50 research outputs found
Identifying the science and technology dimensions of emerging public policy issues through horizon scanning
- Author
- A Stirling
- Adam Heathfield
- Alan Mercer
- Alan Pratt
- Amanda C. Hall
- Andrew Acland
- Andrew R. Watkinson
- Arnoud J. Groen
- Chris Magee
- Christopher P. Tyler
- CJ Tuck
- CM Taylor
- D Pudjianto
- D Snowden
- D Tilman
- David A. Good
- David Cope
- David D. Cleevely
- David Oxenham
- DJ Fiorino
- E Idler
- Edward J. Oughton
- Elizabeth Surkovic
- Fiona A. Lickorish
- G Hammond
- G Rowe
- Gary Kass
- H. Charles J. Godfray
- Harry J. Armstrong
- HCJ Godfray
- Helen C. Bodmer
- Helen Pallett
- J Ginsberg
- J Pretty
- J Rockström
- Jackie Ouchikh
- James A. Dolan
- James Palmer
- Jan Pinkerton
- Jason Chilvers
- Jeff Patmore
- Jessica Bland
- Jim R. Bellingham
- Jonathan Grant
- Jonny Wentworth
- Judith Petts
- K O’Brien
- K Swan
- Kim Worts
- L Wilks
- Leila M. Lueshi
- Lucia Costanzo
- Lutz Bornmann
- M Bech
- M Berdal
- M Douron
- M Scheffer
- M Stafford Smith
- MA Burgman
- MA Cusumano
- MC Fisher
- Miles Parker
- N Hex
- N Kshetri
- Natasha McCarthy
- Neil Stansfield
- Nick Green
- Patrick K. A. Wollner
- R Hickman
- R Jackson
- R Rothwell
- RA Cadogan
- Rebecca Willis
- Richard Ploszek
- Robert Doubleday
- Ross Neilson
- S Kelly
- S Owens
- Sarah Castell
- Simon Burall
- Sophie A. Rocks
- Sunjai Gupta
- T Garnett
- T Hargreaves
- TG Martin
- Tiago Mata
- Tim Leeder
- Tim T. Guilliams
- TM Lenton
- Tony McBride
- Ulrike Hotopp
- V Roudometof
- W Steffen
- Wai Yi Feng
- William J. Sutherland
- WJ Sutherland
- WJ Sutherland
- WJ Sutherland
- WJ Sutherland
- WJ Sutherland
- WN Adger
- Y Woo
- Publication venue
- 'Public Library of Science (PLoS)'
- Publication date
- 30/05/2014
- Field of study
Public policy requires public support, which in turn implies a need to enable the public not just to understand policy but also to be engaged in its development. Where complex science and technology issues are involved in policy making, this takes time, so it is important to identify emerging issues of this type and prepare engagement plans. In our horizon scanning exercise, we used a modified Delphi technique [1]. A wide group of people with interests in the science and policy interface (drawn from policy makers, policy adviser, practitioners, the private sector and academics) elicited a long list of emergent policy issues in which science and technology would feature strongly and which would also necessitate public engagement as policies are developed. This was then refined to a short list of top priorities for policy makers. Thirty issues were identified within broad areas of business and technology; energy and environment; government, politics and education; health, healthcare, population and aging; information, communication, infrastructure and transport; and public safety and national security.Public policy requires public support, which in turn implies a need to enable the public not just to understand policy but also to be engaged in its development. Where complex science and technology issues are involved in policy making, this takes time, so it is important to identify emerging issues of this type and prepare engagement plans. In our horizon scanning exercise, we used a modified Delphi technique [1]. A wide group of people with interests in the science and policy interface (drawn from policy makers, policy adviser, practitioners, the private sector and academics) elicited a long list of emergent policy issues in which science and technology would feature strongly and which would also necessitate public engagement as policies are developed. This was then refined to a short list of top priorities for policy makers. Thirty issues were identified within broad areas of business and technology; energy and environment; government, politics and education; health, healthcare, population and aging; information, communication, infrastructure and transport; and public safety and national security
A recycling pathway for cyanogenic glycosides evidenced by the comparative metabolic profiling in three cyanogenic plant species
- Author
- Adewusi
- Agerbirk
- Ahn
- Birger Lindberg Møller
- Blumenthal
- Both
- Busk
- Campuzano
- Cancilla
- Carl Erik Olsen
- Castric
- Christopher J. Gray
- D'Abrosca
- Daniele Silvestro
- Dictionary of Natural products web version (2004-present)
- Domon
- Du
- Elizabeth H. Neilson
- Fan
- Franks
- Frisch
- Fukuda
- Gleadow
- Gleadow
- Halkier
- Hungeling
- Jaroszewski
- Jaroszewski
- Jaroszewski
- Jenrich
- Jones
- Jørgensen
- Kannangara
- Kanu
- Kasai
- Kim
- King
- Kirsten Jørgensen
- Kitajima
- Kongsawadworakul
- Kuroki
- Kuroki
- Lanucara
- Lechtenberg
- Lechtenberg
- Li
- Li
- Lizotte
- Lizzote
- Lykkesfeldt
- Martin Carratala
- Martina Pičmanová
- Miflin
- Miller
- Mohammed S. Motawia
- Morant
- Møller
- Nahrstedt
- Nanna Bjarnholt
- Neilson
- Neilson
- Niels Agerbirk
- Olechno
- Piotrowski
- Piotrowski
- Pourmohseni
- Prawat
- Raquel Sánchez-Pérez
- Sabine Flitsch
- Sebastian Meier
- Seigler
- Selmar
- Selmar
- Selmar
- Selmar
- Selmar
- Selmar
- Sendker
- Smith
- Swain
- Sánchez-Pérez
- Sánchez-Pérez
- Takeda
- Tanaka
- Wajant
- Zhu
- Publication venue
- 'Portland Press Ltd.'
