
- D Herazo
- D Ludwig
- DJ Bottjer
- DM Opresko
- DM Opresko
- DM Opresko
- DM Opresko
- DM Opresko
- DM Opresko
- DM Opresko
- E Deichman
- FM Bayer
- FM Bayer
- FM Bayer
- G Brook
- GC Williams
- GC Williams
- GH Borrero-Pérez
- GH Borrero-Pérez
- GH Borrero-Pérez
- H Mok
- H Prahl von
- H Reyes-Bonilla
- H Zibrowius
- H Zibrowius
- HA Lessios
- IC Chacón-Gómez
- IC Chacón-Gómez
- IC Chacón-Gómez
- Isabel Cristina Chacón-Gómez
- J Reyes
- J Reyes
- J Reyes
- J Reyes
- J Stolarski
- J Verseveldt
- JA Sánchez
- JA Sánchez
- JA Sánchez
- JA Sánchez
- JA Sánchez
- JA Sánchez
- JA Sánchez
- Javier Reyes
- JC Gering
- JD Restrepo
- JEN Veron
- JF Grassle
- JH Brown
- JM Díaz
- JM Díaz
- JM Guinotte
- JM Pandolfi
- JM Roberts
- JP Dawson
- JW Durham
- K Fabricius
- K Janiszewska
- KE Carpenter
- KJ Gaston
- KR Clarke
- L Botero
- L Collins
- L Saavedra-Díaz
- Leen P. van Ofwegen
- M Adjeroud
- M Benavides-Serrato
- M Houston
- MAVDT
- MD Spalding
- MV Kitahara
- MV Lomolino
- N Cruz
- N Knowlton
- N Santodomingo
- Nadiezhda Santodomingo
- P Bongaerts
- P Flórez-Romero
- P Lattig
- P Lattig
- P Miloslavich
- Paola Flórez
- PK Dayton
- RA Mittermeier
- RW Buddemeier
- RW Buddemeier
- SD Cairns
- SD Cairns
- SD Cairns
- SD Cairns
- SD Cairns
- SD Cairns
- SD Cairns
- SE Kahng
- SE Kahng
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- Field of study
Worldwide comparison of survival from childhood leukaemia for 1995–2009, by subtype, age, and sex (CONCORD-2): a population-based study of individual data for 89 828 children from 198 registries in 53 countries
- Author
- Ab Manan A
- Abdel-Rahman M
- Adamcik J
- Agius D
- Aitken J
- Al Khater Ahm
- Al-Eid H
- Aleinikova Ov
- Allemani C
- Allemani Claudia
- Almar E
- Almon L
- Alonso R
- Alverson J
- Antunes L
- Ardanaz Ee
- Arias-Ortiz Ne
- Arveux P
- Asquez Ra
- Autelitano M
- Azevedo e Silva G
- Bah E
- Baili P
- Baker D
- Bannon F
- Bara S
- Barrios E
- Bastos J
- Bates J
- Bayakly Ar
- Bayo S
- Bella F
- Bento Mj
- Berrino F
- Bertrand C
- Bidaurrazaga J
- Bielska-Lasota M
- Black Rj
- Blaszczyk J
- Bolick Sw
- Bonaventure A
- Bonaventure Audrey
- Borchers R
- Bordoni A
- Bouchardy C
- Bouvier Am
- Bouvier V
- Bouzbid S
- Bradshaw D
- Bravo Le
- Bray F
- Brenner H
- Brewster Dh
- Brockhouse Jt
- Brown H
- Budroni M
- Bulliard Jl
- Busco S
- Calabrano Gh
- Caldarella A
- Calleja N
- Camey B
- Candela G
- Capocaccia R
- Carballo Quintero B
- Carreira H
- Carreira Helena
- Castaing M
- Cesaraccio R
- Chalker E
- Charlton Me
- Chen Jg
- Chen Js
- Chen Wq
- Cheng Lp
- Cheteri MB Keitheri
- Chiang Cj
- Chimedsuren O
- Chiolero A
- Chirlaque Md
- Cirilli C
- Clarke Ca
- Clavel J
- Clavel Jacqueline
- Coldman Aj
- Coleman Michel P
- Coleman Mp
- Colonna M
- Comber H
- Contiero P
- Contrino Ml
- Copeland Ge
- Cornet E
- Cowppli-Bony A
