Ortho-to-para ratio of interstellar heavy water

Despite the low elemental deuterium abundance in the Galaxy, enhanced molecular D/H ratios have been found in the environments of low-mass star forming regions, and in particular the Class 0 protostar IRAS 16293-2422. The CHESS (Chemical HErschel Surveys of Star forming regions) Key Program aims at studying the molecular complexity of the interstellar medium. The high sensitivity and spectral resolution of the HIFI instrument provide a unique opportunity to observe the fundamental 1,1,1 - 0,0,0 transition of the ortho-D2O molecule, inaccessible from the ground, and to determine the ortho-to-para D2O ratio. We have detected the fundamental transition of the ortho-D2O molecule at 607.35 GHz towards IRAS 16293-2422. The line is seen in absorption with a line opacity of 0.62 +/- 0.11 (1 sigma). From the previous ground-based observations of the fundamental 1,1,0 - 1,0,1 transition of para-D2O seen in absorption at 316.80 GHz we estimate a line opacity of 0.26 +/- 0.05 (1 sigma). We show that the observed absorption is caused by the cold gas in the envelope of the protostar. Using these new observations, we estimate for the first time the ortho to para D2O ratio to be lower than 2.6 at a 3 sigma level of uncertainty, to be compared with the thermal equilibrium value of 2:1.Comment: 5 pages, 5 figures, accepted the A&A HIFI Special Issue as a lette

Guillain-Barré syndrome and adjuvanted pandemic influenza A (H1N1) 2009 vaccines: A multinational self-controlled case series in Europe

Background: The risk of Guillain-Barré syndrome (GBS) following the United States' 1976 swine flu vaccination campaign in the USA led to enhanced active surveillance during the pandemic influenza (A(H1N1)pdm09) immunization campaign. This study aimed to estimate the risk

APEX-CHAMP+ high-J CO observations of low-mass young stellar objects: I. The HH 46 envelope and outflow

AIMS Our aim is to characterize the size, mass, density and temperature profiles of the protostellar envelope of HH~46 IRS 1 and its surrounding cloud material as well as the effect the outflow has on its environment.METHODS The CHAMP+ and LABOCA arrays on the APEX telescope, combined with lower frequency line receivers, are used to obtain a large continuum map and smaller heterodyne maps in various isotopologues of CO and HCO+. The high-J lines of CO (6--5 and 7--6) and its isotopologues together with [C I] 2--1, observed with CHAMP+, are used to probe the warm molecular gas in the inner few hundred AU and in the outflowing gas. The data are interpreted with continuum and line radiative transfer models. RESULTS Broad outflow wings are seen in CO low- and high-J lines at several positions, constraining the gas temperatures to a constant value of ~100 K along the red outflow axis and to ~60 K for the blue outflow. The derived outflow mass is of order 0.4--0.8 M_sol, significantly higher than previously found. The bulk of the strong high-J CO line emission has a surprisingly narrow width, however, even at outflow positions. These lines cannot be fit by a passively heated model of the HH 46 IRS envelope. We propose that it originates from photon heating of the outflow cavity walls by ultraviolet photons originating in outflow shocks and the accretion disk boundary layers. At the position of the bow shock itself, the UV photons are energetic enough to dissociate CO. The envelope mass of ~5 M_sol is strongly concentrated towards HH 46 IRS with a density power law of -1.8.Comment: accepted by A&

Inclusion of vaccinated cases (% of population) over study period.

<p>Inclusion of vaccinated cases (% of population) over study period.</p

Inclusion of GBS cases (DK, FI, FR, NL, NO, SE, UK), influenza A(H1N1)pdm09 immunization period (influenza A(H1N1)vac), and percentage of flu positive cases among all tested per country (Flu pos. DK, …, Flu pos. UK; Source: ECDC 2011) over total study period.

<p>Inclusion of GBS cases (DK, FI, FR, NL, NO, SE, UK), influenza A(H1N1)pdm09 immunization period (influenza A(H1N1)vac), and percentage of flu positive cases among all tested per country (Flu pos. DK, …, Flu pos. UK; Source: ECDC 2011) over total study period.</p

Flowchart of case inclusion.

<p>Flowchart of case inclusion.</p

Guillain-Barré syndrome occurrence during follow-up and during the 6-week (42 days) risk periods following influenza A(H1N1)pdm09 vaccination and infection.

<p>Guillain-Barré syndrome occurrence during follow-up and during the 6-week (42 days) risk periods following influenza A(H1N1)pdm09 vaccination and infection.</p