- Publication date
- Field of study
Physical activity and risk of Metabolic Syndrome in an urban Mexican cohort
- Author
- A Bauman
- A Lara
- A Steptoe
- A Varray
- AE López-Caudana
- AL Jurj
- AM Wolf
- B Acosta-Cázares
- B Rosner
- BE Ainsworth
- CA Aguilar-Salinas
- CA Aguilar-Salinas
- Carole Siani
- CC Lin
- Cámara de Diputados del H. Congreso de la Unión
- DE Laaksonen
- DE Laaksonen
- DE Warburton
- E Denova-Gutiérrez
- EL Norman
- Elizabeth Halley-Castillo
- ES Ford
- F Calderón-Hinojosa
- G Hu
- G Hu
- G Olaiz-Fernández
- G Olaiz-Fernández
- Gerardo Huitrón
- HK Neilson
- I Holme
- Institut national de la santé et de la recherche médical
- Instituto Nacional de Estadística Geografía e Informática (INEGI)
- J Salmerón-Castro
- JJ Varo
- JL Johnson
- JM Oppert
- Jorge Salmerón
- JR Churilla
- JR Tate
- Juan O Talavera
- Katia Gallegos-Carrillo
- KB Misra
- KI Proper
- KI Proper
- KL Rennie
- KT Khaw
- L Darina Dosamantes-Carrasco
- L Dong
- M Duclos
- M Hernández-Avila
- MA Martínez-González
- Michel Lamure
- ML Wong
- MR Carnethon
- MT Hamilton
- N Porter
- National Cholesterol Education Program National Heart, Lung and Blood Institute, National Institutes of Health
- NT Son le
- P Méndez-Hernández
- Pablo Méndez-Hernández
- PD Thompson
- PE Rintala
- PW Franks
- PW Wilson
- RC Plotnikoff
- RH Eckel
- RJ Shephard
- S Chasan-Taber
- Secretaría de Salud
- SG Aldana
- TA Lakka
- U Ekelund
- V Fernández-García
- W Haskel
- WH Saris
- World Health Organization
- World Health Organization
- Yvonne Flores
- Publication venue
- BioMed Central
- Publication date
- 31/07/2009
- Field of study
Abstract Background In the Mexican population metabolic syndrome (MS) is highly prevalent. It is well documented that regular physical activity (PA) prevents coronary diseases, type 2 diabetes and MS. Most studies of PA have focused on moderate-vigorous leisure-time activity, because it involves higher energy expenditures, increase physical fitness, and decrease the risk of MS. However, for most people it is difficult to get a significant amount of PA from only moderately-vigorous leisure activity, so workplace activity may be an option for working populations, because, although may not be as vigorous in terms of cardio-respiratory efforts, it comprises a considerable proportion of the total daily activity with important energy expenditure. Since studies have also documented that different types and intensity of daily PA, including low-intensity, seem to confer important health benefits such as prevent MS, we sought to assess the impact of different amounts of leisure-time and workplace activities, including low-intensity level on MS prevention, in a sample of urban Mexican adults. Methods The study population consisted of 5118 employees and their relatives, aged 20 to 70 years, who were enrolled in the baseline evaluation of a cohort study. MS was assessed according to the criteria of the National Cholesterol Education Program, ATP III and physical activity with a validated self-administered questionnaire. Associations between physical activity and MS risk were assessed with multivariate logistic regression models. Results The prevalence of the components of MS in the study population were: high glucose levels 14.2%, high triglycerides 40.9%, high blood pressure 20.4%, greater than healthful waist circumference 43.2% and low-high density lipoprotein 76.9%. The prevalence of MS was 24.4%; 25.3% in men and 21.8% in women. MS risk was reduced among men (OR 0.72; 95%CI 0.57–0.95) and women (OR 0.78; 95%CI 0.64–0.94) who reported an amount of ≥30 minutes/day of leisure-time activity, and among women who reported an amount of ≥3 hours/day of workplace activity (OR 0.75; 95%CI 0.59–0.96). Conclusion Our results indicate that both leisure-time and workplace activity at different intensity levels, including low-intensity significantly reduce the risk of MS. This finding highlights the need for more recommendations regarding the specific amount and intensity of leisure-time and workplace activity needed to prevent MS
Multiple novel prostate cancer susceptibility signals identified by fine-mapping of known risk loci among Europeans
- Author
- Abbasi Z
- Abdul-Hamid M Akhlil
- Abel Paul D
- Abrams Paul H
- Adab Fawzi A
- Adamson Andrew
- Adeyoju A
- Adolfson Jan
- Afzal Naveed
- Ahiaku Ernest K N
- Ahmed Munir
- Al Sudani Mohammed L
- Al-Samarraie Amir S M
- Al-Samerraie [Unknown]
- Al-Singary Waleed
- Al-Sudani [Unknown]
- Alcock Christopher
- Alexander Kimberly
- Ali Zulfiqar
- Almond David J
- Alonzi Roberto
- Aly Markus
- Amin Al Olama Ali
- Anderson John
- Andrews Henry
- Andrews Steven
- Anjum Iqbal
- Anson Ken
- Anyamene Nicola A
- Apakama Ike
- Aparcia F
- Archbold J A A
- Arndt Volker
- Ash D
- Ashford Richard F U
- Auvinen Anssi
- Azzabi A
- Badenoch David
- Bahl Amit
- Bailey Karen
- Bailey M J
- Ball Andrew J
- Banerjee G
- Barber Jim
- Barber N
- Baria [Unknown]
- Barnes Douglas G
- Barros-Silva Joao
- Barwell Julian
- Bashir J
- Basu Pradip
- Bates Christopher A
- Batra Jyotsna
- Bax N A
- Baxter-Smith D
- Bdesha Amar
- Beacock Christopher J M
- Beaney Ronald P
- Beard Ralph
- Beatty John D
- Beck Rupert
- Beese Gail
- Beesley Sharon
- Bell C Richard W
- Bellringer James
- Benlloch Garcia Sara
- Benson Richard
- Beresford [Unknown]
- Bevis Christopher R A
- Bhana Rajanee
- Bhanot S
- Bhatnagar A
- Bhatt R I
- Birch Brian
- Birtle Alison
- Bishop M
- Biyani C Shekhar
- Blacklock A R E
- Blades Rosemary
- Bliss Peter
- Bloomfield David J
- Boddy S
- Bollina Prasad
- Bonnington Sue
- Booth C M
- Bose Pradeep
- Bott Michael C
- Bottomley David
- Boucher Nigel R
- Bowen J
- Bower Mark
- Bowsher W G
- Boyd P J R
- Bradshaw Lynne
- Bramble F James
- Brenner Hermann
- Brewster Simon F
- Briggs Tim
- Brock Cathryn
- Brock Sue
- Bromage Stephen
- Broms Michael
- Brough Richard
- Brown Andrew A
- Brown Paul
- Brown Paul M
- Brown Richard
- Brown Stephen
- Browning Tony J
- Bryan N
- Burgess Neil A
- Burns-Cox Nicholas
- Butterbach Katja
- Butterworth Paul C
- Cahill D
- Callaghan P S
- Calleary John
- Calleja M
- Calman Frances
- Camilleri Philip
- Campbell Alister
- Cannon Andrea
- Cannon-Albright Lisa
- Carnell Dawn M
- Carr T W
- Carter Adam C
- Carter Charles J M
- Carter Simon
- Castle Bruce M
- Catto James
- Cavalli-Bjoerkman Carin
- Chadwick David
- Chahal Rohit
- Chakraborti P
- Chappell [Unknown]
- Charig C
- Chetiyawardana Anula D
- Chilton Christopher
- Chinegwundoh F I
- Chong Irene
- Choudhury Ananya
- Chow Wai-Man
- Christmas Timothy J
- Christova Svetlana
- Churn Mark J
- Cieza-Borrella Clara
