Design and development of a wearable inductive textile sensor to monitor back movements

This thesis focuses on the design and development of a wireless and wearable platform that employs an inductive sensor to track trunk movements when the user bends forward. The inductive textile sensor was designed based on the anthropometrical dimensions of the trunk’s lumbar area of a healthy female. The chosen shape of the sensor was a rectangular flat coil. The inductance behavior was investigated using theoretical calculations and simulations. Formulas developed by Grover and Terman were used to calculate the inductance to validate the inductive textile design. The simulations were used to analyze the change of the inductance when the area, perimeter, height, and width of the rectangle was modified, as well as the effect of the number of turns of the rectangular flat coil. Results from the theoretical calculations and simulations were compared. The inductive textile sensor was integrated at the lumbar section of a sleeveless garment to create a smart wearable platform. The performance of the smart garment was evaluated experimentally on a healthy participant, and it was shown that the designed sensor can detect forward bending movements. The evaluation scenario was further extended to also include twisting and lateral bending of the trunk, and it was observed that the proposed design can successfully discriminate such movements from forward bending of the trunk. An interference test showed that, although moving a cellphone towards the unworn prototype affected the sensor readings, manipulating the cellphone when wearing the prototype, did not compromise the capability of the sensor to detect forward bends. The proposed platform is a promising step towards developing wearable systems to monitor back posture to prevent or treat low back pain associated with poor posture

Assessment of the Effect of Satureja montana and Origanum virens Essential Oils on Aspergillus flavus Growth and Aflatoxin Production at Different Water Activities

© 2020 by the authors. Licensee MDPI, Basel, Switzerland. This article is an open access article distributed under the terms and conditions of the Creative Commons Attribution (CC BY) license (http://creativecommons.org/licenses/by/4.0/).Aflatoxin contamination of foodstuffs poses a serious risk to food security, and it is essential to search for new control methods to prevent these toxins entering the food chain. Several essential oils are able to reduce the growth and mycotoxin biosynthesis of toxigenic species, although their efficiency is strongly influenced by the environmental conditions. In this work, the effectiveness of Satureja montana and Origanum virens essential oils to control Aspergillus flavus growth was evaluated under three water activity levels (0.94, 0.96 and 0.98 aw) using a Bioscreen C, a rapid in vitro spectrophotometric technique. The aflatoxin concentrations at all conditions tested were determined by HPLC-FLD. Aspergillus flavus growth was delayed by both essential oil treatments. However, only S. montana essential oil was able to significantly affect aflatoxin production, although the inhibition percentages widely differed among water activities. The most significant reduction was observed at 0.96 aw, which is coincident with the conditions in which A. flavus reached the highest levels of aflatoxin production. On the contrary, the treatment with S. montana essential oil was not effective in significantly reducing aflatoxin production at 0.94 aw. Therefore, it is important to study the interaction of the new control compounds with environmental factors before their application in food matrices, and in vitro ecophysiological studies are a good option since they provide accurate and rapid results.Peer reviewedFinal Published versio

Smallholder Dairy Farmers in the Peruvian Andes Fulfilling the Role of Extension Agents

Dairy farming in the Peruvian Andes is mostly undertaken by smallholder farmers (4-6 cows/family) and of relatively recent development. In fact, over the last 2 decades dairy farming at high altitudes (3,500‒4200 masl) has grown rapidly, replacing the camelids and sheep farming that once predominated. Dairying growth has been catalysed by subsides from state and private organizations. It promotes high input systems based on feedlot technology. Compared to sheep and camelids farming, dairying at the Andes does not have yet an inherent local/indigenous knowledge associated to it. High altitude Andean ecosystems pose many constraints for dairy farming (hypoxia and high UV radiation, high variation between day and night temperatures, short rainy season, and hence shortage of feed and water; and not less importantly, accelerated climate change (CC)). Under these conditions, not only are productivity and profitability low, but there are high negative environmental impacts and poor animal welfare. In Peru, institutionalised research and extension (R&E) services are precarious. Research tackling current issues of high-altitude livestock farming is almost inexistent, whereas extension in support of farmers is dispersed, poorly funded, of short duration (a few months), focused on transfer of technology suitable to intensive farming systems, and has a high turnover of staff. A systems approach to address the complexity of Andean livestock farming development is lacking. The initiatives from the institutions promoting farming are directed to remediate recurrent problems (e.g., cold stress) or prioritise high cost, low impact activities (e.g., genetic improvement). Here, we present the successful experience of the New Zealand Peru Dairy Support Project (NZPDSP) to promote the adoption of improved low input pastoral dairying husbandry principles, where trained smallholder farmers play a key role as agents of change

