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Citrulline malate supplementation does not improve German Volume Training performance or reduce muscle soreness in moderately trained males and females

Author: A Martinez-Sanchez
A Sureda
AF Creff
Andrew J. Chappell
Annie Anand
B Campbell
B Cunniffe
B Wax
B Wax
C Moinard
D Bendahan
D Vanuxem
DA Jones
Daniel M. Allwood
E Curis
G Wu
J Perez-Guisado
JM Glenn
Kiran Sultana
L Xie
M Ochiai
MA Janeira
PT Cutrufello
R Bescos
RA Meyer
RC Hickner
Rebecca Johns
RJ Haines
Samantha Brown
Trevor Simper
Publication venue: 'Springer Science and Business Media LLC'
Publication date: 01/01/2018
Field of study

Background Use of supplements to aid performance is common practice amongst recreationally active individuals, including those without a sufficient evidence base. This investigation sought to assess whether acute supplementation with 8 g of citrulline malate (CM) (1.11: 1 ratio) would improve anaerobic performance. Methods A randomised double blind placebo control trial was employed, using a counterbalanced design. We recruited recreationally active men and women to take part in an isokinetic chair protocol, based on German Volume Training (GVT) whereby participants attempted to perform 10 sets of 10 repetitions against a force representing 70% of their peak concentric force. Results The number of repetitions achieved over the course of the GVT was 94.0 ± 7.9 and 90.9 ± 13.9 for placebo and CM respectively. There was no significant difference between the placebo and CM treatment for number of repetitions (P = 0.33), isometric (P = 0.60), concentric (P = 0.38), or eccentric (P = 0.65) peak force following the GVT. Total muscle soreness was significantly higher in the CM compared to the placebo treatment following the GVT protocol over 72 h (P = 0.01); although this was not accompanied by a greater workload/number of repetitions in the CM group. Conclusions We conclude that an acute dose of CM does not significantly affect anaerobic performance using an isokinetic chair in recreational active participants. Practical implications include precaution in recommending CM supplementation. Coaches and athletes should be aware of the disparity between the chemical analyses of the products reviewed in the present investigation versus the manufacturers’ claims

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Hochschulbibliothekszentrum des Landes Nordrhein-Westfalen (hbz)

Elective Cancer Surgery in COVID-19-Free Surgical Pathways During the SARS-CoV-2 Pandemic: An International, Multicenter, Comparative Cohort Study.

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Abd Elazeem H. A. S.
Abdalla M.
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Xu M. J.
Xyda S. E.
Xynos E.
Yahaya A. S.
Yanez C.
Yang W.
Yassin N.
Ye G.
Yesantharao P.
Yesilyurt D.
Yetkin G.
Yiallourou A.
Yildirim A.
Yildiz A.
Ying Y.
Yip V.
Yordanov S.
Young R.
Yousof E. A.
Youssef A.
Youssef M.
Yuksel E.
Yurttas C.
Zacharoulis D.
Zafar S. N.
Zakai D.
Zakaria A. D.
Zakaria R.
Zakaria Z.
Zambelli M. F.
Zambon M.
Zamora L.
Zamvar V.
Zani S.
Zanotti S.
Zanus G.
Zapardiel I.
Zarabini A. G.
Zatecky J.
Zegarac M.
Zelic M.
Zeller N.
Zengin A. K.
Zerbib P.
Zervas K.
Zese M.
Zhang H.
Zivanovic M.
Zivkovic M.
Zizzo M.
Zografos C.
Zonta S.
Zorrilla Ortuzar J.
Zourntou S.
Zouzoulas D.
Zubaidi A.
Zullo A.
Publication venue: J Clin Oncol
Publication date: 01/01/2020
Field of study

PURPOSE: As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19-free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS: This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19-free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS: Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19-free surgical pathways. Patients who underwent surgery within COVID-19-free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19-free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score-matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19-free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION: Within available resources, dedicated COVID-19-free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

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Institutional Research Information System University of Turin

Elective cancer surgery in COVID-19-free surgical pathways during the SARS-CoV-2 pandemic: An international, multicenter, comparative cohort study

