Foaming binary solution mixtures of low molecular surfactant and polyelectrolyte

The lifetime of water solution foams of sodium dodecylsulfate (DDS, low molecular weight surfactant) and sodium carboxymethylcellulose (SCMC, polyelectrolyte) and their binary mixtures was experimentally investigated. The effects of ionic strength and acidity on the foam life were also determined. In binary solutions, a synergic effect of DDS and SCMC on the surface tension reduction, most likely resulting from the interaction of the surfactant with polymer, was found. The addition of NaCl into solution or increasing the ionic strength was found to decrease the surface tension and reduce interfacial mobility, hence increased foam lifetime. The relatively low lifetime of binary solution foams in acidic medium was attributed to the reaction between SCMC and acid, which resulted in relatively small reductions in the viscosity and consequently lowered the solution viscosity

Ideal Magnetic Dipole: Scattering and Mantle Cloaking Effects

Artificial magnetic response is one of the recent research topics that is receiving significant attention. Nevertheless, because of the difficulties in exciting not only the magnetic moment but also multipoles of different order, and the presence of losses, the efficiency of its generation is strongly compromised. On the other hand, the presence of a cloaking phenomena can be described in terms of anapole mode, which consists in the compensation of the scattering due to the moment of the electric dipole with the toroidal one. Because of this effect, the remaining part of the field will exhibit a strong(er) magnetic dipole moment response. In the present study, the response of a cloaking device based on a real-life geometry is therefore analysed with particular focus the anapole mode excitation and ideal magnetic dipole behaviour

E.Coli derived camelid antibodies as a sensor for P53 in saliva

Oral squamous cell carcinoma (OSCC) is a malignant tumor with 640,000 new cases annually in the world [1]. Saliva testing is non-invasive procedure that is capable to detect potential biomarkers for OSCC. It was shown that elevated level of p53 protein was identified in OSCC patients at different stages of the disease (ibid). Camelid antibodies containing only variable regions, nanobodies (VHH) and single-chain variable regions (scFv) with VH and VL, are becoming popular in many biological studies including diagnostic applications. It was identified that VL region alone showed higher affinity to p53 than VHH, and dimerization of VL region with another one increases the affinity up to 10 folds [2]. Camelid antibodies have similar affinity to its substrate as human antibodies and can be conjugated to other proteins without functional lose. They can be expressed and secreted in many organisms including E.Coli in high amount, which reduces the cost of antibodies production. Thus, the aim of this project is to design a biosensor, based on available sequence of antibodies, to detect p53 in saliva samples for OSCC diagnosis

Predictive modelling of burnout among Kazakhstani English teacher candidates

Introduction. In Kazakhstan, 55% of English pre-service teacher candidates do not plan to work in public schools after graduation. The current quantitative study, using statistical analysis, sought to determine the causes of this phenomenon.The aim of the present research was to determine the probability of early career burnout among future English teachers using predictive modeling.Methodology and research methods. To create a predictive model, the authors used the following statistical data analysis tools: factor analysis, ordinal regression, and the Сhi-square test. The selection of the above tools provides to predict the probability of work intention in a Kazakhstani public school for more than five years. This period acts as a proxy variable for predicting future teachers’ burnout rates. The study involved 160 pre-service teachers, who received State scholarships for free tuition, with an obligation to work in public schools after graduation.Results and scientific novelty. The data indicated that some respondents would only work for a period of less than five years, due to a sense of despair about their profession. The results demonstrate that pre-service teachers require better training. Furthermore, the authors found a correlation in teaching career expectations and the gender gap, where mature female participants were more likely to carry an intention to work for more than five years.Practical significance. The present study makes a contribution to further research aimed at preventing the shortage and turnover of teaching staff in the workplace by detecting early warning signs of burnout among prospective teachers. The authors identified the indicators of the risk group of novice teachers, who are more prone to burnout due to emotional exhaustion, low self-efficacy, low expectations, and prospects from a teaching career. The authors believe that effective career guidance provides an adequate selection of the most motivated applicants with high occupational expectations.Введение. В Казахстане 55% будущих учителей английского языка не планируют работать в государственных школах после окончания высшего учебного заведения. В настоящем количественном исследовании, используя статистический анализ, авторы попытались определить причины этого явления. Цель исследования – определить вероятность раннего выгорания у будущих учителей английского языка с помощью прогностического моделирования.Методология и методы исследования. Для создания прогностической модели авторы использовали следующие инструменты статистического анализа данных: факторный анализ, порядковую регрессию и тест хи-квадрат. Совокупность вышеуказанных инструментов позволяет прогнозировать намерения работать в казахстанской государственной школе более пяти лет. Этот период выступает в качестве косвенной переменной для прогнозирования уровня выгорания будущих учителей. В исследовании приняли участие 160 будущих преподавателей, получивших государственные стипендии на бесплатное обучение с обязательством работать в государственных школах после окончания учебы. Результаты и научная новизна. Данные показали, что некоторые респонденты будут работать менее пяти лет из-за чувства отчаяния по поводу своей профессии. Результаты показывают, что будущие учителя нуждаются в лучшей подготовке. Кроме того, авторы обнаружили корреляцию между ожиданиями от преподавательской карьеры и гендерным разрывом, когда участники старшего возраста с большей вероятностью намеревались проработать более пяти лет в учебной среде. Практическая значимость. Настоящая работа вносит вклад в дальнейшие исследования, направленные на предотвращение нехватки и текучести преподавательского состава на рабочем месте путем выявления ранних предупреждающих признаков выгорания среди будущих учителей. Определены показатели группы риска начинающих учителей, которые более склонны к выгоранию из-за эмоционального истощения, низких самоэффективности, ожиданий и перспектив педагогической карьеры. По мнению авторов, эффективная профориентация обеспечивает адекватный отбор наиболее мотивированных соискателей с высокими профессиональными ожиданиями