- Clarke Noel W
- Clavijo-Eisele Jorge
- Clements Judith A
- Coe M
- Coetzee Gerhard A
- Cohen N P
- Coker C
- Cole David J
- Cole O
- Cole Trevor
- Collins Angus
- Collins Gerald
- Collinson Matthew
- Conn I
- Connell C
- Conti David V
- Cook Audrey
- Cook Margaret
- Cooke Peter
- Cooksey Graeme
- Coombs L
- Cooper Debbie
- Copland Robert F
- Cornaby Andrew J
- Cornford P A
- Corolis [Unknown]
- Corr John
- Costello C B
- Coull Mrs N
- Cowan Richard
- Cox Angela
- Cox Robert
- Coyle C
- Crew Jeremy
- Crisp John C
- Cross W
- Cruger Dorthe
- Crundwell Malcolm
- Cummings [Unknown]
- Cybulski Cezary
- Dadaev Tokhir
- Dahar Nazeer
- Daniel Francis N
- Darrad J
- Daruwala Pallon
- Das Gautam
- Datta Shibendra
- Davidson S
- Davies Joseph
- Davis Michael
- Davison Owen W
- Dawkins Guy
- Dawson Chris
- De Bolla Alan R
- Dearnaley David
- Desai Ken M
- Deutsch George P
- Dick John
- Dickinson Andrew J
- Dickson Jeanette
- Dikov Tihomir
- Dinneen Michael
- Dixit Sanjay
- Dobbs H Jane
- Doble A
- Doble Andrew
- Dodds David
- Doherty Alan
- Donaldson P
- Donovan Jenny L
- Dooldeniya M
- Douglas S Fiona
- Down Liz
- Drake [Unknown]
- Duchesne Gill M
- Duffy Peter
- Dunn Michael
- Dunsmuir W D
- Durkan Garrett
- Durrani Sajid K
- Easton Douglas
- Eaton Alan C
- Eccles Diane
- Eckert Allison
- Eddy B
- Eden C D
- Edwards J
- Eeles Rosalind A
- El-Modir A
- Elkabir Jeremy
- Elliott Emma
- Elliott P Tony
- Ellis B W
- Ellis R
- Elves Andrew W S
- Elwell Christine
- Emberton Mark
- Emmerson Louise
- England Roland C D
- Errington R D
- Evans D Gareth
- Falconer Alison
- Fawcett Derek
- Featherston C
- Featherstone Carolyn J
- Feggetter Jeremy
- Ferguson C
- Fermont D
- Ferro Michael
- Fisher Cyril
- Fitzgerald Liesel
- Fitzgerlad Liesel M
- Fletcher Matthew
- Folkes A
- Ford Trevor F
- Foster Paul W
- Franks Kevin N
- Freedman Mathew
- Frim Olivera
- Gale Joanna
- Gallegos Christopher
- Gelister James S
- George Anne
- Ghana [Unknown]
- Gibbs Stephanie
- Gilbert Hugh
- Giles Graham G
- Gillatt David
- Glaholm John
- Glass Jonathan M
- Glenister James
- Goode Thomas D
- Gordon E M
- Govindasami Koveela
- Gower Richard L
- Graham John
- Green Damian
- Greenland Jonathan
- Grieve Robert
- Griffiths Thomas R L
- Gronberg Henrik
- Gujral Sandy
- Gupta Nishi
- Gurun Riza Murat
- Gustafsson Sven
- Guy Michelle
- Guy Peter J
- Haiman Christopher A
- Haldar Neil
- Halder N
- Haley James
- Hamdy F C
- Hamdy Freddie
- Hamilton C
- Hammonds John
- Hampson S J
- Hanbury Damien C
- Hardman P D John
- Harland Stephen J
- Harney John M
- Harper Peter
- Harris D
- Harris Sarah
- Harrison G S M
- Harriss D R
- Harvey-Hills N
- Hawkyard Simon
- Hazel Steve
- Hazelett Dennis J
- Heath Catherine M
- Heathcote Peter
- Hehir Michael
- Hellawell Giles O
- Henderson Brian E
- Hendry David
- Henley Mike
- Henrique Rui
- Henry Ann
- Herbert Pippa
- Herkommer Kathleen
- Hetherington John
- Hickish Tamas
- Hicks James A
- Hilman Serena
- Hindley Richard
- Hindmarsh John R
- Hines John
- Hingorani M
- Ho Edwin T S
- Hodgson Shirley
- Hoffman U
- Holden David
- Holding Peter
- Hollingdale A
- Hollins Graham W
- Holmes Simon A V
- Holt Sarah
- Hopper John L
- Horan Gail
- Horwich Alan
- Hoskin Peter
- Howell Graham P
- Howson Joanne
- Hrouda D
- Huddart Robert
- Hudson Liz
- Hughes Michael
- Hughes Owen
- Hughes Rob
- Humber Caroline
- Iacovou John W
- Ibrahim A
- Inglis John A
- Irving Stuart
- Irwin C
- Iversen Peter
- Izatt Louise
- Izegbu Victor
- Jameel Basharat
- James Michael J
- James N
- James R Lester
- Javle Pradip
- Jenkins P
- Jhavar Sameer
- Johansson Jan-Erik
- Jones Chris R
- Jones David A
- Jones Gareth
- Jones Mandy
- Joseph J
- Joss Shelagh
- Jugurnauth-Little Sara
- Kachakova Darina
- Kaisary Amir
- Kaliski Alexandre L
- Kaneva Radka
- Kapur G
- Karim O
- Karlsson Ami
- Karp Stephen J
- Kedda Mary-Anne
- Keeley F X
- Kelkar Anand R
- Kelleher J P
- Kelly John
- Kenwrick Sue
- Kerr Kris
- Key Tim J
- Khan F
- Khaw Kay-Tee
- Khoo Vincent
- Kibel Adam S
- Kierzek Andrzej
- Kimber Rachel M
- Kinder R
- Kirby Roger S
- Kirk David
- Kirkbride Peter
- Kirollos Magdi M
- Klarskov Peter
- Kluzniak Wojciech
- Kockelbergh Roger
- Koenig Philip C W C
- Kooiman Gordon G
- Koreich O
- Kote-Jarai Zsofia
- Koupparis Anthony
- Kourah Mohamed
- Kraus Sigurd
- Kujala Paula
- Kujawa Magda L
- Kulkarni Ravi
- Kumar M
- Kumar Rajeev
- Kunkler Ian H
- Kynaston H
- Kynaston Howard
- Lachlan Katherine L
- Laing Robert
- Lalloo Fiona
- Lancashire M
- Lane Athene
- Langley Stephen E M
- Laniado Marc
- Larner T R
- Lau Maurice W
- Lawrence W T
- Lawson Anne
- Le Roux Pieter J
- Leader Mary
- Lee A
- Lee J O
- Lee L
- Lemburger R John
- Lennon Teresa
- Leone Priscilla
- Leongamornlert Daniel
- Lester Jason
- Leung Hing
- Lewis D Christopher
- Lewis J
- Li Qiuyan
- Lim Hui-Yi
- Lin Hui-Yi
- Liston Thomas
- Livni Naomi
- Livsey Jacqueline
- Lloyd S
- Locke Imogen
- Lodge Richard
- Logue John
- Longmuir Mark
- Lophatananon Artitaya
- Lophatonanon Artitaya
- Lubinski Jan
- Lucas Malcolm G
- Luedeke Manuel
- Luscombe C J
- Lydon Anna
- Lynch Michael
- Lynn Naing N K
- Lyons Norma
- MacDermott James P A
- Macdonagh Ruaraidh P
- Macdonald [Unknown]
- Madaan Sanjeev
- Madhava Kudingila R
- Maeaettaenen Liisa
- Maguire Joseph
- Maher E R
- Mahmood Rana
- Maia Sofia
- Maier Christiane
- Mair Graeme H M
- Malone Greg
- Malone Peter R
- Mangar Stephen A
- Mantle Mark
- Mark I
- Marsden Gemma
- Mason M D
- Mason Malcolm
- Mason Robert
- Matanhelia [Unknown]
- Matenhelia Shyam
- Matthews Philip N
- McAleese J
- McBride Donna
- Mcdonnell Shannon K
- McDonnell Shannon K
- McFarlane Jonathan
- McGrath [Unknown]
- McIlhenny Craig
- McInerney Paul
- McIntosh Gregor
- McKinna F
- McLaren Duncan
- McLarty Esther
- McMenemin Rhona
- McNeill Alan
- McNicholas T A
- Meddings Robert N
- Mee A David
- Melcher Lucinda
- Memon [Unknown]
- Menzes Pravin
- Michael Agnieszka
- Miller Marek
- Mills Robert
- Mitchell S
- Mitev Vanio
- Mithal Natasha
- Mitkova Atanaska
- Mitra Anita
- Mobb Gillian E
- Moffat Leslie E F
- Mokete [Unknown]
- Money-Kyrle Julian
- Montgomery Bruce
- Moody Hilary
- Moody Martin P
- Morgan Angela
- Morley Roland
- Morris Sean B
- Morrison Patrick
- Mort Diana
- Mostafid Amir H
- Motiwala Hanif
- Mufti Gulzar
- Muir Gordon
- Muir Kenneth
- Mumtaz Faiz
- Murphy Michael
- Murray Alexandra
- Murray Keith W
- Murrell Shirley
- Murtola Teemu
- Muthukumar D
- Naerger Harry
- Namasivayam Siva
- Nargund Vinod
- Nawrocki [Unknown]
- Neal David E
- Neilson Donald
- Nethersell A
- Newby Jacqueline C
- Newman Hugh
- Newton R
- Nielsen Sune F
- Nordestgaard Børge G
- O'Boyle P J
