You Are My Way to the Universe: Critical Collective Research Through Feminist Community Building

In diesem Artikel stützen wir uns auf den feministischen Kommunitarismus, um eine Kritik an dem vorherrschenden neoliberalen Modell der Zusammenarbeit in der qualitativen Sozialforschung zu entwickeln. Wir argumentieren, dass feministische Theorien und Praktiken über Gemeinschaftsbildung und politischen Aktivismus das Potenzial haben, die stark institutionalisierte, individualistische und managerialistische Kultur von Zusammenarbeit zu überwinden. Feministische Einsichten können Wissenschaftler*innen helfen, sich in der kollaborativen Forschung zurechtzufinden und Schlüsselfragen wie Reflexivität, Konsensbildung, Wissensvalidierung und Gruppensolidarität anzugehen. Wir nutzen unsere eigene Arbeit im Feministischen Forschungskollektiv und im WomenWeLove-Projekt, um eine alternative Orientierung und einen kollektiven Weg zur Verwirklichung einer transformativen Forschung vorzustellen. Diese feministische Intervention gegen die neoliberale Forschungskultur trägt zu laufenden Überlegungen darüber bei, wie wir mithilfe der qualitativen Sozialforschung Wissen produzieren und warum wir dies in der gegenwärtigen historischen Situation tun sollten. Sie erweitert unsere Vorstellungen von der Verantwortung der Forschenden und schafft neue Möglichkeiten für Widerstand und Emanzipation.In this article, we draw on the scholarship of feminist communitarianism to develop a critique of the predominant neoliberal qualitative social research collaboration model. We argue that feminist theories and praxis about community building and political activism have the potential to transcend the highly institutionalized, individualistic, and managerialist collaborative culture. Feminist insights can help today's researchers navigate collaborative research and address key issues such as reflexivity, consensus formation, knowledge validation, and group solidarity. We use our own work in the Feminist Research Collective and in the WomenWeLove project to present an alternative orientation and a collective way to enact transformative research. This feminist intervention against the neoliberal research culture contributes to the ongoing reflections of how we produce knowledge via qualitative social research and why we shall do so in the current historical juncture, expands our imaginations of researchers' responsibilities, and engenders new possibilities for resistance and emancipation

Gas and Dust Associated with the Strange, Isolated, Star BP Piscium

We have carried out a multiwavelength observational campaign demonstrating some of the remarkable properties of the infrared-bright variable star BP Psc. Surrounded by a compact dusty, gaseous disk, this little-studied late-G (or early-K) type star emits about 75% of its detected energy flux at infrared wavelengths. Evidence for accretion of gas in conjunction with narrow bi-polar jets and Herbig-Haro objects is apparently consistent with classification of BP Psc as a pre-main sequence star, as postulated in most previous studies. If young, then BP Psc would be one of the nearest and oldest known classical T Tauri stars. However, such an evolutionary classification encounters various problems that are absent or much less severe if BP Psc is instead a luminosity class III post-main sequence star. In this case, it would be the first known example of a first ascent giant surrounded by a massive molecular disk with accompanying rapid gas accretion and prominent jets and HH objects. In this model, the genesis of the massive dusty gaseous disk could be a consequence of the envelopment of a low mass companion star. Properties in the disk may be conducive to the current formation of planets, a gigayear or more after the formation of BP Psc itself.Comment: Accepted for Astrophysical Journal New version with minor changes: includes fixing a typo on the 3rd line of the paragraph that follows Equa 4 and adding a new reference (Nordhaus and Blackman 2006

Photoinduced Ligand Exchange and Covalent DNA Binding by Two New Dirhodium Bis-Amidato Complexes

