El nivel de internacionalización de los Grados en Información y Documentación de las universidades españolas : análisis del idioma usado en la bibliografía de sus planes docentes

Para afrontar el reto planteado a la educación superior en la actualidad es imprescindible el conocimiento de distintas lenguas. Dicho conocimiento puede ser incentivado desde la Universidad a través de diversos mecanismos como la movilidad, la formación reglada en idiomas, o la adquisición de la competencia transversal “conocimiento de una lengua extranjera” usando técnicas diversas, como la consulta de referencias bibliográficas en lenguas extranjeras. Es precisamente este último, el principal componente analizado en el presente trabajo, que investiga la internacionalización de los estudios de Grado en Información y Documentación a través del análisis cuantitativo del uso de lenguas extranjeras en las referencias bibliográficas de los planes docentes de los Títulos de Grado en Información y Documentación impartidos por las universidades españolas. Para ello, se analiza un número final de 454 planes docentes con un total de 6924 referencias bibliográficas. Los resultados muestran una baja proporción de referencias en idiomas distintos al castellano, siendo la lengua inglesa la más utilizada de las extranjeras y aumentando dicha proporción en los últimos cursos de los Grados, los más próximos a la incorporación de los egresados al mercado laboral internacional

Dendritic cell deficiencies persist seven months after SARS-CoV-2 infection

Severe Acute Respiratory Syndrome Coronavirus (SARS-CoV)-2 infection induces an exacerbated inflammation driven by innate immunity components. Dendritic cells (DCs) play a key role in the defense against viral infections, for instance plasmacytoid DCs (pDCs), have the capacity to produce vast amounts of interferon-alpha (IFN-α). In COVID-19 there is a deficit in DC numbers and IFN-α production, which has been associated with disease severity. In this work, we described that in addition to the DC deficiency, several DC activation and homing markers were altered in acute COVID-19 patients, which were associated with multiple inflammatory markers. Remarkably, previously hospitalized and nonhospitalized patients remained with decreased numbers of CD1c+ myeloid DCs and pDCs seven months after SARS-CoV-2 infection. Moreover, the expression of DC markers such as CD86 and CD4 were only restored in previously nonhospitalized patients, while no restoration of integrin β7 and indoleamine 2,3-dyoxigenase (IDO) levels were observed. These findings contribute to a better understanding of the immunological sequelae of COVID-19

Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)

Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters. Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs). Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001). Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio

Clonal chromosomal mosaicism and loss of chromosome Y in elderly men increase vulnerability for SARS-CoV-2

The pandemic caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2, COVID-19) had an estimated overall case fatality ratio of 1.38% (pre-vaccination), being 53% higher in males and increasing exponentially with age. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, we found 133 cases (1.42%) with detectable clonal mosaicism for chromosome alterations (mCA) and 226 males (5.08%) with acquired loss of chromosome Y (LOY). Individuals with clonal mosaic events (mCA and/or LOY) showed a 54% increase in the risk of COVID-19 lethality. LOY is associated with transcriptomic biomarkers of immune dysfunction, pro-coagulation activity and cardiovascular risk. Interferon-induced genes involved in the initial immune response to SARS-CoV-2 are also down-regulated in LOY. Thus, mCA and LOY underlie at least part of the sex-biased severity and mortality of COVID-19 in aging patients. Given its potential therapeutic and prognostic relevance, evaluation of clonal mosaicism should be implemented as biomarker of COVID-19 severity in elderly people. Among 9578 individuals diagnosed with COVID-19 in the SCOURGE study, individuals with clonal mosaic events (clonal mosaicism for chromosome alterations and/or loss of chromosome Y) showed an increased risk of COVID-19 lethality

Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)

This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe

Estudio preliminar. Patologías digitales más frecuentes en el pie de la bailaora de flamencoe

Este estudio tiene como objetivos, en primer lugar, dar a conocer las principales deformidades digitales de los pies, asociadas -por su alta incidencia- a la práctica profesional del baile flamenco femenino. Así como, poner de manifiesto la necesidad de llevar a cabo estudios de mayor magnitud para determinar si existe una relación estadísticamente significativa entre la práctica del baile flamenco con las deformidades y patologías podológicas descritas, y la importancia de la investigación en el campo de la medicina del deporte, y de la ortopodología y biomecánica en pos de hallar tratamientos preventivos y/o paliativos en su caso.En este estudio epidemiológico preliminar, llevado a cabo con la colaboración de la Universidad de Sevilla-Área Clínica de Podología y Departamento de Podología- Agencia Andaluza para el Desarrollo del Flamenco, Fundación Cristina Heeren de Arte Flamenco, Centro de Baile Flamenco Ana Moya, y el Centro de Investigación de Flamenco Telethusa, se han evaluado a 28 bailaoras profesionales activas en la provincia de Sevilla, con una actividad mínima de 20h semanales. En dicha muestra se han determinado las patologías podológicas presentes, sintomatología, hábitos de uso de calzado específico, y hábitos podológicos. Los resultados muestran una alta incidencia de patologías digitales como el H.A.V. (juanetes), dedos en garra, y onicopatías