Epidemiology of children's cerebral palsy in The Republic of Kazakhstan

This article discusses the dynamics of the incidence of cerebral palsy for 2013-2017 in the Republic of Kazakhstan.В данной статье рассмотрена динамика заболеваемости детским церебральным параличом за 2013-2017 годы в Республике Казахстан

No evidence of a common DNA variant profile specific to world class endurance athletes

There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world class caliber and sedentary controls. An international consortium (GAMES) was established in order to compare elite endurance athletes and ethnicity-matched controls in a case-control study design. Genome-wide association studies were undertaken on two cohorts of elite endurance athletes and controls (GENATHLETE and Japanese endurance runners), from which a panel of 45 promising markers was identified. These markers were tested for replication in seven additional cohorts of endurance athletes and controls: from Australia, Ethiopia, Japan, Kenya, Poland, Russia and Spain. The study is based on a total of 1520 endurance athletes (835 who took part in endurance events in World Championships and/or Olympic Games) and 2760 controls. We hypothesized that world-class athletes are likely to be characterized by an even higher concentration of endurance performance alleles and we performed separate analyses on this subsample. The meta-analysis of all available studies revealed one statistically significant marker (rs558129 at GALNTL6 locus, p = 0.0002), even after correcting for multiple testing. As shown by the low heterogeneity index (I2 = 0), all eight cohorts showed the same direction of association with rs558129, even though p-values varied across the individual studies. In summary, this study did not identify a panel of genomic variants common to these elite endurance athlete groups. Since GAMES was underpowered to identify alleles with small effect sizes, some of the suggestive leads identified should be explored in expanded comparisons of world-class endurance athletes and sedentary controls and in tightly controlled exercise training studies. Such studies have the potential to illuminate the biology not only of world class endurance performance but also of compromised cardiac functions and cardiometabolic diseases

Athlome Project Consortium: a concerted effort to discover genomic and other "omic" markers of athletic performance.

Despite numerous attempts to discover genetic variants associated with elite athletic performance, injury predisposition, and elite/world-class athletic status, there has been limited progress to date. Past reliance on candidate gene studies predominantly focusing on genotyping a limited number of single nucleotide polymorphisms or the insertion/deletion variants in small, often heterogeneous cohorts (i.e., made up of athletes of quite different sport specialties) have not generated the kind of results that could offer solid opportunities to bridge the gap between basic research in exercise sciences and deliverables in biomedicine. A retrospective view of genetic association studies with complex disease traits indicates that transition to hypothesis-free genome-wide approaches will be more fruitful. In studies of complex disease, it is well recognized that the magnitude of genetic association is often smaller than initially anticipated, and, as such, large sample sizes are required to identify the gene effects robustly. A symposium was held in Athens and on the Greek island of Santorini from 14-17 May 2015 to review the main findings in exercise genetics and genomics and to explore promising trends and possibilities. The symposium also offered a forum for the development of a position stand (the Santorini Declaration). Among the participants, many were involved in ongoing collaborative studies (e.g., ELITE, GAMES, Gene SMART, GENESIS, and POWERGENE). A consensus emerged among participants that it would be advantageous to bring together all current studies and those recently launched into one new large collaborative initiative, which was subsequently named the Athlome Project Consortium

