IRAS versus POTENT Density Fields on Large Scales: Biasing and Omega

The galaxy density field as extracted from the IRAS 1.2 Jy redshift survey is compared to the mass density field as reconstructed by the POTENT method from the Mark III catalog of peculiar velocities. The reconstruction is done with Gaussian smoothing of radius 12 h^{-1}Mpc, and the comparison is carried out within volumes of effective radii 31-46 h^{-1}Mpc, containing approximately 10-26 independent samples. Random and systematic errors are estimated from multiple realizations of mock catalogs drawn from a simulation that mimics the observed density field in the local universe. The relationship between the two density fields is found to be consistent with gravitational instability theory in the mildly nonlinear regime and a linear biasing relation between galaxies and mass. We measure beta = Omega^{0.6}/b_I = 0.89 \pm 0.12 within a volume of effective radius 40 h^{-1}Mpc, where b_I is the IRAS galaxy biasing parameter at 12 h^{-1}Mpc. This result is only weakly dependent on the comparison volume, suggesting that cosmic scatter is no greater than \pm 0.1. These data are thus consistent with Omega=1 and b_I\approx 1. If b_I>0.75, as theoretical models of biasing indicate, then Omega>0.33 at 95% confidence. A comparison with other estimates of beta suggests scale-dependence in the biasing relation for IRAS galaxies.Comment: 35 pages including 10 figures, AAS Latex, Submitted to The Astrophysical Journa

The X-ray Cluster Dipole

We estimate the dipole of the whole sky X-ray flux-limited sample of Abell/ACO clusters (XBACs) and compare it to the optical Abell/ACO cluster dipole. The X-ray cluster dipole is well aligned ($\le 25^{\circ}$) with the CMB dipole, while it follows closely the radial profile of its optical cluster counterpart although its amplitude is $\sim 10 - 30$ per cent lower. In view of the fact that the the XBACs sample is not affected by the volume incompleteness and the projection effects that are known to exist at some level in the optical parent Abell/ACO cluster catalogue, our present results confirm the previous optical cluster dipole analysis that there are significant contributions to the Local Group motion from large distances ($\sim 160h^{-1}$Mpc). In order to assess the expected contribution to the X-ray cluster dipole from a purely X-ray selected sample we compare the dipoles of the XBACs and the Brightest Cluster Sample (Ebeling et al. 1997a) in their overlap region. The resulting dipoles are in mutual good aggreement with an indication that the XBACs sample slightly underestimates the full X-ray dipole (by $\le 5$ per cent) while the Virgo cluster contributes about 10 - 15 per cent to the overall X-ray cluster dipole. Using linear perturbation theory to relate the X-ray cluster dipole to the Local group peculiar velocity we estimate the density parameter to be $\beta_{c_{x}} \simeq 0.24 \pm 0.05$.Comment: 16 pages, latex, + 4 ps figures, submitted to Ap

Nonlinearity and stochasticity in the density--velocity relation

We present results of the investigations of the statistical properties of a joint density and velocity divergence probability distribution function (PDF) in the mildly non-linear regime. For that purpose we use both perturbation theory results, extended here for a top-hat filter, and numerical simulations. In particular we derive the quantitative (complete as possible up to third order terms) and qualitative predictions for constrained averages and constrained dispersions -- which describe the nonlinearities and the stochasticity properties beyond the linear regime -- and compare them against numerical simulations. We find overall a good agreement for constrained averages; however, the agreement for constrained dispersions is only qualitative. Scaling relations for the Omega-dependence of these quantities are satisfactory reproduced. Guided by our analytical and numerical results, we finally construct a robust phenomenological description of the joint PDF in a closed analytic form. The good agreement of our formula with results of N-body simulations for a number of cosmological parameters provides a sound validation of the presented approach. Our results provide a basis for a potentially powerful tool with which it is possible to analyze galaxy survey data in order to test the gravitational instability paradigm beyond the linear regime and put useful constraints on cosmological parameters. In particular we show how the nonlinearity in the density--velocity relation can be used to break the so-called Omega-bias degeneracy in cosmic density-velocity comparisons.Comment: 12 pages, 11 figures; revised version with minor changes in the presentation, accepted for publication in MNRA

De Novo Truncating Mutations in WASF1 Cause Intellectual Disability with Seizures.

