Transmitting Revolution: Radio, Rumor, and the 1953 East German Uprising

This project examines public opinion in the Dresden Region of the German Democratic Republic from the end of World War II through the summer of 1953. I argue that the Socialist Unity Party (SED) projected its legitimacy through an official public sphere by representing publicness to its citizenry. Through banners, the press, and choreographed public demonstrations, it aimed to create the appearance of popular support. Even more significantly, the SED used radio to ground its legitimacy in a burgeoning post-war internationalism that bound residents of the GDR in an imagined community of socialist nations under Stalin’s leadership. At the same time, the regime’s opponents challenged its legitimacy and credibility through a rival public sphere. In this space, foreign broadcasters, especially Radio in the American Sector (RIAS), chipped away at the regime’s credibility and prestige while improvised news and rumor undermined the Party’s state building efforts. Tensions boiled over in the summer of 1953 when RIAS and rumor helped make revolution thinkable. On the seventeenth of June, East Germans took to the streets in hundreds of cities and protested the government. RIAS endowed the occasion with national imaginings before and after East German police and Soviet forces ended the protestors’ hopes for change

Transmitting a revolution : mass communications and the 1956 Hungarian uprising

The 1956 Hungarian Revolution was a remarkable event in a tumultuous year. Utilizing American archival sources, this paper explores the role of mass communications before and during the uprising. The theories developed in historian Benedict Anderson’s Imagined Communities: Reflections on the Origin and Spread of Nationalism (1983) are drawn upon to create an interpretive framework that furthers understanding of the reasons behind, and nature of, the revolution. The paper analyzes two types of mass communications: print media and radio broadcasting. Both means of communicating fostered the establishment of independenceminded communities in local, national, and international realms. The intellectual leadership of the revolution recovered the spirit of Hungary’s war for independence in 1848-49, which they then disseminated through mass-print media. Foreign broadcasting stations operating in Hungary created the perception of a powerful ally in the minds of listeners. These listeners then promoted this knowledge through interpersonal communication, constructing communities bound by the possibility of Western-assisted independence. On 23 October, print media and radio dictated collective action, which constructed a framework for the ignition of an armed uprising in Budapest. Radio transmissions inspired Hungarians throughout the nation to join what became a war for independence

Development and Validation of a Risk Score for Chronic Kidney Disease in HIV Infection Using Prospective Cohort Data from the D:A:D Study

Ristola M. on työryhmien DAD Study Grp ; Royal Free Hosp Clin Cohort ; INSIGHT Study Grp ; SMART Study Grp ; ESPRIT Study Grp jäsen.Background Chronic kidney disease (CKD) is a major health issue for HIV-positive individuals, associated with increased morbidity and mortality. Development and implementation of a risk score model for CKD would allow comparison of the risks and benefits of adding potentially nephrotoxic antiretrovirals to a treatment regimen and would identify those at greatest risk of CKD. The aims of this study were to develop a simple, externally validated, and widely applicable long-term risk score model for CKD in HIV-positive individuals that can guide decision making in clinical practice. Methods and Findings A total of 17,954 HIV-positive individuals from the Data Collection on Adverse Events of Anti-HIV Drugs (D:A:D) study with >= 3 estimated glomerular filtration rate (eGFR) values after 1 January 2004 were included. Baseline was defined as the first eGFR > 60 ml/min/1.73 m2 after 1 January 2004; individuals with exposure to tenofovir, atazanavir, atazanavir/ritonavir, lopinavir/ritonavir, other boosted protease inhibitors before baseline were excluded. CKD was defined as confirmed (>3 mo apart) eGFR In the D:A:D study, 641 individuals developed CKD during 103,185 person-years of follow-up (PYFU; incidence 6.2/1,000 PYFU, 95% CI 5.7-6.7; median follow-up 6.1 y, range 0.3-9.1 y). Older age, intravenous drug use, hepatitis C coinfection, lower baseline eGFR, female gender, lower CD4 count nadir, hypertension, diabetes, and cardiovascular disease (CVD) predicted CKD. The adjusted incidence rate ratios of these nine categorical variables were scaled and summed to create the risk score. The median risk score at baseline was -2 (interquartile range -4 to 2). There was a 1: 393 chance of developing CKD in the next 5 y in the low risk group (risk score = 5, 505 events), respectively. Number needed to harm (NNTH) at 5 y when starting unboosted atazanavir or lopinavir/ritonavir among those with a low risk score was 1,702 (95% CI 1,166-3,367); NNTH was 202 (95% CI 159-278) and 21 (95% CI 19-23), respectively, for those with a medium and high risk score. NNTH was 739 (95% CI 506-1462), 88 (95% CI 69-121), and 9 (95% CI 8-10) for those with a low, medium, and high risk score, respectively, starting tenofovir, atazanavir/ritonavir, or another boosted protease inhibitor. The Royal Free Hospital Clinic Cohort included 2,548 individuals, of whom 94 individuals developed CKD (3.7%) during 18,376 PYFU (median follow-up 7.4 y, range 0.3-12.7 y). Of 2,013 individuals included from the SMART/ESPRIT control arms, 32 individuals developed CKD (1.6%) during 8,452 PYFU (median follow-up 4.1 y, range 0.6-8.1 y). External validation showed that the risk score predicted well in these cohorts. Limitations of this study included limited data on race and no information on proteinuria. Conclusions Both traditional and HIV-related risk factors were predictive of CKD. These factors were used to develop a risk score for CKD in HIV infection, externally validated, that has direct clinical relevance for patients and clinicians to weigh the benefits of certain antiretrovirals against the risk of CKD and to identify those at greatest risk of CKD.Peer reviewe