Behaviour and accidents in young children and adolescents

The Mater-University Study of Pregnancy recruited a cohort of 8,458 Brisbane women during pregnancy. Subsequent follow-ups of mother and child occurred a few days, 6 months, 5 years and 14 years after birth, with the collection of a wide range of biological, sociological and behavioural information as well as measures of mental and physical health. In anticipation of a further cohort follow-up (funded by CARRS-Q) aimed specifically at examining risk-taking behaviour and road crashes in young drivers, the present paper examines the relationship between child and adolescent behaviour and the occurrence of accidents. This indicates that children with behaviour problems, particularly social and attentional disorders at age 5 years are nearly twice as likely to have had an accident in the past three months. While there is some evidence of continuity of accident occurrence (27% of children whose mother’s reported an accident at age 5 years also were also reported to have had an accident requiring medical attention in the last year) this association was weak. Behaviour problems, as measured by the Child Services, police or Juvenile Aid Bureau at age 14 also predict accident occurrence at age 14. ‘Binge drinking’ (consumption of seven or more alcoholic drinks at a time), while rare in this sample (2%) was associated with a doubling of accident risk. The next phase of MUSP will involve administering a questionnaire focused on risk taking behaviour to adolescents, followed up by later record linkage to accident reports and medical records to obtain end-points of road crashes and accident morbidity

The Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia : design, results and future prospects

The impact of many unfavorable childhood traits or diseases, such as low birth weight and mental disorders, is not limited to childhood and adolescence, as they are also associated with poor outcomes in adulthood, such as cardiovascular disease. Insight into the genetic etiology of childhood and adolescent traits and disorders may therefore provide new perspectives, not only on how to improve wellbeing during childhood, but also how to prevent later adverse outcomes. To achieve the sample sizes required for genetic research, the Early Growth Genetics (EGG) and EArly Genetics and Lifecourse Epidemiology (EAGLE) consortia were established. The majority of the participating cohorts are longitudinal population-based samples, but other cohorts with data on early childhood phenotypes are also involved. Cohorts often have a broad focus and collect(ed) data on various somatic and psychiatric traits as well as environmental factors. Genetic variants have been successfully identified for multiple traits, for example, birth weight, atopic dermatitis, childhood BMI, allergic sensitization, and pubertal growth. Furthermore, the results have shown that genetic factors also partly underlie the association with adult traits. As sample sizes are still increasing, it is expected that future analyses will identify additional variants. This, in combination with the development of innovative statistical methods, will provide detailed insight on the mechanisms underlying the transition from childhood to adult disorders. Both consortia welcome new collaborations. Policies and contact details are available from the corresponding authors of this manuscript and/or the consortium websites.Peer reviewe

Genetic association study of childhood aggression across raters, instruments, and age

Childhood aggressive behavior (AGG) has a substantial heritability of around 50%. Here we present a genome-wide association metaanalysis (GWAMA) of childhood AGG, in which all phenotype measures across childhood ages from multiple assessors were included. We analyzed phenotype assessments for a total of 328 935 observations from 87 485 children aged between 1.5 and 18 years, while accounting for sample overlap. We also meta-analyzed within subsets of the data, i.e., within rater, instrument and age. SNP-heritability for the overall meta-analysis AGGoverall was 3.31% (SE= 0.0038). We found no genome-wide significant SNPs for AGGoverall. The gene-based analysis returned three significant genes: ST3GAL3 (P= 1.6E-06), PCDH7 (P= 2.0E-06), and IPO13 (P= 2.5E-06). All three genes have previously been associated with educational traits. Polygenic scores based on our GWAMA significantly predicted aggression in a holdout sample of children (variance explained = 0.44%) and in retrospectively assessed childhood aggression (variance explained = 0.20%). Genetic correlations rg among rater-specific assessment of AGG ranged from rg= 0.46 between self- and teacher-assessment to rg= 0.81 between mother- and teacher-assessment. We obtained moderate-to-strong rgs with selected phenotypes from multiple domains, but hardly with any of the classical biomarkers thought to be associated with AGG. Significant genetic correlations were observed with most psychiatric and psychological traits (range |rg|: 0.19-1.00), except for obsessive-compulsive disorder. Aggression had a negative genetic correlation (rg=∼-0.5) with cognitive traits and age at first birth. Aggression was strongly genetically correlated with smoking phenotypes (range |rg| : 0.46-0.60). The genetic correlations between aggression and psychiatric disorders were weaker for teacher-reported AGG than for mother- and self-reported AGG. The current GWAMA of childhood aggression provides a powerful tool to interrogate the rater-specific genetic etiology of AGG.</p

