Maxillary sinus dimensions with respect to the posterior superior alveolar artery decrease with tooth loss

Background: The posterior superior alveolar (PSA) artery is frequently encountered in the area where the lateral osteotomy is performed during direct sinus augmentation procedures. Objective: To investigate the correlation between patient-dependent variables and measurements related to PSA using cone beam computed tomography (CBCT) data. Methods: Three hundred ninety-four CBCT scans were evaluated to assess the PSA artery diameter and distances to the sinus floor and to alveolar crest. Patient's age, gender, and edentulism status were recorded. Results: The PSA artery tends to be wider in older patients. Distances to the sinus floor or the alveolar crest tend to be shorter in women and in partially and completely edentulous patients. Also, as those distances decrease, the mediolateral width of the sinus increases. Conclusion: Tooth loss leads to maxillary sinus vertical collapse with respect to the PSA artery. The position of the artery is stable; so, the mediolateral dimensions at different heights from the floor increase. Practical implications: The reduced distances from the PSA to the sinus floor and the alveolar crest in edentulous patients potentially increase the risk of injury during maxillary sinus lift. Additionally, when the distance to the sinus floor decreases, the mediolateral dimensions of the sinus at different heights increase, which may complicate the technique and challenge the outcomes.Junta de Andalucía #CTS-138 and #CTS-58

Alimentação e saúde: uma visão do desenho curricular do Bacharel em Ciências da Alimentação

The training of professionals to obtain a Bachelor´s Degree in Food Science requires the development of biomedical science information management skills. This study proposes the curriculum design of an elective course and its integration with the Information and Communication Technologies (ICT). This design was developed based on the professional model and includes the concept of curriculum integration of ICT expressed in a curriculum planning, so that its use responded to educational needs and demands. The programs Wordpress and eXeLearning were used for the preparation of the materials in Web format and the elaboration of Edublog. Conclusions: The designed and implemented resources form a system of integrated means and are comprised of chapters in electronic format, a web course, an Edublog and a monographic product on the impact of sugar consumption on health. Motivation, management and evaluation of scientific information were achieved.La formación de profesionales de la Licenciatura en Ciencias Alimentarias requiere del desarrollo de habilidades en la gestión de información en ciencias biomédicas. El presente trabajo propone el diseño curricular de una asignatura optativa y su integración con las Tecnologías de la Información y las Comunicaciones (TIC). Este diseño se conformó a partir del modelo del profesional, y contempla el concepto de integración curricular de las TIC expresada en una planificación curricular, de forma que su uso respondió a necesidades y demandas educativas. Se utilizaron los programas Wordpress y eXeLearning para la realización de los materiales en formato Web y la elaboración del Edublog. Los recursos diseñados e implementados son un sistema de medios integrados y comprenden capítulos en formato electrónico, un curso web, un Edublog y un producto monográfico sobre el impacto del consumo de azúcar en la salud. Se logró la motivación, gestión y evaluación de la información científica.A formação de profissionais do curso de Graduação em Ciências da Alimentação precisa do desenvolvimento de habilidades na gestão de informação em ciências biomédicas. Este estudo propõe o desenho curricular de uma matéria optativa e sua integração com as Tecnologias da Informação e as Comunicações (TIC). A conformação deste desenho partiu do modelo do profissional e prevê o conceito de integração curricular das TIC expressas em um planejamento curricular, de forma que seu uso respondeu a necessidades e demandas educativas. Para a realização dos materiais em formato Web e a elaboração doEdublog utilizaram-se os programas Wordpress eeXeLearning. Os recursos criados e implementados compõem- se de um sistema de meios integrados e abrangem capítulos em formato eletrônico, um curso web, um Edublog e um produto monográfico sobre o impacto do consumo do açúcar na saúde. Obtiveram-se a motivação, gestão e avaliação da informação cientifica