Dairy Cattle Genetics by Environment Interaction Mismatch Contributes to Poor Mitigation and Adaptation of Grazing Systems to Climate Change Actions in the Peruvian High Andes: A Review

The high Andes of Peru includes fragile ecosystems. Nevertheless, it plays important ecosystem functions (e.g., biodiversity, water supply for the lowlands, CO2 sinks in soil, etc). More than 80% of the livestock population of Peru is farmed in this area, supporting the livelihood of approximately 1’400,000 poor families, who are vulnerable to climate change (CC). Climate change in the high Andes is occurring at accelerated rates, compared to lowlands regions. Prevalent factors in the high Andes, such as hypoxia, high UV radiation, climatic extremes, large variation between maximum and minimum temperatures, seasonality in rainfall (determining highly seasonal forage growth) and CC, not only increase the feed and water needs of animals, but also affect animal production, reproduction, rumen function and welfare, making them more vulnerable to CC. During the last three decades, livestock farming in the high Andes has undergone transformation. The farming of camelids and creole species has been almost replaced by smallholder dairying, which have a higher environmental footprint. Institutions promoting dairying neglect the fitness requirement for the animal genetics to perform in such environments. Recent work of the New Zealand Peru Dairy Support Project (NZPDSP; 2016‒2020) demonstrated that rapid and significant improvements in animal productivity and profitability of dairying can be achieved by promoting adoption of simple and low-cost husbandry practices. Nevertheless, further improvements are constrained by the unfitness of the current animal genetics. Here, based on a literature review and experience from the NZPDSP, we propose a search for dairy cattle genetics that contributes to mitigation and adaptation to CC, while enhancing the livelihoods of the poor

Yearly evolution of organ damage markers in diabetes or metabolic syndrome: data from the LOD-DIABETES study

<p>Abstract</p> <p>Background</p> <p>Cardiovascular disease morbidity-mortality is greater in people with type 2 diabetes mellitus or metabolic syndrome. The purpose of this study was to evaluate the yearly evolution of organ damage markers in diabetes or metabolic syndrome, and to analyze the associated factors.</p> <p>Methods</p> <p>An observational prospective study was carried out in the primary care setting, involving 112 patients: 68 diabetics and 44 subjects with metabolic syndrome, subjected to 12 months of follow-up. Measurements: traditional cardiovascular risk factors (blood pressure, blood glucose, lipids, smoking, body mass index (BMI) and) and non-traditional risk factors (waist circumference, hsC Reactive Protein and fibrinogen); subclinical vascular (carotid intima-media thickness, pulse wave velocity and ankle/brachial index), cardiac (Cornell voltage-duration product), renal organ damage (creatinine, glomerular filtration and albumin/creatinine index), and antihypertensive and lipid-lowering drugs.</p> <p>Results</p> <p>At baseline, the diabetics presented a mean age of 59.9 years, versus 55.2 years in the subjects with metabolic syndrome (p = 0.03). Diastolic blood pressure, total cholesterol and HDL-cholesterol were lower among the patients with diabetes, while blood glucose and HbA1c, as well as antihypertensive and lipid-lowering drug use, were greater. At evaluation after one year, the diabetics showed a decrease in BMI (-0.39), diastolic blood pressure (-3.59), and an increase in fibrinogen (30.23 mg/dL), ankle/brachial index (0.07) and the number of patients with ankle/brachial index pathologic decreased in 6. In turn, the patients with metabolic syndrome showed an increase in HDL-cholesterol (1-91 mg/dL), fibrinogen (25.54 mg/dL), Cornell voltage-duration product (184.22 mm/ms), ankle/brachial index (0.05) and the use of antihypertensive and lipid-lowering drugs, and a reduction in serum glucose (3.74 mg/dL), HOMA, systolic (-6.76 mmHg), diastolic blood pressure (-3.29 mmHg), and pulse wave velocity (-0.72 m/s). The variable that best predicted a decrease in pulse wave velocity in subjects with metabolic syndrome was seen to be an increase in antihypertensive drug use.</p> <p>Conclusions</p> <p>The annual assessment of cardiovascular risk factors and the decrease in pulse wave velocity was more favorable in the patients with metabolic syndrome, probably influenced by the increased percentage of subjects treated with antihypertensive and lipid lowering drugs in this group.</p

