271 research outputs found

    Height and timing of growth spurt during puberty in young people living with vertically acquired HIV in Europe and Thailand.

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    OBJECTIVE: The aim of this study was to describe growth during puberty in young people with vertically acquired HIV. DESIGN: Pooled data from 12 paediatric HIV cohorts in Europe and Thailand. METHODS: One thousand and ninety-four children initiating a nonnucleoside reverse transcriptase inhibitor or boosted protease inhibitor based regimen aged 1-10 years were included. Super Imposition by Translation And Rotation (SITAR) models described growth from age 8 years using three parameters (average height, timing and shape of the growth spurt), dependent on age and height-for-age z-score (HAZ) (WHO references) at antiretroviral therapy (ART) initiation. Multivariate regression explored characteristics associated with these three parameters. RESULTS: At ART initiation, median age and HAZ was 6.4 [interquartile range (IQR): 2.8, 9.0] years and -1.2 (IQR: -2.3 to -0.2), respectively. Median follow-up was 9.1 (IQR: 6.9, 11.4) years. In girls, older age and lower HAZ at ART initiation were independently associated with a growth spurt which occurred 0.41 (95% confidence interval 0.20-0.62) years later in children starting ART age 6 to 10 years compared with 1 to 2 years and 1.50 (1.21-1.78) years later in those starting with HAZ less than -3 compared with HAZ at least -1. Later growth spurts in girls resulted in continued height growth into later adolescence. In boys starting ART with HAZ less than -1, growth spurts were later in children starting ART in the oldest age group, but for HAZ at least -1, there was no association with age. Girls and boys who initiated ART with HAZ at least -1 maintained a similar height to the WHO reference mean. CONCLUSION: Stunting at ART initiation was associated with later growth spurts in girls. Children with HAZ at least -1 at ART initiation grew in height at the level expected in HIV negative children of a comparable age

    Do bad borrowers hurt good borrowers? A model of biased banking competition

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    This paper explores a two-bank model in which, first, one bank correctly estimates the probability of low-quality loan repayment while the other overestimates it, and second, both banks have identical convex costs when granting loans. In this context of optimistically biased banking competition, we show how the unbiased bank follows the biased competitor as long as the bias of the latter is not too large. This would favour bad borrowers, who get better credit conditions at the expense of good borrowers. As a consequence, the presence of a biased bank increases welfare as long as the expected default rate is sufficiently high. Contrariwise, in subprime markets, biased banking competition would be socially harmful.info:eu-repo/semantics/publishedVersio

    Collective and broken pair states of 65,67Ga

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    Excited states of 65Ga and 67Ga nuclei were populated through the 12C(58Ni,Ξ±p) and 12C(58Ni,3p) reactions, respectively, and investigated by in-beam Ξ³-ray spectroscopic methods. The NORDBALL array equipped with a charged particle ball and 11 neutron detectors was used to detect the evaporated particles and Ξ³ rays. The level schemes of 65,67Ga were constructed on the basis of Ξ³Ξ³-coincidence relations up to 8.6 and 10 MeV excitation energy, and IΟ€=27/2 and 33/2+ spin and parity, respectively. The structure of 65,67Ga nuclei was described in the interacting boson-fermion plus broken pair model, including quasiproton, quasiproton-two-quasineutron, and three-quasiproton fermion configurations in the boson-fermion basis states. Most of the states were assigned to quasiparticle + phonon and three quasiparticle configurations on the basis of their electromagnetic decay properties

    New and comprehensive Ξ² - and Ξ²p-decay spectroscopy results in the vicinity of Sn 100

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    26 pags., 30 figs., 11 tabs.A decay spectroscopy experiment on proton-rich nuclei in the vicinity of the doubly magic Sn100 was carried out at RIKEN Nishina Center. More than 20 nuclei with 43≀Z≀50 and N≀51, produced by fragmentation reactions were investigated via analyses of Ξ²-decay, Ξ²p-decay, and subsequent Ξ³-ray data. Owing to higher statistics, the precision on the half-lives of many of the ground states and isomers was improved. Ξ²-decay endpoint energies of 11 states in 8 nuclei were measured for the first time, and the corresponding QEC and excitation energies were generally consistent with various mass models. Many Ξ²-delayed proton emission branching ratios were measured either for the first time or with higher precision compared to literature values, and some of them differed by more than 2Οƒ. Many of the large discrepancies were associated with nuclei with long-lived isomeric states, highlighting large systematic uncertainties involved in these measurements. Twenty-five new Ξ³ rays were observed, and ten new states are proposed with unambiguous excitation energies, spins, and parities. Most of the energies of the excited states were consistent within 300 keV or 20%, whichever was greater, compared to shell model predictions in the proton/neutron (p1/2,g9/2) model space assuming a Sr76 core. A signature of a new (1/2-) isomer in Cd97 with T1/2=0.73(7) s was found, in good agreement with shell model predictions.The authors would like to thank the personnel at the RIKEN Nishina Center for providing the exotic radioactive isotope beam with record intensities. This experiment was performed at RI Beam Factory operated by RIKEN Nishina Center and CNS, University of Tokyo. We acknowledge the EUROBALL Owners Committee for loaning the germanium detectors and the PreSpec Collaboration for the readout electronics of the cluster detectors of EURICA. Support for the WAS3ABi setup was provided by the Rare Isotope Science Project, funded by the Ministry of Education, Science and Technology (MEST) and National Research Foundation (NRF) of Korea, as well as KAKENHI (Grant No. 25247045) of Japan Society for the Promotion of Science (JSPS). The authors acknowledge the support of the DFG cluster of excellence β€œOrigin and Structure of the Universe,” German BMBF under Contract No. 05P15PKFNA and the Spanish Ministerio de EconomΓ­a y Competitividad via Project No. FPA2017- 84756-C4-2-P. Part of the research was funded by the Natural Sciences and Engineering Research Council (NSERC) of Canada and also supported by FJ-NSP (French-Japanese International Associated Laboratory for Nuclear Structure Problems)

