Free space-coupled superconducting nanowire single photon detectors for infrared optical communications

This paper describes the construction of a cryostat and an optical system with a free-space coupling efficiency of 56.5% +/- 3.4% to a superconducting nanowire single-photon detector (SNSPD) for infrared quantum communication and spectrum analysis. A 1K pot decreases the base temperature to T = 1.7 K from the 2.9 K reached by the cold head cooled by a pulse-tube cryocooler. The minimum spot size coupled to the detector chip was 6.6 +/- 0.11 {\mu}m starting from a fiber source at wavelength, {\lambda} = 1.55 {\mu}m. We demonstrated efficient photon counting on a detector with an 8 x 7.3 {\mu}m^2 area. We measured a dark count rate of 95 +/- 3.35 kcps and a system detection efficiency of 1.64% +/- 0.13%. We explain the key steps that are required to further improve the coupling efficiency.Comment: 16 pages, double-space

Inhibition of Melanogenesis by the Pyridinyl Imidazole Class of Compounds: Possible Involvement of the Wnt/β-Catenin Signaling Pathway

While investigating the role of p38 MAPK in regulating melanogenesis, we found that pyridinyl imidazole inhibitors class compounds as well as the analog compound SB202474, which does not inhibit p38 MAPK, suppressed both α-MSH-induced melanogenesis and spontaneous melanin synthesis. In this study, we demonstrated that the inhibitory activity of the pyridinyl imidazoles correlates with inhibition of the canonical Wnt/β-catenin pathway activity. Imidazole-treated cells showed a reduction in the level of Tcf/Lef target genes involved in the β-catenin signaling network, including ubiquitous genes such as Axin2, Lef1, and Wisp1 as well as cell lineage-restricted genes such as microphthalmia-associated transcription factor and dopachrome tautomerase. Although over-expression of the Wnt signaling pathway effector β-catenin slightly restored the melanogenic program, the lack of complete reversion suggested that the imidazoles interfered with β-catenin-dependent transcriptional activity rather than with β-catenin expression. Accordingly, we did not observe any significant change in β-catenin protein expression. The independence of p38 MAPK activity from the repression of Wnt/β-catenin signaling pathway was confirmed by small interfering RNA knockdown of p38 MAPK expression, which by contrast, stimulated β-catenin-driven gene expression. Our data demonstrate that the small molecule pyridinyl imidazoles possess two distinct and opposite mechanisms that modulate β-catenin dependent transcription: a p38 inhibition-dependent effect that stimulates the Wnt pathway by increasing β-catenin protein expression and an off-target mechanism that inhibits the pathway by repressing β-catenin protein functionality. The p38-independent effect seems to be dominant and, at least in B16-F0 cells, results in a strong block of the Wnt/β-catenin signaling pathway

Attitude Control and Stabilization of Spacecraft with a Captured Asteroid

National Aeronautics and Space Administration's Asteroid Redirect Mission (ARM) aims to capture a Near Earth Orbit (NEO) asteroid or a piece of a large asteroid and transport it to the Earth{Moon system. In this paper, we provide a detailed analysis of one of the main control challenges for the first ARM mission concept, namely despinning and three-axis stabilizing the asteroid and spacecraft combination after the ARM spacecraft captures the tumbling NEO asteroid. We first show that control laws, which explicitly use the dynamics of the system in their control law equation, encounter a fundamental limitation due to modeling uncertainties. We show that in the presence of large modeling uncertainties, the resultant disturbance torque for such control laws may well exceed the maximum control torque of the conceptual ARM spacecraft. We then numerically compare the performance of three viable control laws: the robust nonlinear tracking control law, the adaptive nonlinear tracking control law, and the simple derivative plus proportional-derivative linear control strategy. We conclude that under very small mod- eling uncertainties, which can be achieved using online system identification, the robust nonlinear tracking control law guarantees exponential convergence to the fuel-optimal reference trajectory and hence consumes the least fuel. On the other hand, in the presence of large modeling uncertainties, measurement errors, and actuator saturations, the best strategy for stabilizing the asteroid and spacecraft combination is to first despin the system using a derivative (rate damping) linear control law and then stabilize the system in the desired orientation using the simple proportional-derivative linear control law. More-over, the fuel consumed by the conceptual ARM spacecraft using these control strategies is upper bounded by 300 kg for the nominal range of NEO asteroid parameters. We conclude this paper with specific design guidelines for the ARM spacecraft for efficiently stabilizing the tumbling NEO asteroid and spacecraft combination

Ion Thermal Decoupling and Species Separation in Shock-Driven Implosions

Anomalous reduction of the fusion yields by 50% and anomalous scaling of the burn-averaged ion temperatures with the ion-species fraction has been observed for the first time in D[superscript 3]He-filled shock-driven inertial confinement fusion implosions. Two ion kinetic mechanisms are used to explain the anomalous observations: thermal decoupling of the D and [superscript 3]He populations and diffusive species separation. The observed insensitivity of ion temperature to a varying deuterium fraction is shown to be a signature of ion thermal decoupling in shock-heated plasmas. The burn-averaged deuterium fraction calculated from the experimental data demonstrates a reduction in the average core deuterium density, as predicted by simulations that use a diffusion model. Accounting for each of these effects in simulations reproduces the observed yield trends.United States. National Nuclear Security Administration (Grant DE-NA0001857)University of Rochester. Fusion Science Center (Grant 415023-G)National Laser User’s Facility (Grant DE-NA0002035)University of Rochester. Laboratory for Laser Energetics (Grant 415935-G)Lawrence Livermore National Laboratory (Grant B600100

Exploration of the Transition from the Hydrodynamiclike to the Strongly Kinetic Regime in Shock-Driven Implosions

