The influence of motivations and barriers in the benefits. An empirical study of EMAS certified business in Spain

The main objective of this research is to analyze through a structured questionnaire, the influence of the motivations that lead companies to implement Eco-Management and Audit Scheme (EMAS) and the barriers found in the benefits perceived by companies, as well as, the degree of difficulty perceived for the implementation of the different requirements to be fulfilled, which are established in the regulation. An extensive review of the academic literature published on motivations, barriers, difficulties and benefits in environmental standards has been carried out in order to establish the working hypotheses which refer to the relationship between motivations, barriers with the benefits and degree of difficulty in implementing the requirements. The empirical investigation was carried out in a sample of 114 of the 255 companies of the Autonomous Community of Galicia (Spain) that have EMAS certification. The methodology used was the use of the application of a regression analysis to test the hypotheses; previously the measurement scales were validated and an exploratory factorial analysis was applied in order to determine the structure of the different variables considered in the study. The results show that the motivations affect the benefits positively and on the contrary, affect the barriers negatively (reduce them) and it was observed that the greater the barriers, the lower the benefits obtained from the implementation of EMAS (negative influence). The proposed regression models show the joint influence of the motivations and barriers on the benefits considered.info:eu-repo/semantics/acceptedVersio

Effect of calcium carbonate addition to helix aspersa müller diet

In this paper is studied the effect of calcium carbonate addition to diet on growth, mortality rate and feed intake of snails Helix aspersa Müller during the juvenile stage under laboratory conditions. Two treatments have been tested; first one with 12.5 percent and second one with 22.5 percent of calcium carbonate. Five groups of 40 snails have been randomly assigned to each treatment. Results show significant (p<0.05) differences between both treatments; in the second one is obtained a higher growth and lower mortality rate; however there is no significant difference for dry matter intake.En el presente trabajo se estudia el efecto de la adición de carbonato de calcio a la dieta sobre el crecimiento, mortalidad y consumo del caracol Helix aspersa Müller durante la fase de alevinaje y en condiciones de laboratorio. Se plantean dos tratamientos; el I con 12,5 p.100 y el II con 22,5 p.100 de carbonato cálcico. A cada tratamiento se le asignan aleatoriamente cinco lotes de 40 animales. Los resultados muestran diferencias significativas (p<0,05) entre ambos tratamientos; obteniéndose con el tratamiento II mayor crecimiento y menor mortalidad; que no se aprecian diferencias significativas respecto al consumo de materia seca

Dietary Fat Patterns and Outcomes in Acute Pancreatitis in Spain

Background/Objective: Evidence from basic and clinical studies suggests that unsaturated fatty acids (UFAs) might be relevant mediators of the development of complications in acute pancreatitis (AP). Objective: The aim of this study was to analyze outcomes in patients with AP from regions in Spain with different patterns of dietary fat intake. Materials and Methods: A retrospective analysis was performed with data from 1,655 patients with AP from a Spanish prospective cohort study and regional nutritional data from a Spanish cross-sectional study. Nutritional data considered in the study concern the total lipid consumption, detailing total saturated fatty acids, UFAs and monounsaturated fatty acids (MUFAs) consumption derived from regional data and not from the patient prospective cohort. Two multivariable analysis models were used: (1) a model with the Charlson comorbidity index, sex, alcoholic etiology, and recurrent AP; (2) a model that included these variables plus obesity. Results: In multivariable analysis, patients from regions with high UFA intake had a significantly increased frequency of local complications, persistent organ failure (POF), mortality, and moderate-to-severe disease in the model without obesity and a higher frequency of POF in the model with obesity. Patients from regions with high MUFA intake had significantly more local complications and moderate-to-severe disease; this significance remained for moderate-to-severe disease when obesity was added to the model. Conclusions: Differences in dietary fat patterns could be associated with different outcomes in AP, and dietary fat patterns may be a pre-morbid factor that determines the severity of AP. UFAs, and particulary MUFAs, may influence the pathogenesis of the severity of AP

Spectral characterization of laser-accelerated protons with CR-39 nuclear track detector

