Current Star Formation in the Perseus Molecular Cloud: Constraints from Unbiased Submillimeter and Mid-Infrared Surveys

We present a census of the population of deeply embedded young stellar objects (YSOs) in the Perseus molecular cloud complex based on a combination of Spitzer Space Telescope mid-IR data from the c2d legacy team and JCMT/SCUBA submillimeter maps from the COMPLETE team. The mid-IR sources detected at 24 micron and having [3.6]-[4.5] > 1 are located close to the center of the SCUBA cores, typically within 15" of their peaks. The narrowness of the spatial distribution of mid-IR sources around the peaks of the SCUBA cores suggests that no significant dispersal of the newly formed YSOs has occurred. This argues against the suggestion that motions of protostars regulate the time scales over which significant (Bondi-Hoyle) accretion can occur. The most deeply embedded YSOs are found in regions with high extinction, AV > 5, similar to the extinction threshold observed for the SCUBA cores. All the SCUBA cores with high concentrations have embedded YSOs, but not all cores with low concentrations are starless. An unbiased sample of 49 deeply embedded YSOs is constructed. Embedded YSOs are found in 40 of the 72 SCUBA cores with only three cores harboring multiple embedded YSOs within 15". The equal number of SCUBA cores with and without embedded YSOs suggests that the time scale for the evolution through the dense prestellar stages, where the cores are recognized in the submillimeter maps and have central densities of 5e4-1e5 cm^{-3}, is similar to the time scale for the embedded protostellar stages. The current star formation efficiency of cores is estimated to be approximately 10-15%. In contrast, the star formation efficiency averaged over the cloud life time and compared to the total cloud mass is only a few percent, reflecting also the efficiency in assembling cloud material into the dense cores forming stars.Comment: Accepted for publication in ApJ (36 pages, 13 figures

A retrospective study of administration of vaccination for hepatitis B among newborn infants prior to hospital discharge at a midwestern tertiary care center

Infants are at high risk of developing chronic, life-threatening disease as a result of hepatitis B virus infection. Universal vaccination of infants against hepatitis B virus, before discharge from the hospital after delivery is recommended as a measure to eradicate infection and associated mortality and morbidity. The purpose of this study was to determine rates of perinatal hepatitis B vaccine (Hep B) administration at a tertiary care center in Iowa and to assess the impact of maternal factors on Hep B uptake

Bullying at University: The Social and Legal Contexts of Cyberbullying Among University Students

Students within the university sector are ‘digital natives’. Technology is not ‘new’ or ‘alien’ to them, but rather it is an accepted and normalised part of everyday life (Simmons et al., 2016). With this level of expertise and competence, we could assume that university students are relatively happy with their online relationships. However, in recent years there has been a growing realisation that, for some students at least, the online world is a very dangerous place.The age of the students is of key importance here too, as those in higher and further education are young adults, rather than children in need of parental support. From this perspective, the university as an institution has a duty of care to its students in their learning environment regardless of their age. In this article, we consider the social and cultural contexts which either promote or discourage cyberbullying among university students. Finally, the implications for policies, training and awareness-raising are discussed along with ideas for possible future research in this under researched area

Enhanced Extinction of Aversive Memories by High-Frequency Stimulation of the Rat Infralimbic Cortex

Electrical stimulation of the rodent medial prefrontal cortex (mPFC), including the infralimbic cortex (IL), immediately prior to or during fear extinction training facilitates extinction memory. Here we examined the effects of high-frequency stimulation (HFS) of the rat IL either prior to conditioning or following retrieval of the conditioned memory, on extinction of Pavlovian fear and conditioned taste aversion (CTA). IL-HFS applied immediately after fear memory retrieval, but not three hours after retrieval or prior to conditioning, subsequently reduced freezing during fear extinction. Similarly, IL-HFS given immediately, but not three hours after, retrieval of a CTA memory reduced aversion during extinction. These data indicate that HFS of the IL may be an effective method for reducing both learned fear and learned aversion

