182 research outputs found
52PMULTIPARAMETER PLOIDY PROFILING: A POWERFUL TOOL TO INVESTIGATE THE GENOMICS OF DIPLOID TUMOR POPULATIONS
Measurement of the atmospheric muon depth intensity relation with the NEMO Phase-2 tower
The results of the analysis of the data collected with the NEMO Phase-2
tower, deployed at 3500 m depth about 80 km off-shore Capo Passero (Italy), are
presented. Cherenkov photons detected with the photomultipliers tubes were used
to reconstruct the tracks of atmospheric muons. Their zenith-angle distribution
was measured and the results compared with Monte Carlo simulations. An
evaluation of the systematic effects due to uncertainties on environmental and
detector parameters is also included. The associated depth intensity relation
was evaluated and compared with previous measurements and theoretical
predictions. With the present analysis, the muon depth intensity relation has
been measured up to 13 km of water equivalent.Comment: submitted to Astroparticle Physic
Search for muon-neutrino emission from GeV and TeV gamma-ray flaring blazars using five years of data of the ANTARES telescope
The ANTARES telescope is well-suited for detecting astrophysical transient
neutrino sources as it can observe a full hemisphere of the sky at all times
with a high duty cycle. The background due to atmospheric particles can be
drastically reduced, and the point-source sensitivity improved, by selecting a
narrow time window around possible neutrino production periods. Blazars, being
radio-loud active galactic nuclei with their jets pointing almost directly
towards the observer, are particularly attractive potential neutrino point
sources, since they are among the most likely sources of the very high-energy
cosmic rays. Neutrinos and gamma rays may be produced in hadronic interactions
with the surrounding medium. Moreover, blazars generally show high time
variability in their light curves at different wavelengths and on various time
scales. This paper presents a time-dependent analysis applied to a selection of
flaring gamma-ray blazars observed by the FERMI/LAT experiment and by TeV
Cherenkov telescopes using five years of ANTARES data taken from 2008 to 2012.
The results are compatible with fluctuations of the background. Upper limits on
the neutrino fluence have been produced and compared to the measured gamma-ray
spectral energy distribution.Comment: 27 pages, 16 figure
The Antares Collaboration : Contributions to the 34th International Cosmic Ray Conference (ICRC 2015, The Hague)
The ANTARES detector, completed in 2008, is the largest neutrino telescope in the Northern hemisphere. Located at a depth of 2.5 km in the Mediterranean Sea, 40 km off the Toulon shore, its main goal is the search for astrophysical high energy neutrinos. In this paper we collect the 21 contributions of the ANTARES collaboration to the 34th International Cosmic Ray Conference (ICRC 2015). The scientific output is very rich and the contributions included in these proceedings cover the main physics results, ranging from steady point sources, diffuse searches, multi-messenger analyses to exotic physics
All-sky Search for High-Energy Neutrinos from Gravitational Wave Event GW170104 with the ANTARES Neutrino Telescope
Advanced LIGO detected a significant gravitational wave signal (GW170104)
originating from the coalescence of two black holes during the second
observation run on January 4, 2017. An all-sky high-energy
neutrino follow-up search has been made using data from the ANTARES neutrino
telescope, including both upgoing and downgoing events in two separate
analyses. No neutrino candidates were found within s around the GW
event time nor any time clustering of events over an extended time window of
months. The non-detection is used to constrain isotropic-equivalent
high-energy neutrino emission from GW170104 to less than
erg for a spectrum
The ANTARES Collaboration: Contributions to ICRC 2017 Part III: Searches for dark matter and exotics, neutrino oscillations and detector calibration
Papers on the searches for dark matter and exotics, neutrino oscillations and
detector calibration, prepared for the 35th International Cosmic Ray Conference
(ICRC 2017, Busan, South Korea) by the ANTARES Collaboratio
The ANTARES Collaboration: Contributions to ICRC 2017 Part I: Neutrino astronomy (diffuse fluxes and point sources)
Papers on neutrino astronomy (diffuse fluxes and point sources, prepared for
the 35th International Cosmic Ray Conference (ICRC 2017, Busan, South Korea) by
the ANTARES Collaboratio
The ANTARES Collaboration: Contributions to ICRC 2017 Part II: The multi-messenger program
Papers on the ANTARES multi-messenger program, prepared for the 35th
International Cosmic Ray Conference (ICRC 2017, Busan, South Korea) by the
ANTARES Collaboratio
Genetic profiling using plasma-derived cell-free DNA in therapy-naĂŻve hepatocellular carcinoma patients: a pilot study
Hepatocellular carcinomas (HCCs) are not routinely biopsied, resulting in a lack of tumor materials for molecular profiling. Here we sought to determine whether plasma-derived cell-free DNA (cfDNA) captures the genetic alterations of HCC in patients who have not undergone systemic therapy.; Frozen biopsies from the primary tumor and plasma were synchronously collected from 30 prospectively recruited, systemic treatment-naĂŻve HCC patients. Deep sequencing of the DNA from the biopsies, plasma-derived cfDNA and matched germline was carried out using a panel targeting 46 coding and non-coding genes frequently altered in HCCs.; In 26/30 patients, at least one somatic mutation was detected in biopsy and/or cfDNA. Somatic mutations in HCC-associated genes were present in the cfDNA of 63% (19/30) of the patients and could be detected 'de novo' without prior knowledge of the mutations present in the biopsy in 27% (8/30) of the patients. Mutational load and the variant allele fraction of the mutations detected in the cfDNA positively correlated with tumor size and Edmondson grade. Crucially, among the seven patients in whom the largest tumor wasââ„5âcm or was associated with metastasis, at least one mutation was detected 'de novo' in the cfDNA of 86% (6/7) of the cases. In these patients, cfDNA and tumor DNA captured 87% (80/92) and 95% (87/92) of the mutations, suggesting that cfDNA and tumor DNA captured similar proportions of somatic mutations.; In patients with high disease burden, the use of cfDNA for genetic profiling when biopsy is unavailable may be feasible. Our results support further investigations into the clinical utility of cfDNA in a larger cohort of patients
Searches for Point-like and extended neutrino sources close to the Galactic Centre using the ANTARES neutrino Telescope
A search for cosmic neutrino sources using six years of data collected by the ANTARES neutrino telescope has been performed. Clusters of muon neutrinos over the expected atmospheric background have been looked for. No clear signal has been found. The most signal-like accumulation of events is located at equatorial coordinates R.A. = -46 degrees.8 and decl. = -64 degrees.9 and corresponds to a 2.2 sigma background fluctuation. In addition, upper limits on the flux normalization of an E-2 muon neutrino energy spectrum have been set for 50 pre-selected astrophysical objects. Finally, motivated by an accumulation of seven events relatively close to the Galactic Center in the recently reported neutrino sample of the IceCube telescope, a search for point sources in a broad region around this accumulation has been carried out. No indication of a neutrino signal has been found in the ANTARES data and upper limits on the flux normalization of an E-2 energy spectrum of neutrinos from point sources in that region have been set. The 90% confidence level upper limits on the muon neutrino flux normalization vary between 3.5 and 5.1 x 10(-8) GeV cm(-2) s(-1), depending on the exact location of the source
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