Implementation of the project for the introduction of universal primary education in the Russian province during the early twentieth century

The authors of the article suggest to consider the implementation of the project for the introduction of universal primary education in Russian Empire during the early twentieth century, using the example of Kursk provinc

Deep learning(s) in gaming disorder through the user-avatar bond: a longitudinal study using machine learning

Background and aims: Gaming disorder [GD] risk has been associated with the way gamers bond with their visual representation (i.e., avatar) in the game-world. More specifically, a gamer's relationship with their avatar has been shown to provide reliable mental health information about the user in their offline life, such as their current and prospective GD risk, if appropriately decoded. Methods: To contribute to the paucity of knowledge in this area, 565 gamers (Mage = 29.3 years; SD =10.6) were assessed twice, six months apart, using the User-Avatar-Bond Scale (UABS) and the Gaming Disorder Test. A series of tuned and untuned artificial intelligence [AI] classifiers analysed concurrently and prospectively their responses. Results: Findings showed that AI models learned to accurately and automatically identify GD risk cases, based on gamers' reported UABS score, age, and length of gaming involvement, both concurrently and longitudinally (i.e., six months later). Random forests outperformed all other AIs, while avatar immersion was shown to be the strongest training predictor. Conclusion: Study outcomes demonstrated that the user-avatar bond can be translated into accurate, concurrent and future GD risk predictions using trained AI classifiers. Assessment, prevention, and practice implications are discussed in the light of these findings

Эффективность и безопасность эрибулина при различных подтипах рака молочной железы: данные из реальной клинической практики в России

The article presents a pooled experience of the use of eribulin in the real clinical practice of treatment of metastatic breast cancer in Russian oncological institutions. The effectiveness of the drug in monotherapy with HER2‑negative breast cancer was analyzed, groups of patients with most effective use of eribulin were identified depending on the localization of metastases, the most effective lines of therapy. The effectiveness of the drug in combination with trastuzumab in HER2‑positive breast cancer is described, as well as toxic reactions. В статье представлен обобщенный опыт применения эрибулина в реальной клинической практике онкологических учреждений РФ при метастатическом раке молочной железы. Проанализирована эффективность препарата в монотерапии при HER2-отрицательном раке молочных желез, выделены группы больных в зависимости от локализации метастазов, линии терапии, в которых препарат оказался максимально эффективным. Описана эффективность препарата в комбинации с трастузумабом при HER2-положительном раке молочной железы, а также токсические реакции. 

Genome-wide association study of germline variants and breast cancer-specific mortality

BACKGROUND: We examined the associations between germline variants and breast cancer mortality using a large meta-analysis of women of European ancestry. METHODS: Meta-analyses included summary estimates based on Cox models of twelve datasets using ~10

Implementation of the project for the introduction of universal primary education in the Russian province during the early twentieth century

The authors of the article suggest to consider the implementation of the project for the introduction of universal primary education in Russian Empire during the early twentieth century, using the example of Kursk provinc

CLINICAL-DIAGNOSTIC VALUE OF THE STUDY OF NEOPTERIN IN MYOCARDIAL INFARCTION ON THE BACKGROUND OF CHRONIC OBSTRUCTIVE PULMONARY DISEASE

Aim. To determine the significance of the study of neopterin as a marker of the endo-genetic toxicity syndrome in patients with myocardial infarction on the background of chronic obstructive pulmonary disease.Materials and methods. 64 patients with cardiovascular and respiratory pathology and 29 somatically healthy individuals of the Astrakhan region as the con-controlling group were examined. Patients were divided into 3 groups: the first 20 patients with myocardial infarction, the second group – 21 patients with chronic obstructive pulmonary disease and the third 23 patients with a combination of these diseases.Results. In patients with chronic obstructive pulmonary disease in combination with infarction of myocardium revealed the highest values of neopterin in blood serum in comparison with patients with monoiodotyrosine and somatically healthy individuals. Comparison of the values of neopterin with a number of recognized clinical and laboratory markers of endogenous intoxication revealed a positive correlation with heart rate, lactic acid, leukocyte index of intoxication and the ratio of neutrophils/leukocytes.Conclusion. In the course of the study, the clinical diagnostic value of the study of neopterin as a marker of endogenous intoxication in patients in Parkton myocardial on the background of chronic obstructive pulmonary disease has been proved

The evaluation of С-terminal telopeptide of type-i collagen level in patients with chronic heart failure along with atrial fibrillation and postinfarction cardiosclerosis

C-terminal telopeptide of type-I collagen level was studied in 112 chronic heart failure (CHF) patients and in 30 patients without heart failure. As a result, in CHF patients with atrial fibrillation compared to patients with sinus rhythm increase of C-terminal telopeptide of type-I collagen level was revealed. Increase of C-terminal telopeptide of type-I collagen level was also revealed in CHF patients with postinfarction cardiosclerosis compared to patients with no myocardial infarctions history; it reflects the association of maladaptive remodeling of the myocardium in postinfarction cardiosclerosis with intensification of extracellular matrix disorganization and disintegration of interstitial collagen processes

The effect of chronic obstructive pulmonary disease on the level of homocysteinemia and the condition of coronary vessels in patients with myocardial infarction

Objective: to study and compare the level of homocysteine with the results of coronary angiography in patients with myocardial infarction (MI) and concurrent chronic obstructive pulmonary disease (COPD).Subjects and methods. 246 patients with MI were examined. In 137 (55.7%) people, MI developed on the background of COPD, while in 109 (44.3%) patients MI was a single condition. Comparison groups consisted of 55 somatically healthy individuals and 50 patients with COPD. Enzyme immunoassay was used for testing homocysteine levels in plasma samples.Results. Stenoses of only one coronary artery (CA) with hyperhomocysteinemia were rare in patients in both groups (3.5% in patients with myocardial infarction and 3% in patients with myocardial infarction and concurrent COPD), multivessel diseases of CA statistically significantly prevailed. Lesions of 3 vessels or more were detected statistically significantly more often in patients with hyperhomocysteinemia with myocardial infarction and concurrent COPD. Among patients with myocardial infarction with hyperhomocysteinemia, patients with CA narrowing by 50-75% prevailed, and among patients with myocardial infarction with COPD and hyperhomocysteinemia, patients with CA narrowing by 75-99% and complete occlusion were statistically significantly more frequent. That is, in patients with myocardial infarction, concurrent COPD and hyperhomocysteinemia, more pronounced lesion of CA was observed, which was manifested by multivascular lesions, greater severity of occlusion and higher frequency of complete stenosis of CA