A Lack of Civic Commitment?

A recent study on youth leaders.hip and community service, conducted by Peter D. Hart Associates for Public Allies (a Washington, D.C., nonprofit that promotes youth leadership), found that today\u27s young Americans are committed to community service and direct, personal assistance to others. But the survey of 728 people between the ages of 18 and 30 also raised disturbing questions about the young generation\u27s commitment to civic engagement and social change

The Nonprofit Sector and the Will to Change

A greater portion of our nonprofit activities in the future will have to be devoted to policies and actions that can produce constructive change. The extraordinary problems of our society as we enter the twenty-first century — poverty, racism, environmental degradation, lack of health protection, declining trust in governments — can only be tackled by strong policy work, advocacy, and citizen mobilization. The author outlines seven challenges that nonprofits need to address including promoting democracy, strengthening government, asuring public accountability, redefining the nonprofit sector, reforming philanthropy, developing new leadership, and engaging institutions of higher learning in promoting democracies and communities. Providing services is not enough. We need to develop new nonprofit leadership with the vision, competence, and courage

Foundation Trustee Fees: Use and Abuse

The authors present the statistical results and their conclusions from a survey of 238 foundations (based on the 990-PF form). The study examined the prevalence of trustee compensation practices of both large and smaller foundations

The Robertson v. Princeton Case: Too Important to Be Left to the Lawyers

Offers comments from eleven contributors on the Robertson family's donor rights suit against the Woodrow Wilson School of Public and International Affairs for violation of donor intent. Explores its effects on and implications for the nonprofit sector

Relevant distance between two different instances of the same potential energy in protein folding

In the context of complex systems and, particularly, of protein folding, a physically meaningful distance is defined which allows to make useful statistical statements about the way in which energy differences are modified when two different instances of the same potential-energy function are used. When the two instances arise from the fact that different algorithms or different approximations are used, the distance herein defined may be used to evaluate the relative accuracy of the two methods. When the difference is due to a change in the free parameters of which the potential depends on, the distance can be used to quantify, in each region of parameter space, the robustness of the modeling to such a change and this, in turn, may be used to assess the significance of a parameters' fit. Both cases are illustrated with a practical example: the study of the Poisson-based solvation energy in the Trp-Cage protein (PDB code 1L2Y).Comment: 20 pages, 6 figures, LaTeX file, elsart style. v1: Aknowledgments modified. v2: y-values of fig. 5 and 6 corrected. v3: Journal-ref added, aknowledgements modified and fig. 1 and 2 correcte

Evaluation of Clinical and Immunological Markers for predicting Virological Failure in a HIV/AIDS treatment cohort in Busia, Kenya

In resource-limited settings where viral load (VL) monitoring is scarce or unavailable, clinicians must use immunological and clinical criteria to define HIV virological treatment failure. This study examined the performance of World Health Organization (WHO) clinical and immunological failure criteria in predicting virological failure in HIV patients receiving antiretroviral therapy (ART)

Symptomatic and Subclinical Infection with Rotavirus P[8]G9, Rural Ecuador

Prevalence of this genotype is increasing

Cisto de Bartholin, uma revisão bibliográfica

Os cistos ou abscessos de Bartholin são predominantemente encontrados em mulheres em idade fértil, sua incidência é mais frequente e observada no início da puberdade aumentando com a idade até a menopausa, podendo afetar significativamente a vida de uma mulher. A dor e o inchaço podem impedir atos do cotidiano como sentar, caminhar e ter relações sexuais. O diagnóstico é frequentemente clínico porém massas atípicas podem exigir imagens adicionais, biópsia de tecido ou excisão completa. Em alguns casos, os cistos podem ficar aumentados e dolorosos ou infectados. As opções de tratamento estão disponíveis para alívio dos sintomas, bem como para preocupações cosméticas. Antibióticos podem ser necessários em caso de infecção secundária. Pacientes na pós-menopausa podem precisar de mais investigações para descartar a possibilidade de câncer. Cistos e abscessos de Bartholin sintomáticos são responsáveis ​​por um número significativo de todas as consultas ginecológicas por ano

