Self-Pulsating Semiconductor Lasers: Theory and Experiment

We report detailed measurements of the pump-current dependency of the self-pulsating frequency of semiconductor CD lasers. A distinct kink in this dependence is found and explained using rate-equation model. The kink denotes a transition between a region where the self-pulsations are weakly sustained relaxation oscillations and a region where Q-switching takes place. Simulations show that spontaneous emission noise plays a crucial role for the cross-over.Comment: Revtex, 16 pages, 7 figure

Customising Best Practice In Studies Advice For Undergraduate Engineering Students

The attrition rates from undergraduate engineering programmes in the UK remains stubbornly high, despite the best efforts of course teams to engage and support students on their learning journeys. It is generally accepted that there is no single reason for attrition rates from engineering programmes being higher than from other vocational-type university programmes, but many academics believe that an effective Studies Advice system that works for students and staff, could lead to reduced numbers of disengaging and/or failing students. Much has been written on effective approaches to the provision of Studies Advice at University, but it is not clear if the implementation of discipline specific approaches would yield better outcomes. This practice paper describes work that is currently underway at Ulster University to examine engineering students’ perspectives on the Studies Advice approach and to explore how best practice in the university sector might be effectively customised for engineering students. The work describes an initial scoping study, a co-creation exercise with students to establish their baseline understanding of the current system and their ‘wish-list’, and a follow-up focus group session where a number of discipline-specific interventions were explored. Preliminary findings indicate that professional support departments could be more effectively integrated with academic support to provide a wrap-around or ‘single contact point’ for Studies Advice, that formal organised studies advice sessions should be explicit on programme schedules and that an informal ‘buddy or mentor’ student-to-student support system would be beneficial in addressing the UK engineering student attrition issue

Exploring Pompeii: discovering hospitality through research synergy

Hospitality research continues to broaden through an ever-increasing dialogue and alignment with a greater number of academic disciplines. This paper demonstrates how an enhanced understanding of hospitality can be achieved through synergy between archaeology, the classics and sociology. It focuses on classical Roman life, in particular Pompeii, to illustrate the potential for research synergy and collaboration, to advance the debate on hospitality research and to encourage divergence in research approaches. It demonstrates evidence of commercial hospitality activities through the excavation hotels, bars and taverns, restaurants and fast food sites. The paper also provides an example of the benefits to be gained from multidisciplinary analysis of hospitality and tourism

Identification of a plasma signature of psychotic disorder in children and adolescents from the Avon Longitudinal Study of Parents and Children (ALSPAC) cohort

The identification of an early biomarker of psychotic disorder is important as early treatment is associated with improved patient outcome. Metabolomic and lipidomic approaches in combination with multivariate statistical analysis were applied to identify plasma alterations in children (age 11) (38 cases vs 67 controls) and adolescents (age 18) (36 cases vs 117 controls) preceeding or coincident with the development of psychotic disorder (PD) at age 18 in the Avon Longitudinal Study of Parents and Children (ALSPAC). Overall, 179 lipids were identified at age 11, with 32 found to be significantly altered between the control and PD groups. Following correction for multiple comparisons, 8 of these lipids remained significant (lysophosphatidlycholines (LPCs) LPC(18:1), LPC(18:2), LPC(20:3); phosphatidlycholines (PCs) PC(32:2; PC(34:2), PC(36:4), PC(0-34-3) and sphingomyelin (SM) SM(d18:1/24:0)), all of which were elevated in the PD group. At age 18, 23 lipids were significantly different between the control and PD groups, although none remained significant following correction for multiple comparisons. In conclusion, the findings indicate that the lipidome is altered in the blood during childhood, long before the development of psychotic disorder. LPCs in particular are elevated in those who develop PD, indicating inflammatory abnormalities and altered phospholipid metabolism. These findings were not found at age 18, suggesting there may be ongoing alterations in the pathophysiological processes from prodrome to onset of PD

e-MERLIN resolves Betelgeuse at λ5 cm: hotspots at 5R*

published_or_final_versio

ALMA sub-mm maser and dust distribution of VY Canis Majoris

Cool, evolved stars have copious, enriched winds. The structure of these winds and the way they are accelerated is not well known. We need to improve our understanding by studying the dynamics from the pulsating stellar surface to about 10 stellar radii, where radiation pressure on dust is fully effective. Some red supergiants have highly asymmetric nebulae, implicating additional forces. We retrieved ALMA Science Verification data providing images of sub-mm line and continuum emission from VY CMa. This enables us to locate water masers with milli-arcsec precision and resolve the dusty continuum. The 658-, 321- and 325-GHz masers lie in irregular, thick shells at increasing distances from the centre of expansion. For the first time this is confirmed as the stellar position, coinciding with a compact peak offset to the NW of the brightest continuum emission. The maser shells (and dust formation zone) overlap but avoid each other on tens-au scales. Their distribution is broadly consistent with excitation models but the conditions and kinematics appear to be complicated by wind collisions, clumping and asymmetries.Comment: Letter 4 pages, 5 figures plus appendix with 3 figures. Accepted by Astronomy and Astrophysics Letter

Aerodynamic investigations of ventilated brake discs.