No evidence of a common DNA variant profile specific to world class endurance athletes

There are strong genetic components to cardiorespiratory fitness and its response to exercise training. It would be useful to understand the differences in the genomic profile of highly trained endurance athletes of world class caliber and sedentary controls. An international consortium (GAMES) was established in order to compare elite endurance athletes and ethnicity- matched controls in a case-control study design. Genome-wide association studies were undertaken on two cohorts of elite endurance athletes and controls (GENATHLETE and Japanese endurance runners), from which a panel of 45 promising markers was identified. These markers were tested for replication in seven additional cohorts of endurance athletes and controls: from Australia, Ethiopia, Japan, Kenya, Poland, Russia and Spain. The study is based on a total of 1520 endurance athletes (835 who took part in endurance events in World Championships and/or Olympic Games) and 2760 controls. We hypothesized that world-class athletes are likely to be characterized by an even higher concentration of endurance performance alleles and we performed separate analyses on this subsample. The meta-analysis of all available studies revealed one statistically significant marker (rs558129 at GALNTL6 locus, p = 0.0002), even after correcting for multiple testing. As shown by the low heterogeneity index (I2 = 0), all eight cohorts showed the same direction of association with rs558129, even though p-values varied across the individual studies. In summary, this study did not identify a panel of genomic variants common to these elite endurance athlete groups. Since GAMES was underpowered to identify alleles with small effect sizes, some of the suggestive leads identified should be explored in expanded comparisons of world-class endurance athletes and sedentary controls and in tightly controlled exercise training studies. Such studies have the potential to illuminate the biology not only of world class endurance performance but also of compromised cardiac functions and cardiometabolic diseases

Clinical features of post-COVID-19 period. Results of the international register “Dynamic analysis of comorbidities in SARS-CoV-2 survivors (AKTIV SARS-CoV-2)”. Data from 6-month follow-up

Aim. To study the clinical course specifics of coronavirus disease 2019 (COVID-19) and comorbid conditions in COVID-19 survivors 3, 6, 12 months after recovery in the Eurasian region according to the AKTIV register. Material and methods.The AKTIV register was created at the initiative of the Eurasian Association of Therapists. The AKTIV register is divided into 2 parts: AKTIV 1 and AKTIV 2. The AKTIV 1 register currently includes 6300 patients, while in AKTIV 2 — 2770. Patients diagnosed with COVID-19 receiving in- and outpatient treatment have been anonymously included on the registry. The following 7 countries participated in the register: Russian Federation, Republic of Armenia, Republic of Belarus, Republic of Kazakhstan, Kyrgyz Republic, Republic of Moldova, Republic of Uzbekistan. This closed multicenter register with two nonoverlapping branches (in- and outpatient branch) provides 6 visits: 3 in-person visits during the acute period and 3 telephone calls after 3, 6, 12 months. Subject recruitment lasted from June 29, 2020 to October 29, 2020. Register will end on October 29, 2022. A total of 9 fragmentary analyzes of the registry data are planned. This fragment of the study presents the results of the post-hospitalization period in COVID-19 survivors after 3 and 6 months. Results. According to the AKTIV register, patients after COVID-19 are characterized by long-term persistent symptoms and frequent seeking for unscheduled medical care, including rehospitalizations. The most common causes of unplanned medical care are uncontrolled hypertension (HTN) and chronic coronary artery disease (CAD) and/or decompensated type 2 diabetes (T2D). During 3- and 6-month follow-up after hospitalization, 5,6% and 6,4% of patients were diagnosed with other diseases, which were more often presented by HTN, T2D, and CAD. The mortality rate of patients in the post-hospitalization period was 1,9% in the first 3 months and 0,2% for 4-6 months. The highest mortality rate was observed in the first 3 months in the group of patients with class II-IV heart failure, as well as in patients with cardiovascular diseases and cancer. In the pattern of death causes in the post-hospitalization period, following cardiovascular causes prevailed (31,8%): acute coronary syndrome, stroke, acute heart failure. Conclusion. According to the AKTIV register, the health status of patients after COVID-19 in a serious challenge for healthcare system, which requires planning adequate health system capacity to provide care to patients with COVID-19 in both acute and post-hospitalization period