CIBERER : Spanish national network for research on rare diseases: A highly productive collaborative initiative

Altres ajuts: Instituto de Salud Carlos III (ISCIII); Ministerio de Ciencia e Innovación.CIBER (Center for Biomedical Network Research; Centro de Investigación Biomédica En Red) is a public national consortium created in 2006 under the umbrella of the Spanish National Institute of Health Carlos III (ISCIII). This innovative research structure comprises 11 different specific areas dedicated to the main public health priorities in the National Health System. CIBERER, the thematic area of CIBER focused on rare diseases (RDs) currently consists of 75 research groups belonging to universities, research centers, and hospitals of the entire country. CIBERER's mission is to be a center prioritizing and favoring collaboration and cooperation between biomedical and clinical research groups, with special emphasis on the aspects of genetic, molecular, biochemical, and cellular research of RDs. This research is the basis for providing new tools for the diagnosis and therapy of low-prevalence diseases, in line with the International Rare Diseases Research Consortium (IRDiRC) objectives, thus favoring translational research between the scientific environment of the laboratory and the clinical setting of health centers. In this article, we intend to review CIBERER's 15-year journey and summarize the main results obtained in terms of internationalization, scientific production, contributions toward the discovery of new therapies and novel genes associated to diseases, cooperation with patients' associations and many other topics related to RD research

Extraction of rare earth elements via electric field assisted mining applying deep eutectic solvents

This study was partly financed by the Coordenação de Aperfeiçoamento de Pessoal de Nível Superior - Brasil ( CAPES ) - Finance Code 001 Publisher Copyright: © 2022 Elsevier B.V.Rare earth elements play an important role in our society, as they are used in green energy technologies. However, they are considered critical raw materials. For this reason, there is a concern for obtaining alternative and complementary sources for conventional mining. In light of this view, electric field assisted mining arises as a technique to extract species from soils using green electrolytes to help in the extraction of metals. The aim of this paper was to evaluate the effect of different types of biodegradable electrolytes, including the use of deep eutectic solvents, in the electromining process. Six experiments were conducted applying an electric field of 1.0 V cm−1, and all electrolytes were used at a concentration of 0.1 mol L−1. The results showed that different electrolytes achieved different selectivities. The maximum efficiency using acetic acid resulted in 69.1% of Ce4+, citric acid removed 62.3% of La3+, and oxalic acid extracted 21.5% of La3+. The electromining efficiencies using deep eutectic solvents presented minor results. Therefore, considering the biodegradability and selectivity of the organic acids used, electromining showed to be a promising eco-friendly alternative for preferential extraction of metal species from soils.proofpublishe

Optimization of Electric Field Assisted Mining Process Applied to Rare Earths in Soils

The extraction of rare earths has been studied worldwide, however some of these processes have a high cost and can cause negative environmental impacts. In order to mine these species from the soil, Electric Field Assisted Mining arises as an alternative to conventional mining processes. Therefore, the experimental parameters can be improved to obtain better results in the extraction of these species. The aim of this paper is to propose the optimization of the Electric Field Assisted Mining process of yttrium, to obtain the optimal experimental configuration to be applied in real soils. An optimization problem was defined to obtain the maximum extraction mass of yttrium ion (Y3+), considering the limitation for the quantity of electric current density. A hybrid optimization technique was used, based on the sequential application of genetic algorithms and non-linear programming. Different optimal process configurations were obtained, considering distinct limits for the electric current density. The best experimental configuration resulted in 0.5386 V cm−1 electric field strength and 0.10 mol L−1 electrolyte concentration. This condition was reproduced in real soil, which obtained a Y3+ electromining efficiency of 41.48%. The results showed that this technique is promising for the extraction of rare earth in real soils

Os impactos da resolução n. 2.682 e dos programas de reestruturação do Sistema Financeiro Nacional no nível de provisionamento da carteira de crédito do setor bancário The impacts of resolution n. 2.682 and programs to restructure the National Financial System on the provision level of the banking sector's credit portfolio

