Southern African summer-rainfall variability, and its teleconnections, on interannual to interdecadal timescales in CMIP5 models

23 pagesInternational audienceThis study provides the first assessment of CMIP5 model performances in simulating southern Africa (SA) rainfall variability in austral summer (Nov–Feb), and its teleconnections with large-scale climate variability at different timescales. Observed SA rainfall varies at three major timescales: interannual (2–8 years), quasi-decadal (8–13 years; QDV) and interdecadal (15–28 years; IDV). These rainfall fluctuations are, respectively, associated with El Niño Southern Oscillation (ENSO), the Interdecadal Pacific Oscillation (IPO) and the Pacific Decadal Oscillation (PDO), interacting with climate anomalies in the South Atlantic and South Indian Ocean. CMIP5 models produce their own variability, but perform better in simulating interannual rainfall variability, while QDV and IDV are largely underestimated. These limitations can be partly explained by spatial shifts in core regions of SA rainfall variability in the models. Most models reproduce the impact of La Niña on rainfall at the interannual scale in SA, in spite of limitations in the representation of ENSO. Realistic links between negative IPO are found in some models at the QDV scale, but very poor performances are found at the IDV scale. Strong limitations, i.e. loss or reversal of these teleconnections, are also noted in some simulations. Such model errors, however, do not systematically impact the skill of simulated rainfall variability. This is because biased SST variability in the South Atlantic and South Indian Oceans strongly impact model skills by modulating the impact of Pacific modes of variability. Using probabilistic multi-scale clustering, model uncertainties in SST variability are primarily driven by differences from one model to another, or comparable models (sharing similar physics), at the global scale. At the regional scale, i.e. SA rainfall variability and associated teleconnections, while differences in model physics remain a large source of uncertainty, the contribution of internal climate variability is increasing. This is particularly true at the QDV and IDV scales, where the individual simulations from the same model tend to differentiate, and the sampling error increase

IMMACCS: A Multi-Agent Decision-Support System

This report describes work performed by the Collaborative Agent Design Research Center for the US Marine Corps Warfighting Laboratory (MCWL), on the IMMACCS experimental decision-support system. IMMACCS (Integrated Marine Multi-Agent Command and Control System) incorporates three fundamental concepts that distinguish it from existing (i.e., legacy) command and control applications. First, it is a collaborative system in which computer-based agents assist human operators by monitoring, analyzing, and reasoning about events in near real-time. Second, IMMACCS includes an ontological model of the battlespace that represents the behavioral characteristics and relationships among real world entities such as friendly and enemy assets, infrastructure objects (e.g., buildings, roads, and rivers), and abstract notions. This object model provides the essential common language that binds all IMMACCS components into an integrated and adaptive decision-support system. Third, IMMACCS provides no ready made solutions that may not be applicable to the problems that will occur in the real world. Instead, the agents represent a powerful set of tools that together with the human operators can adjust themselves to the problem situations that cannot be predicted in advance. In this respect, IMMACCS is an adaptive command and control system that supports planning, execution and training functions concurrently. The report describes the nature and functional requirements of military command and control, the architectural features of IMMACCS that are designed to support these operational requirements, the capabilities of the tools (i.e., agents) that IMMACCS offers its users, and the manner in which these tools can be applied. Finally, the performance of IMMACCS during the Urban Warrior Advanced Warfighting Experiment held in California in March, 1999, is discussed from an operational viewpoint

Water Permeability of Asymmetric Planar Lipid Bilayers: Leaflets of Different Composition Offer Independent and Additive Resistances to Permeation

To understand how plasma membranes may limit water flux, we have modeled the apical membrane of MDCK type 1 cells. Previous experiments demonstrated that liposomes designed to mimic the inner and outer leaflet of this membrane exhibited 18-fold lower water permeation for outer leaflet lipids than inner leaflet lipids (Hill, W.G., and M.L. Zeidel. 2000. J. Biol. Chem. 275:30176–30185), confirming that the outer leaflet is the primary barrier to permeation. If leaflets in a bilayer resist permeation independently, the following equation estimates single leaflet permeabilities: 1/PAB = 1/PA + 1/PB (Eq. l), where PAB is the permeability of a bilayer composed of leaflets A and B, PA is the permeability of leaflet A, and PB is the permeability of leaflet B. Using for the MDCK leaflet–specific liposomes gives an estimated value for the osmotic water permeability (Pf) of 4.6 × 10−4 cm/s (at 25°C) that correlated well with experimentally measured values in intact cells. We have now constructed both symmetric and asymmetric planar lipid bilayers that model the MDCK apical membrane. Water permeability across these bilayers was monitored in the immediate membrane vicinity using a Na+-sensitive scanning microelectrode and an osmotic gradient induced by addition of urea. The near-membrane concentration distribution of solute was used to calculate the velocity of water flow (Pohl, P., S.M. Saparov, and Y.N. Antonenko. 1997. Biophys. J. 72:1711–1718). At 36°C, Pf was 3.44 ± 0.35 × 10−3 cm/s for symmetrical inner leaflet membranes and 3.40 ± 0.34 × 10−4 cm/s for symmetrical exofacial membranes. From , the estimated permeability of an asymmetric membrane is 6.2 × 10−4 cm/s. Water permeability measured for the asymmetric planar bilayer was 6.7 ± 0.7 × 10−4 cm/s, which is within 10% of the calculated value. Direct experimental measurement of Pf for an asymmetric planar membrane confirms that leaflets in a bilayer offer independent and additive resistances to water permeation and validates the use of