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Abad-Motos A.
Abate E.
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Vidakovic S.
Videira J. F.
Videria J. F.
Vidya R.
Vieira A.
Vieira B.
Vieira Caroco T.
Vieira P.
Vieira Paiva Lopes A. C.
Vignali A.
Vigorita V.
Vijayan D.
Vilatoba M.
Vilendecic Z.
Villalabeitia Ateca I.
Vimalachandran D.
Vinayagam R.
Violante T.
Visgauss J.
Viswambaram P.
Viswanath Y.
Vitali A.
Vitone L.
Vives R. V.
Vo U. G.
Vogel J.
Vollkommer T.
Von Papen M.
Vovola F.
Vucic N.
Vujanac V.
Wade R.
Wadham B.
Waheed S.
Wai K.
Wali A.
Walker C.
Walker D.
Walkes K.
Wallwork K.
Walton G.
Walton T.
Waqar S. H.
Warburton H.
Ward D.
Ward S.
Waris Farooka M.
Warren O.
Waseem S.
Wasim T.
Watson D.
Watson L. J.
Watson N.
Weaver H.
Webber L.
Weitz J.
Welsch T.
Wensley F.
Werner J.
West C.
West D.
Westwood E.
Whelan M.
Whelan P.
Whisker L.
Whitehall E.
Whitmore H.
Wilkin R.
Wilkins A.
Williams G.
Williams J.
Williams K.
Williams M. A.
Williams T.
Williamson K.
Wilson M.
Wimberger P.
Wimmer A.
Winnand P.
Winter D.
Winter S.
Wolfer S.
Wong M. P. K.
Wong S.
Wong W. J.
Woodham A.
Woodun H.
Worku D.
Wright G.
Wullschleger M.
Wustrack R.
Xenaki S.
Xu M. J.
Xyda S. E.
Xynos E.
Yahaya A. S.
Yanez C.
Yang W.
Yassin N.
Ye G.
Yesantharao P.
Yesilyurt D.
Yetkin G.
Yiallourou A.
Yildirim A.
Yildiz A.
Ying Y.
Yip V.
Yordanov S.
Young R.
Yousof E. A.
Youssef A.
Youssef M.
Yuksel E.
Yurttas C.
Zacharoulis D.
Zafar S. N.
Zakai D.
Zakaria A. D.
Zakaria R.
Zakaria Z.
Zambelli M. F.
Zambon M.
Zamora L.
Zamvar V.
Zani S.
Zanotti S.
Zanus G.
Zapardiel I.
Zarabini A. G.
Zatecky J.
Zegarac M.
Zelic M.
Zeller N.
Zengin A. K.
Zerbib P.
Zervas K.
Zese M.
Zhang H.
Zivanovic M.
Zivkovic M.
Zizzo M.
Zografos C.
Zonta S.
Zorrilla Ortuzar J.
Zourntou S.
Zouzoulas D.
Zubaidi A.
Zullo A.
Publication venue: 'American Society of Clinical Oncology (ASCO)'
Publication date: 01/01/2021
Field of study

PURPOSE As cancer surgery restarts after the first COVID-19 wave, health care providers urgently require data to determine where elective surgery is best performed. This study aimed to determine whether COVID-19–free surgical pathways were associated with lower postoperative pulmonary complication rates compared with hospitals with no defined pathway. PATIENTS AND METHODS This international, multicenter cohort study included patients who underwent elective surgery for 10 solid cancer types without preoperative suspicion of SARS-CoV-2. Participating hospitals included patients from local emergence of SARS-CoV-2 until April 19, 2020. At the time of surgery, hospitals were defined as having a COVID-19–free surgical pathway (complete segregation of the operating theater, critical care, and inpatient ward areas) or no defined pathway (incomplete or no segregation, areas shared with patients with COVID-19). The primary outcome was 30-day postoperative pulmonary complications (pneumonia, acute respiratory distress syndrome, unexpected ventilation). RESULTS Of 9,171 patients from 447 hospitals in 55 countries, 2,481 were operated on in COVID-19–free surgical pathways. Patients who underwent surgery within COVID-19–free surgical pathways were younger with fewer comorbidities than those in hospitals with no defined pathway but with similar proportions of major surgery. After adjustment, pulmonary complication rates were lower with COVID-19–free surgical pathways (2.2% v 4.9%; adjusted odds ratio [aOR], 0.62; 95% CI, 0.44 to 0.86). This was consistent in sensitivity analyses for low-risk patients (American Society of Anesthesiologists grade 1/2), propensity score–matched models, and patients with negative SARS-CoV-2 preoperative tests. The postoperative SARS-CoV-2 infection rate was also lower in COVID-19–free surgical pathways (2.1% v 3.6%; aOR, 0.53; 95% CI, 0.36 to 0.76). CONCLUSION Within available resources, dedicated COVID-19–free surgical pathways should be established to provide safe elective cancer surgery during current and before future SARS-CoV-2 outbreaks

Archivio istituzionale della Ricerca - Università degli Studi di Parma

Oral L-citrulline supplementation enhances cycling time trial performance in healthy trained men: Double-blind randomized placebo-controlled 2-way crossover study