Sinus elevation by in situ utilization of bone scrapers : technique and results

Objectives: The objective was to present a novel technique for antrostomy performed before sinus elevation in atrophic maxilla for subsequent implant placement. Material and methods: The study included 10 sinus elevations performed by the proposed technique in nine consecutive patients presenting with inadequate posterior maxillary height. The technique is described, calculating the antrostomy surface area, volume of bone tissue obtained and final height attained in each case. A total of 16 implants were placed. Results: All ten elevations were accomplished. Mean antrostomy surface area was 0.55 mm2 , mean bone volume obtained was 0.56 cm3 and mean height attained was 11.7 mm from a baseline mean height of 5.6 mm. Out of the 16 implants, 14 were inserted immediately after the elevation and 2 were inserted in a second step, after ossification; 93.7% of the implants were osseointegrated at 6 months after prosthesis placement. Conclusion: The use of bone scrapers to create antrostomy for sinus elevation is a simple and very safe procedure. It provides a variable amount of particulate bone graft that is easily handled and highly useful for packing the cavity that will elevate the sinus membrane

Informe planta térmica

La planta térmica es la instalación de varios sistemas que unidos son empleados para la generación de energía eléctrica a partir de la energía del calor [1] (normalmente es obtenida de la quema de combustibles fósiles como el carbón, productos del petróleo o gas natural), energía empleada y transmitida a un fluido para así generar movimiento mecánico que luego será transformado en energía eléctrica. Su funcionamiento está regido por El Ciclo Rankine [2], que es un ciclo termodinámico que se basa en la conversión de calor en trabajo para generar potencia, éste ciclo utiliza un fluido que por lo general es agua, se conforma por cuatro sistemas básicos como una bomba de agua que aumenta la presión del fluido y un poco su temperatura, una caldera que transfiere el calor al agua convirtiendo un vapor a alta temperatura y alta presión, una turbina que consume la energía de presión y velocidad al vapor y por último un condensador que convierte nuevamente el vapor en agua.PregradoTecnólogo en Mecánica AutomotrizTecnología en Mecánica Automotri

An Ex Vivo Model in Human Femoral Heads for Histopathological Study and Resonance Frequency Analysis of Dental Implant Primary Stability

Objective. This study was designed to explore relationships of resonance frequency analysis (RFA)—assessed implant stability (ISQ values) with bone morphometric parameters and bone quality in an ex vivo model of dental implants placed in human femoral heads and to evaluate the usefulness of this model for dental implant studies. Material and Methods. This ex vivo study included femoral heads from 17 patients undergoing surgery for femoral neck fracture due to osteoporosis (OP) ( ) or for total prosthesis joint replacement due to severe hip osteoarthrosis (OA) ( ). Sixty  mm Dentsply Astra implants were placed, followed by RFA. CD44 immunohistochemical analysis for osteocytes was also carried out. Results. As expected, the analysis yielded significant effects of femoral head type (OA versus OA) ( ), but not of the implants ( ) or of the interaction of the two factors ( ). Bonferroni post hoc comparisons showed a lower mean ISQ for implants in decalcified ( ) heads than in fresh ( ) or fixated ( ) heads (both ). The ISQ score (fresh) was significantly higher for those in OA ( ) versus OP ( ) heads. However, mixed linear analysis showed no significant association between ISQ scores and morphologic or histomorphometric results ( in all cases), and no significant differences in ISQ values were found as a function of the length or area of the cortical layer (both ). Conclusion. Although RFA-determined ISQ values are not correlated with morphometric parameters, they can discriminate bone quality (OP versus OA). This ex vivo model is useful for dental implant studies.This investigation was partially supported by Research Group no. CTS-138 (Junta de Andalucía, Spain)

Anti‑inflammatory drugs and uterine cervical cancer cells: Antineoplastic effect of meclofenamic acid