CR-39 nuclear track material is frequently used for the detection of protons accelerated in laser-plasma interactions. The measurement of track densities allows for determination of particle angular distributions, and information on the kinetic energy can be obtained by the use of passive absorbers. We present a precise method of measuring spectral distributions of laser-accelerated protons in a single etching and analysis process. We make use of a one-to-one relation between proton energy and track size and present a precise calibration based on monoenergetic particle beams. While this relation is limited to proton energies below 1 MeV, we show that the range of spectral measurements can be significantly extended by simultaneous use of absorbers of suitable thicknesses. Examples from laser-plasma interactions are presented, and quantitative results on proton energies and particle numbers are compared to those obtained from a time-of-flight detector. The spectrum end points of continuous energy distributions have been determined with both detector types and coincide within 50-100 keV

ACE and CXCL10 as predictive biomarkers in the LEA study

Background: LEA Study (GEICAM/2006-11/GBG51), is a randomized clinical trial comparing bevacizumab in combination with endocrine therapy (ET + B) with endocrine therapy (ET) in postmenopausal women with advanced or metastatic HR-positive/HER2-negative breast cancer (BC) with indication of hormonotherapy as first-line treatment. Patients with secondary hypertension had better progression-free survival (PFS) and overall survival (OS). We have evaluated the role of two hypertension-related biomarkers, Angiotensin-Converting Enzyme (ACE) and Small-Inducible Cytokine B10 (CXCL10) as prognostic and/or predictive biomarkers of benefit to bevacizumab in the first line metastatic disease. Methods: From 380 patients, 266 were included in 33 Spanish sites. Median age was 64 years, 63.5% had measurable disease, 97.4% were metastatic at randomization, 51.5% had visceral disease and 52.6% received previous chemotherapy. PFS was 14.3 months (range 0.8-61.1), OS was 34 months (range 0.8-71.6) and 93 patients had Objective Response (OR). We analyzed 124 plasma samples collected before treatment (52 from ET and 72 from ET + B arms). Circulating levels of ACE and CXCL10 were determined by ELISA. ACE levels of 115ng/ml and 135ng/ml were pre-defined as cutoff values. CXCL10 was explored as a quantitative variable. Results: PFS was 15.1 months (range 1.4-61.1), OS was 31.1 months (range 2.8-61.1) and 40.3% had OR. OR was significantly different between treatment arms (p < 0.001) but not PFS or OS. Median ACE concentration was 130.9ng/ml (range 35.3-315.4). Low ACE (<135ng/ml) had better PFS in the whole population (p = 0.048) and in the ET + B arm (p = 0.041). ACE cutoff of 115 ng/ml was not able to identify any subgroup with better prognosis. Median CXCL10 concentration was 230.3pg/ml (range 15.1-4129.6). A higher expression of CXCL10 was significantly associated with worse OS in the whole population (p < 0.0001) and each treatment arm (p = 0.002 and p = 0.001 in ET and ET + B, respectively). No association with OR were identified neither for ACE nor for CXCL10. Conclusions: ACE levels could be considered a prognostic and a bevacizumab predictive biomarker of PFS. CXCL10 could be prognostic of OS. Confirmatory studies are warranted

Loss of microRNA-135b Enhances Bone Metastasis in Prostate Cancer and Predicts Aggressiveness in Human Prostate Samples

About 70% of advanced-stage prostate cancer (PCa) patients will experience bone metastasis, which severely affects patients' quality of life and progresses to lethal PCa in most cases. Hence, understanding the molecular heterogeneity of PCa cell populations and the signaling pathways associated with bone tropism is crucial. For this purpose, we generated an animal model with high penetrance to metastasize to bone using an intracardiac percutaneous injection of PC3 cells to identify PCa metastasis-promoting factors. Using genomic high-throughput analysis we identified a miRNA signature involved in bone metastasis that also presents potential as a biomarker of PCa progression in human samples. In particular, the downregulation of miR-135b favored the incidence of bone metastases by significantly increasing PCa cells' migratory capacity. Moreover, the PLAG1, JAKMIP2, PDGFA, and VTI1b target genes were identified as potential mediators of miR-135b's role in the dissemination to bone. In this study, we provide a genomic signature involved in PCa bone growth, contributing to a better understanding of the mechanisms responsible for this process. In the future, our results could ultimately translate into promising new therapeutic targets for the treatment of lethal PCa

