50 research outputs found
Motion-Based Design of Passive Damping Systems to Reduce Wind-Induced Vibrations of Stay Cables under Uncertainty Conditions
Stay cables exhibit both great slenderness and low damping, which make them sensitive to
resonant phenomena induced by the dynamic character of external actions. Furthermore, for these
same reasons, their modal properties may vary significantly while in service due to the modification
of the operational and environmental conditions. In order to cope with these two limitations, passive
damping devices are usually installed at these structural systems. Robust design methods are thus
mandatory in order to ensure the adequate behavior of the stay cables without compromising the
budget of the passive control systems. To this end, a motion-based design method under uncertainty
conditions is proposed and further implemented in this paper. In particular, the proposal focuses
on the robust design of di erent passive damping devices when they are employed to control the
response of stay cables under wind-induced vibrations. The proposed method transforms the design
problem into a constrained multi-objective optimization problem, where the objective function is
defined in terms of the characteristic parameters of the passive damping device, together with
an inequality constraint aimed at guaranteeing the serviceability limit state of the structure. The
performance of the proposed method was validated via its application to a benchmark structure with
vibratory problems: The longest stay cable of the Alamillo bridge (Seville, Spain) was adopted for
this purpose. Three di erent passive damping devices are considered herein, namely: (i) viscous; (ii)
elastomeric; and (iii) frictions dampers. The results obtained by the proposed approach are analyzed
and further compared with those provided by a conventional method adopted in the Standards. This
comparison illustrates how the newly proposed method allows reduction of the cost of the three
types of passive damping devices considered in this study without compromising the performance of
the structure.Ministerio de Ciencia, Innovación y Universidades RT12018-099639-B-I00Universidad de Sevilla USE-17047-
Motion-based design of viscous dampers for cable-stayed bridges under uncertainty conditions
Passive damping devices are widely installed to control the vibration level of stay cables of bridges induced by wind action. The design of passive damping devices must ensure the performance for the all the life-cycle of the structure. In this sense, the design should consider the changes of the pre-fixed parameters and environmental conditions. For this purpose, the motion-based design method under uncertainty conditions is used in this study to carry out the design of a viscous damper. Following this approach, the design requirements are established according to the maximum accepted motions of the structure and the damper device is optimized. In order to validate the method, a benchmark structure is considered. The uncertainty conditions are numerically simulated following a probabilistic approach. As simulation method, the Latin Hypercube is employed. The reliability index is used as reference parameter for the probabilistic assessment.Ministerio de Economía y Competitividad of Spain and the European Regional Development Fund under project RTI2018-094945-B-C21Universidad de Sevilla Ref: USE-17047-GSpanish Ministry of Science, Innovation and Universities project SEED-SD RTI2018-099639-B-I0
Coffee consumption increases the antioxidant capacity of plasma and has no effect on the lipid profile or vascular function in healthy adults in a randomized controlled trial
ABSTRACT: Coffee, a source of antioxidants, has controversial effects on cardiovascular health. Objective: We evaluated the bioavailability of chlorogenic acids (CGAs) in 2 coffees and the effects of their consumption on the plasma antioxidant capacity (AC), the serum lipid profile, and the vascular function in healthy adults. Methods: Thirty-eight men and 37 women with a mean 6 SD age of 38.5 6 9 y and body mass index of 24.1 6 2.6 kg/m2 were randomly assigned to 3 groups: a control group that did not consume coffee or a placebo and 2 groups that consumed 400 mL coffee/d for 8 wk containing a medium (MCCGA; 420 mg) or high (HCCGA; 780 mg) CGA content. Both were low in diterpenes (0.83 mg/d) and caffeine (193 mg/d). Plasma caffeic and ferulic acid concentrations were measured by GC, and the plasma AC was evaluated with use of the ferric-reducing antioxidant power method. The serum lipid profile, nitric oxide (NO) plasma metabolites, vascular endothelial function (flow-mediated dilation; FMD), and blood pressure (BP) were evaluated.Results: After coffee consumption (1 h and 8 wk), caffeic and ferulic acid concentrations increased in the coffee-drinking
