二分亀頭を伴った陰茎海綿体異物の1例

We had an opportunity to treat a rare case of foreign body in the corpus cavernosum in a patient with cleft glans penis. The foreign body was a 13 cm wire, which was inserted by the patient himself for masturbation, and was removed surgically. To our knowledge, such a case has never been reported in the literature

Association between Single-Nucleotide Polymorphisms in Selectin Genes and Immunoglobulin A Nephropathy

Although intensive efforts have been undertaken to elucidate the genetic background of immunoglobulin A nephropathy (IgAN), genetic factors associated with the pathogenesis of this disease are still not well understood. We designed a case-control association study that was based on linkage disequilibrium among single-nucleotide polymorphisms (SNPs) in the selectin gene cluster on chromosome 1q24-25, and we found two SNPs in the E-selectin gene (SELE8 and SELE13) and six SNPs in the L-selectin gene (SELL1, SELL4, SELL5, SELL6, SELL10, and SELL11) that were significantly associated with IgAN in Japanese patients. All eight SNPs were in almost complete linkage disequilibrium. SELE8 and SELL10 caused amino acid substitutions from His to Tyr and from Pro to Ser (χ(2)=9.02, P=.0026, odds ratio = 2.73 [95% confidence interval {CI} 1.38–5.38] for His-to-Tyr substitutions; χ(2)=17.4, P=.000031, odds ratio = 3.61 [95% CI 1.91–6.83] for Pro-to-Ser substitutions), and SELL1 could affect promoter activity of the L-selectin gene (χ(2)=19.5, P=.000010, odds ratio = 3.77 [95% CI 2.02–7.05]). The TGT haplotype at these three loci was associated significantly with IgAN (χ(2)=18.67, P=.000016, odds ratio = 1.88 [95% CI 1.41–2.51]). Our results suggest that these eight SNPs in selectin genes may be useful for screening populations susceptible to the IgAN phenotype that involves interstitial infiltration