Author: A Petroczi
A Sureda
A Vanhatalo
AM Jones
AW Leung
Ayako Kamimura
B Campbell
C Foster
C Maxwell
C Moinard
DH Kim
DP Wilkerson
E Curis
E Schwedhelm
EW Albrecht
FJ Larsen
FJ Larsen
G Wu
GS Palmer
H Tuzcu
HH Schmidt
J Nagashima
J Perez-Guisado
JN Mayo
K Akashi
K Currell
K Koppo
K Matsumoto
K Yamada
KE Lansley
KE Lansley
KN Heo
L Castillo
M Hecker
M Munder
M Ochiai
Masahiko Morita
ME Tschakovsky
MJ Romero
MJ Romero
MP Tarazona-Diaz
N Nagai
NM Cermak
O Fricke
PB Laursen
PT Cutrufello
R Bescos
RC Hickner
SJ Bailey
SJ Bailey
SJ Bailey
ST Watts
T Abe
T Hayashi
T Hayashi
T Sugino
Takashi Suzuki
TS Alvares
W Shen
Y Hotta
Y Yabuki
Yoshinori Kobayashi
Publication venue: 'Springer Science and Business Media LLC'
Publication date
Field of study

Crossref

A multicentric prospective analysis of maxillofacial trauma in the elderly population

Author: Aladelusi T.
Alalawy H.
Aquilina P.
Bescos C.
Bojino A.
Bottini G. B.
Carlaw K.
Copelli C.
de Oliveira Gorla L. F.
Duran-Valles F.
Gallafassi D.
Ganasouli D.
Goetzinger M.
Hassanein A. G.
Iocca O.
Jaisani M. R.
Kamel M.
Laverick S.
Pereira-Filho V. A.
Perez Faverani L.
Rae E.
Rahman S. A.
Rahman T.
Roccia F.
Romeo I.
Samieirad S.
Segura-Palleres I.
Sobrero F.
Zanakis S. N.
Publication venue
Publication date: 01/01/2022
Field of study

Background/Aims: The growth of the global elderly population will lead to an increase in traumatic injuries in this group, including those affecting the maxillofacial area, with a heavier load on health systems. The aim of this multicentric prospective study was to understand and evaluate the incidences, causes and patterns of oral and maxillofacial injuries in patients aged over 60 years admitted to 14 maxillofacial surgical departments around the world. Methods: The following data were collected: gender, cause and mechanism of maxillofacial fracture, alcohol and drug abuse at the time of trauma, fracture site, Facial Injury Severity Scale score, associated injury, day of trauma, timing and type of treatment and length of hospitalization. Statistical analyses were performed using non-parametric and association tests, as well as linear regression. Results: Between 30 September 2019 and 4 October 2020, 348 out of 2387 patients (14.6%), 197 men and 151 women (ratio 1.3:1; mean age 72.7 years), were hospitalized. The main causes of the maxillofacial fractures were falls (66.4%), followed by road traffic accidents (21.5%) and assaults (5.2%). Of the 472 maxillofacial fractures, 69.7% were in the middle third of the face, 28% in the lower third and 2.3% in the upper third. Patients with middle third fractures were on average 4.2 years older than patients with lower third fractures (95% CI 1.2–7.2). Statistical analysis showed that women were more involved in fall-related trauma compared with males (p <.001). It was also shown that road traffic accidents cause more fractures in the lower third (p <.001) and in the middle third-lower third complex compared with upper third (p <.001). Conclusions: Maxillofacial fractures in the elderly were more frequent in European and Australian centres and affected men slightly more than women. Falls were the leading cause of fractures, especially among women. The middle third of the face was most often affected, and conservative treatment was the most common choice for the management of such patients

Archivio istituzionale della ricerca - Università di Bari

The Effect of Variable Doses of Inorganic Nitrate-Rich Beetroot Juice on Simulated 2000-m Rowing Performance in Trained Athletes

Author: Bailey SJ
Bailey SJ
Bescos R
Bescós R
Bond H
Campbell B
Cermak NM
Gillies EM
Hopkins WG
Hopkins WG
Hopkins WG
Hord NG
Jeacocke NA
Joyner MJ
Joyner MJ
Jungersten L
Kyparos A
Lansley KE
Lansley KE
Larsen FJ
Larsen FJ
Lundberg JO
Lundberg JO
Marechal G
Murphy M
Peacock O
Pennington JAT
Perez-Guisado J
Schena F
Tanaka T
Vanhatalo A
Vincent SR
Wilkerson DP
Wylie LJ
Wylie LJ
Publication venue: 'Human Kinetics'
Publication date: 01/01/2014
Field of study

