1,489 research outputs found
White matter abnormalities in adults with bipolar disorder type-II and unipolar depression
Discerning distinct neurobiological characteristics of related mood disorders such as bipolar disorder type-II (BD-II) and unipolar depression (UD) is challenging due to overlapping symptoms and patterns of disruption in brain regions. More than 60% of individuals with UD experience subthreshold hypomanic symptoms such as elevated mood, irritability, and increased activity. Previous studies linked bipolar disorder to widespread white matter abnormalities. However, no published work has compared white matter microstructure in individuals with BD-II vs. UD vs. healthy controls (HC), or examined the relationship between spectrum (dimensional) measures of hypomania and white matter microstructure across those individuals. This study aimed to examine fractional anisotropy (FA), radial diffusivity (RD), axial diffusivity (AD), and mean diffusivity (MD) across BD-II, UD, and HC groups in the white matter tracts identified by the XTRACT tool in FSL. Individuals with BD-II (n = 18), UD (n = 23), and HC (n = 24) underwent Diffusion Weighted Imaging. The categorical approach revealed decreased FA and increased RD in BD-II and UD vs. HC across multiple tracts. While BD-II had significantly lower FA and higher RD values than UD in the anterior part of the left arcuate fasciculus, UD had significantly lower FA and higher RD values than BD-II in the area of intersections between the right arcuate, inferior fronto-occipital and uncinate fasciculi and forceps minor. The dimensional approach revealed the depression-by-spectrum mania interaction effect on the FA, RD, and AD values in the area of intersection between the right posterior arcuate and middle longitudinal fasciculi. We propose that the white matter microstructure in these tracts reflects a unique pathophysiologic signature and compensatory mechanisms distinguishing BD-II from UD
An analysis of the risk of cocoa moniliasis occurrence in Brazil as the result of climate change
The unusual protoplanetary disk around the T Tauri star ET Cha
We present new continuum and line observations, along with modelling, of the
faint (6-8) Myr old T Tauri star ET Cha belonging to the eta Chamaeleontis
cluster. We have acquired HERSCHEL/PACS photometric fluxes at 70 mic and 160
mic, as well as a detection of the [OI] 63 mic fine-structure line in emission,
and derived upper limits for some other far-IR OI, CII, CO and o-H2O lines. The
HERSCHEL data is complemented by new ANDICAM B-K photometry, new HST/COS and
HST/STIS UV-observations, a non-detection of CO J=3-2 with APEX, re-analysis of
a UCLES high-resolution optical spectrum showing forbidden emission lines like
[OI] 6300A, [SII] 6731A and 6716A, and [NII] 6583A, and a compilation of
existing broad-band photometric data. We used the thermo-chemical disk code
ProDiMo and the Monte-Carlo radiative transfer code MCFOST to model the
protoplanetary disk around ET Cha. Based on these models we can determine the
disk dust mass Mdust = (2.E-8 - 5.E-8) Msun, whereas the total disk gas mass is
found to be only little constrained, Mgas = (5.E-5 - 3.E-3) Msun. In the
models, the disk extends from 0.022 AU (just outside of the co-rotation radius)
to only about 10 AU. Larger disks are found to be inconsistent with the CO
J=3-2 non-detection. The low velocity component of the [OI] 6300A emission line
is consistent with being emitted from the inner disk. The model can also
reproduce the line flux of H2 v=1-0 S(1) at 2.122 mic. An additional
high-velocity component of the [OI] 6300A emission line, however, points to the
existence of an additional jet/outflow of low velocity (40 - 65) km/s with mass
loss rate ~1.E-9 Msun/yr. In relation to our low estimations of the disk mass,
such a mass loss rate suggests a disk lifetime of only ~(0.05 - 3) Myr,
substantially shorter than the cluster age. The evolutionary state of this
unusual protoplanetary disk is discussed.Comment: accepted by Astronomy & Astrophysics (18 pages, 11 figures and 7
tables). Additional 9-page appendix with 6 figures, 3 tables and 37 equation
Bats Use Magnetite to Detect the Earth's Magnetic Field