groups, although the values of the 2 groups were significantly different (P < 0.001); caffeic and ferulic acid concentrations were undetectable in the control group. At 1 h after consumption, the plasma AC in the control group was significantly lower than the baseline value (22%) and significantly increased in the MCCGA (6%) and HCCGA (5%) groups (P < 0.05). After 8 wk, no significant differences in the lipid, FMD, BP, or NO plasma metabolite values were observed between the groups. Conclusions: Both coffees, which contained CGAs and were low in diterpenes and caffeine, provided bioavailable CGAs and had a positive acute effect on the plasma AC in healthy adults and no effect on blood lipids or vascular function. The group that did not drink coffee showed no improvement in serum lipid profile, FMD, BP, or NO plasma metabolites. This trial was registered at registroclinico.sld.cu as RPCEC00000168
Del color de los ojos al interior del genoma. Nuevas tecnologías aplicadas a la educación: una experiencia en la enseñanza de la Genética
Depto. de Genética, Fisiología y MicrobiologíaFac. de Ciencias BiológicasFALSEsubmitte
Herramientas de aprendizaje para estudiantes de secundaria en el campo de la Genética
Se ha diseñado una actividad: la caracterización molecular de la mutación de un gen que modifica el color de los ojos en Drosophila melanogaster, partiendo de un carácter morfológico, el color de los ojos, se obtendrá la secuencia del gen responsable y su localización en el genoma de la especie. Se pretende desarrollar una actividad práctica que permita a los alumnos de segundo ciclo de la ESO comprender la genética y la genómica y cómo estos conocimientos se pueden aplicar a distintas áreas: salud, biotecnología o impacto ambiental
III Jornadas de Jóvenes Investigadores en Arqueología: Libro de Actas
Libro de Actas de las III Jornadas de Jóvenes Investigadores en Arqueologí
Effectiveness of an intervention for improving drug prescription in primary care patients with multimorbidity and polypharmacy:Study protocol of a cluster randomized clinical trial (Multi-PAP project)
This study was funded by the Fondo de Investigaciones Sanitarias ISCIII (Grant Numbers PI15/00276, PI15/00572, PI15/00996), REDISSEC (Project Numbers RD12/0001/0012, RD16/0001/0005), and the European Regional Development Fund ("A way to build Europe").Background: Multimorbidity is associated with negative effects both on people's health and on healthcare systems. A key problem linked to multimorbidity is polypharmacy, which in turn is associated with increased risk of partly preventable adverse effects, including mortality. The Ariadne principles describe a model of care based on a thorough assessment of diseases, treatments (and potential interactions), clinical status, context and preferences of patients with multimorbidity, with the aim of prioritizing and sharing realistic treatment goals that guide an individualized management. The aim of this study is to evaluate the effectiveness of a complex intervention that implements the Ariadne principles in a population of young-old patients with multimorbidity and polypharmacy. The intervention seeks to improve the appropriateness of prescribing in primary care (PC), as measured by the medication appropriateness index (MAI) score at 6 and 12months, as compared with usual care. Methods/Design: Design:pragmatic cluster randomized clinical trial. Unit of randomization: family physician (FP). Unit of analysis: patient. Scope: PC health centres in three autonomous communities: Aragon, Madrid, and Andalusia (Spain). Population: patients aged 65-74years with multimorbidity (≥3 chronic diseases) and polypharmacy (≥5 drugs prescribed in ≥3months). Sample size: n=400 (200 per study arm). Intervention: complex intervention based on the implementation of the Ariadne principles with two components: (1) FP training and (2) FP-patient interview. Outcomes: MAI score, health services use, quality of life (Euroqol 5D-5L), pharmacotherapy and adherence to treatment (Morisky-Green, Haynes-Sackett), and clinical and socio-demographic variables. Statistical analysis: primary outcome is the difference in MAI score between T0 and T1 and corresponding 95% confidence interval. Adjustment for confounding factors will be performed by multilevel analysis. All analyses will be carried out in accordance with the intention-to-treat principle. Discussion: It is essential to provide evidence concerning interventions on PC patients with polypharmacy and multimorbidity, conducted in the context of routine clinical practice, and involving young-old patients with significant potential for preventing negative health outcomes. Trial registration: Clinicaltrials.gov, NCT02866799Publisher PDFPeer reviewe
Treatment with tocilizumab or corticosteroids for COVID-19 patients with hyperinflammatory state: a multicentre cohort study (SAM-COVID-19)
Objectives: The objective of this study was to estimate the association between tocilizumab or corticosteroids and the risk of intubation or death in patients with coronavirus disease 19 (COVID-19) with a hyperinflammatory state according to clinical and laboratory parameters.