Multivariate Protein Signatures of Pre-Clinical Alzheimer's Disease in the Alzheimer's Disease Neuroimaging Initiative (ADNI) Plasma Proteome Dataset

Background: Recent Alzheimer's disease (AD) research has focused on finding biomarkers to identify disease at the pre-clinical stage of mild cognitive impairment (MCI), allowing treatment to be initiated before irreversible damage occurs. Many studies have examined brain imaging or cerebrospinal fluid but there is also growing interest in blood biomarkers. The Alzheimer's Disease Neuroimaging Initiative (ADNI) has generated data on 190 plasma analytes in 566 individuals with MCI, AD or normal cognition. We conducted independent analyses of this dataset to identify plasma protein signatures predicting pre-clinical AD. Methods and Findings: We focused on identifying signatures that discriminate cognitively normal controls (n = 54) from individuals with MCI who subsequently progress to AD (n = 163). Based on p value, apolipoprotein E (APOE) showed the strongest difference between these groups (p = 2.3×10−13). We applied a multivariate approach based on combinatorial optimization ((α,β)-k Feature Set Selection), which retains information about individual participants and maintains the context of interrelationships between different analytes, to identify the optimal set of analytes (signature) to discriminate these two groups. We identified 11-analyte signatures achieving values of sensitivity and specificity between 65% and 86% for both MCI and AD groups, depending on whether APOE was included and other factors. Classification accuracy was improved by considering “meta-features,” representing the difference in relative abundance of two analytes, with an 8-meta-feature signature consistently achieving sensitivity and specificity both over 85%. Generating signatures based on longitudinal rather than cross-sectional data further improved classification accuracy, returning sensitivities and specificities of approximately 90%. Conclusions: Applying these novel analysis approaches to the powerful and well-characterized ADNI dataset has identified sets of plasma biomarkers for pre-clinical AD. While studies of independent test sets are required to validate the signatures, these analyses provide a starting point for developing a cost-effective and minimally invasive test capable of diagnosing AD in its pre-clinical stages

Genetic Cross-Interaction between APOE and PRNP in Sporadic Alzheimer's and Creutzfeldt-Jakob Diseases

Alzheimer's disease (AD) and Creutzfeldt-Jakob disease (CJD) represent two distinct clinical entities belonging to a wider group, generically named as conformational disorders that share common pathophysiologic mechanisms. It is well-established that the APOE ε4 allele and homozygosity at polymorphic codon 129 in the PRNP gene are the major genetic risk factors for AD and human prion diseases, respectively. However, the roles of PRNP in AD, and APOE in CJD are controversial. In this work, we investigated for the first time, APOE and PRNP genotypes simultaneously in 474 AD and 175 sporadic CJD (sCJD) patients compared to a common control population of 335 subjects. Differences in genotype distribution between patients and control subjects were studied by logistic regression analysis using age and gender as covariates. The effect size of risk association and synergy factors were calculated using the logistic odds ratio estimates. Our data confirmed that the presence of APOE ε4 allele is associated with a higher risk of developing AD, while homozygosity at PRNP gene constitutes a risk for sCJD. Opposite, we found no association for PRNP with AD, nor for APOE with sCJD. Interestingly, when AD and sCJD patients were stratified according to their respective main risk genes (APOE for AD, and PRNP for sCJD), we found statistically significant associations for the other gene in those strata at higher previous risk. Synergy factor analysis showed a synergistic age-dependent interaction between APOE and PRNP in both AD (SF = 3.59, p = 0.027), and sCJD (SF = 7.26, p = 0.005). We propose that this statistical epistasis can partially explain divergent data from different association studies. Moreover, these results suggest that the genetic interaction between APOE and PRNP may have a biological correlate that is indicative of shared neurodegenerative pathways involved in AD and sCJD