- Coza D
- Cremone L
- Cromartie B
- Cueva P
- Curado Mp
- Currow D
- Cusimano R
- Daniel C
- Daoprasert K
- Daoulas M
- De Angelis R
- de Oliveira E Lobo
- de Oliveira Jc
- De Souza Pcf
- Deapen D
- Degré D
- Dehler Si
- Dei Tos Ap
- Del Pino K
- Demers S
- Demetriou Av
- Devigili E
- Dewar Rad
- Di Carlo V
- Di Felice E
- Didkowska Ja
- Dimitrova N
- Diumenjo Mc
- Dong J
- Dyzmann-Sroka A
- Díaz García Jm
- Eberle A
- Edwards Bk
- Eisemann N
- El Mistiri Mm
- El Mistiri Mm
- Emrich K
- Engholm G
- Erb C
- Eser S
- Espinola Sb
- Espinoza Jr
- Ess Sm
- Estève J
- Fabowale Null
- Faivre J
- Falcini F
- Fanetti Ac
- Farley S
- Farrugia H
- Federico M
- Fernández-Delgado R
- Ferretti S
- Finan P
- Fita R
- Fitzpatrick D
- Forjaz G
- Fournier E
- Frick H
- Fulton Jp
- Fusco M
- Galaz Jc
- Galceran J
- Galán Yh
- Ganry O
- Garcilazo Da
- Gatta G
- Gatta Gemma
- Gavin A
- Ge Hm
- Geater Sl
- Gentilini Ma
- George Jt
- Gershman St
- Giacciani Pl
- Giacomin A
- Giles Gg
- Giljahn L
- Glaser Sl
- Gola G
- González Ms
- Gradalska-Lampart M
- Green Ma
- Green Md
- Grosclaude P
- Gu Xp
- Guizard Av
- Guo Gp
- Gózdz S
- Hackl M
- Hamdi-Chérif M
- Hannah H
- Harewood R
- Harewood Rhea
- Harrelson Dg
- Hattori M
- Henau K
- Hendrix J
- Herget K
- Hernandez By
- Herrera Vm
- Herrmann C
- Herrmann Da
- Holleczek B
- Hood M
- Hosain Gm
- Hsieh Mc
- Huang B
- Huang Qh
- Huang Sq
- Hudson Ag
- Hurley Dm
- Huws Dw
- Ibañez Sg
- Innos K
- Ito H
- Jaidane L
- Janes Ta
- Jaramillo L
- Jayalekshmi Pa
- Johnson Cj
- Jozwik D
- Jung Kw
- Jurado Dm
- Jégu J
- Kahn Ar
- Kaizaki Y
- Kajueter H
- Kanemura S
- Kataki Ac
- Katalinic A
- Katayama K
- Keinan-Boker L
- Kepska K
- Key C
- Khan S
- Kieschke J
- Knowlton Rc
- Koike T
- Konzelmann I
- Krishnatreya M
- Kuehni Ce
- Kuehni Claudia E
- Kumar E
- Kumar V
- Kumcher I
- Kwiatkowska K
- La Rosa F
- Lai Ms
- Lalany A
- Lambe M
- Lanza Mf
- Laporte C
- Lapôtre-Ledoux B
- Larrañaga N
- Larønningen S
- Laspada Wd
- Latorre Mrdo
- Launoy G
- Laura Ea
- Le Guyader-Peyrou S
- Lemons D
- Leung G
- Lewis C
- Li Ql
- Li W
- Liepina E
- Lillini R
- Lima Ca
- Liu K
- Liu L
- Louchini R
- Lynch Cf
- Macintyre M
- Mackinnon Ja
- Malila N
- Malle B
- Mang Wk
- Manraj Ss
- Marcos Ai
- Marcos-Gragera R
- Marcos-Gragera Rafael
- Marrett L
- Martin J
- Martínez-Reyes F
- Maspero S
- Maspoli-Conconi M
- Mateos A
- Matsuda T
- Matthes Kl
- Matz M
- Maule Mm
- Maurina A
- Mayer-da-Silva A
- Maynadié M
- Mazzoleni G
- Mazzucco W
- Mcclure C
- Mccrate Fr
- Melo Cd
- Mezyk R
- Michiara M
- Miranda A
- Miyashiro I
- Mokni M
- Molina E
- Molinié F
- Monnereau A
- Montel L
- Montserrat M Ramos
- Moreno F
- Moreno-Iribas Cc
- Mounier M
- Moya Ja
- Mueller L
- Murphy Mfg
- Murphy Michael F G
- Mägi M
- Møller B
- Mühlböck H
- Nakagawa H
- Nandakumar A
- Narimatsu H
- Navarro C
