516 research outputs found
Sensitivity Studies for Third-Generation Gravitational Wave Observatories
Advanced gravitational wave detectors, currently under construction, are
expected to directly observe gravitational wave signals of astrophysical
origin. The Einstein Telescope, a third-generation gravitational wave detector,
has been proposed in order to fully open up the emerging field of gravitational
wave astronomy. In this article we describe sensitivity models for the Einstein
Telescope and investigate potential limits imposed by fundamental noise
sources. A special focus is set on evaluating the frequency band below 10Hz
where a complex mixture of seismic, gravity gradient, suspension thermal and
radiation pressure noise dominates. We develop the most accurate sensitivity
model, referred to as ET-D, for a third-generation detector so far, including
the most relevant fundamental noise contributions.Comment: 13 pages, 7 picture
Scientific Potential of Einstein Telescope
Einstein gravitational-wave Telescope (ET) is a design study funded by the
European Commission to explore the technological challenges of and scientific
benefits from building a third generation gravitational wave detector. The
three-year study, which concluded earlier this year, has formulated the
conceptual design of an observatory that can support the implementation of new
technology for the next two to three decades. The goal of this talk is to
introduce the audience to the overall aims and objectives of the project and to
enumerate ET's potential to influence our understanding of fundamental physics,
astrophysics and cosmology.Comment: Conforms to conference proceedings, several author names correcte
Scientific Objectives of Einstein Telescope
The advanced interferometer network will herald a new era in observational
astronomy. There is a very strong science case to go beyond the advanced
detector network and build detectors that operate in a frequency range from 1
Hz-10 kHz, with sensitivity a factor ten better in amplitude. Such detectors
will be able to probe a range of topics in nuclear physics, astronomy,
cosmology and fundamental physics, providing insights into many unsolved
problems in these areas.Comment: 18 pages, 4 figures, Plenary talk given at Amaldi Meeting, July 201
First narrow-band search for continuous gravitational waves from known pulsars in advanced detector data
Spinning neutron stars asymmetric with respect to their rotation axis are potential sources of
continuous gravitational waves for ground-based interferometric detectors. In the case of known pulsars a
fully coherent search, based on matched filtering, which uses the position and rotational parameters
obtained from electromagnetic observations, can be carried out. Matched filtering maximizes the signalto-
noise (SNR) ratio, but a large sensitivity loss is expected in case of even a very small mismatch
between the assumed and the true signal parameters. For this reason, narrow-band analysis methods have
been developed, allowing a fully coherent search for gravitational waves from known pulsars over a
fraction of a hertz and several spin-down values. In this paper we describe a narrow-band search of
11 pulsars using data from Advanced LIGOâs first observing run. Although we have found several initial
outliers, further studies show no significant evidence for the presence of a gravitational wave signal.
Finally, we have placed upper limits on the signal strain amplitude lower than the spin-down limit for 5 of
the 11 targets over the bands searched; in the case of J1813-1749 the spin-down limit has been beaten for
the first time. For an additional 3 targets, the median upper limit across the search bands is below the
spin-down limit. This is the most sensitive narrow-band search for continuous gravitational waves carried
out so far
Search for non-Gaussian events in the data of the VIRGO E4 engineering run
International audienc
Variation in dopamine D2 and serotonin 5-HT2A receptor genes is associated with working memory processing and response to treatment with antipsychotics
Dopamine D2 and serotonin 5-HT2A receptors contribute to modulate prefrontal cortical physiology and response to treatment with
antipsychotics in schizophrenia. Similarly, functional variation in the genes encoding these receptors is also associated with these
phenotypes. In particular, the DRD2 rs1076560 T allele predicts a lower ratio of expression of D2 short/long isoforms, suboptimal
working memory processing, and better response to antipsychotic treatment compared with the G allele. Furthermore, the HTR2A T
allele is associated with lower 5-HT2A expression, impaired working memory processing, and poorer response to antipsychotics
compared with the C allele. Here, we investigated in healthy subjects whether these functional polymorphisms have a combined effect
on prefrontal cortical physiology and related cognitive behavior linked to schizophrenia as well as on response to treatment with secondgeneration