While the role of magnetic cues for compass orientation has been confirmed in numerous animals, the mechanism of detection is still debated. Two hypotheses have been proposed, one based on a light dependent mechanism, apparently used by birds and another based on a “compass organelle” containing the iron oxide particles magnetite (Fe3O4). Bats have recently been shown to use magnetic cues for compass orientation but the method by which they detect the Earth's magnetic field remains unknown. Here we use the classic “Kalmijn-Blakemore” pulse re-magnetization experiment, whereby the polarity of cellular magnetite is reversed. The results demonstrate that the big brown bat Eptesicus fuscus uses single domain magnetite to detect the Earths magnetic field and the response indicates a polarity based receptor. Polarity detection is a prerequisite for the use of magnetite as a compass and suggests that big brown bats use magnetite to detect the magnetic field as a compass. Our results indicate the possibility that sensory cells in bats contain freely rotating magnetite particles, which appears not to be the case in birds. It is crucial that the ultrastructure of the magnetite containing magnetoreceptors is described for our understanding of magnetoreception in animals
A peculiar class of debris disks from Herschel/DUNES - A steep fall off in the far infrared
Aims. We present photometric data of debris disks around HIP 103389 (HD
199260), HIP 107350 (HN Peg, HD206860), and HIP 114948 (HD 219482), obtained in
the context of our Herschel Open Time Key Program DUNES (DUst around NEarby
Stars). Methods. We used Herschel/PACS to detect the thermal emission of the
three debris disks with a 3 sigma sensitivity of a few mJy at 100 um and 160
um. In addition, we obtained Herschel/PACS photometric data at 70 um for HIP
103389. Two different approaches are applied to reduce the Herschel data to
investigate the impact of data reduction on the photometry. We fit analytical
models to the available spectral energy distribution (SED) data. Results. The
SEDs of the three disks potentially exhibit an unusually steep decrease at
wavelengths > 70 um. We investigate the significance of the peculiar shape of
these SEDs and the impact on models of the disks provided it is real. Our
modeling reveals that such a steep decrease of the SEDs in the long wavelength
regime is inconsistent with a power-law exponent of the grain size distribution
-3.5 expected from a standard equilibrium collisional cascade. In contrast, a
very distinct range of grain sizes is implied to dominate the thermal emission
of such disks. However, we demonstrate that the understanding of the data of
faint sources obtained with Herschel is still incomplete and that the
significance of our results depends on the version of the data reduction
pipeline used. Conclusions. A new mechanism to produce the dust in the
presented debris disks, deviations from the conditions required for a standard
equilibrium collisional cascade (grain size exponent of -3.5), and/or
significantly different dust properties would be necessary to explain the
potentially steep SED shape of the three debris disks presented. (abridged)Comment: 14 pages, 4 figures, accepted by A&
Phenotypic Description of Theobroma cacao L. for Yield and Vigor Traits From 34 Hybrid Families in Costa Rica Based on the Genetic Basis of the Parental Population
A comprehensive understanding of the genetic basis of target traits in any crop is critical to design breeding strategies for the development and release of new improved varieties. In this study, 34 cacao families were evaluated for vigor and yield related traits over the course of 6 years in Costa Rica. Linear mixed models provided the variance components for the partitioning of additive and non-additive effects. Heritabilities of yield over time ranged from 0.085 to 0.576, from 0.127 to 0.399 for vigor, and 0.141 to 0.146 for disease resistance traits. Significant (p < 0.001) general combining abilities were observed for ICS-43 and LcTeen-37 with negative effect on average yield (−0.674, −0.690), respectively. Specific combining abilities for yield had significant (p < 0.001) positive effect from the cross GU-154-L x UF-273 Type 2 (0.703) and strong negative interaction between ICS-43 and LF-1 (−0.975). A weighted index was used to select the top performers while providing the corresponding genetic gains. At an 1% selection intensity, yield component gains ranged from 17.8 to 331.9%. Agronomic traits such as branch angle, trunk diameter and jorquette height had lower genetic gains and lower heritabilities. In addition, the parents in this study were genotyped with a 96-SNP marker off-typing set and a significant positive correlation of 0.39 (p = 0.019) was found between genetic distance and specific combining abilities for yield. Preliminary comparison of clonal parents vs. seedlings yield in the family with the highest SCA suggest for the first time presence of heterobeltiosis in cacao
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