The heat dissipation and performance of a ventilated brake disc strongly depends on the aerodynamic characteristics of the flow through the rotor passages. The aim of this investigation was to provide an improved understanding of ventilated brake rotor flow phenomena, with a view to improving heat dissipation, as well as providing a measurement data set for validation of computational fluid dynamics methods. The flow fields at the exit of four different brake rotor geometries, rotated in free air, were measured using a five-hole pressure probe and a hot-wire anemometry system. The principal measurements were taken using two-component hot-wire techniques and were used to determine mean and unsteady flow characteristics at the exit of the brake rotors. Using phase-locked data processing, it was possible to reveal the spatial and temporal flow variation within individual rotor passages. The effects of disc geometry and rotational speed on the mean flow, passage turbulence intensity, and mass flow were determined. The rotor exit jet and wake flow were clearly observed as characterized by the passage geometry as well as definite regions of high and low turbulence. The aerodynamic flow characteristics were found to be reasonably independent of rotational speed but highly dependent upon rotor geometry

A prospective longitudinal study of performance status, an inflammation-based score (GPS) and survival in patients with inoperable non-small-cell lung cancer

The value of an inflammation-based prognostic score (Glasgow Prognostic score, GPS) was compared with performance status (ECOG-ps) in a longitudinal study of patients (n=101) with inoperable non-small-cell lung cancer (NSCLC). At diagnosis, stratified for treatment, only the GPS (HR 2.32, 95% CI 1.52–3.54, P<0.001) was a significant predictor of survival. In contrast, neither the GPS nor ECOG-ps measured at 3–6 months follow-up were significant predictors of residual survival. This study confirms the prognostic value of the GPS, at diagnosis, in patients with inoperable NSCLC. However, the role of the GPS and ECOG-ps during follow-up has not been established

Percentile indices for assessing changes in heavy precipitation events

Many climate studies assess trends and projections in heavy precipitation events using precipitation percentile (or quantile) indices. Here we investigate three different percentile indices that are commonly used. We demonstrate that these may produce very different results and thus require great care with interpretation. More specifically, consideration is given to two intensity-based indices and one frequency-based index, namely (a) all-day percentiles, (b) wet-day percentiles, and (c) frequency indices based on the exceedance of a percentile threshold. Wet-day percentiles are conditionally computed for the subset of wet events (with precipitation exceeding some threshold, e.g. 1 mm/d for daily precipitation). We present evidence that this commonly used methodology can lead to artifacts and misleading results if significant changes in the wet-day frequency are not accounted for. Percentile threshold indices measure the frequency of exceedance with respect to a percentile-based threshold. We show that these indices yield an assessment of changes in heavy precipitation events that is qualitatively consistent with all-day percentiles, but there are substantial differences in quantitative terms. We discuss the reasons for these effects, present a theoretical assessment, and provide a series of examples using global and regional climate models to quantify the effects in typical applications. Application to climate model output shows that these considerations are relevant to a wide range of typical climate-change applications. In particular, wet-day percentiles generally yield different results, and in most instances should not be used for the impact-oriented assessment of changes in heavy precipitation events

An open label pilot trial of low‐dose lithium for young people at ultra‐high risk for psychosis

Aim: Lithium, even at low doses, appears to offer neuroprotection against a wide variety of insults. In this controlled pilot, we examined the safety (i.e., side‐effect profile) of lithium in a sample of young people identified at ultra‐high risk (UHR) for psychosis. The secondary aim was to explore whether lithium provided a signal of clinical efficacy in reducing transition to psychosis compared with treatment as usual (TAU). Methods: Young people attending the PACE clinic at Orygen, Melbourne, were prescribed a fixed dose (450 mg) of lithium (n = 25) or received TAU (n = 78). The primary outcome examined side‐effects, with transition to psychosis, functioning and measures of psychopathology assessed as secondary outcomes. Results: Participants in both groups were functionally compromised (lithium group GAF = 56.6; monitoring group GAF = 56.9). Side‐effect assessment indicated that lithium was well‐tolerated. 64% (n = 16) of participants in the lithium group were lithium‐adherent to week 12. Few cases transitioned to psychosis across the study period; lithium group 4% (n = 1); monitoring group 7.7% (n = 6). There was no difference in time to transition to psychosis between the groups. No group differences were observed in other functioning and symptom domains, although all outcomes improved over time. Conclusions: With a side‐effect profile either comparable to, or better than UHR antipsychotic trials, lithium might be explored for further research with UHR young people. A definitive larger trial is needed to determine the efficacy of lithium in this cohort