Putting nature in a box: Hans Sloane’s ‘Vegetable Substances’ collection

PhDThe ‘Vegetable Substances’ collection was formed by the physician and collector Sir Hans Sloane (1660-1753) between the 1680s and the 1750s. All sorts of people ranging from ship’s captains in the Americas to surgeons in the East Indies sent natural material from around the world to London. Sometimes this involved a variety of means and intermediaries, and in other instances individuals, including aristocratic women in London and Royal Society Fellows across England, gave items directly to Sloane. When Sloane received these samples of botanical items, he had them sealed into small glass and wood boxes. He then numbered these items and described the sample in a three-volume manuscript catalogue. 12,523 items are listed in Sloane’s hand in this catalogue with varying degrees of information relating to their identification, contributor, provenance and use. Today, the Natural History Museum in London holds Sloane’s surviving catalogue and over 8000 of these ‘Vegetable Substances’ objects. Considering the collection as a whole, this thesis explores the role of the ‘Vegetable Substances’ in early eighteenth-century natural knowledge. Using data provided by the catalogue and Sloane’s surviving correspondence at the British Library, this thesis explores what is in the ‘Vegetable Substances’ and identifies how Sloane formed the collection by surveying the connections he developed with people across the world and how he managed these different relationships. Drawing on these exchanges, this thesis also focuses on the uses of the ‘Vegetable Substances’ by examining its contents in particular eighteenth-century contexts including gardening spaces and medicine.Arts and Humanities Research Council (grant number AH/J00989X/1) and supported by grants from the Natural History Museum, the Bodleian, and the British Society for the History of Scienc

Immanent Anthropology: A Comparative Study of 'Process' in Contemporary France

This paper presents a comparative critique of the ‘processual temporalities’ which infuse both social-scientific theorizing and selected Western cultural practices. Through study of a public-private partnership which emerged from a biotechnology project devised for producing ‘self-cloning’ maize for resource-poor farmers, I analyse how processual temporalities were central to re-gearing knowledge practices towards market-orientated solutions. In a study of characterizations of the ‘state of flux’ which affects life in a French peri-urban village, I explore how processualism is identified as a component of a metropolitan hegemony which villagers ‘resist’ through idealizing ‘enduring temporalities’ of cultural practice. Drawing on Arendt and Deleuze, I analyse processualism as a dominant contemporary chronotope, mediating and disciplining conflictive temporalities and practices, underwriting economic projects of deterritorialization and restructuring – whose idiom is also prominent in social-scientific paradigms. I substitute an ‘immanent anthropology’, which advocates a non-transcendental ontology of cultural practice and analysis – displacing anthropological analysis onto a polychronic temporal foundation

REFINE (reduced frequency ImmuNE checkpoint inhibition in cancers): A multi-arm phase II basket trial testing reduced intensity immunotherapy across different cancers

Background Immune checkpoint inhibitors (ICI) have revolutionised treating advanced cancers. ICI are administered intravenously every 2–6 weeks for up to 2 years, until cancer progression/unacceptable toxicity. Physiological efficacy is observed at lower doses than those used as standard of care (SOC). Pharmacodynamic studies indicate sustained target occupancy, despite a pharmacological half-life of 2–3 weeks. Reducing frequency of administration may be possible without compromising outcomes. The REFINE trial aims to limit individual patient exposure to ICI whilst maintaining efficacy, with potential benefits in quality of life and reduced drug treatment/attendance costs. Methods/Design REFINE is a randomised phase II, multi-arm, multi-stage (MAMS) adaptive basket trial investigating extended interval administration of ICIs. Eligible patients are those responding to conventionally dosed ICI at 12 weeks. In stage I, patients (n = 160 per tumour-specific cohort) will be randomly allocated (1:1) to receive maintenance ICI at SOC vs extended dose interval. REFINE is currently recruiting UK patients with locally advanced or metastatic renal cell carcinoma (RCC) who have tolerated and responded to initial nivolumab/ipilimumab, randomised to receive maintenance nivolumab SOC (480 mg 4 weekly) vs extended interval (480 mg 8 weekly). Additional tumour cohorts are planned. Subject to satisfactory outcomes (progression-free survival) stage II will investigate up to 5 different treatment intervals. Secondary outcome measures include overall survival, quality-of-life, treatment-related toxicity, mean incremental pathway costs and quality-adjusted life-years per patient. REFINE is funded by the Jon Moulton Charity Trust and Medical Research Council, sponsored by University College London (UCL), and coordinated by the MRC CTU at UCL