Characterisation of puroindoline genes in wild tetraploid and hexaploid wheats (Triticum araraticum; T. timopheevii and T. zhukovskyi)

Treatment with cisplatin-containing chemotherapy regimens causes hearing loss in 40-60% of cancer patients. It has been suggested that genetic variants in the genes encoding thiopurine S-methyltransferase (TPMT) and catechol O-methyltransferase (COMT) can predict the development of cisplatin-induced ototoxicity and may explain interindividual variability in sensitivity to cisplatin-induced hearing loss. Two recently published studies however, sought to validate these findings and showed inconsistent results. The aim of this study was to evaluate the role of polymorphisms in the TPMT and COMT genes in cisplatin-induced ototoxicity. Therefore we investigated two independent cohorts of 110 Dutch and 38 Spanish patients with osteosarcoma and performed a meta-analysis including all previously published studies resulting in a total population of 664 patients with cancer. With this largest meta-analysis performed to date, we show that the influence of TPMT and COMT on the development of cisplatin-induced hearing loss may be less important than previously suggested

Dietary glycemic index and retinal microvasculature in adults: a cross-sectional study

[EN] Objective: To analyze the relationship between dietary glycemic index (GI) and retinal microvasculature in adults. Methods: This was a cross-sectional study of 300 subjects from the EVIDENT II study. Dietary GI was calculated using a validated, semi-quantitative food frequency questionnaire. Retinal photographs were digitized, temporal vessels were measured in an area 0.5–1 disc diameter from the optic disc and arteriolar-venular index (AVI) was estimated with semi-automated software. Results: AVI showed a significant difference between the tertiles of GI, after adjusting for potential confounders. The lowest AVI values were observed among subjects in the highest tertile of GI, whereas the greatest were found among those in the lowest tertile (estimated marginal mean of 0.738 vs. 0.768, p = 0.014). Conclusions: In adults, high dietary GI implies lowering AVI values regardless of age, gender and other confounding variables. Trial registration: Clinical Trials.gov Identifier: NCT02016014. Registered 9 December 2013

Fundamentals of active shielding based on implicit control

Active noise control is a methodology to attenuate low frequency noise. The attenuation is usually achieved near the sensor which is used in the controller. In order to achieve the desired attenuation inside a desired zone without locating a sensor inside, a method called active shielding can be used. It works by controlling the pressure at boundaries of the desired zone. This article presents a novel method for implementing active shielding only using pressure sensors. It is based on a new concept called implicit control, which takes into account the locations of sensors. Some simulations validate the presented method for free fields

Influence of Genetic Variants in TPMT and COMT Associated with Cisplatin Induced Hearing Loss in Patients with Cancer:Two New Cohorts and a Meta-Analysis Reveal Significant Heterogeneity between Cohorts

Treatment with cisplatin-containing chemotherapy regimens causes hearing loss in 40-60% of cancer patients. It has been suggested that genetic variants in the genes encoding thiopurine S-methyltransferase (TPMT) and catechol O-methyltransferase (COMT) can predict the development of cisplatin-induced ototoxicity and may explain interindividual variability in sensitivity to cisplatin-induced hearing loss. Two recently published studies however, sought to validate these findings and showed inconsistent results. The aim of this study was to evaluate the role of polymorphisms in the TPMT and COMT genes in cisplatin-induced ototoxicity. Therefore we investigated two independent cohorts of 110 Dutch and 38 Spanish patients with osteosarcoma and performed a meta-analysis including all previously published studies resulting in a total population of 664 patients with cancer. With this largest meta-analysis performed to date, we show that the influence of TPMT and COMT on the development of cisplatin-induced hearing loss may be less important than previously suggested

Climate drives community-wide divergence within species over a limited spatial scale: evidence from an oceanic island

Geographic isolation substantially contributes to species endemism on oceanic islands when speciation involves the colonisation of a new island. However, less is understood about the drivers of speciation within islands. What is lacking is a general understanding of the geographic scale of gene flow limitation within islands, and thus the spatial scale and drivers of geographical speciation within insular contexts. Using a community of beetle species, we show that when dispersal ability and climate tolerance are restricted, microclimatic variation over distances of only a few kilometres can maintain strong geographic isolation extending back several millions of years. Further to this, we demonstrate congruent diversification with gene flow across species, mediated by Quaternary climate oscillations that have facilitated a dynamic of isolation and secondary contact. The unprecedented scale of parallel species responses to a common environmental driver for evolutionary change has profound consequences for understanding past and future species responses to climate variation