antipsychotics in patients with schizophrenia. In a total sample of 620 healthy subjects, we found that subjects with the
rs1076560 T and rs6314 T alleles have greater fMRI prefrontal activity during working memory. Similar results were obtained within the
attentional domain. Also, the concomitant presence of the rs1076560 T/rs6314 T alleles also predicted lower behavioral accuracy during
working memory. Moreover, we found that rs1076560 T carrier/rs6314 CC individuals had better responses to antipsychotic treatment
in two independent samples of patients with schizophrenia (nŒ63 and nŒ54, respectively), consistent with the previously reported
separate effects of these genotypes. These results indicate that DRD2 and HTR2A genetic variants together modulate physiological
prefrontal efficiency during working memory and also modulate the response to antipsychotics. Therefore, these results suggest that
further exploration is needed to better understand the clinical consequences of these genotypeâphenotype relationships
Association of kidney disease measures with risk of renal function worsening in patients with type 1 diabetes
Background: Albuminuria has been classically considered a marker of kidney damage progression in diabetic patients and it is routinely assessed to monitor kidney function. However, the role of a mild GFR reduction on the development of stage 653 CKD has been less explored in type 1 diabetes mellitus (T1DM) patients. Aim of the present study was to evaluate the prognostic role of kidney disease measures, namely albuminuria and reduced GFR, on the development of stage 653 CKD in a large cohort of patients affected by T1DM. Methods: A total of 4284 patients affected by T1DM followed-up at 76 diabetes centers participating to the Italian Association of Clinical Diabetologists (Associazione Medici Diabetologi, AMD) initiative constitutes the study population. Urinary albumin excretion (ACR) and estimated GFR (eGFR) were retrieved and analyzed. The incidence of stage 653 CKD (eGFR < 60 mL/min/1.73 m2) or eGFR reduction > 30% from baseline was evaluated. Results: The mean estimated GFR was 98 \ub1 17 mL/min/1.73m2 and the proportion of patients with albuminuria was 15.3% (n = 654) at baseline. About 8% (n = 337) of patients developed one of the two renal endpoints during the 4-year follow-up period. Age, albuminuria (micro or macro) and baseline eGFR < 90 ml/min/m2 were independent risk factors for stage 653 CKD and renal function worsening. When compared to patients with eGFR > 90 ml/min/1.73m2 and normoalbuminuria, those with albuminuria at baseline had a 1.69 greater risk of reaching stage 3 CKD, while patients with mild eGFR reduction (i.e. eGFR between 90 and 60 mL/min/1.73 m2) show a 3.81 greater risk that rose to 8.24 for those patients with albuminuria and mild eGFR reduction at baseline. Conclusions: Albuminuria and eGFR reduction represent independent risk factors for incident stage 653 CKD in T1DM patients. The simultaneous occurrence of reduced eGFR and albuminuria have a synergistic effect on renal function worsening
A Standard Siren Measurement of the Hubble Constant from GW170817 without the Electromagnetic Counterpart
We perform a statistical standard siren analysis of GW170817. Our analysis does not utilize knowledge of NGC 4993 as the unique host galaxy of the optical counterpart to GW170817. Instead, we consider each galaxy within the GW170817 localization region as a potential host; combining the redshifts from all of the galaxies with the distance estimate from GW170817 provides an estimate of the Hubble constant, H 0. Considering all galaxies brighter than as equally likely to host a binary neutron star merger, we find km sâ1 Mpcâ1 (maximum a posteriori and 68.3% highest density posterior interval; assuming a flat H 0 prior in the range km sâ1 Mpcâ1). We explore the dependence of our results on the thresholds by which galaxies are included in our sample, and we show that weighting the host galaxies by stellar mass or star formation rate provides entirely consistent results with potentially tighter constraints. By applying the method to simulated gravitational-wave events and a realistic galaxy catalog we show that, because of the small localization volume, this statistical standard siren analysis of GW170817 provides an unusually informative (top 10%) constraint. Under optimistic assumptions for galaxy completeness and redshift uncertainty, we find that dark binary neutron star measurements of H 0 will converge as , where N is the number of sources. While these statistical estimates are inferior to the value from the counterpart standard siren measurement utilizing NGC 4993 as the unique host, km sâ1 Mpcâ1 (determined from the same publicly available data), our analysis is a proof-of-principle demonstration of the statistical approach first proposed by Bernard Schutz over 30 yr ago
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