    High-spin structure and electromagnetic transition strengths in Cd-104

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    The recoil distance Doppler shift and Doppler shift attenuation techniques were employed to determine for the first time lifetimes of high spin states in Cd-104in the time range 0.3 ps less than equal to tau less than 1.2 ns. The new experimental results are discussed in the frame of the interacting boson plus broken pair model

    Octupole states in Tl-207 studied through beta decay

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    The beta decay of Hg-207 into the single-proton-hole nucleus Tl-207 has been studied through gamma-ray spectroscopy at the ISOLDE Decay Station (IDS) with the aim of identifying states resulting from coupling of the pi s(1/2)(-1), pi d(3/2)(-1) and pi h(11/2)(-1) shell model orbitals to the collective octupole vibration. Twenty-two states were observed lying between 2.6 and 4.0 MeV, eleven of which were observed for the first time, and 78 new transitions were placed. Two octupole states (s(3/2)-coupled) are identified and three more states (d(3/2)-coupled) are tentatively assigned using spin-parity inferences, while further h(11/2)-coupled states may also have been observed for the first time. Comparisons are made with state-of-the-art large-scale shell model calculations and previous observations made in this region, and systematic underestimation of the energy of the octupole vibrational states is noted. We suggest that in order to resolve the difference in predicted energies for collective and noncollective t = 1 states (t is the number of nucleons breaking the Pb-208 core), the effect of t = 2 mixing may be reduced for octupole-coupled states. The inclusion of mixing with t = 0, 2, 3 excitations is necessary to replicate all t = 1 state energies accurately.Peer reviewe

    Competition between Allowed and First-Forbidden beta Decay : The Case of Hg-208 -> Tl-2(0)8

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    The beta decay of Hg-208 into the one-proton hole, one neutron-particle Tl-208(81)127 nucleus was investigated at CERN-ISOLDE. Shell-model calculations describe well the level scheme deduced, validating the proton-neutron interactions used, with implications for the whole of the N > 126, Z 0(-)beta decay where the daughter state is core excited is unique, and can provide information on mesonic corrections of effective operators.Peer reviewe

    Definitions and incidence of cardiac syndrome X: review and analysis of clinical data

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    There is no consensus regarding the definition of cardiac syndrome X (CSX). We systematically reviewed recent literature using a standardized search strategy. We included 57 articles. A total of 47 studies mentioned a male/female distribution. A meta-analysis yielded a pooled proportion of females of 0.56 (nΒ =Β 1,934 patients, with 95% confidence interval: 0.54–0.59). As much as 9 inclusion criteria and 43 exclusion criteria were found in the 57 articles. Applying these criteria to a population with normal coronary angiograms and treated in 1Β year at a general hospital, the attributable CSX incidence varied between 3 and 11%. The many inclusion and exclusion criteria result in a wide range of definitions of CSX and these have large effects on the incidence. This shows the need for a generally accepted definition of CSX

    A systematic review of the incidence of schizophrenia: the distribution of rates and the influence of sex, urbanicity, migrant status and methodology

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    BACKGROUND: Understanding variations in the incidence of schizophrenia is a crucial step in unravelling the aetiology of this group of disorders. The aims of this review are to systematically identify studies related to the incidence of schizophrenia, to describe the key features of these studies, and to explore the distribution of rates derived from these studies. METHODS: Studies with original data related to the incidence of schizophrenia (published 1965–2001) were identified via searching electronic databases, reviewing citations and writing to authors. These studies were divided into core studies, migrant studies, cohort studies and studies based on Other Special Groups. Between- and within-study filters were applied in order to identify discrete rates. Cumulative plots of these rates were made and these distributions were compared when the underlying rates were sorted according to sex, urbanicity, migrant status and various methodological features. RESULTS: We identified 100 core studies, 24 migrant studies, 23 cohort studies and 14 studies based on Other Special Groups. These studies, which were drawn from 33 countries, generated a total of 1,458 rates. Based on discrete core data for persons (55 studies and 170 rates), the distribution of rates was asymmetric and had a median value (10%–90% quantile) of 15.2 (7.7–43.0) per 100,000. The distribution of rates was significantly higher in males compared to females; the male/female rate ratio median (10%–90% quantile) was 1.40 (0.9–2.4). Those studies conducted in urban versus mixed urban-rural catchment areas generated significantly higher rate distributions. The distribution of rates in migrants was significantly higher compared to native-born; the migrant/native-born rate ratio median (10%–90% quantile) was 4.6 (1.0–12.8). Apart from the finding that older studies reported higher rates, other study features were not associated with significantly different rate distributions (e.g. overall quality, methods related to case finding, diagnostic confirmation and criteria, the use of age-standardization and age range). CONCLUSIONS: There is a wealth of data available on the incidence of schizophrenia. The width and skew of the rate distribution, and the significant impact of sex, urbanicity and migrant status on these distributions, indicate substantial variations in the incidence of schizophrenia
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