Espacios de igualdad entre las competencias profesionales: "el ejemplo de los Talleres Juveniles Brumas"

El presente proyecto recoge la experiencia del Programa de PCPI en Ayudante Técnico en Alojamientos y Catering, desarrollado por la ONG Asociación Cántabra de Lucha Contra el Paro, Los Talleres Juveniles Brumas, dentro de uno de sus proyectos: "El Proyecto Altamira". Dirigido a mujeres jóvenes de entre 15 y 25 años. Su principal objetivo es la inserción sociolaboral de dichas jóvenes, a través de la mejora de su bienestar personal, de la cualificación para el empleo o el acompañamiento en su participación en el mercado de trabajo.Grado en Educación Socia

Técnicas cromatográficas utilizadas en monitorización ambiental

Máster en Enxeñaría AmbientalO Máster de Enxeñería Ambiental impártese na Escola Técnica Superior de Enxeñería (ETSE) da Universidade de Santiago de Compostela, cuns 30 estudantes anuais de nova matrícula. Consta de 90 créditos ECTS e realízase nun período de 18 meses. No primeiro ano (60 ECTS) impártense cinco módulos, que se distribúen dende setembro a xullo. No segundo ano (30 ECTS), nos dous primeiros meses impártense as clases teóricas do módulo seis e o resto dos meses dedícanse ao Proxecto Fin de Máster. Os módulos impartidos nos dous anos de Máster son os que se indican a continuación: Primeiro ano: Módulo I: Fundamentos. Módulo II: Tratamento de Augas Módulo III: Monitorización e Redución da Contaminación Atmosférica Instrumentación e Monitorización Ambiental(IMA) Medio Ambiente e Redución de Emisións Técnicas de Análise Territorial Laboratorio de Modelización Módulo IV: Recuperación de Solos e Xestión de Residuos Módulo V: Prácticas externas Segundo ano: Módulo VI: Xestión Ambiental. Módulo VII: Proxecto Fin de Máster. A materia de Instrumentación e Monitorización Ambiental (IMA) é unha materia obrigatoria de 3 créditos ECTS do Módulo III (Monitorización e redución da contaminación atmosférica). Os contidos impartidos en IMA introducen o alumno nas diferentes técnicas instrumentais empregadas na monitorización ambiental, dende a etapa de mostraxe ata a análise das mostras no laboratorio. O número de horas presenciais é 28, das cales 9 se empregan para o estudo da cromatografía. No primeiro tema da materia estúdase a colección e tratamento da mostra previamente á análise. No segundo tema trátanse os métodos espectroscópicos, fundamentais para realizar un número moi elevado de análises. E por fin, no tema 3 trátanse os métodos cromatográficos, xa que unha vez que temos preparada a mostra e antes de realizar unha cuantificación dun composto, por exemplo utilizando métodos espectroscópicos, frecuentemente é necesario levar a cabo unha separación cromatográfica de dito composto para evitar a presenza doutras sustancias que interfiren na determinación. Así, as técnicas cromatográficas son un grupo de potentes ferramentas de separación, identificación e determinación de compostos químicos en mesturas complexas. Polo tanto son fundamentais nos laboratorios de análise, xa que a maior parte das mostras que chegan a eles son mostras complexas, xa sexa no ámbito clínico, industrial ou medioambiental. Tralo tema de cromatografía trátanse os sensores (tema 4) e os sensores remotos (tema 5). En ámbolos dous casos, o obxectivo é realizar as medicións do modo máis sinxelo posible, a ser posible sen separación previa. Por último, nos temas finais do curso tamén se tratarán algunhas aplicacións da cromatografía relacionadas coa análise de contaminantes en chemineas e nas medidas da calidade de aire.Universidade de Santiago de Compostela. Servizo de Normalización Lingüístic

In Vitro and In Vivo Activity of Citral in Combination with Amphotericin B, Anidulafungin and Fluconazole against Candida auris Isolates

