Molecular mechanisms of cell death: recommendations of the Nomenclature Committee on Cell Death 2018.

Over the past decade, the Nomenclature Committee on Cell Death (NCCD) has formulated guidelines for the definition and interpretation of cell death from morphological, biochemical, and functional perspectives. Since the field continues to expand and novel mechanisms that orchestrate multiple cell death pathways are unveiled, we propose an updated classification of cell death subroutines focusing on mechanistic and essential (as opposed to correlative and dispensable) aspects of the process. As we provide molecularly oriented definitions of terms including intrinsic apoptosis, extrinsic apoptosis, mitochondrial permeability transition (MPT)-driven necrosis, necroptosis, ferroptosis, pyroptosis, parthanatos, entotic cell death, NETotic cell death, lysosome-dependent cell death, autophagy-dependent cell death, immunogenic cell death, cellular senescence, and mitotic catastrophe, we discuss the utility of neologisms that refer to highly specialized instances of these processes. The mission of the NCCD is to provide a widely accepted nomenclature on cell death in support of the continued development of the field

InSAR-based detection method for mapping and monitoring slow-moving landslides in remote regions with steep and mountainous terrain: An application to Nepal

Mapping and monitoring landslides in remote areas with steep and mountainous terrain is logistically challenging, expensive, and time consuming. Yet, in order to mitigate hazards and prevent loss of life in these areas, and to better understand landslide processes, high-resolution measurements of landslide activity are necessary. Satellite-based synthetic aperture radar interferometry (InSAR) provides millimeter-scale measurements of ground surface deformation that can be used to identify and monitor landslides in remote areas where ground-based monitoring techniques are not feasible. Here we present a novel InSAR deformation detection approach, which uses double difference time-series with local and regional spatial filters and pixel clustering methods to identify and monitor slow-moving landslides without making a priori assumptions of the location of landslides. We apply our analysis to freely available Copernicus Sentinel-1 satellite data acquired between 2014 and 2017 centered on the Trishuli River drainage basin in Nepal. We found a minimum of 6 slow-moving landslides that all occur within the Ranimatta lithologic formation (phyllites, metasandstones, metabasics). These landslides have areas ranging from 0.39 to 1.66 km2 and long-term dry-season displacement rates ranging from 2.1 to 8.8 cm/yr. Due to periods of low coherence during the monsoon season (June – September) each year, and following the 25 April 2015 Mw7.8 Gorkha earthquake, our time series analysis is limited to the 2014–2015 and 2016–2017 dry seasons (September–May). We found that each of the landslides displayed slightly higher rates during the 2014 period, likely as a result of higher cumulative rainfall that fell during the 2014 monsoon season. Although we do not have high quality InSAR data to show the landslide evolution directly following the Gorkha earthquake, the similar rates of movement before (2014–2015) and after (2016–2017) Gorkha suggest the earthquake had negligible long-term impact on these landslides. Our findings highlight the potential for region-wide mapping of slow-moving landslides using freely available remote sensing data in remote areas such as Nepal and future work will benefit from expanding our methodology to other regions around the world

Degenerative venous aneurysm of a reverse saphenous vein femoral artery to femoral artery cross over graft: Case report and literature review of saphenous vein graft aneurysm

A true aneurysm formation in an arterialized vein graft used for lower limb arterial occlusive disease is a rare complication. The saphenous vein is the preferred conduit for infrainguinal bypass. For extra-anatomical bypass-like femorofemoral crossover, a synthetic graft is preferred. A successful outcome of femorofemoral crossover bypass with autogenous vein is well described. This case report is regarding a 67-year-old male who underwent femorofemoral crossover bypass with reversed saphenous vein graft 15 years ago for arterial occlusive disease, who now presented with degenerative aneurysm of the graft with an incidental infrarenal Abdominal Aortic Aneurysm. He underwent aortobifemoral bypass with jump graft to right internal iliac artery and resection of aneurysms. Histopathology of venous aneurysmal wall showed graft wall calcification with fibrin and collagen deposits. The causes of saphenous vein graft aneurysm have been described to be mostly atherosclerotic but it may be a part of systemic dilating pathology