- Nennecke A
- Newman L
- Ngan Kc
- Nikiforuk C
- Nikšić M
- Nimri O
- Nishri De
- Nogueira Lm
- Noonan G
- Nortje Sh
- O'Brien Dk
- Oberaigner W
- Ogunbiyi Oj
- Oki I
- Pannozzo F
- Pascucci C
- Pate A
- Pathy N Bhoo
- Patil M
- Pavlou P
- Pawlish Ks
- Peake M
- Peris-Bonet R
- Peris-Bonet Rafael
- Phillips C
- Piffer S
- Piñeros M
- Piñeros Marion
- Pongnikorn D
- Primic-Žakelj M
- Pérez-Meza Ml
- Quinto R
- Quirós Jr
- Rachet B
- Radziszewska Au
- Rao C
- Rashbass J
- Rees Jr
- Rego Ra
- Ricci P
- Richards J
- Robb Ki
- Rogers Db
- Rosso S
- Rousseau Dl
- Rubertone Jj
- Ruta M
- Ryan S
- Rycroft R
- Sacchetto L
- Sacerdote C
- Safaei Diba C
- Sant M
- Sant Milena
- Sanz N
- Sapkota Sd
- Sassi F
- Scandiuzzi C
- Schindler M
- Schubert Ss
- Schwartz Ag
- Schwartz Sm
- Schymura Mj
- Scott C
- Scuderi T
- Sebastian P
- Seppä K
- Serraino D
- Sewpaul-Sungkur R
- Sgargi P
- Shack L
- Shen X
- Shen Y
- Shibata A
- Siesling S
- Silva Ma
- Silverman Bg
- Sirri E
- Slack Sj
- Smailyte G
- Soeberg Mj
- Somdyala Nim
- Song Gh
- Spika D
- Spika Devon
- Spitale A
- Sriplung H
- Stabenow R
- Stare J
- Stefan Daniela C
- Stefan Dc
- Stephens R
- Stephenson L
- Stern K
- Stiller Ca
- Stiller Charles A
- Stokes Bc
- Storm H
- Stracci F
- Stroup A
- Stuart-Panko H
- Sugiyama H
- Sundseth H
- Sureda P Franch
- Sutera A
- Suwanrungruang K
- Suzanna E
- Swaminathan R
- Swaminathan R
- Sweeney C
- Sánchez Mj
- Tagliabue G
- Tanaka Lf
- Tang Jg
- Threlfall T
- Tisano F
- Todescu Ai
- Torres P
- Torres-Cintrón Cr
- Tortolero-Luna G
- Trojanowski M
- Troussard X
- Tryggvadóttir L
- Trétarre B
- Tucker Tc
- Tumino R
- Turner D
- Tuvshingerel S
- Uribe Cj
- Usala M
- Usel M
- Utada M
- Valerianova Z
- Valkov My
- Van Eycken L
- Vargas S
- Velten M
- Veneziano Cla
- Veneziano Db
- Venn A
- Vercelli M
- Verma Y
- Vicentini M
- Vigneau F
- Vilardell Gil Ml
- Visser O
- Vitale Mf
- Vitarelli S
- Vriends Ka
- Walsh Pm
- Wang J
- Wang N
- Wang S
- Ward Kc
- Warther B
- Wei K
- Weir Hk
- West D
- White C
- Whiteside Ma
- Wiangnon S
- Wiggins C
- Williamson Ll
- Wohler B
- Wojciechowska U
- Won Yj
- Woods Rr
- Woronoff As
- Wright S
- Wu Xc
- Yakut Ci
- Yang L
- Yang Xp
- Yoshii M
- You H
- Yépez Jg
- Yépez Mc
- Zaidi Z
- Zanetti R
- Zborovskaya Aa
- Zeissig Sr
- Zeng H
- Zhang B
- Zhang Jh
- Zhang P
- Zhao Dl
- Zhu Fd
- Zorzi M
- Zucchetto A
- Zvolský M
- Ólafsdóttir Ej
- Šekerija M
- Žagar T
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2017
- Field of study
Background Global inequalities in access to health care are reflected in differences in cancer survival. The CONCORD programme was designed to assess worldwide differences and trends in population-based cancer survival. In this population-based study, we aimed to estimate survival inequalities globally for several subtypes of childhood leukaemia.