Candida auris is an emerging fungal pathogen responsible for hospital outbreaks of invasive candidiasis associated with high mortality. The treatment of these mycoses is a clinical challenge due to the high resistance levels of this species to current antifungal drugs, and alternative therapeutic strategies are needed. In this study, we evaluated the in vitro and in vivo activities of combinations of citral with anidulafungin, amphotericin B or fluconazole against 19 C. auris isolates. The antifungal effect of citral was in most cases similar to the effect of the antifungal drugs in monotherapy. The best combination results were obtained with anidulafungin, with synergistic and additive interactions against 7 and 11 of the 19 isolates, respectively. The combination of 0.06 μg/mL anidulafungin and 64 μg/mL citral showed the best results, with a survival rate of 63.2% in Caenorhabditis elegans infected with C. auris UPV 17-279. The combination of fluconazole with citral reduced the MIC of fluconazole from > 64 to 1–4 μg/mL against 12 isolates, and a combination of 2 μg/mL fluconazole and 64 μg/mL citral was also effective in reducing mortality in C. elegans. Amphotericin B combined with citral, although effective in vitro, did not improve the activity of each compound in vivo.The research group was funded by the Consejería de Educación, Universidades e Investigación (GIC IT-1607-22) of Gobierno Vasco-Eusko Jaurlaritza and by the Spanish Ministry of Science and Innovation (PID2020-117983RB-I00)

Desarrollo de un sistema de gestión de investigación (CRIS) para la consolidación del Repositorio Institucional NINIVE de la Universidad Autónoma de San Luis Potosí

La Biblioteca Virtual Universitaria (BVU) de la Universidad Autónoma de San Luis Potosí (UASLP) fue creada en el 2006 bajo un modelo propio como parte de la estructura del Sistema de Bibliotecas. El Repositorio Institucional NINIVE, implementado por la BVU en el 2012 contiene a la fecha (agosto de 2016) más de 2,450 documentos digitales entre tesis de licenciatura y posgrado, libros, artículos de revistas universitarias, objetos de aprendizaje e informes de Rectoría. Para la consolidación del Repositorio Institucional NINIVE en una primera fase, se presentó un proyecto para su financiamiento en la Convocatoria publica 2015 del Consejo Nacional de Ciencia y Tecnología (CONACYT), mismo que fue aprobado para su ejecución durante el periodo junio – noviembre de 2016. El proyecto consiste en desarrollar un Modelo de Servicios para la consolidación del Repositorio Institucional NINIVE de la UASLP. Uno de sus objetivos o componentes principales es el desarrollo a nivel prototipo de un Sistema Institucional de Gestión de Investigación (SIGI) bajo un modelo de CRIS (Current Research Information System), como una estrategia de sensibilización y promoción con la comunidad científica para el deposito o auto archivo de las publicaciones y productos de investigación en el Repositorio NINIVE. Para la implementación del sistema se proponen cinco estrategias generales: 1) Realizar un estudio de benchmarking; 2) Diseñar el currículum universitario u hoja del vida del investigador; 3) Adoptar el estándar internacional ORCID para generar los identificadores únicos digitales de los investigadores; 4) Diseñar e implementar los módulos del sistema y aplicaciones (API´s) necesarias para su interoperabilidad; 5) Integrar un grupo piloto de investigadores para fines de retroalimentación, validación y pruebas de usabilidad. El objetivo de esta propuesta es presentar el modelo y arquitectura del sistema SIGI así como también los resultados y avances del proyecto.Ibero-American Science and Technology Education Consortium (ISTEC

Bioaccumulation of titanium dioxide nanoparticles in green (Ulva sp.) and red (Palmaria palmata) seaweed