- O'Brien J
- O'Brien Tim S
- O'Donnell H
- O'Donoghue E
- O'Donoghue Neil
- O'Reilly P
- O'Rourke J S
- O'Sullivan Joe
- O'Sullivan Patricia
- Oakley Neil
- Ogden Chris
- Ohja Hemant
- Oliver Tim
- Omara Tracy
- Ong Eng K
- Osborn David
- Ostler Peter
- Owen J
- Palfrey Edward
- Panades Miguel
- Panakis Niki
- Pancharatnam M
- Pandha Hardev
- Pantelides Michalakis L
- Panwar U
- Parikh Omi
- Park Hyun
- Park Jong Y
- Parker Chris
- Parker Christopher H
- Parys Bohdan T
- Pascoe Sarah
- Pashayan Nora
- Patel Anup
- Paterson Joan
- Pathack S
- Pati Jhumur
- Patterson Helen
- Pattu [Unknown]
- Paul A
- Paul Alan
- Paulo Paula
- Payne Heather
- Peake David
- Pedersen John
- Pedley I
- Pengelly A
- Peracha Amjad M
- Perry Matthew
- Persad Raj
- Peters John
- Pharoah Paul
- Philp N H
- Philp T
- Pickering Lisa M
- Pigott Katharine
- Pinto Pedro
- Plail R
- Plowman P Nicholas
- Pocock Richard D
- Pope A J
- Popert Rick
- Popov Elenko
- Porter Tim
- Potter John M
- Pow-Sang Julio
- Powell Christopher
- Powell Philip
- Powles Thomas B
- Prasad Krishna
- Prasad Seshadri Sri
- Prejbisz J W
- Prescott Stephen
- Protheroe Andrew
- Qureshi Khaver N
- Raby Nigel
- Radlein Selina
- Ragavan Narasimhan
- Raju Palaniappa G S
- Ramachandra Prakash B
- Raman R
- Rane Abhay
- Rankin Julia
- Rao Y
- Ratan Hari L
- Ravi Ramachandran
- Ravishankar K
- Read [Unknown]
- Reddy Paul J
- Rimington Peter R
- Rinckleb Antje
- Rincon Maria
- Riska Shaun
- Ritchie Peter A
- Roberts J Trevor
- Robertson Andrew
- Robinson Angus
- Robinson Anne C
- Robinson Lee Q
- Rochester Mark A
- Roder Andreas
- Rogers P B
- Rosario Derek
- Rosenbaum Tomas P
- Rothwell Neil
- Rowbotham Carl
- Rowe [Unknown]
- Rowley Kathryn
- Ruddy Deborah
- Rundle John
- Russell John M
- Ryan P G
- Sabharwal A
- Saggar Anand K
- Samanci Ali
- Sangar Vijay K
- Santos Joana
- Saunders Edward J
- Saunders Pamela
- Sawyer Emma J
- Saxby M F
- Schaid Daniel J
- Schleutker Johanna
- Schumacher Fredrick
- Schwaibold Hartwig
- Scoble John E
- Scrase Christopher
- Selim [Unknown]
- Sellers Thomas
- Sells Henry
- Sethia Krishna K
- Severi Gianluca
- Shackley David C
- Shaffer [Unknown]
- Shah Nihil
- Shakespeare D
- Shanley Sue
- Sharma Neerah K
- Sheehan Denise J
- Sherwin Elizabeth
- Shum Poh Lin
- Side Lucy
- Sidek Norma
- Signorello Lisa B
- Sikora Karol
- Simcock R
- Sinclair Andrew M
- Singh Pravin
- Siva M
- Slavov Chavdar
- Smith James
- Smith Michael F
- Sokal Michael
- Sole Graham M
- Southey Melissa C
- Speakman Mark J
- Spiers Alexander
- Spurdle Amanda
- Sreenivasan Thiagarajan
- Srihari Narayanan N
- Srinivasan [Unknown]
- Sriram Rajagopalan
- Staffurth John N
- Stanford Janet L
- Stattin Paer
- Stegmaier Christa
- Stephens Sarah
- Stewart D
- Stockdale Andrew
- Stott Mark A
- Stower M J
- Strachan John R
- Stuart Nicholas S A
- Sugden Elaine
- Summerton Duncan
- Sundar Santhanam
- Sundaram S K
- Suresh Gokarakonda
- Susnerwala Shabbir
- Swami Kuchibhotla S
- Symons Stephanie J
- Syndikus Isabel
- Taari Kimmo
- Tahir Saad
- Tammela Teuvo L
- Tammela Teuvo L J
- Tanquay J
- Taylor J W
- Taylor John W
- Teixeira Manuel R
- Terry T
- Thibodeau Stephen N
- Thomas Robert J
- Thomas Stephen A
- Thompson Alan
- Thompson Pauline
- Thomson Alastair H
- Thurston A
- Tidball Sarah
- Tillmans Lori
- Tilsley Owen
- Tindall Stuart F
- Tipples K
- Tong [Unknown]
- Toussi Hamid
- Toy Elizabeth W
- Travis Ruth C
- Trembath Richard C
- Tulloch David N
- Turner Kevin J
- Turner Megan
- Tweedle James
- Tymrakiewicz Malgorzata
- Tyrell C J
- Umez-Eronini N
- Urwin Graeme H
- Vale Justin A
- Van As [Unknown]
- Van As Nicholas
- Vasanthan Subramaniam
- Vesey Sean
- Vilarino-Varela Maria
- Violet John
- Virdi Jaspal
- Viñuela Ana
- Vlahova Aleksandrina
- Vogel Walther
- Wade Robert
- Wahlfors Tiina
- Waite Katherine
- Walker E M
- Walker Roger
- Wallace David M A
- Wallinder Hans
- Wang Liang
- Watkin Nicholas A
- Watson M E
- Waxman J H
- Waymont Brian
- Weaver Andrew
- Webb Ralph J
- Wedderburn Andrew
- Weischer Maren
- Wells Paula
- Wemyss-Holden G D
- Weston P M T
- Wheatley Duncan
- Whelan P
- Whillis D
- Whitmore Ian
- Wiklund Fredrik
- Wilde Adam D
- Wiles Vicki
- Wilkins Marie
- Wilkinson Rosemary
- Williams John H
- Williams Simon
- Willis Michael
- Wills Michael I
- Wilson J R
- Wilson Richard
- Winkler Mathias H
- Wise Marcus
- Wokozorczyk Dominika
- Wokołorczyk Dominika
- Wood Glenn
- Woodhams Simon
- Woodhouse C
- Woodward Cathryn
- Woolf [Unknown]
- Woolfenden K A
- Worlding Jane
- Wright Mark
- Wu Huihai
- WYLIE [Unknown]
- Wylie James P
- Wynne Chris
- Yeadon Trina
- Zachariah Babu
- Zang Angelika
- Zarkar A
- Zheng Wei
- Publication venue
- 'Oxford University Press (OUP)'
- Publication date
- 01/01/2015
- Field of study
Genome-wide association studies (GWAS) have identified numerous common prostate cancer (PrCa) susceptibility loci. We have
fine-mapped 64 GWAS regions known at the conclusion of the iCOGS study using large-scale genotyping and imputation in
25 723 PrCa cases and 26 274 controls of European ancestry. We detected evidence for multiple independent signals at 16
regions, 12 of which contained additional newly identified significant associations. A single signal comprising a spectrum of
correlated variation was observed at 39 regions; 35 of which are now described by a novel more significantly associated lead SNP,
while the originally reported variant remained as the lead SNP only in 4 regions. We also confirmed two association signals in
Europeans that had been previously reported only in East-Asian GWAS. Based on statistical evidence and linkage disequilibrium
(LD) structure, we have curated and narrowed down the list of the most likely candidate causal variants for each region.
Functional annotation using data from ENCODE filtered for PrCa cell lines and eQTL analysis demonstrated significant
enrichment for overlap with bio-features within this set. By incorporating the novel risk variants identified here alongside the
refined data for existing association signals, we estimate that these loci now explain ∼38.9% of the familial relative risk of PrCa,
an 8.9% improvement over the previously reported GWAS tag SNPs. This suggests that a significant fraction of the heritability of
PrCa may have been hidden during the discovery phase of GWAS, in particular due to the presence of multiple independent
signals within the same regio
The Association Between Familial Risk and Brain Abnormalities Is Disease Specific: An ENIGMA-Relatives Study of Schizophrenia and Bipolar Disorder
- Author
- Agartz Ingrid
- Alda Martin
- Aleman André
- Alpert Kathryn I.