Next-generation sequencing has been invaluable in the elucidation of the genetic etiology of many subtypes of intellectual disability in recent years. Here, using exome sequencing and whole-genome sequencing, we identified three de novo truncating mutations in WAS protein family member 1 (WASF1) in five unrelated individuals with moderate to profound intellectual disability with autistic features and seizures. WASF1, also known as WAVE1, is part of the WAVE complex and acts as a mediator between Rac-GTPase and actin to induce actin polymerization. The three mutations connected by Matchmaker Exchange were c.1516C>T (p.Arg506Ter), which occurs in three unrelated individuals, c.1558C>T (p.Gln520Ter), and c.1482delinsGCCAGG (p.Ile494MetfsTer23). All three variants are predicted to partially or fully disrupt the C-terminal actin-binding WCA domain. Functional studies using fibroblast cells from two affected individuals with the c.1516C>T mutation showed a truncated WASF1 and a defect in actin remodeling. This study provides evidence that de novo heterozygous mutations in WASF1 cause a rare form of intellectual disability

Prognostic model to predict postoperative acute kidney injury in patients undergoing major gastrointestinal surgery based on a national prospective observational cohort study.

Background: Acute illness, existing co-morbidities and surgical stress response can all contribute to postoperative acute kidney injury (AKI) in patients undergoing major gastrointestinal surgery. The aim of this study was prospectively to develop a pragmatic prognostic model to stratify patients according to risk of developing AKI after major gastrointestinal surgery. Methods: This prospective multicentre cohort study included consecutive adults undergoing elective or emergency gastrointestinal resection, liver resection or stoma reversal in 2-week blocks over a continuous 3-month period. The primary outcome was the rate of AKI within 7 days of surgery. Bootstrap stability was used to select clinically plausible risk factors into the model. Internal model validation was carried out by bootstrap validation. Results: A total of 4544 patients were included across 173 centres in the UK and Ireland. The overall rate of AKI was 14·2 per cent (646 of 4544) and the 30-day mortality rate was 1·8 per cent (84 of 4544). Stage 1 AKI was significantly associated with 30-day mortality (unadjusted odds ratio 7·61, 95 per cent c.i. 4·49 to 12·90; P < 0·001), with increasing odds of death with each AKI stage. Six variables were selected for inclusion in the prognostic model: age, sex, ASA grade, preoperative estimated glomerular filtration rate, planned open surgery and preoperative use of either an angiotensin-converting enzyme inhibitor or an angiotensin receptor blocker. Internal validation demonstrated good model discrimination (c-statistic 0·65). Discussion: Following major gastrointestinal surgery, AKI occurred in one in seven patients. This preoperative prognostic model identified patients at high risk of postoperative AKI. Validation in an independent data set is required to ensure generalizability

Research and Client-Based Projects

This chapter will:; ; ; Show how to develop a needs analysis based on sound research principles;; ; ; Examine a number of different client-based projects that have taken a business discourse approach to teaching;; ; ; Discuss different ways in which business discourse research can be used in the classroom;; ; ; Present a case study that illustrates how business discourse projects can be incorporated into teaching practices together with a set of tasks related to the use of business discourse research in the classroom and a set of further readings

Invasive Predators Deplete Genetic Diversity of Island Lizards

Invasive species can dramatically impact natural populations, especially those living on islands. Though numerous examples illustrate the ecological impact of invasive predators, no study has examined the genetic consequences for native populations subject to invasion. Here we capitalize on a natural experiment in which a long-term study of the brown anole lizard (Anolis sagrei) was interrupted by rat invasion. An island population that was devastated by rats recovered numerically following rat extermination. However, population genetic analyses at six microsatellite loci suggested a possible loss of genetic diversity due to invasion when compared to an uninvaded island studied over the same time frame. Our results provide partial support for the hypothesis that invasive predators can impact the genetic diversity of resident island populations

On the Centrality of Redemption: Linking the State and Credit Theories of Money Through a Financial Approach to Money

The paper presents a financial approach to monetary analysis that links the credit and state theories of money. A premise of the functional approach to money is that "money is what money does." In this approach, monetary and mercantile mechanics are conflated, which leads to the conclusion that unconvertible monetary instruments are worthless. The financial approach to money strictly separates the two mechanics and argues that major monetary disruptions occurred when the two were conflated. Monetary instruments have always been promissory notes. As such, their financial characteristics are central to their value and liquidity. One of the main financial requirements of any monetary instrument is that it be redeemable at any time. As long as this is the case, the fair value of an unconvertible monetary instrument is its face value. While the functional approach does not recognize the centrality of redemption, the paper shows that redemption plays a critical role in the state and credit views of money. Payments due to issuer and/or convertibility on demand are central to the possibility of par circulation. The paper shows that this has major implications for monetary analysis, both in terms of understanding monetary history and in terms of performing monetary analysis