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The Impact of Stratospheric Ozone Recovery on Tropopause Height Trends
The evolution of the tropopause in the past, present, and future climate is examined by analyzing a set of long-term integrations with stratosphere-resolving chemistry climate models (CCMs). These CCMs have high vertical resolution near the tropopause, a model top located in the mesosphere or above, and, most important, fully interactive stratospheric chemistry. Using such CCM integrations, it is found that the tropopause pressure (height) will continue to decrease (increase) in the future, but with a trend weaker than that in the recent past. The reduction in the future tropopause trend is shown to be directly associated with stratospheric ozone recovery. A significant ozone recovery occurs in the Southern Hemisphere lower stratosphere of the CCMs, and this leads to a relative warming there that reduces the tropopause trend in the twenty-first century.
The future tropopause trends predicted by the CCMs are considerably smaller than those predicted by the Intergovernmental Panel on Climate Change Fourth Assessment Report (AR4) models, especially in the southern high latitudes. This difference persists even when the CCMs are compared with the subset of the AR4 model integrations for which stratospheric ozone recovery was prescribed. These results suggest that a realistic representation of the stratospheric processes might be important for a reliable estimate of tropopause trends. The implications of these finding for the Southern Hemisphere climate change are also discussed
TEMPRANILLO is a regulator of juvenility in plants
Many plants are incapable of flowering in inductive daylengths during the early juvenile vegetative phase (JVP). Arabidopsis mutants with reduced expression of TEMPRANILLO (TEM), a repressor of FLOWERING LOCUS T (FT) had a shorter JVP than wild-type plants. Reciprocal changes in mRNA expression of TEM and FT were observed in both Arabidopsis and antirrhinum, which correlated with the length of the JVP. FT expression was induced just prior to the end of the JVP and levels of TEM1 mRNA declined rapidly at the time when FT mRNA levels were shown to increase. TEM orthologs were isolated from antirrhinum (AmTEM) and olive (OeTEM) and were expressed most highly during their juvenile phase. AmTEM functionally complemented AtTEM1 in the tem1 mutant and over-expression of AmTEM prolonged the JVP through repression of FT and CONSTANS (CO). We propose that TEM may have a general role in regulating JVP in herbaceous and woody species
Optical variability properties of high luminosity AGN classes
We present the results of a comparative study of the intra-night optical
variability (INOV) characteristics of radio-loud and radio-quiet quasars, which
involves a systematic intra-night optical monitoring of seven sets of high
luminosity AGNs covering the redshift range {\it z} to {\it z}
. The sample, matched in the optical luminosity -- redshift (M
-- z) plane, consists of seven radio-quiet quasars (RQQs), eight radio
lobe-dominated quasars (LDQs), six radio core-dominated quasars (CDQs) and five
BL Lac objects (BLs). Systematic CCD observations, aided by a careful data
analysis procedure, have allowed us to detect INOV with amplitudes as low as
1%. Present observations cover a total of 113 nights (720 hours) with only a
single quasar monitored as continuously as possible on a night. Considering
cases of only unambiguous detections of INOV we have estimated duty cycles
(DCs) of 17%, 12%, 20% and 72% respectively for RQQs, LDQs, CDQs, and BLs. The
low amplitude and low DC of INOV shown by RQQs compared to BLs can be
understood in terms of their having optical synchrotron jets which are modestly
misdirected from us. From our fairly extensive dataset, no unambiguous general
trend of a correlation between the INOV amplitude and the apparent optical
brightness of the quasar is noticed.Comment: 36 pages, 14 Figures, due to large size Fig. 5,6,11 and 12 are not
included. Intersted people contact to [email protected]. Submitted to
Journal of Astrophysics and Astronom
UBVRI Light Curves of 44 Type Ia Supernovae
We present UBVRI photometry of 44 type-Ia supernovae (SN Ia) observed from
1997 to 2001 as part of a continuing monitoring campaign at the Fred Lawrence
Whipple Observatory of the Harvard-Smithsonian Center for Astrophysics. The
data set comprises 2190 observations and is the largest homogeneously observed
and reduced sample of SN Ia to date, nearly doubling the number of
well-observed, nearby SN Ia with published multicolor CCD light curves. The
large sample of U-band photometry is a unique addition, with important
connections to SN Ia observed at high redshift. The decline rate of SN Ia
U-band light curves correlates well with the decline rate in other bands, as
does the U-B color at maximum light. However, the U-band peak magnitudes show
an increased dispersion relative to other bands even after accounting for
extinction and decline rate, amounting to an additional ~40% intrinsic scatter
compared to B-band.Comment: 84 authors, 71 pages, 51 tables, 10 figures. Accepted for publication
