225 research outputs found
The influence of urban wastes on the interstitial water chemistry in coastal marine sediments of Cadiz Bay
The authors determined, with visual profiles, the concentration of nutrients (i.e. ammonia, nitrate, phosphate and silica), inorganic carbon and sulphate in the interstitial water of Cadiz Bay, as well as organic carbon in sediment, using samples from three stations on Sancti Petri sound. These three stations suffer from different contamination levels due to untreated urban wastewater. Our results show a degradation of the organic matter, principally in the first 30 cm of sediment. These concentration changes are important in the superficial water layer, indicating the efficiency of aerobic oxidation, the organic matter's principal mineralisation mechanism. Two stations, those nearest to the waste point, had the highest organic carbon concentrations in their sediment, as well as the highest vertical gradients of nutrient concentrations in their interstitial water. Sulphate reduction is the principal mechanism involved in the oxidation of organic matter. On the other hand, at the other station studied, with lower organic carbon levels, the gradients were smoother.Se han caracterizado los perfiles verticales en el agua intersticial de las concentraciones de nutrientes (amonio, nitrato, fosfato y silicato), carbono inorgánico y sulfato, así como de carbono orgánico en el sedimento en tres estaciones del caño de Sancti Petri, sujetas a distinto grado de contaminación por vertidos urbanos sin depurar. Analizando globalmente las variaciones con la profundidad de las concentraciones de las distintas especies estudiadas, se puede afirmar que existe una degradación continuada de la materia orgánica, al menos, en los primeros 30 cm del sedimento. Esta hipótesis se encuentra reforzada por la propia disminución de la concentración de carbono orgánico en el sedimento con la profundidad. Estos cambios de concentración son especialmente acusados en la lámina de agua más superficial, poniendo de manifiesto la eficiencia de la oxidación aeróbica como mecanismo de mineralización de la materia orgánica. Las dos estaciones más próximas al vertido, que poseen concentraciones de carbono orgánico más elevadas en el sedimento, presentan también mayores gradientes verticales de concentración de nutrientes en el agua intersticial, y la sulfatorreducción adquiere una mayor importancia relativa como vía de oxidación de la materia orgánica. Por el contrario, en la estación situada en el extremo sur del caño, menos afectada por los aportes de materia orgánica, se observan gradientes más suaves.Instituto Español de Oceanografí
Factor analysis of linear alkylbenzene sulphonate (LAS) vertical distribution in coastal sediments of Cadiz Bay (southwest Spain)
El comportamiento del alquilbenceno lineal sulfonato (LAS) en los sistemas costeros no se conoce con precisión, y este conocimiento es aun menor si nos restringimos al compartimento sedimentario. En este trabajo se aplica un análisis factorial a los resultados obtenidos para distintas variables determinadas en tres estaciones, tanto en sedimento como en agua intersticial, con el objetivo de evaluar sus interrelaciones con el LAS. Las variables analizadas presentan dos modos principales de distribución con la profundidad en el compartimento sedimentario: lineal y/o exponencial. En casi todos los casos, el LAS se asocia a ambos modos de distribución, lo que indica que su concentración sufre una disminución con la profundidad, pero se produce de forma especialmente acusada en la capa superficial.Very little is known concerning the behaviour of linear alkylbenzene sulphonate (LAS) in coastal systems, and even less when we consider the sedimentary field only. In the present study, a factor analysis is applied to the results obtained for different variables at three stations, both in the sediment and in interstitial water, with the aim of evaluating their relationship with LAS. The variables analysed have two main types of distribution in the sedimentary area in relation to depth: linear and/or exponential. LAS is, in most cases, associated with both types of distribution, indicating that its concentration decreases with depth, especially in the surface layer.Instituto Español de Oceanografí
El uso del Pizarrón Digital Interactivo como recurso tecnológico innovador para las y los jóvenes mexicanos en formación