Crossref

ACU Research Bank

The health of the Roma people: a review of the published literature

BACKGROUND—The Roma people originated in northern India and have been known in Europe for nearly a thousand years. For much of that time they have been the subjects of discrimination and oppression, culminating in the extermination of half a million Roma in the Nazi death camps. While it is widely believed that the health of Roma people is often poorer than the majority population, these inequalities remain largely unresearched. METHODS—Published literature on the health of the Roma people was identified using Medline. Opinion pieces were excluded, as were papers relating to anthropometry and to genetic markers. The resultant papers were analysed by country of study and by disease type or care group. RESULTS—Some 70% of papers identified related to just three countries; Spain and the Czech and Slovak Republics. Much literature concentrates upon communicable disease or reproductive health. The limited evidence suggests increased morbidity from non-communicable disease, but there is little published on this topic. Evidence on health care, though fragmentary, suggests poorer access to health services and uptake of preventative care. DISCUSSION—Published research on the health needs of the Roma population is sparse. The topics that have received attention suggest a focus on concepts of contagion or social Darwinism, indicating a greater concern with the health needs of the majority populations with which they live. There is a need for both further research into the health of Roma people; with particular emphasis on non-communicable disease; and also for interventions that improve Roma health. Such research must, however, be handled with sensitivity, recognising the social and political context of the society concerned.   Keywords: gypsies; inequalities; ethnicity; social exclusio

Crossref

PubMed Central

Head and neck cancer surgery during the COVID-19 pandemic: An international, multicenter, observational cohort study