Methods Cancer registries participating in CONCORD were asked to submit tumour registrations for all children aged 0-14 years who were diagnosed with leukaemia between Jan 1, 1995, and Dec 31, 2009, and followed up until Dec 31, 2009. Haematological malignancies were defined by morphology codes in the International Classification of Diseases for Oncology, third revision. We excluded data from registries from which the data were judged to be less reliable, or included only lymphomas, and data from countries in which data for fewer than ten children were available for analysis. We also excluded records because of a missing date of birth, diagnosis, or last known vital status. We estimated 5-year net survival (ie, the probability of surviving at least 5 years after diagnosis, after controlling for deaths from other causes [background mortality]) for children by calendar period of diagnosis (1995-99, 2000-04, and 2005-09), sex, and age at diagnosis (< 1, 1-4, 5-9, and 10-14 years, inclusive) using appropriate life tables. We estimated age-standardised net survival for international comparison of survival trends for precursor-cell acute lymphoblastic leukaemia (ALL) and acute myeloid leukaemia (AML).
Findings We analysed data from 89 828 children from 198 registries in 53 countries. During 1995-99, 5-year agestandardised net survival for all lymphoid leukaemias combined ranged from 10.6% (95% CI 3.1-18.2) in the Chinese registries to 86.8% (81.6-92.0) in Austria. International differences in 5-year survival for childhood leukaemia were still large as recently as 2005-09, when age-standardised survival for lymphoid leukaemias ranged from 52.4% (95% CI 42.8-61.9) in Cali, Colombia, to 91.6% (89.5-93.6) in the German registries, and for AML ranged from 33.3% (18.9-47.7) in Bulgaria to 78.2% (72.0-84.3) in German registries. Survival from precursor-cell ALL was very close to that of all lymphoid leukaemias combined, with similar variation. In most countries, survival from AML improved more than survival from ALL between 2000-04 and 2005-09. Survival for each type of leukaemia varied markedly with age: survival was highest for children aged 1-4 and 5-9 years, and lowest for infants (younger than 1 year). There was no systematic difference in survival between boys and girls.
Interpretation Global inequalities in survival from childhood leukaemia have narrowed with time but remain very wide for both ALL and AML. These results provide useful information for health policy makers on the effectiveness of health-care systems and for cancer policy makers to reduce inequalities in childhood survival
Improved functionalization of oleic acid-coated iron oxide nanoparticles for biomedical applications
- Author
- Abid M
- Accini JL
- Acuña S
- Adawi F
- Adenuga B
- Adina PM
- Ageev F
- Aguilar-Orozco R
- Ahmad Z
- Aimaretti G
- Aizenberg D
- Akahori H
- Akhmedzhanov N
- Akinboboye O
- Akright L
- Al Mahmeed W
- Alanko J
- Alappat P
- Alawad M
- Alfonso T
- Alimard R
- Alvarez C
- Alvarisqueta A
- Alzohaili O
- Ambos A
- Amerena J
- Amolina I
- Andjelic Jelic M
- Andrade M
- Andrews R
- Antorrena I
- Arana C
- Araneda G
- Arango J
- Ariani M
- Arnold S
- Arora C
- Arteaga JM
- Assaad S
- Atar S
- Avram RI
- Azad N
- Azzam S
- Baccaro C
- Bailey G
- Bain S
- Barbarash O
- Barbarich V
- Bartolacci I
- Bascil Tutuncu N
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- Publication venue
- Springer Nature
- Publication date
- 01/01/2012
- Field of study
Superparamagnetic iron oxide nanoparticles
can providemultiple benefits for biomedical applications
in aqueous environments such asmagnetic separation or
magnetic resonance imaging. To increase the colloidal
stability and allow subsequent reactions, the introduction
of hydrophilic functional groups onto the particles’
surface is essential. During this process, the original
coating is exchanged by preferably covalently bonded
ligands such as trialkoxysilanes. The duration of the
silane exchange reaction, which commonly takes more
than 24 h, is an important drawback for this approach. In
this paper, we present a novel method, which introduces
ultrasonication as an energy source to dramatically
accelerate this process, resulting in high-quality waterdispersible nanoparticles around 10 nmin size. To prove
the generic character, different functional groups were
introduced on the surface including polyethylene glycol
chains, carboxylic acid, amine, and thiol groups. Their
colloidal stability in various aqueous buffer solutions as
well as human plasma and serum was investigated to
allow implementation in biomedical and sensing
applications.status: publishe
A922 Sequential measurement of 1 hour creatinine clearance (1-CRCL) in critically ill patients at risk of acute kidney injury (AKI)
- Author
- Abbott TE
- Abdallah RI
- Abdel-Aal IR
- Abdelmonem SA
- Abdo WF
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- Abellán AN
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- AKI Research Group
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- Chiumello D
