1,278 research outputs found
The physiological variability of channel density in hippocampal CA1 pyramidal cells and interneurons explored using a unified data-driven modeling workflow
Every neuron is part of a network, exerting its function by transforming multiple spatiotemporal synaptic input patterns into a single spiking output. This function is specified by the particular shape and passive electrical properties of the neuronal membrane, and the composition and spatial distribution of ion channels across its processes. For a variety of physiological or pathological reasons, the intrinsic input/output function may change during a neuron’s lifetime. This process results in high variability in the peak specific conductance of ion channels in individual neurons. The mechanisms responsible for this variability are not well understood, although there are clear indications from experiment and modeling that degeneracy and correlation among multiple channels may be involved. Here, we studied this issue in biophysical models of hippocampal CA1 pyramidal neurons and interneurons. Using a unified data-driven simulation workflow and starting from a set of experimental recordings and morphological reconstructions obtained from rats, we built and analyzed several ensembles of morphologically and biophysically accurate single cell models with intrinsic electrophysiological properties consistent with experimental findings. The results suggest that the set of conductances expressed in any given hippocampal neuron may be considered as belonging to two groups: one subset is responsible for the major characteristics of the firing behavior in each population and the other responsible for a robust degeneracy. Analysis of the model neurons suggests several experimentally testable predictions related to the combination and relative proportion of the different conductances that should be expressed on the membrane of different types of neurons for them to fulfill their role in the hippocampus circuitry
Counting valence quarks at RHIC and LHC
We consider the Nuclear Modification Ratios in heavy ion collisions, R_CP and
R_AA, in the region of intermediate transverse momentum, and study the
dependency upon the constituent quark composition of the observed hadron.
Adopting a two component recombination/fragmentation model, validated by
experimental information from STAR and PHENIX, we show that a clear distinction
is predicted for the f0(980) between the assumptions of or
diquark-antidiquark content.Comment: 14 pages, 11 eps figures, added figures and minor corrections, to
appear in Phys. Lett.
A switchable controlled-NOT gate in a spin-chain NMR quantum computer
A method of switching a controlled-NOT gate in a solid-stae NMR quantum
computer is presented. Qubits of I=1/2 nuclear spins are placed periodically
along a quantum spin chain (1-D antiferromagnet) having a singlet ground state
with a finite spin gap to the lowest excited state caused by some quantum
effect. Irradiation of a microwave tuned to the spin gap energy excites a
packet of triplet magnons at a specific part of the chain where control and
target qubits are involved. The packet switches on the Suhl-Nakamura
interaction between the qubits, which serves as a controlled NOT gate. The
qubit initialization is achieved by a qubit initializer consisting of
semiconducting sheets attached to the spin chain, where spin polarizations
created by the optical pumping method in the semiconductors are transferred to
the spin chain. The scheme allows us to separate the initialization process
from the computation, so that one can optimize the computation part without
being restricted by the initialization scheme, which provides us with a wide
selection of materials for a quantum computer.Comment: 8 pages, 5 figure
Calculating Quenching Weights
We calculate the probability (``quenching weight'') that a hard parton
radiates an additional energy fraction due to scattering in spatially extended
QCD matter. This study is based on an exact treatment of finite in-medium path
length, it includes the case of a dynamically expanding medium, and it extends
to the angular dependence of the medium-induced gluon radiation pattern. All
calculations are done in the multiple soft scattering approximation
(Baier-Dokshitzer-Mueller-Peign\'e-Schiff--Zakharov ``BDMPS-Z''-formalism) and
in the single hard scattering approximation (N=1 opacity approximation). By
comparison, we establish a simple relation between transport coefficient, Debye
screening mass and opacity, for which both approximations lead to comparable
results. Together with this paper, a CPU-inexpensive numerical subroutine for
calculating quenching weights is provided electronically. To illustrate its
applications, we discuss the suppression of hadronic transverse momentum
spectra in nucleus-nucleus collisions. Remarkably, the kinematic constraint