Methods: A cohort study was performed in 60 Spanish hospitals including 778 patients with COVID-19 and clinical and laboratory data indicative of a hyperinflammatory state. Treatment was mainly with tocilizumab, an intermediate-high dose of corticosteroids (IHDC), a pulse dose of corticosteroids (PDC), combination therapy, or no treatment. Primary outcome was intubation or death; follow-up was 21 days. Propensity score-adjusted estimations using Cox regression (logistic regression if needed) were calculated. Propensity scores were used as confounders, matching variables and for the inverse probability of treatment weights (IPTWs).
Results: In all, 88, 117, 78 and 151 patients treated with tocilizumab, IHDC, PDC, and combination therapy, respectively, were compared with 344 untreated patients. The primary endpoint occurred in 10 (11.4%), 27 (23.1%), 12 (15.4%), 40 (25.6%) and 69 (21.1%), respectively. The IPTW-based hazard ratios (odds ratio for combination therapy) for the primary endpoint were 0.32 (95%CI 0.22-0.47; p < 0.001) for tocilizumab, 0.82 (0.71-1.30; p 0.82) for IHDC, 0.61 (0.43-0.86; p 0.006) for PDC, and 1.17 (0.86-1.58; p 0.30) for combination therapy. Other applications of the propensity score provided similar results, but were not significant for PDC. Tocilizumab was also associated with lower hazard of death alone in IPTW analysis (0.07; 0.02-0.17; p < 0.001).
Conclusions: Tocilizumab might be useful in COVID-19 patients with a hyperinflammatory state and should be prioritized for randomized trials in this situatio
Derecho ex cathedra. 1847-1936 Diccionario de catedráticos españoles
Edición revisada 2020.Publicación de las entradas biográficas del Diccionario de catedráticos españoles de Derecho, accesible en http://www.uc3m.es/diccionariodecatedraticos. Al dar forma de libro al material hemos prescindido de algunos elementos informativos, que se mantienen en la página electrónica indicada. Se recogen ahora solamente a los ingresados en el cuerpo con anterioridad a la guerra civil.Publication of the biographical entries of the Diccionario de catedráticos españoles de Derecho, accessible at http://www.uc3m.es/diccionariodecatedraticos. By giving those material book form, we have dispensed with some informative elements, however kept on the web page. Only professors apointed prior to the Civil War are now included.Esta publicación forma parte del proyecto “La memoria del jurista español: génesis y
desarrollo de las disciplinas jurídicas” (ref. DER2014-55035-C2-1-P/DER2014-55035-C2-2-P), financiado por el Ministerio de Economía, Industria y Competitividad (España)
Semilleros de Investigación 2013, n.° 28
"Unijus promueve y apoya el desarrollo e implementación de programas y proyectos de investigación que aporten al conocimiento de la realidad nacional e internacional, de las instituciones jurídicas, políticas y sociales, así como de las teorías jurídicas y políticas que contribuyan a la construcción de nuevas propuestas para la solución de las problemáticas que aquejan la sociedad.
Por tal motivo, es fundamental el apoyo constante a la formación de semilleros de investigación en la Facultad de Derecho, Ciencias Políticas y Sociales de la Sede Bogotá, así como la consolidación de los semilleros ya existentes. En el año 2013, se desarrollaron las Convocatorias No. 01 y 02 de 2013 para la Selección de Semilleros de Investigación de la Facultad de Derecho, Ciencias Políticas y Sociales. Como resultado de dicho proceso fueron seleccionadas trece propuestas de investigación integradas por un total de 47 estudiantes, quienes a su vez se encontraban vinculados a 7 grupos de investigación.""Presentación
Acercamiento a la reforma del Consejo de Seguridad de las Naciones Unidas:
Una mirada a las propuestas de México, Argentina y Brasil
Reflections on Legal Education: an Approach to the Escuela de Derecho Propio Laureano Inampués Cuatín
Iliana Jineth Yepes Acuña, Simón Camilo Hernández Gaona, Paula Alejandra Poveda Cocuy, Francisco Javier Quito Córdoba, Sonia Catalina Villamizar Almeyda
Grupo de investigación en Relaciones Internacionales y Asuntos Globales - RIAG
Intervención en el Bronx: Análisis descriptivo de una apuesta alternativa en política pública de seguridad humana
Intervention in the Bronx: Descriptive Analysis of an alternative bet on Public Policy and human security