- Andreassen Ole A.
- Aydogan Aybala Saricicek
- Bearden Carrie E.
- Bertolino Alessandro
- Bois Catherine
- Bonvino Aurora
- Bramon Elvira
- Brouwer Rachel M.
- Buimer Elizabeth E. L.
- Cahn Wiepke
- Cannon Dara M.
- Cannon Tyrone D.
- Caseras Xavier
- Castro-Fornieles Josefina
- Chen Qiang
- Ching Christopher R. K.
- Chung Yoonho
- de Haan Lieuwe
- de la Serna Elena
- de Zwarte Sonja M. C.
- di Giorgio Annabella
- Doucet Gaelle E.
- Eker Mehmet Cagdas
- Erk Susanne
- Fears Scott C.
- Foley Sonya F.
- Frangou Sophia
- Frankland Andrew
- Fullerton Janice M.
- Glahn David C.
- Goghari Vina M.
- Goldman Aaron L.
- Gonul Ali Saffet
- Gruber Oliver
- Hajek Tomas
- Hawkins Emma L.
- Heinz Andreas
- Hillegers Manon H. J.
- Hulshoff Pol Hilleke E.
- Hultman Christina M.
- Ingvar Martin
- Jahanshad Neda
- Johansson Viktoria
- Jönsson Erik G.
- Kahn René S.
- Kane Fergus
- Kempton Matthew J.
- Koenis Marinka M. G.
- Kopecek Miloslav
- Krabbendam Lydia
- Krämer Bernd
- Lawrie Stephen M.
- Lenroot Rhoshel K.
- Marcelis Machteld
- Marsman Jan-Bernard C.
- Mattay Venkata S.
- McDonald Colm
- Meyer-Lindenberg Andreas
- Michielse Stijn
- Mitchell Philip B.
- Moreno Dolores
- Murray Robin M.
- Mwangi Benson
- Najt Pablo
- Neilson Emma
- Newport Jason
- Overs Bronwyn
- Ozerdem Aysegul
- Picchioni Marco M.
- Richter Anja
- Roberts Gloria
- Schofield Peter R.
- Simsek Fatma
- Soares Jair C.
- Sugranyes Gisela
- Thompson Paul M.
- Toulopoulou Timothea
- Tronchin Giulia
- Turner Jessica A.
- van Erp Theo G. M.
- van Haren Neeltje E. M.
- van Os Jim
- Walter Henrik
- Wang Lei
- Weinberger Daniel R.
- Whalley Heather C.
- Yalin Nefize
- Publication venue
- 'Elsevier BV'
- Publication date
- 01/01/2019
- Field of study
Background: Schizophrenia and bipolar disorder share genetic liability, and some structural brain abnormalities are common to both conditions. First-degree relatives of patients with schizophrenia (FDRs-SZ) show similar brain abnormalities to patients, albeit with smaller effect sizes. Imaging findings in first-degree relatives of patients with bipolar disorder (FDRs-BD) have been inconsistent in the past, but recent studies report regionally greater volumes compared with control subjects. Methods: We performed a meta-analysis of global and subcortical brain measures of 6008 individuals (1228 FDRs-SZ, 852 FDRs-BD, 2246 control subjects, 1016 patients with schizophrenia, 666 patients with bipolar disorder) from 34 schizophrenia and/or bipolar disorder family cohorts with standardized methods. Analyses were repeated with a correction for intracranial volume (ICV) and for the presence of any psychopathology in the relatives and control subjects. Results: FDRs-BD had significantly larger ICV (d = +0.16, q <.05 corrected), whereas FDRs-SZ showed smaller thalamic volumes than control subjects (d = −0.12, q <.05 corrected). ICV explained the enlargements in the brain measures in FDRs-BD. In FDRs-SZ, after correction for ICV, total brain, cortical gray matter, cerebral white matter, cerebellar gray and white matter, and thalamus volumes were significantly smaller; the cortex was thinner (d < −0.09, q <.05 corrected); and third ventricle was larger (d = +0.15, q <.05 corrected). The findings were not explained by psychopathology in the relatives or control subjects. Conclusions: Despite shared genetic liability, FDRs-SZ and FDRs-BD show a differential pattern of structural brain abnormalities, specifically a divergent effect in ICV. This may imply that the neurodevelopmental trajectories leading to brain anomalies in schizophrenia or bipolar disorder are distinct
Search for gravitational-lensing signatures in the full third observing run of the LIGO-Virgo network
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- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aiello Lorenzo
- Ain A.
- Ajith Parameswaran
- Akutsu Tomotada
- Albanesi S.
- Alfaidi R. A.
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Amato Alex
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antonio Font Roda Jose
- Apostolatos T.
- Appavuravther E. Z.
- Appert S.
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- Arai Koji
- Araya Akito
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- Areeda Joseph
- Arif Shaikh Md
- Aritomi Naoki
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- Aronson S. M.
- Arène M.
- Asada Hideki
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
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- Banerjee Biswajit
- Bankar Deepak
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- Cornish Neil
- Corsi Alessandra
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- Coulon J. -P.
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- Ferrante Isidoro
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- Fiori Alessio
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- Goncharov Boris
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- Kandhasamy Shivaraj
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhou R.
- Zhu Xingjiang
- Zhu Zong-Hong
- Zimmerman Aaron
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- Árpád Gergely László
- 劉 國欽
- 曹周键
- 王谨
- 都丸 隆行
- Publication venue
- Publication date
- 01/04/2023
- Field of study
Gravitational lensing by massive objects along the line of sight to the source causes distortions of gravitational wave-signals; such distortions may reveal information about fundamental physics, cosmology and astrophysics. In this work, we have extended the search for lensing signatures to all binary black hole events from the third observing run of the LIGO--Virgo network. We search for repeated signals from strong lensing by 1) performing targeted searches for subthreshold signals, 2) calculating the degree of overlap amongst the intrinsic parameters and sky location of pairs of signals, 3) comparing the similarities of the spectrograms amongst pairs of signals, and 4) performing dual-signal Bayesian analysis that takes into account selection effects and astrophysical knowledge. We also search for distortions to the gravitational waveform caused by 1) frequency-independent phase shifts in strongly lensed images, and 2) frequency-dependent modulation of the amplitude and phase due to point masses. None of these searches yields significant evidence for lensing. Finally, we use the non-detection of gravitational-wave lensing to constrain the lensing rate based on the latest merger-rate estimates and the fraction of dark matter composed of compact objects
Search for eccentric black hole coalescences during the third observing run of LIGO and Virgo
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Acernese F.
- Ackley Kendall
- Adamcewicz C.
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal D.
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Almualla M.
- Altin Paul
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Anand S.
- Ananyeva A.
- Andersen R.
- Anderson Stuart
- Anderson Warren G.
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- Yeung T. Y.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zevin Michael
- Zhang Jue
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- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhang Yanqi
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- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhou R.
- Zhu Zong-Hong
- Zimmerman Aaron
- Zucker M. E.
- Zweizig John
- Álvarez-López S.
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/08/2023
- Field of study
Despite the growing number of confident binary black hole coalescences observed through gravitational waves so far, the astrophysical origin of these binaries remains uncertain. Orbital eccentricity is one of the clearest tracers of binary formation channels. Identifying binary eccentricity, however, remains challenging due to the limited availability of gravitational waveforms that include effects of eccentricity. Here, we present observational results for a waveform-independent search sensitive to eccentric black hole coalescences, covering the third observing run (O3) of the LIGO and Virgo detectors. We identified no new high-significance candidates beyond those that were already identified with searches focusing on quasi-circular binaries. We determine the sensitivity of our search to high-mass (total mass M>70 M⊙) binaries covering eccentricities up to 0.3 at 15 Hz orbital frequency, and use this to compare model predictions to search results. Assuming all detections are indeed quasi-circular, for our fiducial population model, we place an upper limit for the merger rate density of high-mass binaries with eccentricities 0<e≤0.3 at 0.33 Gpc−3 yr−1 at 90\% confidence level
Observation of gravitational waves from the coalescence of a 2.5−4.5 M⊙ compact object and a neutron star
- Author
- Abac Adrian
- Abbott R.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aghaei Abchouyeh Maryam
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akcay Sarp
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi Simone
- Alex iandolo Guido
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés Vallejo Peña Sergio
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi Stefano
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L.