Two new dirhodium complexes, the head-to-tail (<i>H,T</i>) and head-to-head (<i>H,H</i>) isomers of <i>cis</i>-[Rh₂(HNOCCH₃)₂(CH₃CN)₆]²⁺, were synthesized, separated, and characterized following the reaction of Rh₂(HNOCCH₃)₄ with trimethyloxonium tetrafluoroborate in CH₃CN. The products were characterized by ¹H NMR spectroscopy, mass spectrometry, elemental analysis, and single crystal X-ray diffraction. Each bis-amidato isomer has a total of six CH₃CN ligands, two along the internuclear Rh–Rh axis, CH₃CN_<i>ax</i>, two in equatorial positions <i>trans</i> to the oxygen atoms of the bridging amidato groups, CH₃CN_<i>eq</i>^<i>O</i>, and two in equatorial positions <i>trans</i> to the amidato nitrogen atoms, CH₃CN_<i>eq</i>^<i>N</i>. When aqueous solutions of the complexes are irradiated with low energy light (λ_irr ≥ 495 nm, 60 min), both types of CH₃CN_<i>eq</i> ligands undergo efficient ligand exchange with solvent H₂O molecules to form monoaqua, followed by bis-aqua, adducts, releasing two CH₃CN_<i>eq</i> ligands in the process. The quantum yields, Φ_400nm, for the <i>H,T</i> and <i>H,H</i> isomers to form monoaqua adducts are 0.43 and 0.38, respectively, which are substantially greater than the 0.13 yield observed for <i>cis</i>-[Rh₂(O₂CCH₃)₂(CH₃CN)₆]²⁺; importantly, no ligand exchange is observed when the complexes are kept in the dark. Finally, low energy excitation (λ_irr ≥ 610 nm, 30 min) of the <i>H,T</i> isomer was shown to generate photoproducts that covalently bind to linearized DNA, making <b>2</b> a potential agent for photochemotherapy that does not require the formation of ¹O₂, as is typical of organic photodynamic therapy (PDT) agents

SUPERIORITY OF LOW ENERGY 160 KV X-RAYS COMPARED TO HIGH ENERGY 6 MV X-RAYS IN HEAVY ELEMENT RADIOSENSITIZATION FOR CANCER TREATMENT

Author Institution: Biophysics Graduate Program; Biophysics Graduate Program, Departments of Astronomy and; Chemistry; Department of Astronomy; Pathology, The Ohio State University; Department of Chemistry, The Ohio State UniversityHigh energy X-rays in the MeV range are generally employed in conventional radiation therapy from linear accelerators (LINAC) to ensure sufficient penetration depths. However, lower energy X-rays in the keV range may be more effective when coupled with heavy element (high-Z or HZ) radiosensitizers. Numerical simulations of X-ray energy deposition for tumor phantoms sensitized with HZ radiosensitizers were performed using the Monte Carlo code Geant4. The results showed enhancement in energy deposition to radiosensitized phantoms relative to unsensitized phantoms for low energy X-rays in the keV range. In contrast, minimal enhancement was seen using high energy X-rays in the MeV range. Dose enhancement factors (DEFs) were computed and showed radiosensitization only in the low energy range &lt; 200 keV, far lower than the energy of the majority of photons in the LINAC energy range. \emph{In vitro} studies were carried to demonstrate the tumoricidal effects of HZ sensitized F98 rat glioma cells following irradiation with both low energy 160 kV and high energy 6 MV X-ray sources. The platinum compound, pyridine terpyridine Pt(II) nitrate, was initially used because it was 7x less toxic that an equivalent amount of carboplatin {\it in vitro} studies. This would allow us to separate the radiotoxic and the chemotoxic effects of HZ sensitizers. Results from this study showed a 10-fold dose dependent reduction in surviving fractions (SF) of radiosensitized cells treated with low energy 160 kV X-rays compared to those treated with 6 MV X-rays. This is in agreement with our simulations that show an increase in dose deposition in radiosensitized tumors for low energy X-rays. Due to unforeen \emph{in vivo} toxicity, however, another \emph{in vitro} study was performed using the commonly used, Pt-based chemotherapeutic drug carboplatin which confirmed earlier results. This lays the ground work for a planned \emph{in vivo} study using F98 glioma bearing rats. This study demonstrates that while high energy X-rays are commonly used in cancer radiotherapy, low energy keV X-rays might be much more effective with HZ radiosensitization

Fractionnement de la ration concentrée du poulain

International audienceL’ostéochondrose est une pathologie de l’ossification juvénile multifactorielle qui touche 15 à 35% des équidés français, se développant dès la gestation et évoluant jusqu’aux 18 mois des poulains. L’apport de concentrés en excès dans la ration et la croissance rapide augmentent l’incidence de la pathologie. L’augmentation des pics de glucose et des pics d’insuline dans le sang à la suite des repas concentrés a été reliée à une augmentation des lésions d’ostéochondrose. Or, le fractionnement de l’alimentation concentrée en plusieurs repas pourrait permettre de réduire les pics d’insulinémie post-prandiale du poulain. L’objectif de ce projet était donc d’étudier les effets du fractionnement en 8 repas/jour (vs 2 repas/jour) de l’alimentation concentrée durant le premier hiver sur la croissance, le métabolisme glucidique et le développement de l’ostéochondrose chez le poulain. Les conclusions de l’étude sont que fractionnement de l’alimentation concentrée en 8 repas/jour ne modifie pas le métabolisme glucidique à long terme ni la prévalence de l’ostéochondrose mais augmente l’efficacité alimentaire de la ration