Home enteral nutrition in Spain: NADYA registry 2010

Objetivos: Describir los resultados del registro de nutrición enteral domiciliaria (NED) del grupo NADYASENPE del año 2010. Material y métodos: Se recopilaron los datos introducidos en el registro desde el 1 de enero al 31 de diciembre de 2010. Resultados: Se registraron 6.591 pacientes (51% varones) con 6.688 episodios de NED, procedentes de 32 hospitales. La edad media en los menores de 14 años (4%) fue de 1 ± 2 años (m ± DS) y de 69,9 ± 17,8 en los mayores de 14 años. El 76% de los pacientes recibieron la NED por un tiempo superior a 2 años. La patología más prevalente fue la neurológica 42%, seguida de la neoplasia 28% (en su mayoría cáncer de cabeza y cuello 18%). La información referente a la vía de acceso sólo se recogió en 626 casos (9,4%), el 51% de los pacientes utilizaron sonda nasogástrica, 27% gastrostomías, 10% vía oral y 3% yeyunostomías. Sólo 251 episodios finalizaron a lo largo del año, siendo el motivo más frecuente el fallecimiento del paciente en el 57% de los casos y el paso a la alimentación oral en el 14%. El 29% de los pacientes presentaban una actividad limitada y el 39% estaba confinado en cama/ sillón. El 68% de los adultos requerían ayuda total o parcial. El suministro del producto se realizó desde el hospital o la farmacia de referencia en el 63% y 34%, respectivamente. El suministro del material fungible se realizó desde el hospital o atención primaria en el 83% y 16%, respectivamente. Conclusiones: Los resultados obtenidos en el registro de NED del año 2010 muestran características muy similares a las recogidas en los años previos en cuanto al número y características de los pacientes registrados. Seguimos encontrando problemas en la recogida de datos relativos a la vía de acceso y finalización de los episodiosObjective: To describe the results of the home enteral nutrition (HEN) registry of the NADYA-SENPE group in 2010. Material and methods: We retrieved the data of the patients recorded from January 1st to December 31st 2010. Results: We registered 6,591 patients (51% males) with 6,688 episodes of HEN, from 32 hospitals. Mean age in those younger than 14 yr (4%) was 1 ± 2 yrs (m ± SD) and 69,9 ± 17,8 yrs in those older than 14 yr. The length of HEN was longer than 2 yrs in 76% of the patients. The most frequent underlying disease was neurological disorders 42%, followed by cancer 28% (mostly head and neck cancer 18%). We had information related to the enteral access route in only 626 cases (9,4%), 51% of them used nasogastric tubes, 27% gastrostomies, 10% oral route and 3% jejunostomies. Only 251 episodes were closed during the year, mostly due to patient death 57% and progress to oral diet 14%. The activity level was limited in 29% of the patients and 39% of them were bed- or chairridden. Total or partial help was needed by 68% of the patients. The hospitals and the private pharmacies delivered the enteral formula in 63% and 34% of the cases, respectively. The hospitals and the primary care centres delivered the disposables in 83% and16% of the cases, respectively. Conclusions: The results of the 2010 HEN registry are similar to those published in previous years regarding the number and characteristics of the patients. We continue finding problems in the entrance of data referred to the enteral access route and the closing of the episode

Registro español de nutrición enteral domiciliaria del año 2009; Grupo NADYA-SENPE