- Arif Shaikh Md
- Aritomi N.
- Armato Federico
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Attadio Francesca
- Aubin Florian
- AVALLONE Guerino
- Azrad D.
- Babak Stanislav
- Badaracco Francesca
- Badger C.
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- Baier Jeremy
- Baiotti Luca
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- Basalaev Artem
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- Berger Beverly
- Bernuzzi Sebastiano
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- Bertolini A.
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- Beveridge Damon
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- Cesarini Elisabetta
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- Chalathadka Subrahmanya Shreevathsa
- Chan M.
- Chandra K.
- Chang R. -J.
- Chao Shiuh
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- Charlton E. L.
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- Chassande-Mottin Eric
- Chatterjee Chayan
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- Chaty Sylvain
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- Chen A.
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- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 都丸 隆行
- Publication venue
- Publication date
- 23/04/2024
- Field of study
Ultralight vector dark matter search using data from the KAGRA O3GK run
- Author
- Abac A. G.
- Abbott R.
- Abe H.
- Abouelfettouh I.
- Acernese F.
- Ackley Kendall
- Adamcewicz Christian
- Adhicary S.
- Adhikari Naresh
- Adhikari Rana X.
- Adkins V. K.
- Adya V. B.
- Affeldt C.
- Afif Ismail M.
- Agarwal Deepali
- Agathos Michalis
- Aguiar Odylio D.
- Aguilar I.
- Aiello Lorenzo
- Ain Anirban
- Ajith Parameswaran
- Akseli Hannuksela Otto
- Akutsu Tomotada
- Al-Jodah Ammar
- Al-Shammari S.
- Albanesi S.
- Alberto Trani Alessandro
- Alfaidi Reem Atallah E
- Allocca Annalisa
- Alléné C.
- Altin Paul
- Alvarez-Lopez Sofia
- Amato Alex
- Amez-Droz L.
- Amorosi A.
- Amra C.
- Anand S.
- Ananyeva A.
- Anderson Stuart
- Anderson Warren G.
- Andia Manuel
- Ando M.
- Andrade T.
- Andrea Prodi Giovanni
- Andres Nicolas
- Andric Tomislav
- Andrés-Carcasona Marc
- Anglin J.
- Anne Bizouard Marie
- Ansoldi S.
- Antelis Javier M.
- Antier Sarah
- Antoni Ramis Vidal Felip
- Antonietta Palaia Maria
- Antonio Font Roda Jose
- Aoumi M.
- Appavuravther E. Z.
- Appert S.
- Apple S. K.
- Arai Koji
- Araya Akito
- Araya Melody
- Areeda Joseph
- Argianas L. Granda
- Arif Shaikh Md
- Aritomi Naoki
- Armato F.
- Arnaud Nicolas
- Arogeti Megan
- Aronson Scott
- Arun K. G.
- Ashton Gregory
- Aso Yoichi
- Assiduo M.
- Aston S. M.
- Astone Pia
- Aubin Florian
- AVALLONE Guerino
- Babak Stanislav
- Badaracco Francesca
- Badger C.
- Bae Sangwook
- Bagnasco Stefano
- Bagui E.
- Bai Y.
- Baier Jeremy
- Bajpai Rishabh
- Baka T.
- Ball M.
- Ballardin G.
- Ballmer S. W.
- Banagiri Sharan
- Banerjee Biswajit
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- Chalathadka Subrahmanya Shreevathsa
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- Chanial Pierre
- Chao Shiuh
- Chapman-Bird Christian
- Charlton E. L.
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- CHASSANDE-MOTTIN Eric
- Chatterjee Chayan
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- Chaty Sylvain
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- Chen A.
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- CHIOFALO MARIA. LUISA.
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- Christensen Nelson
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- Ciani Giacomo
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- Conti Livia
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- Corsi Alessandra
- Cortese Stefano
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- Cumming Alan
- Cuoco E.
- Cusinato Marco
- César Martins Julio
- D'Angelo Beatrice
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- De Bolle Jorden
- De Laurentis Martina
- De Lillo Federico
- de Lluc Planas Maria
- De Marco F.
- De Matteis Fabio
- De Pietri Roberto
- De Rosa Rosario
- de rossi camilla
- De Simone R.
- de Souza Melo S. Assis
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- Degallaix Jerome
- Del Pozzo Walter
- Delfavero Vera
- Dell'Aquila Daniele
- Deléglise Samuel
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- Dhani A.
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- Di Fronzo Chiara
- di giovanni Fabrizio
- Di Giovanni M.
- Di Girolamo Tristano
- Di Michele Alessandro
- Di Renzo Francesco
- DI. PALMA Irene
- Diab R.
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- Dideron G.
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- Dietrich Tim
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- Eisenmann M.
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- Elizabeth Ramirez Guevara Karla
- Emma Mattia
- Engelby E.
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- Erasmo Peña Arellano Fabián
- Errico L.
- error error
- error error
- error error
- Estellés Estrella Héctor
- Estevez Dimitri
- Etzel T.
- Evans Matthew J.
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- Fabrizi Federica
- Faedi F.
- Fafone Viviana
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- Fenyvesi Edit
- Ferguson Deborah
- Ferrante Isidoro
- Ferreira T. A.
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- Fishbach Maya
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- Fiumara V.
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- Fleischer Svenja
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- Forsyth P. W. F.
- Franceschetti K.
- Franchini N.
- Francisco Nuño Siles José
- Frasca S.
- Frasconi Franco
- Frei Zsolt
- Freise Andreas
- Freitas Osvaldo
- Frey Raymond
- Frischhertz W.
- Frolov V. V.
- Fuentes-Garcia Melina
- Fujii S.
- Fujimori T.
- Fujimoto Hiroki
- Fujita Tomohiro
- Fukunaga I.
- Fulda P.
- Fung Wong Chun
- Fyffe M.
- Gabella William
- Gadre Bhooshan
- Gaetano Fronzé Gabriele
- Gair Jonathan
- Galaudage Shanika
- Gallardo S.
- Gallego B.
- Gamba Rossella
- Gamboa Aldo
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- Tapia San Martín E. N.
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- Tarafder R.
- Taranto C.
- Taruya Atsushi
- Tasson Jay
- Teloi M.
- Tenorio Rodrigo
- Themann H.
- Theodoropoulos A.
- Thirugnanasambandam M. P.
- Thomas M.
- Thomas P.
- Thompson Jonathan
- Thondapu S. R.
- Thorne K. A.
- Thrane E.
- Tissino Jacopo
- Tiwari A.
- tiwari shubhanshu
- Tiwari Srishti
- tiwari vaibhav
- Todd M. R.
- Toivonen Andrew
- Toland Karl
- Tolley Arthur E.
- Tomita K.
- Tomura Tomonobu
- Tong-Yu C.
- Toriyama A.
- Toropov Nikita
- Torres Forne Alejandro
- Torrie C. I.
- Toscani Martina
- Tosta e Melo Iara
- Tournefier Edwige
- TRAPANANTI Angela
- Travasso Flavio
- Traylor G.
- Trenado Juan
- Trevor M.
- Tripathee Aashish
- Troiano L.
- Trovato Agata
- Trozzo L.
- Trudeau R. J.
- Tso R.
- Tsuchida Satoshi
- Tsukada L.
- Tsutsui Takuya
- Turbang Kevin
- Turconi Margherita
- Turski C.
- Ubach Helena
- Ubhi A. S.
