N-flation from multiple DBI type actions

In this letter we present a new N-flation model constructed by making use of multiple scalar fields which are being described by their own DBI action. We show that the dependence of the e-folding number and of the curvature perturbation on the number of fields changes compared with the normal N-flation model. Our model is also quite different from the usual DBI N-flation which is still based on one DBI action but involves many moduli components. Some specific examples of our model have been analyzed.Comment: 4 pages, 1 figur

Effectiveness of Traditional Chinese Medicine Compound JieDuTongLuoShengJin Granules Treatment in Primary Sjögren’s Syndrome: A Randomized, Double-Blind, Placebo-Controlled Clinical Trial

Objective. To evaluate the clinical therapeutic efficacy and safety of JieDuTongLuoShengJin granules + HCQ in patients with pSS. Methods. 40 patients with low-activity-level pSS and without visceral involvement participated in this study and were randomized to receive either JieDuTongLuoShengJin granules with HCQ or placebo with HCQ. Patients and investigators were blinded to treatment allocation. The primary endpoint was week 12 ESSPRI score, while secondary endpoints included ESSDAI, salivary and lacrimal gland function, and some laboratory variables. Safety-related data were also assessed. Results. Comparing with the placebo group, the treatment group experienced statistically significant improvement in the mean change from baseline for the primary endpoint of ESSPRI score and also in PGA. Moreover, in comparison with baseline values, the treatment group had significantly improved ESSDAI score, unstimulated saliva flow rate, and several laboratory variables. However, upon comparison of the two groups, there were no significant differences for them. The incidence of AEs was 10.0%, one in treatment group and three in placebo group. Conclusion. Treatment with a combination of JieDuTongLuoShengJin granules with HCQ is effective in improving patients’ subjective symptoms and some objective indicators of pSS. These results indicate that JieDuTongLuoShengJin is promising as a safe and effective treatment of pSS

Comparative Transcriptomics and Proteomics of Atractylodes lancea in Response to Endophytic Fungus Gilmaniella sp. AL12 Reveals Regulation in Plant Metabolism

The fungal endophyte Gilmaniella sp. AL12 can establish a beneficial association with the medicinal herb Atractylodes lancea, and improve plant growth and sesquiterpenoids accumulation, which is termed “double promotion.” Our previous studies have uncovered the underling primary mechanism based on some physiological evidences. However, a global understanding of gene or protein expression regulation in primary and secondary metabolism and related regulatory processes is still lacking. In this study, we employed transcriptomics and proteomics of Gilmaniella sp. AL12-inoculated and Gilmaniella sp. AL12-free plants to study the impact of endophyte inoculation at the transcriptional and translational levels. The results showed that plant genes involved in plant immunity and signaling were suppressed, similar to the plant response caused by some endophytic fungi and biotroph pathogen. The downregulated plant immunity may contribute to plant-endophyte beneficial interaction. Additionally, genes and proteins related to primary metabolism (carbon fixation, carbohydrate metabolism, and energy metabolism) tended to be upregulated after Gilmaniella sp. AL12 inoculation, which was consistent with our previous physiological evidences. And, Gilmaniella sp. AL12 upregulated genes involved in terpene skeleton biosynthesis, and upregulated genes annotated as β-farnesene synthase and β-caryophyllene synthase. Based on the above results, we proposed that endophyte-plant associations may improve production (biomass and sesquiterpenoids accumulation) by increasing the source (photosynthesis), expanding the sink (glycolysis and tricarboxylic acid cycle), and enhancing the metabolic flux (sesquiterpenoids biosynthesis pathway) in A. lancea. And, this study will help to further clarify plant-endophyte interactions

Global patterns of woody residence time and its influence on model simulation of aboveground biomass

Woody residence time (τw) is an important parameter that expresses the balance between mature forest recruitment/growth and mortality. Using field data collected from the literature, this study explored the global forest τw and investigated its influence on model simulations of aboveground biomass (AGB) at a global scale. Specifically, τw was found to be related to forest age, annual temperature, and precipitation at a global scale, but its determinants were different among various plant function types. The estimated global forest τw based on the filed data showed large spatial heterogeneity, which plays an important role in model simulation of AGB by a dynamic global vegetation model (DGVM). The τw could change the resulting AGB in tenfold based on a site-level test using the Monte Carlo method. At the global level, different parameterization schemes of the Integrated Biosphere Simulator using the estimated τw resulted in a twofold change in the AGB simulation for 2100. Our results highlight the influences of various biotic and abiotic variables on forest τw. The estimation of τw in our study may help improve the model simulations and reduce the parameter\u27s uncertainty over the projection of future AGB in the current DGVM or Earth System Models. A clearer understanding of the responses of τw to climate change and the corresponding sophisticated description of forest growth/mortality in model structure is also needed for the improvement of carbon stock prediction in future studies