Clear evidence of the transition from hydrodynamiclike to strongly kinetic shock-driven implosions is, for the first time, revealed and quantitatively assessed. Implosions with a range of initial equimolar D[superscript 3]He gas densities show that as the density is decreased, hydrodynamic simulations strongly diverge from and increasingly overpredict the observed nuclear yields, from a factor of ∼2 at 3.1  mg/cm[superscript 3] to a factor of 100 at 0.14  mg/cm[superscript 3]. (The corresponding Knudsen number, the ratio of ion mean-free path to minimum shell radius, varied from 0.3 to 9; similarly, the ratio of fusion burn duration to ion diffusion time, another figure of merit of kinetic effects, varied from 0.3 to 14.) This result is shown to be unrelated to the effects of hydrodynamic mix. As a first step to garner insight into this transition, a reduced ion kinetic (RIK) model that includes gradient-diffusion and loss-term approximations to several transport processes was implemented within the framework of a one-dimensional radiation-transport code. After empirical calibration, the RIK simulations reproduce the observed yield trends, largely as a result of ion diffusion and the depletion of the reacting tail ions.United States. Dept. of Energy (Grant DE-NA0001857)United States. Dept. of Energy (Grant DE-FC52-08NA28752)University of Rochester. Fusion Science Center (5-24431)National Laser User’s Facility (DE-NA0002035)University of Rochester. Laboratory for Laser Energetics (415935-G)Lawrence Livermore National Laboratory (B597367

Follicular lymphoma international prognostic index.

The prognosis of follicular lymphomas (FL) is heterogeneous and numerous treatments may be proposed. A validated prognostic index (PI) would help in evaluating and choosing these treatments. Characteristics at diagnosis were collected from 4167 patients with FL diagnosed between 1985 and 1992. Univariate and multivariate analyses were used to propose a PI. This index was then tested on 919 patients. Five adverse prognostic factors were selected: age (> 60 years vs or = 120 g/L), number of nodal areas (> 4 vs or = 3 adverse factors, 27% of patients, HR = 4.3). This Follicular Lymphoma International Prognostic Index (FLIPI) appeared more discriminant than the International Prognostic Index proposed for aggressive non-Hodgkin lymphomas. Results were very similar in the confirmation group. The FLIPI may be used for improving treatment choices, comparing clinical trials, and designing studies to evaluate new treatments

ORAI1 calcium channel orchestrates skin homeostasis

To achieve and maintain skin architecture and homeostasis, keratinocytes must intricately balance growth, differentiation, and polarized motility known to be governed by calcium. Orai1 is a pore subunit of a store-operated Ca(2+) channel that is a major molecular counterpart for Ca(2+) influx in nonexcitable cells. To elucidate the physiological significance of Orai1 in skin, we studied its functions in epidermis of mice, with targeted disruption of the orai1 gene, human skin sections, and primary keratinocytes. We demonstrate that Orai1 protein is mainly confined to the basal layer of epidermis where it plays a critical role to control keratinocyte proliferation and polarized motility. Orai1 loss of function alters keratinocyte differentiation both in vitro and in vivo. Exploring underlying mechanisms, we show that the activation of Orai1-mediated calcium entry leads to enhancing focal adhesion turnover via a PKCβ-Calpain-focal adhesion kinase pathway. Our findings provide insight into the functions of the Orai1 channel in the maintenance of skin homeostasis

A Single-Photon Imager Based on Microwave Plasmonic Superconducting Nanowire

Detecting spatial and temporal information of individual photons by using single-photon-detector (SPD) arrays is critical to applications in spectroscopy, communication, biological imaging, astronomical observation, and quantum-information processing. Among the current SPDs1,detectors based on superconducting nanowires have outstanding performance2, but are limited in their ability to be integrated into large scale arrays due to the engineering difficulty of high-bandwidth cryogenic electronic readout3-8. Here, we address this problem by demonstrating a scalable single-photon imager using a single continuous photon-sensitive superconducting nanowire microwave-plasmon transmission line. By appropriately designing the nanowire's local electromagnetic environment so that the nanowire guides microwave plasmons, the propagating voltages signals generated by a photon-detection event were slowed down to ~ 2% of the speed of light. As a result, the time difference between arrivals of the signals at the two ends of the nanowire naturally encoded the position and time of absorption of the photon. Thus, with only two readout lines, we demonstrated that a 19.7-mm-long nanowire meandered across an area of 286 {\mu}m * 193 {\mu}m was capable of resolving ~590 effective pixels while simultaneously recording the arrival times of photons with a temporal resolution of 50 ps. The nanowire imager presents a scalable approach to realizing high-resolution photon imaging in time and space

Fighting Misconceptions to Improve Compliance with Influenza Vaccination among Health Care Workers: An Educational Project

The compliance with influenza vaccination is poor among health care workers (HCWs) due to misconceptions about safety and effectiveness of influenza vaccine. We proposed an educational prospective study to demonstrate to HCWs that influenza vaccine is safe and that other respiratory viruses (RV) are the cause of respiratory symptoms in the months following influenza vaccination. 398 HCWs were surveyed for adverse events (AE) occurring within 48 h of vaccination. AE were reported by 30% of the HCWs. No severe AE was observed. A subset of 337 HCWs was followed up during four months, twice a week, for the detection of respiratory symptoms. RV was diagnosed by direct immunofluorescent assay (DFA) and real time PCR in symptomatic HCWs. Influenza A was detected in five episodes of respiratory symptoms (5.3%) and other RV in 26 (27.9%) episodes. The incidence density of influenza and other RV was 4.3 and 10.8 episodes per 100 HCW-month, respectively. The educational nature of the present study may persuade HCWs to develop a more positive attitude to influenza vaccination