Author: Abbott T.
Abbott T. E. F.
Abdallah M.
Abdelkarem M. M.
Abdulkareem A.
Abellan M.
Abou Chaar M. K.
Abouassi A.
Abur P. P.
Achalandabaso B. M.
Adamina M.
Adamoli L.
Ademuyiwa A. O.
Agarwal A.
Aguilera Lorena M.
Ahad S.
Akeel N.
Al H. H.
Al-Masri M.
Al-Najjar H.
Alakaloko F.
Alameer E.
Alawneh F.
Albertsmeiers M.
Alcaide M. F.
Alderson D.
Alexoudi V.
Alfaro-Goldaracena A.
Alhassan B.
Alhefdhi A.
Alintoprak F.
Alkarak S.
Allison J.
Almasri M.
Almeida A.
Alomair A.
Alonso-Lamberti L.
Alotaibi N.
Alqannas M.
Alresaini F.
Alsaif A.
Alsalamah R.
Alsaraireh O.
Alser O.
Alshaar M.
Alshahrani M.
Alsharif F.
Alshryda S.
Alsobhi S.
Alvarez M. R.
Alyami M.
Alzamanan M.
Ameerally P.
Ansarin M.
Antic S.
Antoniades K.
Anula R.
Anwar S.
Aoun S. G.
Arnaud A. P.
Arrangoiz R.
Ashcroft J.
Astreidis I.
Augestad K. M.
Ayasra F.
Ayub B.
Azam M.
Azevedo J.
Baietti A. M.
Balercia P.
Ballouhey Q.
Ban V. S.
Bandovas J. P.
Bankhead-Kendall B. K.
Barbier L.
Barlow E.
Barrabe A.
Barry C. P.
Batjer H. H.
Batstone M.
Batstone M.
Batstone M.
Bayhan Z.
Beasley N.
Becerra Garcia F. C.
Beech N.
Bekheit M.
Bellanti L.
Beltramini G. A.
Benkabbou A.
Benson R. A.
Benson R. A.
Bergonzani M.
Bertelli G.
Bertoli G.
Bescos C.
Beswick D.
Bettoni J.
Betz C. S.
Bewarder J.
Bhangu A.
Bhangu A.
Biasini M.
Bissolotti G.
Blanco-Colino R.
Boccalatte L. A.
Boeck M.
Bokhari A.
Borges N.
Bottcher A.
Boucher S.
Bowden J.
Brana I.
Brar A.
Breda D.
Breen K. A.
Breheret R.
Breik O.
Bretherton C.
Brown L.
Buarque I. L.
Buerba G. A.
Burg S.
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Burgess C.
Burke J.
Busch C. J.
Bussu F.
Buta M.
Bywater E.
Caimari B.
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Campisi G.
Cano-Valderrama O.
Cao H.
Capoglu R.
Carabias A.
Carrasco P. M.
Caruana E. J.
Caruso J.
Catarzi L.
Cavaleiro S.
Cayetano P. L.
Chaar M.
Chai A. K. W.
Chakrabortee S.
Chan C.
Chaudhry D.
Chew D.
Chidambaram S.
Chiesa-Estomba C. M.
Choudhry A.
Christensen P.
Christidis P.
Chu F.
Chumbinho B.
Cicconi S.
Cicconi S.
Cipriani R.
Citgez B.
Colak E.
Colao G. L.
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Collard B.
Comini L. V.
Consorti G.
Cope D.
Cordera F.
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Cotoia A.
Coughlin P.
Cox D.
Cukier M.
Cunha M. F.
Cvetkovic A.
Cymes W.
D'Angelo G.
Dafnios N.
Dakpe S.
Davidson G. H.
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De Barros J.
De Berardinis R.
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De La Cruz Monroy M. F. I.
De Oliveira Lopez A. L.
De Pablo Garcia-Cuenca A.
De Virgilio A.
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Deligiannidis D.
Demirli Atici S.
Desai A.
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Di Martino M.
Diez-Valladares L.
Djurisic I.
Dominguez I.
Drake T. M.
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Elhusseini M.
Elliott M.
Emile S.
Enjuto D.
Eskander M.
Espino Segura-Illa M.
Espinosa C. A.
Espitalier F.
Etchill E.
Ethunandan M.
Evans J. P.
Faria C. S.
Farik S.
Farsi A.
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Faustino A.
Fernandes V.
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Ferraz I.
Ferreli F.
Ferron C.
Figari M. F.
Figueiredo de Barros I.
Fiore M.
Fiore M.
Firat N.
Fitzgerald C.
Fitzgerald J. E.
Flavin M.
Fleming J.
Ford S.
Frade S.
Franza M.
Fraser L.
Freitas A.
Fu H.
Fullmer T.
Fusetti S.
Fuson A.
Gabre-Kidan A.
Gacic S.
Gaino F.
Galis B.
Gallo G.
Galvao D.
Ganly I.
Ganly I.
Ganly I.
Garcia A. M.
Garcia Perez J. M.
Garcia R. E.
Garcia-Quijada J.
Garcia-Sancho Tellez L.
Garmanova T.
Garrido R.
Garrido S.
Gasparini G.
Gatti A.
Geddes A.
Ghazali N.
Ghosh D.
Ghufoor K.
Gianni' A.
Giannini L.
Gibson D.
Gigliotti J.
Gill C.
Gimenez F. C.
Giralt Lopez de Sagredo J.
Gkrinia E.
Glasbey J.
Glasbey J.
Glasbey J. C.
Glasbey J. C.
Goddard J.
Gomes G. M. A.
Gomes J.
Gomez Diaz C. J.
Gomez F. L.
Gomez L. L.
Gomez-Pedraza A.
Gonullu E.
Gonzalez Garcia J. A.
Goran M.
Gordini L.
Gore S.
Gosau M.
Graystone J.
Grecinos G.
Green L.
Griffiths E. A.
Grivas T.
Gross N.
Grundl M.
Gueutier A.
Gujjuri R. R.
Ha P. K.
Habeeb A.
Hajiioannou J.
Halkias C.
Halliday E.
Hannah A.
Hardie C.
Hardie J.
Harries R.
Harrison E. M.
Hassan N.
Heaton C. M.
Henry A.
Heras A. J.
Heritage E.
Hernandez Bartolome M. A.
Hisham I.
Ho M. W. S.
Ho M. W. S.
Ho M. W. S.
Holzle F.
Houston R.
Howe D.
Huang L.
Humphries S.
Hutchinson P. J.
Hwang S.
Ibrahim A.
Idle M.
Inic Z.
Ioannidis O.
Ionescu A.
Irune E.
Isik A.
Jackson R.
Jackson R.
Jariod Ferrer U. M.
Jeftic N.
Jelovac D.
Jenkinson M. D.
Jenny H.
Jevric M.
Jezdic Z.
Jimenez T. M.
Jimenez V.
Jokic V.
Jones C. S.
Jones T.
Jonker P.
Jotic A.
Kaafarani H. M. A.
Kahn A.
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Kam da Silva Andrade A.
Kamarajah S. K.
Kanatas A.
Kang C.
Kauffmann P.
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Keatley J. M.
Kent A.
Khatkar H.
Khatri C.
Khaw R. A.
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King E.
Kinsella J.
Kiong K.
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Kleeff J.
Knight A.
Knitschke M.
Kocer B.
Koenig D.
Kolias A.
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Korais C.
Kornblith L.
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Kovacevic B.
Krdzic I.
Kruijff S.
Kucuk G. O.
Kulkarni G.
Kumar A.
Kun-Darbois J.
Kuzmanovic C.
Ladd M. R.
Laloze J.
Lami M.
Lanfranco D.
Larranaga J. J.
Larruscain E.
Lau K.
Lavagen N.
Lawani I.
Lawday S.
Lazaro A.
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Lederhuber H.
Lee R. H.
Lemma F.
Lennon P.
Lester S.
Leventoglu S.
Li E.
Li Z.
Liew Y. T.
Lin D. J.
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Litvin A.
Lizzi V.
Loehrer A.
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Manickavasagam J.
Mann H. S.
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Marco G. A.
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Salgado I.
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Sanchez del Pueblo C.
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Sanz Ortega G.
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Saponaro G.
Saratziotis A.
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Sayyed R.
Schache A.
Schache A. G.
Schache A. G.
Schache A. G.
Schilling C.
Schneider R.
Schnitzbauer A. A.
Scott R.
Scurrah R.
Sekhon G. K.
Selbong U.
Serralta de Colsa D.
Serrano Gonzalez J.
Seyi-Olajide J. O.
Shahine M.
Sharma N.
Sharma N.
Shaw R.
Shaw R.
Shaw R.
Shaw R.
Shaw S.
Sheahan P.
Shields H.
Sholadoye T. T.
Shu S.
Siaw-Acheampong K.
Silva N.
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Silveira H.
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Singh A.
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Sinha D.
Sistiaga-Suarez J. A.
Skoulakis C.
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Smeets R.
Smolka W.
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Song J.
Soreide K.
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Spinelli A.
Spriano G.
Spurnic I.
Stavroglou A.
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Sundar S.
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Taylor E. H.
Teixeira M.
Testelin S.
Thiruchelvam J.
Thole S.
Thomas E.
Thompson A.
Thompson D.
Tilaveridis I.
Timon C.
Tiwari A.
Toia F.
Tolani M. A.
Torres A.
Torretta S.
Tousidonis M.
Townend P.
Trabulsi N.
Trivic A.
Troncoso P. P.
Trout I. M.
Tsai L.
Tsoulfas G.
Uludag M.
Uson-Bouthelier T.
Usseglio J.
Uyanik M. S.
Vahtsevanos K.
Valle Rubio A.
van der Plas W.
van Ramshorst G. H.
Varazzani A.
Varley I.
Velagapudi S.
Venetis G.
Venn M. L.
Vervoort D.
Vidya R.
Vieira A.
Vimalachandran D.
Vo U. G.
Vollkommer T.
Vovola F.
Vucic N.
Vujanac V.
Wai K. C.
Walker C.
Walker D.
Walton G.
Warren O. J.
Waseem S.
Wedderburn D.
Wensley F.
Wilkin R. J. W.
Williams T.
Winnand P.
Winter S. C.
Winter S. C.
Winter S. C.
Wolfer S.
Wright N.
Xu M. J.
Yesantharao P.
Ying Y.
Zakai D.
Zarabini A. G.
Zeller N.
Publication venue: 'Wiley'
Publication date: 01/01/2021
Field of study