Understanding human-machine networks: A cross-disciplinary survey

© 2017 ACM. In the current hyperconnected era, modern Information and Communication Technology (ICT) systems form sophisticated networks where not only do people interact with other people, but also machines take an increasingly visible and participatory role. Such Human-Machine Networks (HMNs) are embedded in the daily lives of people, both for personal and professional use. They can have a significant impact by producing synergy and innovations. The challenge in designing successful HMNs is that they cannot be developed and implemented in the same manner as networks of machines nodes alone, or following a wholly human-centric view of the network. The problem requires an interdisciplinary approach. Here, we review current research of relevance to HMNs across many disciplines. Extending the previous theoretical concepts of sociotechnical systems, actor-network theory, cyber-physical-social systems, and social machines, we concentrate on the interactions among humans and between humans and machines. We identify eight types of HMNs: public-resource computing, crowdsourcing, web search engines, crowdsensing, online markets, social media, multiplayer online games and virtual worlds, and mass collaboration. We systematically select literature on each of these types and review it with a focus on implications for designing HMNs. Moreover, we discuss risks associated with HMNs and identify emerging design and development trends

Towards a literary account of mental health from James’ Principles of Psychology

YesThe field of mental health tends to treat its literary metaphors as literal realities with the concomitant loss of vague “feelings of tendency” in “unusual experiences”. I develop this argument through the prism of William James’ (1890) “The Principles of Psychology”. In the first part of the paper, I reflect upon the relevance of James’ “The Psychologist’s Fallacy” to a literary account of mental health. In the second part of the paper, I develop the argument that “connotations” and “feelings of tendency” are central to resolving some of the more difficult challenges of this fallacy. I proceed to do this in James’ spirit of generating imaginative metaphors to understand experience. Curiously, however, mental health presents a strange paradox in William James’ (1890) Principles of Psychology. He constructs an elaborate conception of the “empirical self” and “stream of thought” but chooses not to use these to understand unusual experiences – largely relying instead on the concept of a “secondary self.” In this article, I attempt to make more use of James’ central division between the “stream of thought” and the “empirical self” to understand unusual experiences. I suggest that they can be usefully understood using the loose metaphor of a “binary star” where the “secondary self” can be seen as an “accretion disk” around one of the stars. Understood as literary rather the literal, this metaphor is quite different to more unitary models of self-breakdown in mental health, particularly in its separation of “self” from “the stream of thought” and I suggest it has the potential to start a re-imagination of the academic discourse around mental health

Laughing at lunacy: othering and comic ambiguity in popular humour about mental distress

Jokes and humour about mental distress are said by anti-stigma campaigners to be no laughing matter. The article takes issue with this viewpoint arguing that this is clearly not the case since popular culture past and present has laughed at the antics of those perceived as ‘mad’. Drawing on past and present examples of the othering of insanity in jokes and humour the article incorporates a historical perspective on continuity and change in humour about madness/mental distress, which enables us to recognise that psychiatry is a funny-peculiar enterprise and its therapeutic practices in past times are deserving of funny ha-ha mockery and mirth in the present. By doing so, the article also argues that humour and mental distress illuminate how psychiatric definitions and popular representations conflict and that some psychiatric service users employ comic ambiguity to reflexively puncture their public image as ‘nuts’