Is higher physical fitness associated with better psychological health in young pediatric cancer survivors? A cross-sectional study from the iBoneFIT project

Objective: To examine the associations of self-perceived and objectively-measured physical fitness with psychological well-being and distress indicators in young pediatric cancer survivors. Materials and Methods: A total of 116 participants (12.1 ± 3.3 years, 56.9% boys) from the iBoneFIT project participated in this cross-sectional study. Objectively-measured physical fitness (muscular fitness) was obtained by handgrip strength and standing long jump tests for the upper and lower body, respectively. Self-perceived physical fitness was obtained by the International Fitness Scale (IFIS). Positive and negative affect were assessed by the positive affect schedule for children (PANAS-C), happiness by Subjective Happiness Scale (SHS), optimism by Life Orientation Test-Revised (LOT-R), self-esteem by the Rosenberg Self-Esteem Scale (RSE), anxiety by State–Trait Anxiety Inventory for Children (STAIC-R), and depression by Children Depression Inventory (CDI). Multiple linear regressions adjusted by key covariates were performed to analyze associations. Results: No associations were found between objectively-measured muscular fitness and any of the psychological well-being and distress indicators (p > 0.05). Self-perceived overall fitness and flexibility were positively associated with positive affect (β ≥ 0.258, p < 0.05). Self-perceived cardiorespiratory fitness, speed/ agility, and flexibility were negatively associated with depression (β ≥ −0.222, p < 0.05). Finally, self-perceived cardiorespiratory fitness was also negatively associated with anxiety and negative affect (β ≥ −0.264, p < 0.05). Conclusions: Perceived physical fitness, but not objectively physical fitness, seems to be inversely related to psychological distress variables and to less extent positively related to psychological well-being. The findings from this study highlight the importance of promoting self-perceived fitness in the pediatric oncology population.Ministry of Science and Innovation, Spain (MICINN) Spanish Government PID2020-117302RA-I00La Caixa Foundation LCF/BQ/PR19/11700007European Union's Horizon 2020 research and inno-vation programme under the Marie Sklodowska Curie 10102892

El Hallux Abductus Valgus en la bailaora de flamenco.

The hallux abductus valgus (HAV), commonly known as bunion, is defined as first toe lateral curvature and its rotation in valgus. Its origin can be derived from multiple factors, such as the existence of pathomechanics etiology: subastragalina joint hiperpronation, excessive length of first metatarsal and/or first toe, or peroneus longus muscle failure. Statiscally, it affects more to females than males, and as regards flamenco dance there are two factors which are closely related to such high levels of deformity: high-heeled shoes and narrow toe cap use, and some sports gesture methodsEl Hallux Abductus Valgus (HAV), comúnmente llamado juanete, se define como la desviación lateral del primer dedo del pie y su rotación en valgo. Su origen es multifactorial, existiendo etiología patomecánica de base: hiperpronación subastragalina, excesiva longitud del primer metatarsiano y/o del primer dedo, o la insuficiencia del músculo peroneo largo. Estadísticamente, afecta más al sexo femenino que al masculino, y, en relación al baile flamenco, hay dos factores que se han asociado con una alta incidencia: uso del calzado de tacón y puntera estrecha, y ciertas modalidades del gesto deportivo. Mediante estudio observacional transversal realizado en diferentes academias de flamenco de Andalucía, Área Clínica de Podología de la Universidad de Sevilla y centros privados de Investigación y Podología, sobre 32 bailaoras de flamenco, se determina que existe una muy alta prevalencia de hallux abductus valgus en la bailaora profesional de flamenco

Increased translation as a novel pathogenic mechanism in Huntington's disease

Huntington's disease is a neurodegenerative disorder caused by a CAG repeat expansion in exon 1 of the huntingtin gene. Striatal projection neurons are mainly affected, leading to motor symptoms, but molecular mechanisms involved in their vulnerability are not fully characterized. Here, we show that eIF4E binding protein (4E-BP), a protein that inhibits translation, is inactivated in Huntington's disease striatum by increased phosphorylation. Accordingly, we detected aberrant de novo protein synthesis. Proteomic characterization indicates that translation specifically affects sets of proteins as we observed upregulation of ribosomal and oxidative phosphorylation proteins and downregulation of proteins related to neuronal structure and function. Interestingly, treatment with the translation inhibitor 4EGI-1 prevented R6/1 mice motor deficits, although corticostriatal long-term depression was not markedly changed in behaving animals. At the molecular level, injection of 4EGI-1 normalized protein synthesis and ribosomal content in R6/1 mouse striatum. In conclusion, our results indicate that dysregulation of protein synthesis is involved in mutant huntingtin-induced striatal neuron dysfunction