resulting from finite in-medium path length reduces significantly the
transverse momentum dependence of the nuclear modification factor, thus leading
to consistency with the data measured at the Relativistic Heavy Ion Collider
(RHIC).Comment: 45 pages LaTeX, 20 eps-figure
Impacts of local human activities on the Antarctic environment
We review the scientific literature, especially from the past decade, on the impacts of human activities on the Antarctic environment. A range of impacts has been identified at a variety of spatial and temporal scales. Chemical contamination and sewage disposal on the continent have been found to be long-lived. Contemporary sewage management practices at many coastal stations are insufficient to prevent local contamination but no introduction of non-indigenous organisms through this route has yet been demonstrated. Human activities, particularly construction and transport, have led to disturbances of flora and fauna. A small number of non-indigenous plant and animal species has become established, mostly on the northern Antarctic Peninsula and southern archipelagos of the Scotia Arc. There is little indication of recovery of overexploited fish stocks, and ramifications of fishing activity oil bycatch species and the ecosystem could also be far-reaching. The Antarctic Treaty System and its instruments, in particular the Convention for the Conservation of Antarctic Marine Living Resources and the Environmental Protocol, provide a framework within which management of human activities take place. In the face of the continuing expansion of human activities in Antarctica, a more effective implementation of a wide range of measures is essential, in order to ensure comprehensive protection of the Antarctic environment, including its intrinsic, wilderness and scientific values which remains a fundamental principle of the Antarctic Treaty System. These measures include effective environmental impact assessments, long-term monitoring, mitigation measures for non-indigenous species, ecosystem-based management of living resources, and increased regulation of National Antarctic Programmes and tourism activities
HI in Local Group analogs: what does it tell us about galaxy formation?
We present the results of our HI survey of six loose groups of galaxies
analogous to the Local Group. The survey was conducted using the Parkes
telescope and the Australia Telescope Compact Array to produce a census of all
the gas-rich galaxies and potential analogs to the high-velocity clouds (HVCs)
within these groups down to M(HI)<10^7 M(sun) as a test of models of galaxy
formation. We present the HI mass function and halo mass function for these
analogous groups and compare them with the Local Group and other environments.
We also demonstrate that our non-detection of HVC analogs in these groups
implies that they must have low HI masses and be clustered tightly around
galaxies, including around our own Milky Way, and are not distributed
throughout the Local Group.Comment: 5 pages, To appear in ESO Astrophysics Symposia: "Groups of Galaxies
in the Nearby Universe
Performance of prototypes for the ALICE electromagnetic calorimeter
The performance of prototypes for the ALICE electromagnetic sampling
calorimeter has been studied in test beam measurements at FNAL and CERN. A
array of final design modules showed an energy resolution of about
11% / 1.7 % with a uniformity of the response
to electrons of 1% and a good linearity in the energy range from 10 to 100 GeV.
The electromagnetic shower position resolution was found to be described by 1.5
mm 5.3 mm /. For an electron identification
efficiency of 90% a hadron rejection factor of was obtained.Comment: 10 pages, 10 figure
HI in the Outskirts of Nearby Galaxies
The HI in disk galaxies frequently extends beyond the optical image, and can
trace the dark matter there. I briefly highlight the history of high spatial
resolution HI imaging, the contribution it made to the dark matter problem, and
the current tension between several dynamical methods to break the disk-halo
degeneracy. I then turn to the flaring problem, which could in principle probe
the shape of the dark halo. Instead, however, a lot of attention is now devoted
to understanding the role of gas accretion via galactic fountains. The current
cold dark matter theory has problems on galactic scales, such as
the core-cusp problem, which can be addressed with HI observations of dwarf
galaxies. For a similar range in rotation velocities, galaxies of type Sd have
thin disks, while those of type Im are much thicker. After a few comments on
modified Newtonian dynamics and on irregular galaxies, I close with statistics
on the HI extent of galaxies.Comment: 38 pages, 17 figures, invited review, book chapter in "Outskirts of
Galaxies", Eds. J. H. Knapen, J. C. Lee and A. Gil de Paz, Astrophysics and
Space Science Library, Springer, in pres
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