Predictors of hospital discharge and mortality in patients with diabetes and COVID-19: updated results from the nationwide CORONADO study

AIMS/HYPOTHESIS: This is an update of the results from the previous report of the CORONADO (Coronavirus SARS-CoV-2 and Diabetes Outcomes) study, which aims to describe the outcomes and prognostic factors in patients with diabetes hospitalised for coronavirus disease-2019 (COVID-19). METHODS: The CORONADO initiative is a French nationwide multicentre study of patients with diabetes hospitalised for COVID-19 with a 28-day follow-up. The patients were screened after hospital admission from 10 March to 10 April 2020. We mainly focused on hospital discharge and death within 28 days. RESULTS: We included 2796 participants: 63.7% men, mean age 69.7 ± 13.2 years, median BMI (25th-75th percentile) 28.4 (25.0-32.4) kg/m(2). Microvascular and macrovascular diabetic complications were found in 44.2% and 38.6% of participants, respectively. Within 28 days, 1404 (50.2%; 95% CI 48.3%, 52.1%) were discharged from hospital with a median duration of hospital stay of 9 (5-14) days, while 577 participants died (20.6%; 95% CI 19.2%, 22.2%). In multivariable models, younger age, routine metformin therapy and longer symptom duration on admission were positively associated with discharge. History of microvascular complications, anticoagulant routine therapy, dyspnoea on admission, and higher aspartate aminotransferase, white cell count and C-reactive protein levels were associated with a reduced chance of discharge. Factors associated with death within 28 days mirrored those associated with discharge, and also included routine treatment by insulin and statin as deleterious factors. CONCLUSIONS/INTERPRETATION: In patients with diabetes hospitalised for COVID-19, we established prognostic factors for hospital discharge and death that could help clinicians in this pandemic period. TRIAL REGISTRATION: Clinicaltrials.gov identifier: NCT04324736

Reactivite du vinylacetylene vis-a-vis de complexes mono et binucleaires du molybdene et du tungstene. Application a la separation d'alcynes dans un melange d'hydrocarbures d'une coupe 'C_4'

SIGLEAvailable from INIST (FR), Document Supply Service, under shelf-number : T 78570 / INIST-CNRS - Institut de l'Information Scientifique et TechniqueFRFranc

Reaction of vinylacetylene with [Mo(.eta.5-C5H5)(CO)2]2. Reactivity of [{Mo(.eta.5-C5H5)(CO)2}(.mu.-HC.tplbond.CCH:CH2)]. Crystal structures of [{Mo(.eta.5-C5H5)(CO)2}2(.mu.-.eta.2,.eta.3-HC.tplbond.CCHCH3)][BF4] and of [[{Mo(.eta.5-C5H5)(CO)2}2]2-.mu.-(.mu.-HC.tplbond.CCH2CH2)2]

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Electrochemistry of [Mo2Cp2(CO)4μ-η2:η 3-HC≡C-C(R1)(R2)]+ complexes (R1 =H, R2 = H, Me, Et, Fc; R1 = Me, R2 = Me, Ph). Control of the reduction process (two-electron vs one-electron) by the substituents R1 and R2: EHMO rationalization

International audienceThe electrochemical reduction of [Mo2Cp2(CO)4_μ-η2:η 3-HC≡C-C(R1)(R2)_]+ complexes has been investigated by cyclic voltammetry, controlled-potential electrolysis, and coulometry. On the cyclic voltammetry time scale, the complexes with R1 = H, R2 = H (1+), Me (2+), Et (3+) undergo an irreversible or a quasi-reversible one-electron reduction whereas the analogues with R1 = H, R2 = Fc (4+) and R1 = Me, R2 = Me (5+) and Ph (6+) reduce in a single-step, reversible or quasi-reversible, two-electron process. Two different chemical reactions are involved in the overall reduction mechanism. The first chemical step is assigned as a structural rearrangement, responsible for slowing down the heterogeneous electron transfer. Extended Huckel MO calculations indicate that in the case of the complexes with R1 = H, R2 = Fc and R1 = Me, R2 = Me or Ph, a small increase in the distance between one metal center and the carbon of the C(R1)(R2) group could trigger the two-electron transfer process. The second chemical reaction leading to the final product(s) of the reduction involves radical species, even when a two-electron transfer is observed by cyclic voltammetry. The final products formed in these processes have been identified either by 1H NMR spectroscopy of the compounds extracted from the catholyte after controlled-potential electrolyses or from a comparison of their characteristic redox potentials with those of authentic samples. The nature of the final product(s), either a dimer or μ-alkyne and μ-enyne complexes, is also dependent on the nature of R1 and R2

Exposure to high static or pulsed magnetic fields does not affect cellular processes in the yeast Saccharomyces cerevisiae

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Guerre en Ukraine : enjeux humains, juridiques, culturels (La)

L’Enssib, le Centre Gabriel Naudé et ELICO ont organisé le 5 avril dernier une table ronde pluridisciplinaire sur la guerre en Ukraine. Des spécialistes de science politique, de droit international, de science de l’information et de la préservation du patrimoine ont apporté un éclairage sur les conséquences de l’invasion russe sur la société ukrainienne et ont abordé des questions liées au patrimoine ukrainien

Potential physiological role of plant glycosidase inhibitors

Carbohydrate-active enzymes including glycosidases, transglycosidases, glycosyltransferases, polysaccharide lyases and carbohydrate esterases are responsible for the enzymatic processing of carbohydrates in plants. A number of carbohydrate-active enzymes are produced by microbial pathogens and insects responsible of severe crop losses. Plants have evolved proteinaceous inhibitors to modulate the activity of several of these enzymes. The continuing discovery of new inhibitors indicates that this research area is still unexplored and may lead to new exciting developments. To date, the role of the inhibitors is not completely understood. Here we review recent results obtained on the best characterised inhibitors, pointing to their possible biological role in vivo. Results recently obtained with plant transformation technology indicate that this class of inhibitors has potential biotechnological applications