A bioaccumulation study in red (Palmaria palmata) and green (Ulva sp.) seaweed has been carried out after exposure to different concentrations of citrate-coated titanium dioxide nanoparticles (5 and 25 nm) for 28 days. The concentration of total titanium and the number and size of accumulated nanoparticles in the seaweeds has been determined throughout the study by inductively coupled plasma mass spectrometry (ICP-MS) and single particle-ICP-MS (SP-ICP-MS), respectively. Ammonia was used as a reaction gas to minimize the effect of the interferences in the 48Ti determination by ICP-MS. Titanium concentrations measured in Ulva sp. were higher than those found in Palmaria palmata for the same exposure conditions. The maximum concentration of titanium (61.96 ± 15.49 μg g−1) was found in Ulva sp. after 28 days of exposure to 1.0 mg L−1 of 5 nm TiO2NPs. The concentration and sizes of TiO2NPs determined by SP-ICP-MS in alkaline seaweed extracts were similar for both seaweeds exposed to 5 and 25 nm TiO2NPs, which indicates that probably the element is accumulated in Ulva sp. mainly as ionic titanium or nanoparticles smaller than the limit of detection in size (27 nm). The implementation of TiO2NPs in Ulva sp. was confirmed by electron microscopy (TEM/STEM) in combination with energy dispersive X-Ray analysis (EDX)The authors wish to thank the fnancial support of Ministerio de Economía y Competitividad (project INNOVANANO, reference RT2018-099222-B-100), European Union (INTERREG Atlantic Area, project NANOCULTURE, reference EAPA590/2018), and Xunta de Galicia (Grupo de Referencia Competitiva, grant number ED431C 2022/29)S

Hydroxychloroquine is associated with a lower risk of polyautoimmunity: data from the RELESSER Registry

Objectives. This article estimates the frequency of polyautoimmunity and associated factors in a large retrospective cohort of patients with SLE. Methods. RELESSER (Spanish Society of Rheumatology Lupus Registry) is a nationwide multicentre, hospital-based registry of SLE patients. This is a cross-sectional study. The main variable was polyautoimmunity, which was defined as the co-occurrence of SLE and another autoimmune disease, such as autoimmune thyroiditis, RA, scleroderma, inflammatory myopathy and MCTD. We also recorded the presence of multiple autoimmune syndrome, secondary SS, secondary APS and a family history of autoimmune disease. Multiple logistic regression analysis was performed to investigate possible risk factors for polyautoimmunity. Results. Of the 3679 patients who fulfilled the criteria for SLE, 502 (13.6%) had polyautoimmunity. The most frequent types were autoimmune thyroiditis (7.9%), other systemic autoimmune diseases (6.2%), secondary SS (14.1%) and secondary APS (13.7%). Multiple autoimmune syndrome accounted for 10.2% of all cases of polyautoimmunity. A family history was recorded in 11.8%. According to the multivariate analysis, the factors associated with polyautoimmunity were female sex [odds ratio (95% CI), 1.72 (1.07, 2.72)], RP [1.63 (1.29, 2.05)], interstitial lung disease [3.35 (1.84, 6.01)], Jaccoud arthropathy [1.92 (1.40, 2.63)], anti-Ro/SSA and/or anti-La/SSB autoantibodies [2.03 (1.55, 2.67)], anti-RNP antibodies [1.48 (1.16, 1.90)], MTX [1.67 (1.26, 2.18)] and antimalarial drugs [0.50 (0.38, 0.67)]. Conclusion. Patients with SLE frequently present polyautoimmunity. We observed clinical and analytical characteristics associated with polyautoimmunity. Our finding that antimalarial drugs protected against polyautoimmunity should be verified in future studies

The influence of heart disease on characteristics, quality of life, use of health resources, and costs of COPD in primary care settings