Uterine cervical cancer (UCC) is one of the main causes of cancer-associated mortality in women. Inflammation has been identified as an important component of this neoplasia; in this context, anti-inflammatory drugs represent possible prophylactic and/or therapeutic alternatives that require further investigation. Anti-inflammatory drugs are common and each one may exhibit a different antineoplastic effect. As a result, the present study investigated different anti-inflammatory models of UCC in vitro and in vivo. Celecoxib, sulindac, nimesulide, dexamethasone, meclofenamic acid, flufenamic acid and mefenamic acid were tested in UCC HeLa, VIPA, INBL and SiHa cell lines. The cytotoxicity of the drugs was evaluated in vitro. Celecoxib, sulindac, nimesulide, mefenamic acid and flufenamic acid presented with slight to moderate toxicity (10–40% of cell death corresponding to 100 µM) in certain cell lines, while meclofenamic acid exhibited significant cytotoxicity in all essayed cell lines (50–90% of cell death corresponding to 100 µM). The meclofenamic acid was tested in murine models (immunodeficient and immunocompetent) of UCC, which manifested a significant reduction in tumor growth and increased mouse survival. It was demonstrated that of the evaluated anti-inflammatory drugs, meclofenamic acid was the most cytotoxic, with a significant antitumor effect in murine models. Subsequent studies are necessary to evaluate the clinical utility of this drug

Efectividad del plan de contingencia de la Unidad de Enfermedad Inflamatoria Intestinal ante la infección de Covid-19.

Fundamentos: La toma de decisiones en los hospitales y en sus propios servicios asistenciales apenas está referenciada en la literatura. Durante el período de pandemia por Covid-19, los servicios asistenciales han puesto en marcha planes de contingencia para minimizar las consecuencias del coronavirus en los profesionales y pacientes. Sin embargo, apenas se comparte el despliegue de esos planes de contingencia, ni sus resultados, privando de referencias para refutar, comparar o emular los citados planes a otros servicios asistenciales u hospitales. El objetivo del trabajo fue la descripción de la puesta en marcha de dichos planes ante la pandemia de Covid-19 en la Unidad de Enfermedad Inflamatoria Intestinal de un Servicio de Digestivo en el Área Sanitaria de Pontevedra e O Salnés (Galicia). Métodos: Un equipo de directivos y profesionales adaptaron al entorno sanitario las 10 medidas recomendadas por Deloitte para afrontar una pandemia. A continuación, se formularon las medidas como listado de comprobación. A partir del ciclo de mejora Plan-Do-Check-Act, se agruparon las 10 medidas en las siguientes categorías: gestión del riesgo, gestión organizacional y toma de decisiones. Por último, un equipo externo realizó una evaluación cualitativa de la puesta en marcha del plan de contingencia realizado. Resultados: La Unidad de Enfermedad Inflamatoria Intestinal del Servicio de Digestivo realizó un plan de contingencia que presenta un cumplimiento de las 10 medidas recomendadas para hacer frente a la pandemia de Covid-19 con garantías. Conclusiones: Compartir el despliegue del plan de contingencia y sus resultados es útil para identificar buenas prácticas. Este trabajo ofrece un método para evaluar las tomas de decisiones en los plantes de contingencia en situaciones de pandemia. Los resultados sitúan a la Unidad de Enfermedad Inflamatoria Intestinal en el rango de la excelencia

CPEB alteration and aberrant transcriptome-polyadenylation lead to a treatable SLC19A3 deficiency in Huntington's disease