Ana María Tarazona Galvis, Carolina Cristancho Zarco, Andrés Felipe Espinosa Zuluaga, Fredy Hernando Caro y Sergio Iván González Machetá
Grupo de Investigación en Seguridad y Defensa -GISDE
Conflictos socioterritoriales en la región Andina Oriental de Colombia: una mirada al campesinado y a las formas contemporáneas de la lucha por la tierra y el territorio
Socio-territorial Conflicts in the East Andes Region of Colombia: A glance at the Peasantry and Contemporary Ways of Struggle for Land and Territory
Catherine Moore Torres, Julián Eduardo Naranjo Vasco
Grupo Interdisciplinario de Estudios Políticos y Sociales - Theseus
Territorios, resistencias y espacialidad en la geopolítica de la globalización
Territory, Strength and Spatiality in the Geopolitics of Globalization
Sindy Katherine Castro Herrera, Camila Andrea Galindo Martínez, Paula Andrea Ricaurte Ávila, Natalia Briceño Hernández, John Freddy Gómez Celi, Ángela Beatriz Torres Tamayo
Grupo Interdisciplinario de Estudios Políticos y Sociales - Theseus
Territorio y construcción de subjetividades en Bogotá. Transferencias entre lo rural y lo urbano en las localidades de Chapinero, Usme y Ciudad Bolívar
Territory and construction of subjectivities in Bogotá. Transfers between the rural and the urban in the localities of Chapinero, Usme and Ciudad Bolívar
Javier Alejandro Jiménez González, David Fernando Salamanca Paternina, Diana Paola López Bojacá
Grupo de Investigación Presidencialismo y Participación
Los jóvenes y la paz: la incógnita de La Habana
Young People and Peace: the Unknown of Havana
Sara Camila Arias Castañeda, Reina Alejandra Jiménez Díaz, Brahiam Fernando Quintana Martínez, Fernando Villada Agudelo
Grupo de investigación Presidencialismo y Participación
Análisis jurídico-crítico de la producción normativa en materia ambiental en el período 2003-2013 con énfasis en el Proyecto de reforma al Código Nacional de Recursos Naturales Renovables
Legal-Critical Analysis of Legislation Production in Environmental Law in the Period of 2003-2013 with an Emphasis on the National Code of Renewable Natural Resources
Diana Sofía Díaz Castro, Natalia Alejandra Rodríguez Vargas, Adriana María Guerrero Arias
Grupo de Investigación en Derechos Colectivos y Ambientales - GIDCA
Conflictividad ambiental por monocultivos de palma aceitera en Tibú, Norte de Santander
Environmental Conflict for Oil Palm Plantations in Tibú, North of Santander
José Agustín Labrador Forero, Carlos Eduardo Olaya Díaz
Grupo de Investigación en Derechos Colectivos y Ambientales - GIDCA
Campañas electorales: lo que se puede y lo que se debería comunicar
Electoral Campaigns: what can be communicated and what should be communicated
Daniela Alvarado Rincón, Freddy Leonardo González Araque y Augusto Federico Padilla
Grupo de investigación Cultura Jurídico Política, Instituciones y Globalización
Tratamiento jurídico-social de la obscenidad en Colombia: Aproximación desde la jurisprudencia de la Corte Constitucional
Legal and social treatment of obscenity in Colombia: Approximation from the jurisprudence of the Constitutional Court
Germán Darío Rodríguez González, Luisa Fernanda Ortiz Rodríguez, Diego Ricardo Cárdenas Nonsoque
Grupo de investigación Cultura Jurídico Política, Instituciones y Globalización
Mujeres indígenas y prácticas de justicia
Indigenous Women and Practices of Justice
Luisa María Ocaña Muñoz, Sibelys Katina Mejía Rodríguez, Viviana Patricia López Rubio, Damaris Alejandra Quintero Leyva
Grupo de investigación Escuela de Justicia Comunitaria de la Universidad Nacional (EJCUN)
Justicia en red: Caminando hacia el empoderamiento y la construcción de ciudadanía para Bogotá
Justice in Network: towards the Empowerment and the Construction of Citizenship in Bogotá
Alejandra Méndez Molano, Jenny Alejandra Tamayo Tamayo
Grupo de investigación Escuela de Justicia Comunitaria de la Universidad Nacional (EJCUN)
Reflexiones sobre la educación legal: Una aproximación a la Escuela de Derecho Propio Laureano Inampués Cuatín
Reflections on Legal Education: an Approach to the Escuela de Derecho Propio Laureano Inampués Cuatín
Krisly Tatiana Amaya Osorio, Juan Sebastián Urdaneta Forero, Miguel Ángel Salas Dorado
Grupo de investigación Escuela de Justicia Comunitaria de la Universidad Nacional (EJCUN)