- Chiurazzi C
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- Cho Y
- Cho YJ
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- Chouvarda I
- Christopher KB
- Chrétien JM
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- Chumaev A
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- Cinel I
- Cinnella G
- Citerio G
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- Combes A
- Concha P
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- Constan A
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- Conti G
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- Cuthbertson BH
- Cutuli SL
- Câmara M
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- da Silva VZ
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- Dalhuisen A
- Dalorzo M
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- De Brito-Ashurst I
- De Cassai A
- De Freitas FF
- De Gasperi A
- de Hoyos EA
- De la Calle-Pedrosa N
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- Engelberts D
- ENVIN-HELICS Study Group
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- FINNRESUSCI Study Group
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- Fleischmann E
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- GETGAG Working Group
- GETGAG/SEMICYUC
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- IPREA Study Group
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- Japan Septic Disseminated Intravascular Coagulation (JSEPTIC DIC) study group
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- Jayasinghe S
- Jean-Baptiste S
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- Jensen JU
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- JSEPTIC (Japanese Society of Education for Physicians and Trainees in Intensive Care) Clinical Trial Group
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- Juanas CA
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- Kumbamu A
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- PICS- HCPA: Programa Intrahospitalar de Combate à Sepse do Hospital de Clínicas de Porto Alegre
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- Psarologakis C
- Puerto-Morlán A
- Pugliese F
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- Rapid Diagnosis of Infections in the Critically Ill Team
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- Ros Martínez J
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- Rosario LE
- Rosario LE
- Rosario LE
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- Rosario LE
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- Ruiz FC
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- Ruiz-Rodriguez JC
- Ruiz-Rodríguez JC
- Ruiz-Ruano RDEL
- Runge I
- Runge I
- Runge I
- Rutherford WB
- Rutten AM
- Rydingsward JE
- Saadat F
- Sabetian G
- Sabeļņikovs O
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- Santana PS
- Santana SR
- Santana SR
- Santiago AI
- Santiago AI
- Santos F
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- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz ER
- Sanz NM
- Sanz NM
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- Savin I
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- Sawamura A
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- Schneider AG
- Schoenenberger JA
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- Spatenkova V
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- Spronk PE
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- St George’s University of London
- Stamm J
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- Stubbs C
- Student Research Committee - Shiraz University of Medical Sciences
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- Su L
- Su PL
- Su PL
- Suchomel P
- Suh GJ
- Suh GJ
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- Suh GY
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- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez MJ
- Sánchez PC
- Sánchez PC
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- Tabatabaei HR
- Tabei SH
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- Taccone FS
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- Torrance HD
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- Wijayatilake DS
- Wildenberg L
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- WIND study group
- WIND study group
- WIND study group
- Winder-Rhodes S
- Witter T
- Wolf M
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- Yılmaz G
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- Yoshitake E
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- Zýková I
- Álvarez JT
- Álvarez-Lerma F
- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2016
- Field of study
Meeting abstrac
Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)1.
- Author
- Abdel-Aziz AK
- Abdelfatah S
- Abdellatif M
- Abdoli A
- Abel S
- Abeliovich H
- Abildgaard MH
- Abudu YP
- Acevedo-Arozena A
- Adamopoulos IE
- Adeli K
- Adolph TE
- Adornetto A
- Aflaki E
- Agam G
- Agarwal A
- Aggarwal BB
- Agnello M
- Agostinis P
- Agrewala JN
- Agrotis A