- Uchiyama Takashi
- Udall Rhiannon
- Uehara Tomoyuki
- Ueno Koh
- Unnikrishnan C. S.
- Ushiba Takafumi
- Vacatello Michele
- Vahlbruch Henning
- Vaidya Nina
- Vajente Gabriele
- Vajpeyi A.
- Valdes Guillermo
- Valencia J.
- Valentini Michele
- Vallejo-Peña S. A.
- Vallero S.
- Valsan Vinaya
- Valérie Martinez
- van Bakel N.
- van Beuzekom Martin
- van Dael Mathyn
- Van de Walle A.
- van den Brand Johannes
- Van Den Broeck C.
- van der Sluys Marc
- van Dongen Jesse
- Van Haevermaet Hans
- van Heijningen Joris
- van Putten Maurice
- Van Ranst Zeb
- van Remortel Nick
- Vander-Hyde D. C.
- Vandra K.
- Vanosky J.
- Vardaro M.
- Vargas A. F.
- varma vijay
- Vasuth Matyas
- vecchio alberto
- Vedovato G.
- Veitch John
- Veitch Peter
- Venikoudis S.
- Venneberg Jasper
- Verdier Patrice
- Verkindt Didier
- Verma B.
- Verma P.
- Verma Yogesh
- Vermeulen Sander M.
- Veske Doğa
- Vetrano F.
- Veutro A.
- Vibhute Ajay
- Viceré Andrea
- Vidyant S.
- Viets Aaron
- Vijaykumar Aditya
- Vilkha A.
- Villa-Ortega Verónica
- Vincent Erin
- Vinet J. -Y.
- Viret S.
- Virgo Collaboration
- Virtuoso Andrea
- Vitale Salvatore
- Vocca H.
- Voigt Daniel
- von Reis E. R. G.
- von Wrangel J. S. A.
- Vyatchanin Sergey P.
- Wade L. E.
- Wade Madeline
- Wagner Katelyn
- Walet R. C.
- Walker M.
- Wallace G. S.
- Wallace L.
- Wang Haoyu
- Wang J. Z.
- Wang W. H.
- Wang Z.
- Waratkar Gaurav
- Ward R. L.
- Warner J.
- Was Michal
- Washimi Tatsuki
- Washington N. Y.
- Watarai D.
- Wayt K. E.
- Weaver B.
- Weaving C. R.
- Webster S. A.
- Weinert M.
- Weinstein Alan J.
- Weiss R.
- Weizmann Kiendrebeogo R.
- Weller C. M.
- Weller Robert
- Wellmann F.
- Wen L.
- Wette Karl
- Weßels P.
- Whelan John
- White D. D.
- Whiting Bernard F.
- Whittle Chris
- Wildberger J. B.
- Wilk O. S.
- Wilken Dennis
- Willetts K.
- Williams Daniel
- Williams Michael J.
- Williams N. S.
- Willis Joshua
- Willke Benno
- Wils Milan
- Wipf C. C.
- Woan Graham
- Woehler J.
- Wofford Jared
- Wolfe N. E.
- Won Lee Hyung
- Won Seo Jin
- Wong D.
- Wong Henry T.
- Wright J. L.
- Wright Mick
- Wu Chien-Ming
- Wu David S.
- Wu Hsun-Chung
- Wysocki Daniel
- Xiao Liting
- Xu Victoria
- Xu Yumeng
- Yaala M. Ben
- Yadav Nikesh
- Yakovlev Alexey
- Yamamoto Hiroaki
- Yamamoto Kazuhiro
- Yamamoto M.
- Yamamoto Takahiro
- Yamamoto Takahiro S.
- Yamamura S.
- Yamazaki Ryo
- Yan S.
- Yan T.
- Yang F.
- Yang Fengwei
- Yang Kate Z.
- Yang L. -C.
- Yang Yi
- Yarbrough Zach
- Yeh S. -W.
- Yelikar A. B.
- Yeung S. M. C.
- Yin X.
- Yokoyama Jun'ichi
- Yokozawa T.
- Yoo Jooheon
- Yu Hang
- Yuzurihara Hirotaka
- Zadrożny A.
- Zahoor Jan Aasim
- Zannelli A. J.
- Zanolin M.
- Zeeshan M.
- Zelenova T.
- Zendri J. -P.
- Zeoli M.
- Zerrad M.
- Zevin Michael
- Zhang A. C.
- Zhang Jue
- Zhang L.
- Zhang Rui
- Zhang T.
- Zhang Ya
- Zhao C.
- Zhao Yue
- Zhao Yuhang
- Zheng Yanyan
- Zhong Haowen
- Zhong S.
- Zhou R.
- Zhu Zong-Hong
- Zucker M. E.
- Zweizig John
- Árpád Gergely László
- 劉 國欽
- 曹周键
- 都丸 隆行
- Publication venue
- Publication date
- 01/03/2024
- Field of study
Among the various candidates for dark matter (DM), ultralight vector DM can be probed by laser interferometric gravitational wave detectors through the measurement of oscillating length changes in the arm cavities. In this context, KAGRA has a unique feature due to differing compositions of its mirrors, enhancing the signal of vector DM in the length change in the auxiliary channels. Here we present the result of a search for U(1)B−L gauge boson DM using the KAGRA data from auxiliary length channels during the first joint observation run together with GEO600. By applying our search pipeline, which takes into account the stochastic nature of ultralight DM, upper bounds on the coupling strength between the U(1)B−L gauge boson and ordinary matter are obtained for a range of DM masses. While our constraints are less stringent than those derived from previous experiments, this study demonstrates the applicability of our method to the lower-mass vector DM search, which is made difficult in this measurement by the short observation time compared to the auto-correlation time scale of DM
Fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin with gemtuzumab ozogamicin improves event-free survival in younger patients with newly diagnosed aml and overall survival in patients with npm1 and flt3 mutations
- Author
- Ackroyd Sam
- Addada Juanah (Jo)
- Ademokun Debo
- Ahmed Alhassani Thubeena M.
- Ahmed Khalil
- Aitchison Robin
- Al-Ani Maryam
- Aldouri Maadh
- Alfred Arun
- Allford Sarah
- Alvares Caroline
- Andrews Vivienne
- Anjum Farahn
- Ardeshna Kirit
- Arnold Claire
- Arnold Claire
- Austen Belinda
- Bake Bart
- Barker Helen
- Basu Supratik
- Batten Leona M.
- Beier Ommen Hans
- Berkhan Leanne
- Betteridge Sophie
- Blombery Piers
- Bokhari Syed
- Bond Lee
- Borg Anton
- Borregaard Niels
- Bowen Angela
- Bowen David
- Bowett Peter
- Brearton Gillian
- Burgess Jordan
- Burns Sarah
- Butler Andrew
- Byrne Jenny
- Cahalin Paul
- Canham Joanna
- Carr Robert
- Cavenagh Jamie
- Chacko Joseph
- Chalmers Isobel
- Chandra Deepak
- Chapman Oliver
- Chapple Mary
- Chatterjee Poulami
- Chodhouri Senthil S.
- Chvuka Shingi
- Copplestone Adrian
- Corbett Gillian
- Corbett Timothy
- Corser Robert
- Craddock Charles
- Craig Jenny
- Craig Joanne
- Cranfield Tanya
- Crawley Charles
- Creach Desmond
- Crowe Josephine
- Culligan Dominic
- Cullis Jonathan
- Cuthbert Robert
- Cutting Robert
- Cutting Robert
- Dalley Chris
- Dang Ray
- Dasgupta Emma
- Dasgupta Ranjit
- David Marianna
- Davidson Kerri
- Davies Simon
- Dennis Mike
- Devanny Ian
- DeVos Johannes
- Dignum Helen
- Dillon Richard
- Doocey Richard
- Dungarwalla Moez
- Dyer Peter
- Eagleton Helen
- Eden Ayed
- Edwards David
- Edwards Hugh
- Ellis Lauren
- Emmett Shannon
- Eve Heather
- Evely Roger
- Everington Tamara
- Fail Tom
- Farrell Katrina
- Fenella Willis Neoh
- Ferguson Paul
- Fernandes Savio
- Fernyhough Liam
- Finnegan Damian
- Fletcher Andrew
- Fletcher Andrew
- Forsyth Peter
- Francis McMullin Mary
- Freeman Sylvie D.