Defining and Detecting Malaria Epidemics in the Highlands of Western Kenya

Epidemic detection algorithms are being increasingly recommended for malaria surveillance in sub-Saharan Africa. We present the results of applying three simple epidemic detection techniques to routinely collected longitudinal pediatric malaria admissions data from three health facilities in the highlands of western Kenya in the late 1980s and 1990s. The algorithms tested were chosen because they could be feasibly implemented at the health facility level in sub-Saharan Africa. Assumptions of these techniques about the normal distribution of admissions data and the confidence intervals used to define normal years were also investigated. All techniques identified two “epidemic” years in one of the sites. The untransformed Cullen method with standard confidence intervals detected the two “epidemic” years in the remaining two sites but also triggered many false alarms. The performance of these methods is discussed and comments made about their appropriateness for the highlands of western Keny

Формирование эмоциональной культуры как компонента инновационной культуры студентов

Homozygosity has long been associated with rare, often devastating, Mendelian disorders1 and Darwin was one of the first to recognise that inbreeding reduces evolutionary fitness2. However, the effect of the more distant parental relatedness common in modern human populations is less well understood. Genomic data now allow us to investigate the effects of homozygosity on traits of public health importance by observing contiguous homozygous segments (runs of homozygosity, ROH), which are inferred to be homozygous along their complete length. Given the low levels of genome-wide homozygosity prevalent in most human populations, information is required on very large numbers of people to provide sufficient power3,4. Here we use ROH to study 16 health-related quantitative traits in 354,224 individuals from 102 cohorts and find statistically significant associations between summed runs of homozygosity (SROH) and four complex traits: height, forced expiratory lung volume in 1 second (FEV1), general cognitive ability (g) and educational attainment (nominal p<1 × 10−300, 2.1 × 10−6, 2.5 × 10−10, 1.8 × 10−10). In each case increased homozygosity was associated with decreased trait value, equivalent to the offspring of first cousins being 1.2 cm shorter and having 10 months less education. Similar effect sizes were found across four continental groups and populations with different degrees of genome-wide homozygosity, providing convincing evidence for the first time that homozygosity, rather than confounding, directly contributes to phenotypic variance. Contrary to earlier reports in substantially smaller samples5,6, no evidence was seen of an influence of genome-wide homozygosity on blood pressure and low density lipoprotein (LDL) cholesterol, or ten other cardio-metabolic traits. Since directional dominance is predicted for traits under directional evolutionary selection7, this study provides evidence that increased stature and cognitive function have been positively selected in human evolution, whereas many important risk factors for late-onset complex diseases may not have been

Common variants at ABCA7, MS4A6A/MS4A4E, EPHA1, CD33 and CD2AP are associated with Alzheimer's disease

We sought to identify new susceptibility loci for Alzheimer's disease through a staged association study (GERAD+) and by testing suggestive loci reported by the Alzheimer's Disease Genetic Consortium (ADGC) in a companion paper. We undertook a combined analysis of four genome-wide association datasets (stage 1) and identified ten newly associated variants with P ≤ 1 × 10−5. We tested these variants for association in an independent sample (stage 2). Three SNPs at two loci replicated and showed evidence for association in a further sample (stage 3). Meta-analyses of all data provided compelling evidence that ABCA7 (rs3764650, meta P = 4.5 × 10−17; including ADGC data, meta P = 5.0 × 10−21) and the MS4A gene cluster (rs610932, meta P = 1.8 × 10−14; including ADGC data, meta P = 1.2 × 10−16) are new Alzheimer's disease susceptibility loci. We also found independent evidence for association for three loci reported by the ADGC, which, when combined, showed genome-wide significance: CD2AP (GERAD+, P = 8.0 × 10−4; including ADGC data, meta P = 8.6 × 10−9), CD33 (GERAD+, P = 2.2 × 10−4; including ADGC data, meta P = 1.6 × 10−9) and EPHA1 (GERAD+, P = 3.4 × 10−4; including ADGC data, meta P = 6.0 × 10−10)