Objetivo: Describir las características de la Nutrición Enteral Domiciliaria (NED) en España, registrada por el grupo NADYA-SENPE durante el año 2009. Material y métodos: Recopilación y análisis descriptivo de los datos del registro de NED del grupo NADYASENPE desde el 1 de enero al 31 de diciembre de 2009. Resultados: Se registraron 6.540 pacientes, 5,11% más que en el año anterior y 6.649 episodios de NED (3.135 en mujeres, 47,93%) pertenecientes a 32 centros hospitalarios. Siendo 6.238 (95,38%) mayores de 14 años. La edad media en los menores de 14 años fue de 3,67 ± 2,86 y de 72,10 ± 16,89 en los mayores de 14 años. La enfermedad de base que se registró con más frecuencia fue la neurológica en 2.732 (41,77%) ocasiones, seguida de la neoplasia en 1838; 28,10%. La vía de acceso se registró en 1.123 (17,17%) de los episodios, siendo más frecuente la administración por sonda nasogástrica 562 (50,04%). El tiempo medio de tratamiento nutricional fue de 323 días (10,77 meses). Finalizaron 606 episodios de NED, siendo el motivo más frecuentes el fallecimiento del enfermo, lo que aconteció en 295 (48,68%) ocasiones y el paso a alimentación oral en 219 (36,14%). Los pacientes mantenían una actividad normal en 2162 episodios de NED (32,55%) y en 2468 (37,13%) hacían vida “cama-sillón”. El grado de dependencia fue “total” en 2598 (39,07%) de los episodios registrado. El suministro de la fórmula nutricional se realizó desde el hospital en 4.183 (62,91%) casos y por la farmacia de referencia en 2.262 (el 34,02%) y el material fungible se suministró desde el hospital en 3.531 (53,11%) de los casos. Conclusiones: El número de pacientes con NED registrados es superior al del año 2008, continuando con el incremento progresivo desde el inicio del registro. Las características de los mismos mantiene el mismo perfil que en años anteriores con pequeñas variaciones.Objective: To describe the Home Enteral Nutrition Characteristics (HEN) recorded by the group NADYASENPE during 2009. Material and methods: collection and analysis of the data voluntary recorded in the HEN registry from the NADYASENPE group from January 1st to December 31st. Results: 6.540 HEN patients were registered, 5.11% more than the previous year and 6,649 episodes (3,135 in women, 47,93%) from 32 different hospitals. 6,238 of them (95,38%) were over 14 years. The mean age of the patients under 14 yr was 3,67 ± 2,86 and it was 72,10 ± 16,89 in those over 14 yr group. The base illness registered more frequently was the neurological disorders in 2,732 (41,77%) patients, followed by cancer patients in 1,838; 28,10%. The enteral access route was registered in 1,123 (17,17%) of the episodes, being more frequent the administration by nasogastric tube 562 (50,04%). The mean length of nutritional treatment by episode was 323 days (10,77 months). 606 episodes of HEN ended, being the principal reasons for discontinuing treatment the patient death in 295 (48,68%) occasions. The transition to oral feeding occurred in 219 (36,14%) cases. Patients maintained normal activity in 2162 (32,55%) HEN episodes and 2,468 (37,13%) cases were living “bedcouch”. The level of dependence was “total” in 2,598 (39,07%) of the episodes recorded. The nutritional formula was provided by the hospital in 4,183 (62,91%) cases and by the reference pharmacy in 2,262 (el 34,02%). Consumables were provided by the hospital in 3,531 (53,11%) cases. Conclusions: The number of HEN patients recorded increased from the year 2008, continuing the gradual growth increase since the start of registration. The characteristics of the patients remain in the same profile as in previous years

Sistema acuapónico con humedal subsuperficial para producción de carpa (Cyprinus carpio L.), fresa (Fragaria x ananassa (Duchesne ex Weston) y canola (Brassica napus L.)