Huntington’s disease (HD) is a hereditary neurodegenerative disorder of the basal ganglia for which disease-modifying treatments are not yet available. Although gene-silencing therapies are currently being tested, further molecular mechanisms must be explored to identify druggable targets for HD. Cytoplasmic polyadenylation element binding proteins 1 to 4 (CPEB1 to CPEB4) are RNA binding proteins that repress or activate translation of CPE-containing transcripts by shortening or elongating their poly(A) tail. Here, we found increased CPEB1 and decreased CPEB4 protein in the striatum of patients and mouse models with HD. This correlated with a reprogramming of polyadenylation in 17.3% of the transcriptome, markedly affecting neurodegeneration-associated genes including PSEN1, MAPT, SNCA, LRRK2, PINK1, DJ1, SOD1, TARDBP, FUS, and HTT and suggesting a new molecular mechanism in neurodegenerative disease etiology. We found decreased protein content of top deadenylated transcripts, including striatal atrophy–linked genes not previously related to HD, such as KTN1 and the easily druggable SLC19A3 (the ThTr2 thiamine transporter). Mutations in SLC19A3 cause biotin-thiamine–responsive basal ganglia disease (BTBGD), a striatal disorder that can be treated with a combination of biotin and thiamine. Similar to patients with BTBGD, patients with HD demonstrated decreased thiamine in the cerebrospinal fluid. Furthermore, patients and mice with HD showed decreased striatal concentrations of thiamine pyrophosphate (TPP), the metabolically active form of thiamine. High-dose biotin and thiamine treatment prevented TPP deficiency in HD mice and attenuated the radiological, neuropathological, and motor HD-like phenotypes, revealing an easily implementable therapy that might benefit patients with HD

Ceniza y lava: revelaciones científicas junto al volcán

Para la exposición se ha contado con el apoyo del Museo de la Ciencia y el Cosmos (La Laguna, Tenerife) del Cabildo de Tenerife, uno de los centros más visitados en la comunidad canaria por su enfoque interactivo de la divulgación científica. Ceniza y lava acerca el fenómeno geológico al público general para que experimente y comprenda la naturaleza, promoviendo la percepción de lo plausible en nuestro entorno y que adquiera conocimientos básicos para actuar. A diferencia de otros eventos divulgativos similares, esta exposición busca acercar a la población la experiencia investigadora implementada por tierra, mar y aire con sus hallazgos: materiales recopilados, metodologías utilizadas y conclusiones adquiridas, y lo hace de una manera inmersiva, interactiva y didáctica. La exhibición, programada del 29 de junio de 2023 al 30 de junio de 2024, permite ver, y en algunos casos manipular, materiales e instrumentos utilizados en las investigaciones y que por primera vez se han recopilado y museizado para ser exhibidos. Se compone de dos partes: 1) Ceniza y lava. En esta primera sala se recrea la erupción a través de diversos elementos: proyecciones impactantes, datos clave en una pared, línea del tiempo geológica de La Palma, visión nocturna de la erupción a gran escala, evolución diaria de las coladas sobre una reproducción 3D de la isla de 2 m de longitud y caleidoscopio inmersivo de un tubo lávico. 2) Revelaciones científicas. La transición de una sala a otra se realiza a través de una carpa, réplica de un puesto de mando avanzado que sirvió de zona de trabajo, reunión, atención a medios e incluso de descanso del personal investigador. En la segunda sala se accede a materiales, herramientas y descubrimientos realizados en la erupción desde las perspectivas de tierra, mar y aire. Esta exposición es fruto de la sinergia entre el personal científico de los centros CSIC en Canarias que se desplazó a la erupción y el de otras entidades como GE3BCN, el servicio de PRL del CSIC, el MUNA o el GES del Gobierno de Canarias, entre otros.Los equipos de investigación de los centros de la Delegación del CSIC en Canarias (IPNA, IEO e IGME) desempeñaron un papel crucial en la erupción de La Palma abordándola desde diferentes perspectivas: tierra, mar y aire. Su misión: entender el comportamiento del volcán y proporcionar información valiosa a las autoridades locales y equipos de emergencias para la toma de decisiones en gestión de desastres y protección de la población. Con idea de visibilizar este trabajo, esta labor se plasmó en una exposición 360° que es un testimonio poderoso de cómo la colaboración científica puede iluminar fenómenos naturales y su impacto en nuestra comunidad.FECYTOrganismo Autónomo de Museos y Centros de Tenerife (OAMC)Delegación del CSIC en CanariasPeer reviewedEnlace a la visita virtual de la exposición: https://meta.yonders.io/tour/museo-ciencia-y-cosmo