Open Systems Viewed Through Their Conservative Extensions

A typical linear open system is often defined as a component of a larger conservative one. For instance, a dielectric medium, defined by its frequency dependent electric permittivity and magnetic permeability is a part of a conservative system which includes the matter with all its atomic complexity. A finite slab of a lattice array of coupled oscillators modelling a solid is another example. Assuming that such an open system is all one wants to observe, we ask how big a part of the original conservative system (possibly very complex) is relevant to the observations, or, in other words, how big a part of it is coupled to the open system? We study here the structure of the system coupling and its coupled and decoupled components, showing, in particular, that it is only the system's unique minimal extension that is relevant to its dynamics, and this extension often is tiny part of the original conservative system. We also give a scenario explaining why certain degrees of freedom of a solid do not contribute to its specific heat.Comment: 51 page

Genetic Variation in Selenoprotein Genes, Lifestyle, and Risk of Colon and Rectal Cancer

BACKGROUND: Associations between selenium and cancer have directed attention to role of selenoproteins in the carcinogenic process. METHODS: We used data from two population-based case-control studies of colon (n = 1555 cases, 1956 controls) and rectal (n = 754 cases, 959 controls) cancer. We evaluated the association between genetic variation in TXNRD1, TXNRD2, TXNRD3, C11orf31 (SelH), SelW, SelN1, SelS, SepX, and SeP15 with colorectal cancer risk. RESULTS: After adjustment for multiple comparisons, several associations were observed. Two SNPs in TXNRD3 were associated with rectal cancer (rs11718498 dominant OR 1.42 95% CI 1.16,1.74 pACT 0.0036 and rs9637365 recessive 0.70 95% CI 0.55,0.90 pACT 0.0208). Four SNPs in SepN1 were associated with rectal cancer (rs11247735 recessive OR 1.30 95% CI 1.04,1.63 pACT 0.0410; rs2072749 GGvsAA OR 0.53 95% CI 0.36,0.80 pACT 0.0159; rs4659382 recessive OR 0.58 95% CI 0.39,0.86 pACT 0.0247; rs718391 dominant OR 0.76 95% CI 0.62,0.94 pACT 0.0300). Interaction between these genes and exposures that could influence these genes showed numerous significant associations after adjustment for multiple comparisons. Two SNPs in TXNRD1 and four SNPs in TXNRD2 interacted with aspirin/NSAID to influence colon cancer; one SNP in TXNRD1, two SNPs in TXNRD2, and one SNP in TXNRD3 interacted with aspirin/NSAIDs to influence rectal cancer. Five SNPs in TXNRD2 and one in SelS, SeP15, and SelW1 interacted with estrogen to modify colon cancer risk; one SNP in SelW1 interacted with estrogen to alter rectal cancer risk. Several SNPs in this candidate pathway influenced survival after diagnosis with colon cancer (SeP15 and SepX1 increased HRR) and rectal cancer (SepX1 increased HRR). CONCLUSIONS: Findings support an association between selenoprotein genes and colon and rectal cancer development and survival after diagnosis. Given the interactions observed, it is likely that the impact of cancer susceptibility from genotype is modified by lifestyle

CMS physics technical design report : Addendum on high density QCD with heavy ions

Peer reviewe

IR-SPECTROSCOPY OF PHENYLRADICALS IN HELIUMNANODROPLETS

Author Institution: Department of Physical Chemistry II, Ruhr-University Bochum, D-44780 Bochum, GermanyThe study of aryl radicals is of paramount importance for a different number of reasons. These reactive species are critical intermediates in reactions of explosives and combustion processes, in the generation and the deposition of soot and the formation of organic pollutants . Furthermore these species play an important role in the carcinogenesis and the photocyclic tumour therapy. Based on their high reactivity it is not possible to investigate those substances at room temperature. For this reason previous experimental studies were carried out by embedding the radicals in a low temperature argon matrix , . In the present experimental study we wanted to investigate phenyl radicals as a prototype for aryl radicals in helium nanodroplets. In contrast to measurements in an argon matrix (10 K) we were able to get temperatures as low as 0.37 K. Using azobenzene as a precursor the phenyl radicals are generated with the help of a home-made pyrolysis oven at temperatures in the 600 - 1100 K range. The optimization of the phenyl source was carried out by observing the efficiency of the pyrolysis according to changes of different experimental parameters. After obtaining formation of the reactive species and their incorporation into the ultracold helium droplets, the radicals were spectroscopically studied in the spectral region of 3045 cm$^{-1}$ - 3085 cm$^{-1}$