in the Astronomical Journal. Version with high-res figures and electronic
data at http://astron.berkeley.edu/~saurabh/cfa2snIa
An outbreak of post-acupuncture cutaneous infection due to Mycobacterium abscessus
BACKGROUND: Despite the increasing popularity of acupuncture, the importance of infection control is not adequately emphasized in Oriental medicine. In December 2001, an Oriental medical doctor in Seoul, South Korea, encountered several patients with persistent, culture-negative skin lesions on the trunk and extremities at the sites of prior acupuncture treatment. We identified and investigated an outbreak of Mycobacterium abscessus cutaneous infection among the patients who attended this Oriental medicine clinic. METHODS: Patients were defined as clinic patients with persistent cutaneous infections at the acupuncture sites. Medical records for the previous 7 months were reviewed. Clinical specimens were obtained from the patients and an environmental investigation was performed. M. abscessus isolates, cultured from patients, were compared by pulsed-field gel electrophoresis (PFGE). RESULTS: Forty patients who attended the Oriental medicine clinic and experienced persistent cutaneous wound infections were identified. Cultures from five of these patients proved positive, and all other diagnoses were based on clinical and histopathologic examinations. All environmental objects tested were negative for M. abscessus, however, most were contaminated by various nosocomial pathogens. Molecular analysis using PFGE found all wound isolates to be identical. CONCLUSION: We have identified a large outbreak of rapidly growing mycobacterial infection among patients who received acupuncture at a single Oriental medicine clinic. Physicians should suspect mycobacterial infections in patients with persistent cutaneous infections following acupuncture, and infection control education including hygienic practice, should be emphasized for Oriental medical doctors practicing acupuncture
Accuracy of five algorithms to diagnose gambiense human African trypanosomiasis.
Algorithms to diagnose gambiense human African trypanosomiasis (HAT, sleeping sickness) are often complex due to the unsatisfactory sensitivity and/or specificity of available tests, and typically include a screening (serological), confirmation (parasitological) and staging component. There is insufficient evidence on the relative accuracy of these algorithms. This paper presents estimates of the accuracy of five algorithms used by past Médecins Sans Frontières programmes in the Republic of Congo, Southern Sudan and Uganda
Measurement of the muon decay spectrum with the ICARUS liquid Argon TPC
Examples are given which prove the ICARUS detector quality through relevant
physics measurements. We study the muon decay energy spectrum from a sample of
stopping muon events acquired during the test run of the ICARUS T600 detector.
This detector allows the spatial reconstruction of the events with fine
granularity, hence, the precise measurement of the range and dE/dx of the muon
with high sampling rate. This information is used to compute the calibration
factors needed for the full calorimetric reconstruction of the events. The
Michel rho parameter is then measured by comparison of the experimental and
Monte Carlo simulated muon decay spectra, obtaining rho = 0.72 +/- 0.06(stat.)
+/- 0.08(syst.). The energy resolution for electrons below ~50 MeV is finally
extracted from the simulated sample, obtaining (Emeas-Emc)/Emc =
11%/sqrt(E[MeV]) + 2%.Comment: 16 pages, 8 figures, LaTex, A4. Some text and 1 figure added. Final
version as accepted for publication in The European Physical Journal
Further investigation of white dwarfs in the open clusters NGC2287 and NGC3532
We report the results of a CCD imaging survey, complimented by astrometric
and spectroscopic follow-up studies, that aims to probe the fate of
heavy-weight intermediate mass stars by unearthing new, faint, white dwarf
members of the rich, nearby, intermediate age open clusters NGC3532 and
NGC2287. We identify a total of four white dwarfs with distances, proper
motions and cooling times which can be reconciled with membership of these
populations. We find that WDJ0643-203 in NGC2287, with an estimated mass of
M=1.02-1.16Msun, is potentially the most massive white dwarf so far identified
within an open cluster. Guided by the predictions of modern theoretical models
of the late-stage evolution of heavy-weight intermediate mass stars, we
conclude that there is a distinct possibility it has a core composed of O and
Ne. We also determine that despite the cooling times of the three new white
dwarfs in NGC3532 and the previously known degenerate member NGC3532-10
spanning ~90Myr, they all have remarkably similar masses (M~0.9-1Msun). This is
fully consistent with the results from our prior work on a heterogeneous sample
of ~50 white dwarfs from 12 stellar populations, on the basis of which we
argued that the stellar initial mass-final mass relation is less steep at
Minit>4Msun than in the adjacent lower initial mass regime. This change in the