Background: The aims of this study were to provide data on the safety of head and neck cancer surgery currently being undertaken during the coronavirus disease 2019 (COVID-19) pandemic. Methods: This international, observational cohort study comprised 1137 consecutive patients with head and neck cancer undergoing primary surgery with curative intent in 26 countries. Factors associated with severe pulmonary complications in COVID-19–positive patients and infections in the surgical team were determined by univariate analysis. Results: Among the 1137 patients, the commonest sites were the oral cavity (38%) and the thyroid (21%). For oropharynx and larynx tumors, nonsurgical therapy was favored in most cases. There was evidence of surgical de-escalation of neck management and reconstruction. Overall 30-day mortality was 1.2%. Twenty-nine patients (3%) tested positive for severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) within 30 days of surgery; 13 of these patients (44.8%) developed severe respiratory complications, and 3.51 (10.3%) died. There were significant correlations with an advanced tumor stage and admission to critical care. Members of the surgical team tested positive within 30 days of surgery in 40 cases (3%). There were significant associations with operations in which the patients also tested positive for SARS-CoV-2 within 30 days, with a high community incidence of SARS-CoV-2, with screened patients, with oral tumor sites, and with tracheostomy. Conclusions: Head and neck cancer surgery in the COVID-19 era appears safe even when surgery is prolonged and complex. The overlap in COVID-19 between patients and members of the surgical team raises the suspicion of failures in cross-infection measures or the use of personal protective equipment. Lay Summary: Head and neck surgery is safe for patients during the coronavirus disease 2019 pandemic even when it is lengthy and complex. This is significant because concerns over patient safety raised in many guidelines appear not to be reflected by outcomes, even for those who have other serious illnesses or require complex reconstructions. Patients subjected to suboptimal or nonstandard treatments should be carefully followed up to optimize their cancer outcomes. The overlap between patients and surgeons testing positive for severe acute respiratory syndrome coronavirus 2 is notable and emphasizes the need for fastidious cross-infection controls and effective personal protective equipment

Archivio istituzionale della Ricerca - Università degli Studi di Parma

PubliCatt

Archivio Istituzionale della Ricerca- Università degli Studi di Foggia

IRIS UniversitÃ Politecnica delle Marche

Preoperative nasopharyngeal swab testing and postoperative pulmonary complications in patients undergoing elective surgery during the SARS-CoV-2 pandemic.

