Noise radiation from a ducted rotor in a swirling-translating flow

This PhD dissertation investigates the noise radiation produced by a rotor inside a duct, which is convected by a swirling-translating mean flow. The study is based on an extension of Gennaretti's and Morino's boundary element method to the frequency domain for scattering problems in conjunction with a spinning rotor source model in the presence of a swirling-translating flow. Firstly, two different source models of the rotor are analyzed in absence of mean flow. The parametric study of the two dipole components distributed over a ring or a disc shows that the source radius is a crucial parameter. The scattered pressure directivity patterns of the ring and disc source models are in perfect agreement when a particular ratio between the two model radii is adopted. Therefore, the present analysis justifies the preference for the ring source model due to its simplicity. The proposed formulation is validated by means of exact solutions and used to investigate the effects of the translating flow Mach number and swirling flow angular velocity on noise radiation both in the far and in the near field. The scattered sound is highly affected by the convecting mean flow. The modal content of the scattered field increases when increasing the translating flow Mach number, while a swirling flow leads to a reduction of the mode propagation, if co-rotating with respect to the azimuthal order of the spinning source, or an increase of the modal content, if counter-rotating with respect to the source. This is clearly confirmed by the scattered pressure patterns and levels both in the far and in the near field for all the source frequencies. In general, the mean translating flow moves the main lobes of the directivity patterns downstream, whereas in some cases the mean swirling flow appears to neglect this effect and the downstream lobe is completely shifted. However, the investigation on the in-duct propagation shows that the main effect of the convecting mean flow is to change the modal duct characteristics, more than the pattern itself. This results in turn in the strong modification of the patterns noted in the far field.EThOS - Electronic Theses Online ServiceGBUnited Kingdo

Genome-wide association between YAP/TAZ/TEAD and AP-1 at enhancers drives oncogenic growth

YAP/TAZ are nuclear effectors of the Hippo pathway regulating organ growth and tumorigenesis. Yet, their function as transcriptional regulators remains underinvestigated. By ChIP-seq analyses in breast cancer cells, we discovered that the YAP/TAZ transcriptional response is pervasively mediated by a dual element: TEAD factors, through which YAP/TAZ bind to DNA, co-occupying chromatin with activator protein-1 (AP-1, dimer of JUN and FOS proteins) at composite cis-regulatory elements harbouring both TEAD and AP-1 motifs. YAP/TAZ/TEAD and AP-1 form a complex that synergistically activates target genes directly involved in the control of S-phase entry and mitosis. This control occurs almost exclusively from distal enhancers that contact target promoters through chromatin looping. YAP/TAZ-induced oncogenic growth is strongly enhanced by gain of AP-1 and severely blunted by its loss. Conversely, AP-1-promoted skin tumorigenesis is prevented in YAP/TAZ conditional knockout mice. This work highlights a new layer of signalling integration, feeding on YAP/TAZ function at the chromatin level

bending stiffness of truss reinforced steel concrete composite beams

This paper is concerned with a special steel-concrete composite beam in which the resisting system is a truss structure whose bottom chord is made of a steel plate supporting the precast floor system. This system works in two distinct phases with two different resisting mechanisms: during the construction phase, the truss structure bears the precast floor system and the resisting system is that of a simply supported steel truss; once the concrete has hardened, the truss structure becomes the reinforcing element of a steel-concrete composite beam, where it is also in a pre-stressed condition due to the loads carried before the hardening of concrete. Within this framework, the effects of the diagonal bars on the bending stiffness of this composite beam are investigated. First, a closed-form solution for the evaluation of the equivalent bending stiffness is derived. Subsequently, the influence of geometrical and mechanical characteristics of shear reinforcement is studied. Finally, results obtained from parametric and numerical analyses are discussed