Los jóvenes hoy en día utilizan la tecnología como una forma de vida, ya que dependen de ella para relacionarse con su medio, en la escuela, casa o en su círculo social, al ser nativos digitales le dan importancia a acciones relacionadas con herramientas tecnológicas: celulares, tabletas, lap top y cualquier tipo de aparato, es decir, el hecho de que las y los jóvenes tengan una relación de apego con el internet, produce que como sociedad se modifiquen costumbres, hábitos y actitudes. Sin embargo el aspecto más relevante a modificar es la educación, las nuevas generaciones requieren el implemento de la tecnología en su vida cotidiana por lo que se hace hincapié en esta investigación el uso del PDI en educación superior. Cambios vertiginosos influyen en nuestras condiciones de vida, la tecnología ha cambiado la vida en el ámbito y social. Los cambios han sido graduales en la educación. Es indudable que han quedado atrás las prácticas de enseñanza tradicional en donde se considere al alumno como mero receptor de información donde las clases son tediosas. Ante esta situación, se considera que se debe incluir y adoptar estrategias didácticas y recursos que se adapten a la actualidad contextual, debido a que las Tecnologías de la información y la comunicación (TIC) son útiles en el proceso de aprendizaje enseñanza. El objetivo de esta investigación es comparar la eficiencia de los conocimientos que alcanzan los estudiantes al realizar actividades de enseñanza aprendizaje incorporando las tecnologías de la información, específicamente el PDI y actividades de TIC. Esta investigación se aborda bajo el enfoque cuantitativo, se encontró que aunque los profesores reciban capacitación sobre el PDI, también requieren tener voluntad de cambio en su práctica docente, invirtiendo tiempo y dedicación para modificar métodos y estrategias adecuándolas con el PDI.Young people today use technology as a way of life, because they depend on it to interact with their environment, at school, home or in your social circle, being digital natives attach importance to actions related to technological tools: phones, tablets, lap top and any device, ie, the fact that the young people have an attachment relationship with the internet, as a society produces customs, habits and attitudes are changed. However the most important aspect is to change education, new generations require the attachment of technology in your life cotidiana so it is stress upon this research the use of PDI in higher education. Rapid changes affecting our living conditions, technology has changed life in the field and social. The changes have been gradual in education. There is no doubt left behind traditional teaching practices where the student is considered as a mere recipient of information where classes are tedious. In this situation, it is considered to be included and adopt teaching strategies and resources to adapt to the present context, because the information and communications technology (ICT ) are useful in the teaching learning process. The objective of this research is to compare the efficiency of knowledge acquired by students to engage in teaching and learning incorporating information technology, specifically the PDI and ICT activities. This research is dealt with under the quantitative approach, we found that although teachers are trained on the PDI also required to have desire for change in their teaching, investing time and effort to change methods and adapting them to the PDI strategies
Antitumor activity of lurbinectedin in second-line small cell lung cancer patients who are candidates for re-challenge with the first-line treatment
Introduction: The National Comprehensive Cancer Network guidelines recommend re-challenge with the first-line treatment for relapsed small cell lung cancer (SCLC) with chemotherapy-free interval (CTFI)=180 days. A phase II study (NCT02454972) showed remarkable antitumor activity in SCLC patients treated with lurbinectedin 3.2 mg/m2 1 -h intravenous infusion every 3 weeks as second-line therapy. We report results for the pre-planned subset of patients with CTFI = 180 days.
Material and Methods: Twenty patients aged =18 years with pathologically proven SCLC diagnosis, pretreated with only one prior platinum-containing line, no CNS metastases, and with CTFI = 180 days were evaluated. The primary efficacy endpoint was the overall response rate (ORR) assessed by the Investigators according to RECIST v1.1.
Results: ORR was 60.0 % (95 %CI, 36.1-86.9), with a median duration of response of 5.5 months (95 %CI, 2.9-11.2) and disease control rate of 95.0 % (95 %CI, 75.1-99.9). Median progression-free survival was 4.6 months (95 %CI, 2.6-7.3). With a censoring of 55.0 %, the median overall survival was 16.2 months (95 %CI, 9.6-upper level not reached). Of note, 60.9 % and 27.1 % of patients were alive at 1 and 2 years, respectively. The most common grade 3/4 adverse events and laboratory abnormalities were hematological disorders (neutropenia, 55.0 %; anemia; 10.0 % thrombocytopenia, 10.0 %), fatigue (10.0 %) and increased liver function tests (GGT, 10 %; ALT and AP, 5.0 % each). No febrile neutropenia was reported.
Conclusion: Lurbinectedin is an effective treatment for platinum-sensitive relapsed SCLC, especially in patients with CTFI = 180 days, with acceptable safety and tolerability. These encouraging results suggest that lurbinectedin can be another valuable therapeutic option rather than platinum re-challenge
The exposure of the hybrid detector of the Pierre Auger Observatory
The Pierre Auger Observatory is a detector for ultra-high energy cosmic rays.