Curvaton Dynamics and the Non-Linearity Parameters in Curvaton Model

We investigate the curvaton dynamics and the non-linearity parameters in curvaton model with potential slightly deviating from the quadratic form in detail. The non-linearity parameter $g_{NL}$ will show up due to the curvaton self-interaction. We also point out that the leading order of non-quadratic term in the curvaton potential can be negative, for example in the axion-type curvaton model. If a large positive $g_{NL}$ is detected, the axion-type curvaton model will be preferred.Comment: 14 pages, 4 figures; refs adde

Is Noncommutative Eternal Inflation Possible?

We investigate the condition for eternal inflation to take place in the noncommutative spacetime. We find that the possibility for eternal inflation's happening is greatly suppressed in this case. If eternal inflation cannot happen in the low energy region where the noncommutativity is very weak (the UV region), it will never happen during the whole inflationary history. Based on these conclusions, we argue that an initial condition for eternal inflation is available from the property of spacetime noncommutativity.Comment: 14 pages, 2 figures, accepted by JCA

The effects of interactions between proline and carbon nanostructures on organocatalysis in the Hajos-Parrish-Eder-Sauer-Wiechert reaction

The non-covalent interactions of S-(-)-proline with the surfaces of carbon nanostructures (fullerene, nanotubes and graphite) change the nucleophilic-electrophilic and acid-base properties of the amino acid, thus tuning its activity and selectivity in the organocatalytic Hajos-Parrish-Eder-Sauer-Wiechert (HPESW) reaction. Whilst our spectroscopy and microscopy measurements show no permanent covalent bonding between S-(-)-proline and carbon nanostructures, a systematic investigation of the catalytic activity and selectivity of the organocatalyst in the HPESW reaction demonstrates a clear correlation between the pyramidalisation angle of carbon nanostructures and the catalytic properties of S-(-)-proline. Carbon nanostructures with larger pyramidalisation angles have a stronger interaction with the nitrogen atom lone pair of electrons of the organocatalyst, thereby simultaneously decreasing the nucleophilicity and increasing the acidity of the organocatalyst. These translate into lower conversion rates but higher selectivities towards the dehydrated product of Aldol addition

Curvaton with Polynomial Potential

In general a weakly self-interacting curvaton field is expected and the curvaton potential takes the polynomial form. The curvaton potential can be dominated by the self-interaction term during the period of inflation if the curvaton field stays at a large vacuum expectation value. We use the $\delta {\cal N}$ formalism to calculate the primordial curvature perturbation in the various possible scenarios which make the curvaton model much richer.Comment: 18 pages; a mistake in sec.2.2.2 corrected, enhancement of $g_{NL}$ in the mixed scenarion discussed, version for publication in JCA

Hawking-Moss Tunneling in Noncommutative Eternal Inflation

The quantum behavior of noncommutative eternal inflation is quite different from the usual knowledge. Unlike the usual eternal inflation, the quantum fluctuation of noncommutative eternal inflation is suppressed by the Hubble parameter. Due to this, we need to reconsider many conceptions of eternal inflation. In this paper we study the Hawking-Moss tunneling in noncommutative eternal inflation using the stochastic approach. We obtain a brand-new form of the tunneling probability for this process and find that the Hawking-Moss tunneling is more unlikely to take place in the noncommutative case than in the usual one. We also conclude that the lifetime of a metastable de-Sitter (dS) vacuum in the noncommutative spacetime is longer than that in the commutative case.Comment: 12 pages, 1 figure, accepted by JCA

An Updated Review of Tyrosinase Inhibitors

Tyrosinase is a multifunctional, glycosylated, and copper-containing oxidase, which catalyzes the first two steps in mammalian melanogenesis and is responsible for enzymatic browning reactions in damaged fruits during post-harvest handling and processing. Neither hyperpigmentation in human skin nor enzymatic browning in fruits are desirable. These phenomena have encouraged researchers to seek new potent tyrosinase inhibitors for use in foods and cosmetics. This article surveys tyrosinase inhibitors newly discovered from natural and synthetic sources. The inhibitory strength is compared with that of a standard inhibitor, kojic acid, and their inhibitory mechanisms are discussed