gradient of the relation could account for the secondary peak observed in the
mass distribution of the field white dwarf population and mitigate the need to
invoke close binary evolution to explain its existence. Spectroscopic
investigation of numerous additional candidate white dwarf members of NGC3532
unearthed by a recent independent study would be useful to confirm (or
otherwise) these conclusions.Comment: 8 Figures, 8 tables. Accepted for publication in MNRA
The Functions of Myosin II and Myosin V Homologs in Tip Growth and Septation in Aspergillus nidulans
Because of the industrial and medical importance of members of the fungal genus Aspergillus, there is considerable interest in the functions of cytoskeletal components in growth and secretion in these organisms. We have analyzed the genome of Aspergillus nidulans and found that there are two previously unstudied myosin genes, a myosin II homolog, myoB (product = MyoB) and a myosin V homolog, myoE (product = MyoE). Deletions of either cause significant growth defects. MyoB localizes in strings that coalesce into contractile rings at forming septa. It is critical for septation and normal deposition of chitin but not for hyphal extension. MyoE localizes to the Spitzenkörper and to moving puncta in the cytoplasm. Time-lapse imaging of SynA, a v-SNARE, reveals that in myoE deletion strains vesicles no longer localize to the Spitzenkörper. Tip morphology is slightly abnormal and branching occurs more frequently than in controls. Tip extension is slower than in controls, but because hyphal diameter is greater, growth (increase in volume/time) is only slightly reduced. Concentration of vesicles into the Spitzenkörper before incorporation into the plasma membrane is, thus, not required for hyphal growth but facilitates faster tip extension and a more normal hyphal shape
International Exercise Recommendations in Older Adults (ICFSR): Expert Consensus Guidelines
The human ageing process is universal, ubiquitous and inevitable. Every physiological function is being continuously diminished. There is a range between two distinct phenotypes of ageing, shaped by patterns of living - experiences and behaviours, and in particular by the presence or absence of physical activity (PA) and structured exercise (i.e., a sedentary lifestyle). Ageing and a sedentary lifestyle are associated with declines in muscle function and cardiorespiratory fitness, resulting in an impaired capacity to perform daily activities and maintain independent functioning. However, in the presence of adequate exercise/PA these changes in muscular and aerobic capacity with age are substantially attenuated. Additionally, both structured exercise and overall PA play important roles as preventive strategies for many chronic diseases, including cardiovascular disease, stroke, diabetes, osteoporosis, and obesity; improvement of mobility, mental health, and quality of life; and reduction in mortality, among other benefits. Notably, exercise intervention programmes improve the hallmarks of frailty (low body mass, strength, mobility, PA level, energy) and cognition, thus optimising functional capacity during ageing. In these pathological conditions exercise is used as a therapeutic agent and follows the precepts of identifying the cause of a disease and then using an agent in an evidence-based dose to eliminate or moderate the disease. Prescription of PA/structured exercise should therefore be based on the intended outcome (e.g., primary prevention, improvement in fitness or functional status or disease treatment), and individualised, adjusted and controlled like any other medical treatment. In addition, in line with other therapeutic agents, exercise shows a dose-response effect and can be individualised using different modalities, volumes and/or intensities as appropriate to the health state or medical condition. Importantly, exercise therapy is often directed at several physiological systems simultaneously, rather than targeted to a single outcome as is generally the case with pharmacological approaches to disease management. There are diseases for which exercise is an alternative to pharmacological treatment (such as depression), thus contributing to the goal of deprescribing of potentially inappropriate medications (PIMS). There are other conditions where no effective drug therapy is currently available (such as sarcopenia or dementia), where it may serve a primary role in prevention and treatment. Therefore, this consensus statement provides an evidence-based rationale for using exercise and PA for health promotion and disease prevention and treatment in older adults. Exercise prescription is discussed in terms of the specific modalities and doses that have been studied in randomised controlled trials for their effectiveness in attenuating physiological changes of ageing, disease prevention, and/or improvement of older adults with chronic disease and disability. Recommendations are proposed to bridge gaps in the current literature and to optimise the use of exercise/PA both as a preventative medicine and as a therapeutic agent
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