<p>Abstract</p> <p>Background</p> <p>To evaluate the influence of heart disease on clinical characteristics, quality of life, use of health resources, and costs of patients with COPD followed at primary care settings under common clinical practice conditions.</p> <p>Methods</p> <p>Epidemiologic, observational, and descriptive study (EPIDEPOC study). Patients ≥ 40 years of age with stable COPD attending primary care settings were included. Demographic, clinical characteristics, quality of life (SF-12), seriousness of the disease, and treatment data were collected. Results were compared between patients with or without associated heart disease.</p> <p>Results</p> <p>A total of 9,390 patients with COPD were examined of whom 1,770 (18.8%) had heart disease and 78% were males. When comparing both patient groups, significant differences were found in the socio-demographic characteristics, health profile, comorbidities, and severity of the airway obstruction, which was greater in patients with heart disease. Differences were also found in both components of quality of life, physical and mental, with lower scores among those patients with heart disease. Higher frequency of primary care and pneumologist visits, emergency-room visits and number of hospital admissions were observed among patients with heart diseases. The annual total cost per patient was significantly higher in patients with heart disease; 2,937 ± 2,957 vs. 1,749 ± 2,120, p < 0.05. Variables that were showed to be independently associated to COPD in subjects with hearth conditions were age, being inactive, ex-smokers, moderate physical exercise, body mass index, concomitant blood hypertension, diabetes, anxiety, the SF-12 physical and mental components and per patient per year total cost.</p> <p>Conclusion</p> <p>Patients with COPD plus heart disease had greater disease severity and worse quality of life, used more healthcare resources and were associated with greater costs compared to COPD patients without known hearth disease.</p

¿Necesitamos un asistente virtual para apoyo y formación permanente de profesores, alumnos y egresados en nuestra página web?

Se trata de identificar las necesidades no resueltas y otras cuestiones de interés, y proponer la utilización del asistente virtual como herramienta de apoyo en el acceso, la formación presente y futura, con carácter permanente, al alumno y al profesor; ello supone su utilidad en el momento presente y en el futuro, como herramienta de formación y acceso permanente. La originalidad del Proyecto estriba precisamente en el planteamiento de la incorporación de la asistencia virtual e inteligencia artificial para la asistencia y apoyo a los alumnos y profesores. El uso de la tecnología es cada vez más mayor, y puede revertir en beneficio al alumno desde una perspectiva más amplia de la que un profesor individualmente puede ofrecerle; se lograría así el acceso a la información con una intervención humana mínima, en cualquier momento y en cuestiones generales de amplio espectro, al que cada profesor en su especialidad no llega a abarcar, y los programas voluntarios de mentorías tampoco

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Role of age and comorbidities in mortality of patients with infective endocarditis

[Purpose]: The aim of this study was to analyse the characteristics of patients with IE in three groups of age and to assess the ability of age and the Charlson Comorbidity Index (CCI) to predict mortality. [Methods]: Prospective cohort study of all patients with IE included in the GAMES Spanish database between 2008 and 2015.Patients were stratified into three age groups:<65 years,65 to 80 years,and ≥ 80 years.The area under the receiver-operating characteristic (AUROC) curve was calculated to quantify the diagnostic accuracy of the CCI to predict mortality risk. [Results]: A total of 3120 patients with IE (1327 < 65 years;1291 65-80 years;502 ≥ 80 years) were enrolled.Fever and heart failure were the most common presentations of IE, with no differences among age groups.Patients ≥80 years who underwent surgery were significantly lower compared with other age groups (14.3%,65 years; 20.5%,65-79 years; 31.3%,≥80 years). In-hospital mortality was lower in the <65-year group (20.3%,<65 years;30.1%,65-79 years;34.7%,≥80 years;p < 0.001) as well as 1-year mortality (3.2%, <65 years; 5.5%, 65-80 years;7.6%,≥80 years; p = 0.003).Independent predictors of mortality were age ≥ 80 years (hazard ratio [HR]:2.78;95% confidence interval [CI]:2.32–3.34), CCI ≥ 3 (HR:1.62; 95% CI:1.39–1.88),and non-performed surgery (HR:1.64;95% CI:11.16–1.58).When the three age groups were compared,the AUROC curve for CCI was significantly larger for patients aged <65 years(p < 0.001) for both in-hospital and 1-year mortality. [Conclusion]: There were no differences in the clinical presentation of IE between the groups. Age ≥ 80 years, high comorbidity (measured by CCI),and non-performance of surgery were independent predictors of mortality in patients with IE.CCI could help to identify those patients with IE and surgical indication who present a lower risk of in-hospital and 1-year mortality after surgery, especially in the <65-year group