Transcriptional addiction in cancer cells is mediated by YAP/TAZ through BRD4

Cancer cells rely on dysregulated gene expression. This establishes specific transcriptional addictions that may be therapeutically exploited. Yet, the mechanisms that are ultimately responsible for these addictions are poorly understood. Here, we investigated the transcriptional dependencies of transformed cells to the transcription factors YAP and TAZ. YAP/TAZ physically engage the general coactivator bromodomain-containing protein 4 (BRD4), dictating the genome-wide association of BRD4 to chromatin. YAP/TAZ flag a large set of enhancers with super-enhancer-like functional properties. YAP/TAZ-bound enhancers mediate the recruitment of BRD4 and RNA polymerase II at YAP/TAZ-regulated promoters, boosting the expression of a host of growth-regulating genes. Treatment with small-molecule inhibitors of BRD4 blunts YAP/TAZ pro-tumorigenic activity in several cell or tissue contexts, causes the regression of pre-established, YAP/TAZ-addicted neoplastic lesions and reverts drug resistance. This work sheds light on essential mediators, mechanisms and genome-wide regulatory elements that are responsible for transcriptional addiction in cancer and lays the groundwork for a rational use of BET inhibitors according to YAP/TAZ biology

Measurement of the top quark forward-backward production asymmetry and the anomalous chromoelectric and chromomagnetic moments in pp collisions at √s = 13 TeV

Abstract The parton-level top quark (t) forward-backward asymmetry and the anomalous chromoelectric (d̂ t) and chromomagnetic (μ̂ t) moments have been measured using LHC pp collisions at a center-of-mass energy of 13 TeV, collected in the CMS detector in a data sample corresponding to an integrated luminosity of 35.9 fb−1. The linearized variable AFB(1) is used to approximate the asymmetry. Candidate t t ¯ events decaying to a muon or electron and jets in final states with low and high Lorentz boosts are selected and reconstructed using a fit of the kinematic distributions of the decay products to those expected for t t ¯ final states. The values found for the parameters are AFB(1)=0.048−0.087+0.095(stat)−0.029+0.020(syst),μ̂t=−0.024−0.009+0.013(stat)−0.011+0.016(syst), and a limit is placed on the magnitude of | d̂ t| < 0.03 at 95% confidence level. [Figure not available: see fulltext.

Measurement of t(t)over-bar normalised multi-differential cross sections in pp collisions at root s=13 TeV, and simultaneous determination of the strong coupling strength, top quark pole mass, and parton distribution functions

Peer reviewe

MUSiC : a model-unspecific search for new physics in proton-proton collisions at root s=13TeV

Results of the Model Unspecific Search in CMS (MUSiC), using proton-proton collision data recorded at the LHC at a centre-of-mass energy of 13 TeV, corresponding to an integrated luminosity of 35.9 fb(-1), are presented. The MUSiC analysis searches for anomalies that could be signatures of physics beyond the standard model. The analysis is based on the comparison of observed data with the standard model prediction, as determined from simulation, in several hundred final states and multiple kinematic distributions. Events containing at least one electron or muon are classified based on their final state topology, and an automated search algorithm surveys the observed data for deviations from the prediction. The sensitivity of the search is validated using multiple methods. No significant deviations from the predictions have been observed. For a wide range of final state topologies, agreement is found between the data and the standard model simulation. This analysis complements dedicated search analyses by significantly expanding the range of final states covered using a model independent approach with the largest data set to date to probe phase space regions beyond the reach of previous general searches.Peer reviewe

Measurement of prompt open-charm production cross sections in proton-proton collisions at root s=13 TeV

The production cross sections for prompt open-charm mesons in proton-proton collisions at a center-of-mass energy of 13TeV are reported. The measurement is performed using a data sample collected by the CMS experiment corresponding to an integrated luminosity of 29 nb(-1). The differential production cross sections of the D*(+/-), D-+/-, and D-0 ((D) over bar (0)) mesons are presented in ranges of transverse momentum and pseudorapidity 4 < p(T) < 100 GeV and vertical bar eta vertical bar < 2.1, respectively. The results are compared to several theoretical calculations and to previous measurements.Peer reviewe