- Friis Lone
- Ganczakowski Mary
- Gandhi Anna Cowley S.
- Ganly Peter
- Gelly Keith
- Gharib Maged
- Gibbons Steve
- Gibbs Simon
- Gilkes Amanda
- Gilles Julie
- Gomez Cesar
- Goodman Hugh
- Goodrick Margaret
- Grand Effie
- Grey-Davies Elisabeth
- Groch Henri
- Hada Sunil
- Hall Rachel
- Hamilton Malcolm
- Hanlon Katharine
- Harrison Beth
- Hasan Yasmin
- Haskins Lea
- Hatcliffe Faye
- Hawkins Timothy
- Heartin Earnest
- Hemmaway Claire
- Hemmaway Claire
- Hendry Louise
- Hervey Victoria
- Hinson Emily L.
- Hodson Andrew
- Holm Mette
- Horne Gillian
- Horne Gillian
- Houghton John
- Hoyle Christine
- Hunter Ann
- Hunter Hannah
- Islam Shahid
- Ismail Saad
- Jack Fergus
- Jackson Nicholas
- Jacob Abraham
- Janes Sarah
- Janmohamed Riaz
- Jenner Matthew
- Jobanputra Shailesh
- Johnson Peter
- Jones Christopher
- Joseph Joe
- Jowitt Simon
- Juul Nielsen Ove
- Kaczmarski Richard
- Kakalamudi Sudhakar
- Kallenbach Maria
- Kampmann Peter
- Kaul Stuti
- Kaur Harpreet
- Keat Sally
- Kell Jonathan
- Kelsey P.
- Kerr Paul
- Kerr Ron
- Khwaja Asim
- Kjeldsen Lars
- Knapper Steve
- Knapper Steven
- Knechtli Christopher
- Kottaridis Panagiotis
- Krishnamurthy Pramila
- Krishnamurthy Suchitra
- Krogh Jensen Morten
- Kwan Mark
- Laing Alison
- Laird Jane
- Lawes Matthew
- Linch David
- Lindsay Kathrine
- Lindsay-Holmes Srividhya Sarah
- Longmuir Karyn
- Lovell Richard
- Lush Chris
- Lush Richard
- Lykke Petersen Soeren
- Lyons Simon
- Maclean Peter
- MacWhonell Alan
- Maddams Rebecca
- Maddox Jamie
- Mamat Mohd
- Mangos Hilda
- Mannari Deepak
- Marcher Claus
- Marks David
- Marshall Scott
- Martin Murray
- Maughan Elizabeth
- Maxwell Norgaard Jan
- McCaig Alison
- McCloskey Kayleigh
- McIntyre Victoria
- McLintock Lorna
- Medd Patrick
- Mehta Priyanka
- Mehta Priyanka
- Meiklejohn David
- Micallef-Eynaud Paul
- Milligan Donald
- Mills Juliet
- Milne Alison
- Mitchell Lindsey
- Mohite Unmesh
- Moreton Paul
- Moss Paula
- Mucklow Stuart
- Munro Laura
- Murphy John
- Murray Jim
- Murrin Richard
- Narat Santosh
- Narayanan Mekkali
- Neilson Jeff
- Neylon Annette
- Ngu Loretta
- Nicholson Emma
- Nicholson Toby
- Nicolle Annette
- Niemann Carsten
- Nokes Tim
- O'Hea Anne-Marie
- Omran Asad
- Orchard Kim
- Othman Jad
- Oun Hajer
- Overgaard Ulrik Malthe
- Paneesha Shankara
- Patel Amit
- Paterson Pamela
- Patil Kavita
- Pattinson Jonathan
- Pattinson Jonathan
- Patton Nigel
- Pechey Victoria
- Pemberton Lucy
- Peniket Andy
- Peters Jayne
- Plews Diane
- Popat Rakesh
- Potter Mike
- Potter Nicola
- Pottinger Bryson
- Powell Matthew
- Pullon Humphrey
- Raafat Alaeddin
- Raj Kavita
- Reilly John
- Richardson Deborah
- Roberts Patrick
- Roddie P.H.
- Rogers Stephen
- Rose Peter
- Roy Ashok
- Rudin Claudius
- Ruell Jackie
- Rule Simon
- Russell Nigel
- Russell Nigel H.
- Rye Adam
- Rye Adam
- Rymes Nicholas
- Sadik Walid
- Sadullah Shala
- Salesh Sana
- Sampson Rebecca
- Saravanamuttu Kandeepan
- Sati Hamdi
- Severinsen Marianne
- Shafeek Salim
- Sidra Gamal
- Simpson Sylwia
- Smith Jeffery
- Smith Mark
- Smith Steve
- Snowden John
- Somerfield Sven
- Somervaille Tim
- Sorour Youssef
- Spearing Ruth
- Stanchev Atanas
- Stokley Simone
- Sud Amit
- Sugai Taku
- Tauro Sudhir
- Tholouli Eleni
- Thomas Wayne
- Thomas-Dewing Rowena
- Tighe Jane
- Tomlins Jo
- Tuegar Salah
- Udby Peter Møller Lene
- Vavyla Maria
- Virchis Andres
- Walewska Renata
- Wandoo Farooq
- Wei Bjerrum Ole
- Welch Emma
- Went Richard
- Wexler Sarah
- White Denise
- Wilhelm-Benartzi Charlotte
- Wiliams Adrian
- Williams Mark
- Williamson Peter
- Wilson-Morkeh Isaac
- Wodzinski Mark
- Wright David
- Xu Chin Kate
- Yong Kwee
- Zaman Sonya
- Zhao New Oo Rui
- Publication venue
- American Society of Clinical Oncology
- Publication date
- 30/04/2024
- Field of study
Purpose
To determine the optimal induction chemotherapy regimen for younger adults with newly diagnosed AML without known adverse risk cytogenetics.
Patients and Methods
One thousand thirty-three patients were randomly assigned to intensified (fludarabine, cytarabine, granulocyte colony-stimulating factor, and idarubicin [FLAG-Ida]) or standard (daunorubicin and Ara-C [DA]) induction chemotherapy, with one or two doses of gemtuzumab ozogamicin (GO). The primary end point was overall survival (OS).
Results
There was no difference in remission rate after two courses between FLAG-Ida + GO and DA + GO (complete remission [CR] + CR with incomplete hematologic recovery 93% v 91%) or in day 60 mortality (4.3% v 4.6%). There was no difference in OS (66% v 63%; P = .41); however, the risk of relapse was lower with FLAG-Ida + GO (24% v 41%; P < .001) and 3-year event-free survival was higher (57% v 45%; P < .001). In patients with an NPM1 mutation (30%), 3-year OS was significantly higher with FLAG-Ida + GO (82% v 64%; P = .005). NPM1 measurable residual disease (MRD) clearance was also greater, with 88% versus 77% becoming MRD-negative in peripheral blood after cycle 2 (P = .02). Three-year OS was also higher in patients with a FLT3 mutation (64% v 54%; P = .047). Fewer transplants were performed in patients receiving FLAG-Ida + GO (238 v 278; P = .02). There was no difference in outcome according to the number of GO doses, although NPM1 MRD clearance was higher with two doses in the DA arm. Patients with core binding factor AML treated with DA and one dose of GO had a 3-year OS of 96% with no survival benefit from FLAG-Ida + GO.
Conclusion
Overall, FLAG-Ida + GO significantly reduced relapse without improving OS. However, exploratory analyses show that patients with NPM1 and FLT3 mutations had substantial improvements in OS. By contrast, in patients with core binding factor AML, outcomes were excellent with DA + GO with no FLAG-Ida benefit