Delayed presentation of an isolated gallbladder rupture following blunt abdominal trauma: a case report

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Search for the standard model Higgs boson in the H to ZZ to 2l 2nu channel in pp collisions at sqrt(s) = 7 TeV

A search for the standard model Higgs boson in the H to ZZ to 2l 2nu decay channel, where l = e or mu, in pp collisions at a center-of-mass energy of 7 TeV is presented. The data were collected at the LHC, with the CMS detector, and correspond to an integrated luminosity of 4.6 inverse femtobarns. No significant excess is observed above the background expectation, and upper limits are set on the Higgs boson production cross section. The presence of the standard model Higgs boson with a mass in the 270-440 GeV range is excluded at 95% confidence level.Comment: Submitted to JHE

Search for the standard model Higgs boson in the H to ZZ to ll tau tau decay channel in pp collisions at sqrt(s)=7 TeV

A search is reported for the standard model Higgs boson in the decay mode H to ZZ to tau plus lepton pairs, where the leptons are either electrons or muons, in proton-proton collisions at sqrt(s)=7 TeV, corresponding to an integrated luminosity of 4.7 inverse femtobarn collected with the CMS detector at the LHC. No evidence is found for a significant deviation from the background expectation. An upper limit four to twelve times larger than the predicted value is set at 95% confidence level for the product of the standard model Higgs boson production cross section and decay branching fraction in the mass range 190 < m(H) < 600 GeV.Comment: Submitted to JHE

Search for the standard model Higgs boson produced in association with W and Z bosons in pp collisions at root s=7 TeV

A search for the Higgs boson produced in association with a W or Z boson in proton-proton collisions at a center-of-mass energy of 7 TeV is performed with the CMS detector at the LHC using the full 2011 data sample, from an integrated luminosity of 5 fb−1. Higgs boson decay modes to ττ and WW are explored by selecting events with three or four leptons in the final state. No excess above background expectations is observed, resulting in exclusion limits on the product of Higgs associated production cross section and decay branching fraction for Higgs boson masses between 110 and 200 GeV in these channels. Combining these results with other CMS associated production searches using the same dataset in the H→ γγ and H→ b b¯ decay modes, the cross section for associated Higgs boson production 3.3 times the standard model expectation or larger is ruled out at the 95% confidence level for a Higgs boson mass of 125 GeV

Facile Preparation of Drug-Loaded Tristearin Encapsulated Superparamagnetic Iron Oxide Nanoparticles Using Coaxial Electrospray Processing

Naturally occurring polymers are promising biocompatible materials that have many applications for emerging therapies, drug delivery systems, and diagnostic agents. The handling and processing of such materials still constitutes a major challenge, which can limit the full exploitation of their properties. This study explores an ambient environment processing technique: coaxial electrospray (CO-ES) to encapsulate genistein (an isoflavonoid and model drug), superparamagnetic iron oxide nanoparticles (SPIONs, 10–15 nm), and a fluorophore (BODIPY) into a layered (triglyceride tristearin shell) particulate system, with a view to constructing a theranostic agent. Mode mapping of CO-ES led to an optimized atomization engineering window for stable jetting, leading to encapsulation of SPIONs within particles of diameter 0.65–1.2 μm and drug encapsulation efficiencies of around 92%. Electron microscopy was used to image the encapsulated SPIONs and confirm core–shell triglyceride encapsulation in addition to further physicochemical characterization (AFM, FTIR, DSC, and TGA). Cell viability assays (MTT, HeLa cells) were used to determine optimal SPION loaded particles (∼1 mg/mL), while in vitro release profile experiments (PBS, pH = 7.4) demonstrate a triphasic release profile. Further cell studies confirmed cell uptake and internalization at selected time points (t = 1, 2, and 4 h). The results suggest potential for using the CO-ES technique as an efficient way to encapsulate SPIONs together with sensitive drugs for the development of multimodal particles that have potential application for combined imaging and therapy