Objective: a greenhouse pilot aquaponic system was installed, operated, and evaluated to produce carps-strawberry-canola. Design / methodology / approach: the proposed aquaponics system was made of 4 modules: 1) module for the production of carp (Cyprinus Carpio comunis), 2) hydroponic module, deep flow type for the production of duckweed (Lemna minor L.) used to feed the carps, 3) hydroponic module for the strawberry production (Fragaria × ananassa), 4) hydroponic module with substrate (medium gravel) for the canola production (Brassica napus). The carps (Cyprinus carpio) had an average weight of 0.92 g at the beginning of the study (July 2018), the density was 500 carps/ 0.7 m3 of water. From September to December, a sample of 5% was taken to quantify their growth (length and weight) employing a Vernier, and a triple beam balance (OHAUS®). The carps were fed only with duckweed (Lemna minor L.). The carps were fed daily with 1.5% of duckweed as fresh matter concerning the average live weight of the 500 carps. Module 2 had an area of ??0.26 m2. The dry matter of duckweed was quantified using a PVC cylinder that had an area of ??0.010 m2, and then the fresh sample was weighed and dried at 105º C until constant weight. Module 3 (0.42 m2) had 23 plants in a vegetative state, the growth of 5 plants was evaluated by measuring the size of the root (cm), the height of the plant (cm), the length and width of the leaves (cm) and the foliar area (cm2). Module 4 had 0.42 m2, canola seed was sown at a density of 1.2 g/m2 that represented 185 seedlings. The growth of 9 plants was evaluated by measuring the same variables of strawberry plants. Results: in module 1, an average weight per carp of 17.7 g was obtained, representing an average weight increase of 16.8 g in the period from September to December. Module 2 produced 12 kg of duckweed in a fresh basis with 5.6% of dry matter. duckweed production was maintained using the nutrients from the effluent of module 1. In module 3, it was observed that strawberry plants presented an increase of 2.5 g in the fresh weight, 1 cm in root size, 0.9 cm in plant height, 0.2 cm in leaf length, 0.2 cm in leaf width and 0.4 cm2 in the leaf area. In module 4, there was an increase of 8.1 g in plant height, 0.2 cm in the leaf length, 0.2 cm in the leaf width and 0.1 cm2 in the leaf area. Limitations of the study/ implications: for the canola crop, only results of the vegetative growth were reported. For the carps, only three months were reported. However, there was evidence of the feasibility of the system. Findings/ Conclusions: an aquaponic system was installed, operated, and evaluated to produce carps-strawberry-canola. The duckweed was the only source of dry matter for carps. The effluent from the carp module provided nutrients for strawberry growth, bearing fruits of the right color. Canola plants developed adequately, although they had a purple color on the leaves, indicating a possible phosphorus deficiency.Objetivo: se instaló, opero y evaluó un sistema acuapónico piloto bajo invernadero para la producción de carpa-fresa-canola utilizando lenteja de agua como única fuente de alimento. Diseño/metodología/aproximación: el sistema acuapónico propuesto consistió en 4 módulos: 1) módulo para la producción de carpa (Cyprinus Carpio comunis), 2) módulo hidropónico tipo flujo profundo para la producción de lenteja de agua (Lemna minor L.) que se utilizó para alimentar a las carpas, 3) módulo hidropónico tipo raíz flotante para el cultivo de fresa (Fragaria × ananassa), 4) módulo hidropónico con sustrato (grava media) para el cultivo de canola (Brassica napus). En el módulo 1 se crio carpa (Cyprinus carpio) con peso promedio inicial de 0.92 g, a una densidad de 500 peces/0.7 m3 de agua en el mes de julio de 2018. De septiembre a diciembre del mismo año se tomó una muestra del 5% de la población para medir su crecimiento (longitud y peso) empleando un vernier de campo, y se obtuvo el peso (g) por carpa con una balanza granataria. Las carpas se alimentaron solamente con lenteja de agua (Lemna minor L.), se les ofreció 1.5% de peso fresco de Lemna con respecto al peso promedio de las 500 carpas. El módulo 2 tuvo un área de 0.26 m2, se cuantifico la producción de materia seca de la lenteja de agua mediante un cilindro de PVC con un área de 0.010 m2, la muestra fresca se pesó al momento del muestreo y posteriormente se secó a 105º C hasta peso constante. En el módulo 3 de 0.42 m2 se cultivaron 23 plantas de fresa en estado vegetativo, se monitoreó el crecimiento de 5 plantas mediante la medición del tamaño de la raíz (cm), la altura de la planta (cm), el largo y ancho de las hojas (cm) y el área foliar. El módulo 4 tuvo una superficie de 0.42 m2, se sembró semilla de canola a una densidad de 1.2 g/m2 que representó 185 plántulas. Se monitorio el crecimiento de 9 plantas y se evaluaron las mismas variables para las plantas de fresa. &nbsp; Resultados: en el módulo 1 se obtuvo un peso promedio por carpa de 17.7 g representando un incremento de peso promedio de 16.8 g en el periodo de septiembre a diciembre. En el módulo 2 se produjo 12 kg de lenteja de agua fresca en un área de 0.26 m2 con 5.6% de materia seca. La producción de lenteja de agua se mantuvo utilizando los nutrientes del efluente del módulo 1. En el módulo 3 se observó que las plantas de fresa se adaptaron al sistema hidropónico tipo raíz flotante. En promedio se cuantifico un incremento de 2.5 g en el peso fresco de la planta, 1 cm en el tamaño de raíz, 0.9 cm en la altura de planta, 0.2 cm en el largo de hoja, 0.2 cm en el ancho de hoja y 0.4 cm2 en el área foliar. En el módulo 4 se cuantifico en promedio un incremento de 8.1 g en la altura de planta, 0.2 cm en el largo de hoja, 0.2 cm en el ancho hoja y 0.1 cm en el área foliar. Limitaciones del estudio/implicaciones: se reportan resultados del crecimiento vegetativo para la canola, para las carpas solamente se reporta el crecimiento en tres meses, no obstante, se muestra evidencia de la factibilidad del sistema. Hallazgos/conclusiones: se instaló, operó y evaluó un sistema acuapónico recirculante para la producción de carpa-fresa-canola. La lenteja de agua funcionó como la única fuente de alimento para el crecimiento de la carpa. El efluente del módulo carpa proporcionó nutrientes para el crecimiento de la fresa, dando frutos de buen color. Las plantas de canola se desarrollaron adecuadamente, aunque presentaron un color purpura en las hojas, lo que indicó una posible deficiencia de fosforo