1,088 research outputs found
Low energy actuation technique of bistable composites for aircraft morphing
Morphing structures for lightweight and energy-efficient aircraft mobile surfaces have been investigated for several years. This paper presents a novel lightweight, passive and low-energy morphing surface concept based on the "lever effect" of a bistable composite plate that can be integrated in aircraft moving surfaces. By using appropriate boundary conditions, it is demonstrated that the magnitude of the activation force on the bistable composite can be tailored to match the differential pressure on the aircraft's airfoil. As a consequence, the bistable laminate can be used as a passive morphing surface. Both numerical simulations and experimental testing are used to prove this concept on a NACA 2412 airfoil structure. The results show that, by choosing proper configuration of constraints, lay-up and aspect ratio of the bistable composite, it is possible to tailor and activate the snap-through mechanism in a passive manner. The proposed concept would save significant weight when compared to an active morphing concept
INFN What Next: Ultra-relativistic Heavy-Ion Collisions
This document was prepared by the community that is active in Italy, within
INFN (Istituto Nazionale di Fisica Nucleare), in the field of
ultra-relativistic heavy-ion collisions. The experimental study of the phase
diagram of strongly-interacting matter and of the Quark-Gluon Plasma (QGP)
deconfined state will proceed, in the next 10-15 years, along two directions:
the high-energy regime at RHIC and at the LHC, and the low-energy regime at
FAIR, NICA, SPS and RHIC. The Italian community is strongly involved in the
present and future programme of the ALICE experiment, the upgrade of which will
open, in the 2020s, a new phase of high-precision characterisation of the QGP
properties at the LHC. As a complement of this main activity, there is a
growing interest in a possible future experiment at the SPS, which would target
the search for the onset of deconfinement using dimuon measurements. On a
longer timescale, the community looks with interest at the ongoing studies and
discussions on a possible fixed-target programme using the LHC ion beams and on
the Future Circular Collider.Comment: 99 pages, 56 figure
A serum circulating miRNA diagnostic test to identify asymptomatic high-risk individuals with early stage lung cancer
Lung cancer is the first cause of cancer mortality worldwide, and its early detection is currently the main available strategy to improve disease prognosis. While early diagnosis can be successfully achieved through tomography-based population screenings in high-risk individuals, simple methodologies are needed for effective cancer prevention programs. We developed a test, based on the detection of 34 microRNAs (miRNAs) from serum, that could identify patients with early stage non-small cell lung carcinomas (NSCLCs) in a population of asymptomatic high-risk individuals with 80% accuracy. The signature could assign disease probability accurately either in asymptomatic or symptomatic patients, is able to distinguish between benign and malignant lesions, and to capture the onset of the malignant disease in individual patients over time. Thus, our test displays a number of features of clinical relevance that project its utility in programs for the early detection of NSCLC
Measurement of the angular correlation between the two gamma rays emitted in the radioactive decays of a Co source with two NaI(Tl) scintillator
We implemented a didactic experiment to study the angular correlation between
the two gamma rays emitted in typical Co radioactive decays. We used two
NaI(Tl) scintillators, already available in our laboratory, and a low-activity
Co source. The detectors were mounted on two rails, with the source at
their center. The first rail was fixed, while the second could be rotated
around the source. We performed several measurements by changing the angle
between the two scintillators in the range from to .
Dedicated background runs were also performed, removing the source from the
experimental setup. We found that the signal rate increases with the angular
separation between the two scintillators, with small discrepancies from the
theoretical expectations.Comment: 15 pages, 12 figure
Degradation dynamics of micrornas revealed by a novel pulse-chase approach
The regulation of miRNAs is critical to the definition of cell identity and behavior in normal physiology and disease. To date, the dynamics of miRNA degradation and the mechanisms involved in remain largely obscure, in particular, in higher organisms. Here, we developed a pulse-chase approach based on metabolic RNA labeling to calculate miRNA decay rates at genome-wide scale in mammalian cells. Our analysis revealed heterogeneous miRNA half-lives, with many species behaving as stable molecules (T1/2 > 24 h), while others, including passenger miRNAs and a number (25/129) of guide miRNAs, are quickly turned over (T1/2 = 4-14 h). Decay rates were coupled with other features, including genomic organization, transcription rates, structural heterogeneity (isomiRs), and target abundance, measured through quantitative experimental approaches. This comprehensive analysis highlighted functional mechanisms that mediate miRNA degradation, as well as the importance of decay dynamics in the regulation of the miRNA pool under both steady-state conditions and during cell transitions
The ALICE Silicon Pixel Detector: readiness for the first proton beam
The Silicon Pixel Detector (SPD) is the innermost element of the ALICE Inner Tracking
System (ITS). The SPD consists of two barrel layers of hybrid silicon pixels surrounding the
beam pipe with a total of 48 10^7 pixel cells. The SPD features a very low material budget, a 99.9%
efficient bidimensional digital response, a 12 micron spatial precision in the bending plane (rf ) and a
prompt signal as input to the L0 trigger. The SPD commissioning in the ALICE experimental area
is well advanced and it includes calibration runs with internal pulse and cosmic ray runs. In this
contribution the commissioning of the SPD is reviewed and the first results from runs with cosmic
rays and circulating proton beams are presented
Two-pion Bose-Einstein correlations in central Pb-Pb collisions at = 2.76 TeV
The first measurement of two-pion Bose-Einstein correlations in central Pb-Pb
collisions at TeV at the Large Hadron Collider is
presented. We observe a growing trend with energy now not only for the
longitudinal and the outward but also for the sideward pion source radius. The
pion homogeneity volume and the decoupling time are significantly larger than
those measured at RHIC.Comment: 17 pages, 5 captioned figures, 1 table, authors from page 12,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/388
Multiplicity dependence of jet-like two-particle correlations in p-Pb collisions at = 5.02 TeV
Two-particle angular correlations between unidentified charged trigger and
associated particles are measured by the ALICE detector in p-Pb collisions at a
nucleon-nucleon centre-of-mass energy of 5.02 TeV. The transverse-momentum
range 0.7 5.0 GeV/ is examined,
to include correlations induced by jets originating from low
momen\-tum-transfer scatterings (minijets). The correlations expressed as
associated yield per trigger particle are obtained in the pseudorapidity range
. The near-side long-range pseudorapidity correlations observed in
high-multiplicity p-Pb collisions are subtracted from both near-side
short-range and away-side correlations in order to remove the non-jet-like
components. The yields in the jet-like peaks are found to be invariant with
event multiplicity with the exception of events with low multiplicity. This
invariance is consistent with the particles being produced via the incoherent
fragmentation of multiple parton--parton scatterings, while the yield related
to the previously observed ridge structures is not jet-related. The number of
uncorrelated sources of particle production is found to increase linearly with
multiplicity, suggesting no saturation of the number of multi-parton
interactions even in the highest multiplicity p-Pb collisions. Further, the
number scales in the intermediate multiplicity region with the number of binary
nucleon-nucleon collisions estimated with a Glauber Monte-Carlo simulation.Comment: 23 pages, 6 captioned figures, 1 table, authors from page 17,
published version, figures at
http://aliceinfo.cern.ch/ArtSubmission/node/161
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