Author: Aawsaj Y
Abad Gurumeta A
Abad-Motos A
Abate E
Abatini C
Abbadessa F
Abbas AM
Abbassi-Ghadi N
Abbott D
Abbott T
Abbott TEF
Abd Elazeem HAS
Abdalla M
Abdallah M
Abdelaal SA
Abdeldayem H
Abdelkarem MM
Abdelkarim M
Abdelmajeed A
Abdelrahman A
Abdelrahman S
Abdelsamed A
Abdou M
Abdulkareem A
Abdulwahed E
Abdur-Rahman L
Abel MK
Abellan M
Abosamak NE
Abou Chaar MK
Abou-Khalil J
Abouassi A
Aboulkassem H
Abreu da Silva A
Abu Za'nouneh FJ
Abu J
Abu-Nayla I
Abubakar A
Abukhalaf S
Acebes Garcia F
Achalandabaso Boira M
Acher A
Acrich E
Adamina M
Adamina M
Adamoli L
Addae-Boateng E
Ademuyiwa AO
Aderombi A
Adeyeye A
Adiamah A
Adishesh M
Agapov M
Agarwal A
Aggarwal A
Aghayeva A
Agilinko J
Agnes A
Agostini C
Agoston P
Agrawal A
Agresta F
Aguado H
Aguzzoli L
Ahad S
Ahmadi N
Ahmed NR
Ahmeidat A
Ahn JH
Aiken T
Aime A
Ajlan A
Akalin M
Akaydin E
Akeel N
Akgor U
Akhtar MA
Akilli H
Akin E
Akkour K
Akkulak M
Akmenkalne L
Al Abdallah M
Al Abdel S
Al Awwad S
Al Habes H
Al Maadany FS
Al Raddadi R
AL Sayed M
Al-Habib A
Al-Habsi R
Al-Ishaq Z
Al-Khayal K
Al-Masri M
Al-Mohammad A
Al-mukhtar A
Al-Najjar H
Al-omishy H
Al-Sarireh B
Al-Tamimi Y
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EuroSurg
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Eveno C
Evoy D
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Feo CF
Feo CV
Fernandes U
Fernandes V
Fernandez Bernabe P
Fernandez Camunas A
Fernandez Pablos FJ
Fernandez Rodriguez P
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Fernandez PV
Fernandez-Lopez A
Fernando D
Ferrari F
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Ferraz I
Ferreira Pinto AP
Ferreira C
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Fidalgo H
Fidelis L
Figari M
Figueiredo de Barros I
Findlay L
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Fiore M
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Foo CC
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Fordington S
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Foulkes R
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Frena A
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Freyschlag C
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Frio F
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Fritzmann J
Frongia F
Fruscio R
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Fulginiti SF
Fullmer T
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Gabre-Kidan A
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Gagliardi F
Gahunia S
Gaino F
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Galliamov E
Gallo G
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Garberini DMA
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Garcia Gutierrez JJ
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Garcia Pineda V
Garcia Porcel VJ
Garcia Rico E
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Garcia Santos EP
Garcia Senorans PM
Garcia Septiem J
Garcia Soria V
Garcia Villayzan JE
Garcia JS
Garcia PM
Garcia-Conde M
Garcia-Loarte Gomez E
Garcia-Moreno Nisa F
Garcia-Quijada J
Garcia-Sancho Tellez L
Garfinkle R
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Gascon Ferrer I
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Gaskill C
Gasparini G
Gata V
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Gavalda Pellice MGP
Gearon D
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Gegundez Simon A
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Gemmell C
Gemmill E
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Gennaro M
Gentilli S
Georgiades F
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Gerchunoff JI
Geretto P
Ghallab I
Ghaly G
Ghamgh R
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Ghannam A
Ghazali N
Ghebre R
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Ginesu GC
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Giralt Lopez de Sagredo J
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Gkekas I
Gklavas A
Gkrinia E
Glasbey JC
Glasbey JC
Glasbey JC
Glasbey JC
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Glencer A
GlobalPaedSurg
GlobalSurg
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Golda T
Gomes da Costa A
Gomes GMA
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Gomez Diaz CJ
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Gomez Latorre L
Gomez Portugal PE
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Gomez Sanz T
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Gonzalez Valverde FM
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Gonzalez J
Gonzalez-Gonzalez E
Gonzalez-Nicolas Trebol MT
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Gracia-Roche C
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Grau-Talens EJ
Graystone J
Grechenig M
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Gricks B
Grieco C
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Griffiths E
Griffiths EA
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Griffiths O
Grigoroiu M
Grilo JV
Grimaldi DMS
Grimes H
Grimley E
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Guariglia CA
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Publication venue: Br J Surg
Publication date: 11/11/2020
Field of study