Changes to commercial service provision among sex workers from Queensland, Australia

Introduction - The role of commercial sex in facilitating infection transmission is a subject of ongoing empirical enquiry, with little attention to the variety and extent of ‘non-traditional’ commercial services that pose a lesser risk of infection. This study sought to examine the supply and demand of a wide range of traditional and non-traditional commercial sexual services among sex workers and their clients from Queensland, Australia. Methods - Cross-sectional convenience sampling was used to compare female sex workers in 1991 (n=200, aged 16-46 years) and 2003 (n=247, aged 18-57 years) and from male clients in 2003. The client sample comprised 160 male clients aged between 19 and 72 years. Results - Over the comparison period there was a significant increase in the provision of ‘exotic’ or non-traditional sexual services. In 2003, the availability of bondage and discipline, submission, fantasy, use of sex toys, golden showers, fisting and lesbian double acts had increased dramatically, while ‘traditional’ services had mostly remained at similar levels. Moreover, the proportion of sex workers in some industry sectors providing ‘exotic’ commercial services seem to have risen over time. Conclusion - Undoubtedly, the sex industry has professionalised and now includes more sophisticated and specialized suppliers. As with any commercial business, the diversification of services is largely driven with client demand, with the ‘menu’ being generally broader than the majority of client preferences. However, although clients demands for particular commercial sexual services seems to have been met, with regard to anal sex and anal play, supply has failed to meet client demand. Disclosure of Interest Statement: Funding for the 2003 study was provided by the Prostitution Licensing Authority. Acknowledgement and sincere thanks to the men and women who participated in this study

Australian occupational mortality, 1965–67: cause specific or general susceptibility

Summary There have been few attempts to examine theories of disease causation using occupational mortality data. This may be due in part to the fact that only a few countries have systematically produced details of occupational mortality. It is well known that some occupational groups are clearly at increased mortality risk from a number of specific causes of death (e.g. industrial workers and accidents). Other occupational groups may be at increased risk from a number of causes of death (e.g. miners and lung cancer, emphysema, industrial accidents). A third, and more interesting group of workers, are those who may be at increased risk from most causes of death. Such workers may be described as being subject to a general susceptibility to disease and death. Using Australian mortality data, a number of occupational groups and their mortality patterns are examined. Two theories of disease causation (psychosom‐aticist and sociosomaticist) have been advanced to explain the finding that some occupational groups exhibit a general susceptibility to most causes of death

The health of female sex workers from three industry sectors in Queensland, Australia

Previous studies have reported poor mental health amongst sex workers without distinguishing the context in which commercial sex is provided. This study describes the self-reported mental and physical health of female sex workers in three industry sectors in Queensland, Australia. In 2003, cross-sectional convenience sampling was used to collect data from 247 female sex workers working in licensed brothels (n = 102), as private sole operators (n = 103) and illegally (n = 42). The average age was 32 years (range 18-57), with most participants being born either in Australia or New Zealand. Overall, there were few differences in the physical health of women from different industry sectors. Illegal (and predominantly street-based) sex workers were four times more likely to report poor mental health with some of this difference attributable to the particular social background of this group. Much of the increased levels of poor mental health among illegal sex workers were associated with more negative experiences before, and subsequent to entering the sex industry. These patterns were not seen among women from the legal industry sectors. This research suggests that illegal, street-based sex workers, from whom many previous results have been derived, may show patterns of disadvantage, and health outcomes not seen in sex workers from other industry sectors.Australia Women Sex work Sex industry Physical health Mental health Illegal sex work Violence