It consists of a surface array to measure secondary particles at ground level
and a fluorescence detector to measure the development of air showers in the
atmosphere above the array. The "hybrid" detection mode combines the
information from the two subsystems. We describe the determination of the
hybrid exposure for events observed by the fluorescence telescopes in
coincidence with at least one water-Cherenkov detector of the surface array. A
detailed knowledge of the time dependence of the detection operations is
crucial for an accurate evaluation of the exposure. We discuss the relevance of
monitoring data collected during operations, such as the status of the
fluorescence detector, background light and atmospheric conditions, that are
used in both simulation and reconstruction.Comment: Paper accepted by Astroparticle Physic
Update on the correlation of the highest energy cosmic rays with nearby extragalactic matter
Data collected by the Pierre Auger Observatory through 31 August 2007 showed
evidence for anisotropy in the arrival directions of cosmic rays above the
Greisen-Zatsepin-Kuz'min energy threshold, \nobreak{eV}. The
anisotropy was measured by the fraction of arrival directions that are less
than from the position of an active galactic nucleus within 75 Mpc
(using the V\'eron-Cetty and V\'eron catalog). An updated
measurement of this fraction is reported here using the arrival directions of
cosmic rays recorded above the same energy threshold through 31 December 2009.
The number of arrival directions has increased from 27 to 69, allowing a more
precise measurement. The correlating fraction is , compared
with expected for isotropic cosmic rays. This is down from the early
estimate of . The enlarged set of arrival directions is
examined also in relation to other populations of nearby extragalactic objects:
galaxies in the 2 Microns All Sky Survey and active galactic nuclei detected in
hard X-rays by the Swift Burst Alert Telescope. A celestial region around the
position of the radiogalaxy Cen A has the largest excess of arrival directions
relative to isotropic expectations. The 2-point autocorrelation function is
shown for the enlarged set of arrival directions and compared to the isotropic
expectation.Comment: Accepted for publication in Astroparticle Physics on 31 August 201
Atmospheric effects on extensive air showers observed with the Surface Detector of the Pierre Auger Observatory
Atmospheric parameters, such as pressure (P), temperature (T) and density,
affect the development of extensive air showers initiated by energetic cosmic
rays. We have studied the impact of atmospheric variations on extensive air
showers by means of the surface detector of the Pierre Auger Observatory. The
rate of events shows a ~10% seasonal modulation and ~2% diurnal one. We find
that the observed behaviour is explained by a model including the effects
associated with the variations of pressure and density. The former affects the
longitudinal development of air showers while the latter influences the Moliere
radius and hence the lateral distribution of the shower particles. The model is
validated with full simulations of extensive air showers using atmospheric
profiles measured at the site of the Pierre Auger Observatory.Comment: 24 pages, 9 figures, accepted for publication in Astroparticle
Physic
The Fluorescence Detector of the Pierre Auger Observatory
The Pierre Auger Observatory is a hybrid detector for ultra-high energy
cosmic rays. It combines a surface array to measure secondary particles at
ground level together with a fluorescence detector to measure the development
of air showers in the atmosphere above the array. The fluorescence detector
comprises 24 large telescopes specialized for measuring the nitrogen
fluorescence caused by charged particles of cosmic ray air showers. In this
paper we describe the components of the fluorescence detector including its
optical system, the design of the camera, the electronics, and the systems for
relative and absolute calibration. We also discuss the operation and the
monitoring of the detector. Finally, we evaluate the detector performance and
precision of shower reconstructions.Comment: 53 pages. Submitted to Nuclear Instruments and Methods in Physics
Research Section
Advanced functionality for radio analysis in the Offline software framework of the Pierre Auger Observatory
The advent of the Auger Engineering Radio Array (AERA) necessitates the
development of a powerful framework for the analysis of radio measurements of
cosmic ray air showers. As AERA performs "radio-hybrid" measurements of air
shower radio emission in coincidence with the surface particle detectors and
fluorescence telescopes of the Pierre Auger Observatory, the radio analysis
functionality had to be incorporated in the existing hybrid analysis solutions
for fluoresence and surface detector data. This goal has been achieved in a
natural way by extending the existing Auger Offline software framework with
radio functionality. In this article, we lay out the design, highlights and
features of the radio extension implemented in the Auger Offline framework. Its
functionality has achieved a high degree of sophistication and offers advanced
features such as vectorial reconstruction of the electric field, advanced
signal processing algorithms, a transparent and efficient handling of FFTs, a
very detailed simulation of detector effects, and the read-in of multiple data
formats including data from various radio simulation codes. The source code of
this radio functionality can be made available to interested parties on
request.Comment: accepted for publication in NIM A, 13 pages, minor corrections to
author list and references in v
Search for First Harmonic Modulation in the Right Ascension Distribution of Cosmic Rays Detected at the Pierre Auger Observatory
We present the results of searches for dipolar-type anisotropies in different
energy ranges above eV with the surface detector array of
the Pierre Auger Observatory, reporting on both the phase and the amplitude
measurements of the first harmonic modulation in the right-ascension
distribution. Upper limits on the amplitudes are obtained, which provide the
most stringent bounds at present, being below 2% at 99% for EeV
energies. We also compare our results to those of previous experiments as well
as with some theoretical expectations.Comment: 28 pages, 11 figure
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