BACKGROUND: Surgical services are preparing to scale up in areas affected by COVID-19. This study aimed to evaluate the association between preoperative SARS-CoV-2 testing and postoperative pulmonary complications in patients undergoing elective cancer surgery. METHODS: This international cohort study included adult patients undergoing elective surgery for cancer in areas affected by SARS-CoV-2 up to 19 April 2020. Patients suspected of SARS-CoV-2 infection before operation were excluded. The primary outcome measure was postoperative pulmonary complications at 30 days after surgery. Preoperative testing strategies were adjusted for confounding using mixed-effects models. RESULTS: Of 8784 patients (432 hospitals, 53 countries), 2303 patients (26.2 per cent) underwent preoperative testing: 1458 (16.6 per cent) had a swab test, 521 (5.9 per cent) CT only, and 324 (3.7 per cent) swab and CT. Pulmonary complications occurred in 3.9 per cent, whereas SARS-CoV-2 infection was confirmed in 2.6 per cent. After risk adjustment, having at least one negative preoperative nasopharyngeal swab test (adjusted odds ratio 0.68, 95 per cent confidence interval 0.68 to 0.98; P = 0.040) was associated with a lower rate of pulmonary complications. Swab testing was beneficial before major surgery and in areas with a high 14-day SARS-CoV-2 case notification rate, but not before minor surgery or in low-risk areas. To prevent one pulmonary complication, the number needed to swab test before major or minor surgery was 18 and 48 respectively in high-risk areas, and 73 and 387 in low-risk areas. CONCLUSION: Preoperative nasopharyngeal swab testing was beneficial before major surgery and in high SARS-CoV-2 risk areas. There was no proven benefit of swab testing before minor surgery in low-risk areas

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Archivio istituzionale della ricerca - Università di Palermo

Crossref

AIR Universita degli studi di Milano

UCL Discovery

eScholarship - University of California

Archivio istituzionale della ricerca - Alma Mater Studiorum Università di Bologna

IRIS UniversitÃ Politecnica delle Marche

Apollo (Cambridge)

Bern Open Repository and Information System (BORIS)

Ezetimibe added to statin therapy after acute coronary syndromes

Author: Aagnes I
Aambakk MB
Aase O
Aaser E
Abdel-Latief A
Abell T
Aboufakher R
Abramson B
Abrantes J
Achilli A
Adams A
Adams K
Adamus J
Addington J
Adgey A
Adjei A
Agarwal J
Aggarwal A
Aggarwal K
Aggarwal R
Agocha A
Agraou B
Aguirre O
Ahmed A
Ahmed O
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Édes I
Östberg S
Publication venue: 'Massachusetts Medical Society'
Publication date: 01/01/2015
Field of study

BACKGROUND: Statin therapy reduces low-density lipoprotein (LDL) cholesterol levels and the risk of cardiovascular events, but whether the addition of ezetimibe, a nonstatin drug that reduces intestinal cholesterol absorption, can reduce the rate of cardiovascular events further is not known. METHODS: We conducted a double-blind, randomized trial involving 18,144 patients who had been hospitalized for an acute coronary syndrome within the preceding 10 days and had LDL cholesterol levels of 50 to 100 mg per deciliter (1.3 to 2.6 mmol per liter) if they were receiving lipid-lowering therapy or 50 to 125 mg per deciliter (1.3 to 3.2 mmol per liter) if they were not receiving lipid-lowering therapy. The combination of simvastatin (40 mg) and ezetimibe (10 mg) (simvastatin-ezetimibe) was compared with simvastatin (40 mg) and placebo (simvastatin monotherapy). The primary end point was a composite of cardiovascular death, nonfatal myocardial infarction, unstable angina requiring rehospitalization, coronary revascularization ( 6530 days after randomization), or nonfatal stroke. The median follow-up was 6 years. RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001). The Kaplan-Meier event rate for the primary end point at 7 years was 32.7% in the simvastatin-ezetimibe group, as compared with 34.7% in the simvastatin-monotherapy group (absolute risk difference, 2.0 percentage points; hazard ratio, 0.936; 95% confidence interval, 0.89 to 0.99; P = 0.016). Rates of pre-specified muscle, gallbladder, and hepatic adverse effects and cancer were similar in the two groups. CONCLUSIONS: When added to statin therapy, ezetimibe resulted in incremental lowering of LDL cholesterol levels and improved cardiovascular outcomes. Moreover, lowering LDL cholesterol to levels below previous targets provided additional benefit

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