- Aguilar PV
- Ahmad ST
- Ahmed ZM
- Ahumada-Castro U
- Aits S
- Aizawa S
- Akkoc Y
- Akoumianaki T
- Akpinar HA
- Al-Abd AM
- Al-Akra L
- Al-Gharaibeh A
- Alaoui-Jamali MA
- Alberti S
- Alcocer-Gómez E
- Alessandri C
- Ali M
- Alim Al-Bari MA
- Aliwaini S
- Alizadeh J
- Almacellas E
- Almasan A
- Alonso A
- Alonso GD
- Altan-Bonnet N
- Altieri DC
- Alves da Costa C
- Alves S
- Alzaharna MM
- Amadio M
- Amantini C
- Amaral C
- Ambrosio S
- Amer AO
- Ammanathan V
- An Z
- Andersen SU
- Andrabi SA
- Andrade-Silva M
- Andres AM
- Angelini S
- Ann D
- Anozie UC
- Ansari MY
- Antas P
- Antebi A
- Antón Z
- Anwar T
- Apetoh L
- Apostolova N
- Araki T
- Araki Y
- Arasaki K
- Araya J
- Araújo WL
- Arden C
- Arguelles S
- Arias E
- Arikkath J
- Arimoto H
- Ariosa AR
- Armstrong-James D
- Arnauné-Pelloquin L
- Aroca A
- Arroyo DS
- Arsov I
- Artero R
- Arévalo M-A
- Asaro DML
- Aschner M
- Ashrafizadeh M
- Ashur-Fabian O
- Atanasov AG
- Au AK
- Auberger P
- Auner HW
- Aurelian L
- Autelli R
- Avagliano L
- Aveic S
- Aveleira CA
- Avin-Wittenberg T
- Aydin Y
- Ayton S
- Ayyadevara S
- Azzopardi M
- Baba M
- Backer JM
- Backues SK
- Bae D-H
- Bae O-N
- Bae SH
- Baehrecke EH
- Baek A
- Baek S-H
- Baek SH
- Bagetta G
- Bagniewska-Zadworna A
- Bai H
- Bai J
- Bai X
- Bai Y
- Bairagi N
- Baksi S
- Balazadeh S
- Balbi T
- Baldari CT
- Balduini W
- Ballabio A
- Ballester M
- Balzan R
- Bandopadhyay R
- Banerjee S
- Banerjee S
- Bao Y
- Baptista MS
- Baracca A
- Barbati C
- Bargiela A
- Barilà D
- Barlow PG
- Barmada SJ
- Barreiro E
- Barreto GE
- Bartek J
- Bartel B
- Bartolome A
- Barve GR
- Basagoudanavar SH
- Bassham DC
- Bast RC
- Basu A
- Batoko H
- Batten I
- Baulieu EE
- Baumgarner BL
- Bayry J
- Beale R
- Beau I
- Beaumatin F
- Bechara LRG
- Beck GR
- Beers MF
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- Ávalos Y
- Önal G
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- Čolić M
- Đokić J
- Žerovnik E
- Publication venue
- 'Informa UK Limited'
- Publication date
- 01/01/2021
- Field of study
In 2008, we published the first set of guidelines for standardizing research in autophagy. Since then, this topic has received increasing attention, and many scientists have entered the field. Our knowledge base and relevant new technologies have also been expanding. Thus, it is important to formulate on a regular basis updated guidelines for monitoring autophagy in different organisms. Despite numerous reviews, there continues to be confusion regarding acceptable methods to evaluate autophagy, especially in multicellular eukaryotes. Here, we present a set of guidelines for investigators to select and interpret methods to examine autophagy and related processes, and for reviewers to provide realistic and reasonable critiques of reports that are focused on these processes. These guidelines are not meant to be a dogmatic set of rules, because the appropriateness of any assay largely depends on the question being asked and the system being used. Moreover, no individual assay is perfect for every situation, calling for the use of multiple techniques to properly monitor autophagy in each experimental setting. Finally, several core components of the autophagy machinery have been implicated in distinct autophagic processes (canonical and noncanonical autophagy), implying that genetic approaches to block autophagy should rely on targeting two or more autophagy-related genes that ideally participate in distinct steps of the pathway. Along similar lines, because multiple proteins involved in autophagy also regulate other cellular pathways including apoptosis, not all of them can be used as a specific marker for bona fide autophagic responses. Here, we critically discuss current methods of assessing autophagy and the information they can, or cannot, provide. Our ultimate goal is to encourage intellectual and technical innovation in the field
Search for strongly interacting massive particles generating trackless jets in proton-proton collisions at s = 13 TeV
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- Publication venue
- 'Springer Science and Business Media LLC'
- Publication date
- 01/01/2022
- Field of study
A search for dark matter in the form of strongly interacting massive particles (SIMPs) using the CMS detector at the LHC is presented. The SIMPs would be produced in pairs that manifest themselves as pairs of jets without tracks. The energy fraction of jets carried by charged particles is used as a key discriminator to suppress efficiently the large multijet background, and the remaining background is estimated directly from data. The search is performed using proton-proton collision data corresponding to an integrated luminosity of 16.1 fb - 1 , collected with the CMS detector in 2016. No significant excess of events is observed above the expected background. For the simplified dark matter model under consideration, SIMPs with masses up to 100 GeV are excluded and further sensitivity is explored towards higher masses
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