1,115 research outputs found
An integrable spin chain for the SL(2,R)/U(1) black hole sigma model
We introduce a spin chain based on finite-dimensional spin-1/2 SU(2)
representations but with a non-hermitian `Hamiltonian' and show, using mostly
analytical techniques, that it is described at low energies by the SL(2,R)/U(1)
Euclidian black hole Conformal Field Theory. This identification goes beyond
the appearance of a non-compact spectrum: we are also able to determine the
density of states, and show that it agrees with the formulas in [J. Math. Phys.
42, 2961 (2001)] and [JHEP 04, 014 (2002)], hence providing a direct `physical
measurement' of the associated reflection amplitude.Comment: 6 pages, 3 figures, in RevTeX. Corrected some typo
A new fireworm (Amphinomidae) from the Cretaceous of Lebanon identified from three-dimensionally preserved myoanatomy
© 2015 Parry et al. Open Access This article is distributed under the terms of the Creative Commons Attribution 4.0
International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and
reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to
the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver
(http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated. The attached file is the published version of the article
Identification of T-Cell Antigens Specific for Latent Mycobacterium Tuberculosis Infection
BACKGROUND: T-cell responses against dormancy-, resuscitation-, and reactivation-associated antigens of Mycobacterium tuberculosis are candidate biomarkers of latent infection in humans. METHODOLOGY/PRINCIPAL FINDINGS: We established an assay based on two rounds of in vitro restimulation and intracellular cytokine analysis that detects T-cell responses to antigens expressed during latent M. tuberculosis infection. Comparison between active pulmonary tuberculosis (TB) patients and healthy latently M. tuberculosis-infected donors (LTBI) revealed significantly higher T-cell responses against 7 of 35 tested M. tuberculosis latency-associated antigens in LTBI. Notably, T cells specific for Rv3407 were exclusively detected in LTBI but not in TB patients. The T-cell IFNgamma response against Rv3407 in individual donors was the most influential factor in discrimination analysis that classified TB patients and LTBI with 83% accuracy using cross-validation. Rv3407 peptide pool stimulations revealed distinct candidate epitopes in four LTBI. CONCLUSIONS: Our findings further support the hypothesis that the latency-associated antigens can be exploited as biomarkers for LTBI
Applying refinement to the use of mice and rats in rheumatoid arthritis research
Rheumatoid arthritis (RA) is a painful, chronic disorder and there is currently an unmet need for effective therapies that will benefit a wide range of patients. The research and development process for therapies and treatments currently involves in vivo studies, which have the potential to cause discomfort, pain or distress. This Working Group report focuses on identifying causes of suffering within commonly used mouse and rat âmodelsâ of RA, describing practical refinements to help reduce suffering and improve welfare without compromising the scientific objectives. The report also discusses other, relevant topics including identifying and minimising sources of variation within in vivo RA studies, the potential to provide pain relief including analgesia, welfare assessment, humane endpoints, reporting standards and the potential to replace animals in RA research
Using theatre in education in a traditional lecture oriented medical curriculum
<p>Abstract</p> <p>Background</p> <p>Lectures supported by theatrical performance may enhance learning and be an attractive alternative to traditional lectures. This study describes our experience with using theatre in education for medical students since 2001.</p> <p>Methods</p> <p>The volunteer students, coached by experienced students, were given a two-week preparation period to write and prepare different dramatized headache scenarios during three supervised meetings. A theatrical performance was followed by a student presentation about history taking and clinical findings in diagnosing headache. Finally, a group discussion led by students dealt with issues raised in the performance. The evaluation of the theatre in education lecture "A Primary Care Approach to Headache" was based on feedback from students.</p> <p>Results</p> <p>More than 90% of 43 responding students fully agreed with the statement "Theatrical performance made it easier to understand the topic". More than 90% disagreed with the statements "Lecture halls were not appropriate for this kind of interaction" and "Students as teachers were not appropriate". Open-ended questions showed that the lesson was thought of as fun, good and useful by most students. The headache questions in the final exam showed results that were similar to average exam results for other questions.</p> <p>Conclusion</p> <p>Using theatrical performance in medical education was appreciated by most students and may facilitate learning and enhance empathy and team work communication skills.</p
Active and passive smoking and the risk of myocardial infarction in 24,968 men and women during 11Â year of follow-up: the TromsĂž Study
Academic Performance and Behavioral Patterns
Identifying the factors that influence academic performance is an essential
part of educational research. Previous studies have documented the importance
of personality traits, class attendance, and social network structure. Because
most of these analyses were based on a single behavioral aspect and/or small
sample sizes, there is currently no quantification of the interplay of these
factors. Here, we study the academic performance among a cohort of 538
undergraduate students forming a single, densely connected social network. Our
work is based on data collected using smartphones, which the students used as
their primary phones for two years. The availability of multi-channel data from
a single population allows us to directly compare the explanatory power of
individual and social characteristics. We find that the most informative
indicators of performance are based on social ties and that network indicators
result in better model performance than individual characteristics (including
both personality and class attendance). We confirm earlier findings that class
attendance is the most important predictor among individual characteristics.
Finally, our results suggest the presence of strong homophily and/or peer
effects among university students
IceCube - the next generation neutrino telescope at the South Pole
IceCube is a large neutrino telescope of the next generation to be
constructed in the Antarctic Ice Sheet near the South Pole. We present the
conceptual design and the sensitivity of the IceCube detector to predicted
fluxes of neutrinos, both atmospheric and extra-terrestrial. A complete
simulation of the detector design has been used to study the detector's
capability to search for neutrinos from sources such as active galaxies, and
gamma-ray bursts.Comment: 8 pages, to be published with the proceedings of the XXth
International Conference on Neutrino Physics and Astrophysics, Munich 200
Muon Track Reconstruction and Data Selection Techniques in AMANDA
The Antarctic Muon And Neutrino Detector Array (AMANDA) is a high-energy
neutrino telescope operating at the geographic South Pole. It is a lattice of
photo-multiplier tubes buried deep in the polar ice between 1500m and 2000m.
The primary goal of this detector is to discover astrophysical sources of high
energy neutrinos. A high-energy muon neutrino coming through the earth from the
Northern Hemisphere can be identified by the secondary muon moving upward
through the detector. The muon tracks are reconstructed with a maximum
likelihood method. It models the arrival times and amplitudes of Cherenkov
photons registered by the photo-multipliers. This paper describes the different
methods of reconstruction, which have been successfully implemented within
AMANDA. Strategies for optimizing the reconstruction performance and rejecting
background are presented. For a typical analysis procedure the direction of
tracks are reconstructed with about 2 degree accuracy.Comment: 40 pages, 16 Postscript figures, uses elsart.st
Results from the Antarctic Muon and Neutrino Detector Array (AMANDA)
We show new results from both the older and newer incarnations of AMANDA
(AMANDA-B10 and AMANDA-II, respectively). These results demonstrate that AMANDA
is a functioning, multipurpose detector with significant physics and
astrophysics reach. They include a new higher-statistics measurement of the
atmospheric muon neutrino flux and preliminary results from searches for a
variety of sources of ultrahigh energy neutrinos: generic point sources,
gamma-ray bursters and diffuse sources producing muons in the detector, and
diffuse sources producing electromagnetic or hadronic showers in or near the
detector.Comment: Invited talk at the XXth International Conference on Neutrino Physics
and Astrophysics (Neutrino 2002), Munich, Germany, May 25-30, 200
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