BDAQ53, a versatile pixel detector readout and test system for the ATLAS and CMS HL-LHC upgrades

BDAQ53 is a readout system and verification framework for hybrid pixel detector readout chips of the RD53 family. These chips are designed for the upgrade of the inner tracking detectors of the ATLAS and CMS experiments. BDAQ53 is used in applications where versatility and rapid customization are required, such as in laboratory testing environments, test beam campaigns, and permanent setups for quality control measurements. It consists of custom and commercial hardware, a Python-based software framework, and FPGA firmware. BDAQ53 is developed as open source software with both software and firmware being hosted in a public repository.Comment: 6 pages, 6 figure

An early Cambrian greenhouse climate

The oceans of the early Cambrian (~541 to 509 million years ago) were the setting for a marked diversification of animal life. However, sea temperatures — a key component of the early Cambrian marine environment — remain unconstrained, in part because of a substantial time gap in the stable oxygen isotope (delta 18 O) record before the evolution of euconodonts. We show that previously overlooked sources of fossil biogenic phosphate have the potential to fill this gap. Pristine phosphatic microfossils from the Comley Limestones, UK, yield a robust delta 18 O signature, suggesting sea surface temperatures of 20° to 25°C at high southern paleolatitudes (~65°S to 70°S) between ~514 and 509 million years ago. These sea temperatures are consistent with the distribution of coeval evaporite and calcrete deposits, peak continental weathering rates, and also our climate model simulations for this interval. Our results support an early Cambrian greenhouse climate comparable to those of the late Mesozoic and early Cenozoic, offering a framework for exploring the interplay between biotic and environmental controls on Cambrian animal diversification

Graphene-Like ZnO: A Mini Review

The isolation of a single layer of graphite, known today as graphene, not only demonstrated amazing new properties but also paved the way for a new class of materials often referred to as two-dimensional (2D) materials. Beyond graphene, other 2D materials include h-BN, transition metal dichalcogenides (TMDs), silicene, and germanene, to name a few. All tend to have exciting physical and chemical properties which appear due to dimensionality effects and modulation of their band structure. A more recent member of the 2D family is graphene-like zinc oxide (g-ZnO) which also holds great promise as a future functional material. This review examines current progress in the synthesis and characterization of g-ZnO. In addition, an overview of works dealing with the properties of g-ZnO both in its pristine form and modified forms (e.g., nano-ribbon, doped material, etc.) is presented. Finally, discussions/studies on the potential applications of g-ZnO are reviewed and discussed

Clostridium difficile Infection and Proton Pump Inhibitor Use in Hospitalized Pediatric Cystic Fibrosis Patients

Children with cystic fibrosis (CF) often take proton pump inhibitors (PPIs), which helps improve efficacy of fat absorption with pancreatic enzyme replacement therapy. However, PPI use is known to be associated with Clostridium difficile-(C. diff-) associated diarrhea (CDAD). We retrospectively evaluated the incidence of C. diff infection from all pediatric hospital admissions over a 5-year period at a single tertiary children's hospital. We found significantly more C. diff-positive stool tests in hospitalized patients with CF compared to patients with no diagnosis of CF. However, use of a PPI was not associated with an increased risk of CDAD in hospitalized CF patients. In summary, C. diff infection is more common in hospitalized pediatric CF patients although PPI use may not be a risk factor for CDAD development in this patient population

Esophageal motility disorders on high-resolution manometry: Chicago classification version 4.0©

Chicago Classification v4.0 (CCv4.0) is the updated classification scheme for esophageal motility disorders using metrics from high-resolution manometry (HRM). Fifty-two diverse international experts separated into seven working subgroups utilized formal validated methodologies over two-years to develop CCv4.0. Key updates in CCv.4.0 consist of a more rigorous and expansive HRM protocol that incorporates supine and upright test positions as well as provocative testing, a refined definition of esophagogastric junction (EGJ) outflow obstruction (EGJOO), more stringent diagnostic criteria for ineffective esophageal motility and description of baseline EGJ metrics. Further, the CCv4.0 sought to define motility disorder diagnoses as conclusive and inconclusive based on associated symptoms, and findings on provocative testing as well as supportive testing with barium esophagram with tablet and/or functional lumen imaging probe. These changes attempt to minimize ambiguity in prior iterations of Chicago Classification and provide more standardized and rigorous criteria for patterns of disorders of peristalsis and obstruction at the EGJ

Quantification of false positive reduction in nucleic acid purification on hemorrhagic fever DNA.

Columbia University has developed a sensitive highly multiplexed system for genetic identification of nucleic acid targets. The primary obstacle to implementing this technology is the high rate of false positives due to high levels of unbound reporters that remain within the system after hybridization. The ability to distinguish between free reporters and reporters bound to targets limits the use of this technology. We previously demonstrated a new electrokinetic method for binary separation of kb pair long DNA molecules and oligonucleotides. The purpose of this project 99864 is to take these previous demonstrations and further develop the technique and hardware for field use. Specifically, our objective was to implement separation in a heterogeneous sample (containing target DNA and background oligo), to perform the separation in a flow-based device, and to develop all of the components necessary for field testing a breadboard prototype system