Após a implantação do Plano Real, o Sistema Financeiro Nacional (SFN) passou a experimentar grandes e significativas transformações. A elevação da taxa de juros e o fim das receitas inflacionárias trouxeram o risco de falência para algumas instituições financeiras. Nesse contexto, o governo lançou uma série de medidas com o objetivo de sanear o SFN, destacando-se a Resolução n. 2.682 do Conselho Monetário Nacional (CMN), que visava aperfeiçoar a regulamentação de provisionamento das carteiras de crédito das instituições financeiras. O presente trabalho procura responder à seguinte questão: qual o impacto da Resolução n. 2.682 e dos Programas de Reestruturação do SFN no nível de Provisão para Créditos de Liquidação Duvidosa (PCLD) das instituições financeiras? Realizou-se pesquisa bibliográfica e documental, analisando-se o comportamento da carteira de crédito dos bancos integrantes do SFN. Após os programas saneadores implementados pelo governo e a regulamentação de provisionamento, editada pelo CMN através da Resolução n. 2.682, verificou-se uma mudança do patamar de provisionamento da carteira de crédito, que passou dos 2,2% verificados em dezembro de 1995 para os 6,8% registrados em dezembro de 2005.<br>After the implantation of the Plano Real, the Sistema Financeiro Nacional - SFN (National Financial System) started going through great and significant changes. The rising of interest rates and the end of the inflationary revenues brought along the risk of bankruptcy for some financial institutions. In this context, the government launched a series of measures in order to reorganize the national financial system, particularly Resolution No. 2.682 of the Conselho Monetario Nacional - CMN (National Monetary Council), aiming at improving regulations on financial institutions' provisioning of credit portfolios. This study intends to answer the following question: what is the impact of resolution No. 2.682 and the Restructuring Programs of the National Financial System on the financial institutions' level of Provisão para Creditos de Liquidação Duvidosa - PCLD (Doubtful Liquidation Credit Provision)? A documental and bibliographical research was carried out, as well as a behavioral analysis of the credit portfolio of the National Financial System. The study reveals that, after the reorganization programs implanted by the government and the provisioning regulation edited by the CMN, there was a change in the provisioning status of credit portfolios, which rose from 2.2% in December 1995 to 8.8% registered in December 2005

Välttelevän kiintymyssuhteen merkitys lapsen hyvinvoinnille

Tarkoituksena tässä opinnäytetyössä on koota tutkimustietoa välttelevästä kiintymyssuhteesta ja sen merkityksestä lapsen hyvinvoinnille. Tavoitteena oli kehittää ammatillista osaamista teoriapohjan osalta ja käsitellä tutkittavaa aihetta psykiatrisen hoitotyön näkökulmasta, mikä on suuntautumiseni. Tutkimuskysymys on jaettu kahteen osaan: vanhempien ja lapsen välinen kiintymyssuhde ja lapsen kehitys ja hyvinvointi. Näiden osien ulottuvilta on haettu tutkimusartikkeleita, tutkimusraportteja ja asiantuntijakirjoituksia, joista on koottu tiivistelmiä kirjallisuuskatsauksen tapaan. Pohdinnassa on eritelty aineistoa tarkemmin tutkimuskysymyksen osalta. Kiintymyssuhde kehittyy lapsella varhaisen vuorovaikutuksen kautta 0–2-vuotiaana. Jos vanhemmat laiminlyövät kommunikoinnin lapsen kanssa, emotionaalinen kehitys jää vajaaksi eikä lapsi opi ilmaisemaan omia tarpeitaan ja tunteitaan. Välttelevän kiintymyssuhteen seuraukset voivat olla laajat epäsosiaalisuudesta kognitiivisiin häiriöihin. Epäsosiaalisuuteen kytkeytyviin häiriöihin kuuluu puhumattomuus, eristäytyminen ja laajemmin kroonistunut masennus, mihin taas liittyy vahva itsetuhoisuuden riski

Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder

Peer reviewe

Exploratory study of ultraviolet B (UVB) radiation and age of onset of bipolar disorder

International audienceBackground: Sunlight contains ultraviolet B (UVB) radiation that triggers the production of vitamin D by skin. Vitamin D has widespread effects on brain function in both developing and adult brains. However, many people live at latitudes (about > 40 N or S) that do not receive enough UVB in winter to produce vitamin D. This exploratory study investigated the association between the age of onset of bipolar I disorder and the threshold for UVB sufficient for vitamin D production in a large global sample.Methods: Data for 6972 patients with bipolar I disorder were obtained at 75 collection sites in 41 countries in both hemispheres. The best model to assess the relation between the threshold for UVB sufficient for vitamin D production and age of onset included 1 or more months below the threshold, family history of mood disorders, and birth cohort. All coefficients estimated at P ≤ 0.001.Results: The 6972 patients had an onset in 582 locations in 70 countries, with a mean age of onset of 25.6 years. Of the onset locations, 34.0% had at least 1 month below the threshold for UVB sufficient for vitamin D production. The age of onset at locations with 1 or more months of less than or equal to the threshold for UVB was 1.66 years younger.Conclusion: UVB and vitamin D may have an important influence on the development of bipolar disorder. Study limitations included a lack of data on patient vitamin D levels, lifestyles, or supplement use. More study of the impacts of UVB and vitamin D in bipolar disorder is needed to evaluate this supposition